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PubMed:1715516 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 25-52 protein denotes T-cell transcription factor
T2 213-226 cell_type denotes T lymphocytes
T3 303-326 protein denotes T-cell antigen receptor
T4 330-344 DNA denotes cytokine genes
T5 386-418 protein denotes putative intracellular receptors
T6 507-516 protein denotes isomerase
T7 557-566 protein denotes isomerase
T8 594-623 cell_line denotes cyclosporin-resistant mutants
T9 702-720 protein denotes inhibitory complex
T10 742-751 protein denotes isomerase
T11 780-789 protein denotes isomerase
T12 802-822 protein denotes transcription factor
T13 824-829 protein denotes NF-AT
T14 1009-1016 cell_type denotes T cells
T15 1077-1098 protein denotes transcription factors
T16 1107-1111 protein denotes AP-1
T17 1116-1126 protein denotes NF-kappa B
T18 1153-1158 protein denotes NF-AT
T19 1192-1208 protein denotes antigen receptor
T20 1338-1343 protein denotes NF-AT
T21 1396-1417 protein denotes cytoplasmic component
T22 1453-1468 protein denotes nuclear subunit

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-89 Sentence denotes Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A.
S2 90-209 Sentence denotes Cyclosporin A and FK506 inhibit T- and B-cell activation and other processes essential to an effective immune response.
S3 210-381 Sentence denotes In T lymphocytes these drugs disrupt an unknown step in the transmission of signals from the T-cell antigen receptor to cytokine genes that coordinate the immune response.
S4 382-477 Sentence denotes The putative intracellular receptors for FK506 and cyclosporin are cis-trans prolyl isomerases.
S5 478-799 Sentence denotes Binding of the drug inhibits isomerase activity, but studies with other prolyl isomerase inhibitors and analysis of cyclosporin-resistant mutants in yeast suggest that the effects of the drug result from the formation of an inhibitory complex between the drug and isomerase, and not from inhibition of isomerase activity.
S6 800-1127 Sentence denotes A transcription factor, NF-AT, which is essential for early T-cell gene activation, seems to be a specific target of cyclosporin A and FK506 action because transcription directed by this protein is blocked in T cells treated with these drugs, with little or no effect on other transcription factors such as AP-1 and NF-kappa B.
S7 1128-1344 Sentence denotes Here we demonstrate that NF-AT is formed when a signal from the antigen receptor induces a pre-existing cytoplasmic subunit to translocate to the nucleus and combine with a newly synthesized nuclear subunit of NF-AT.
S8 1345-1469 Sentence denotes FK506 and cyclosporin A block translocation of the cytoplasmic component without affecting synthesis of the nuclear subunit.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 25-31 NP denotes T-cell
C1 23-52 NP denotes a T-cell transcription factor
C3 64-88 NP denotes FK-506 and cyclosporin A
C4 90-113 NP denotes Cyclosporin A and FK506
C5 180-208 NP denotes an effective immune response
C6 213-226 NP denotes T lymphocytes
C7 227-238 NP denotes these drugs
C9 303-309 NP denotes T-cell
C8 299-326 NP denotes the T-cell antigen receptor
C10 330-344 NP denotes cytokine genes
C11 345-349 NP denotes that
C12 361-380 NP denotes the immune response
C13 423-444 NP denotes FK506 and cyclosporin
C14 489-497 NP denotes the drug
C15 507-525 NP denotes isomerase activity
C16 780-798 NP denotes isomerase activity
C17 800-822 NP denotes A transcription factor
C18 824-829 NP denotes NF-AT
C19 831-836 NP denotes which
C20 917-940 NP denotes cyclosporin A and FK506
C21 982-994 NP denotes this protein
C22 1009-1016 NP denotes T cells
C23 1030-1041 NP denotes these drugs
C24 1071-1098 NP denotes other transcription factors
C25 1107-1126 NP denotes AP-1 and NF-kappa B
C26 1153-1158 NP denotes NF-AT
C27 1188-1208 NP denotes the antigen receptor
C28 1217-1251 NP denotes a pre-existing cytoplasmic subunit
C30 1338-1343 NP denotes NF-AT
C29 1299-1343 NP denotes a newly synthesized nuclear subunit of NF-AT
C31 1345-1368 NP denotes FK506 and cyclosporin A
C32 1392-1417 NP denotes the cytoplasmic component
C33 1449-1468 NP denotes the nuclear subunit
R1 C1 C18 coref-ident a T-cell transcription factor,NF-AT
R2 C4 C3 coref-ident Cyclosporin A and FK506,FK-506 and cyclosporin A
R3 C6 C2 coref-ident T lymphocytes,T-cell
R4 C7 C4 coref-ident these drugs,Cyclosporin A and FK506
R5 C9 C6 coref-ident T-cell,T lymphocytes
R6 C11 C10 coref-relat that,cytokine genes
R7 C12 C5 coref-ident the immune response,an effective immune response
R8 C13 C4 coref-ident FK506 and cyclosporin,Cyclosporin A and FK506
R9 C14 C13 coref-ident the drug,FK506 and cyclosporin
R10 C16 C15 coref-ident isomerase activity,isomerase activity
R11 C17 C18 coref-appos A transcription factor,NF-AT
R12 C19 C18 coref-relat which,NF-AT
R13 C20 C13 coref-ident cyclosporin A and FK506,FK506 and cyclosporin
R14 C21 C18 coref-ident this protein,NF-AT
R15 C22 C9 coref-ident T cells,T-cell
R16 C23 C20 coref-ident these drugs,cyclosporin A and FK506
R17 C25 C24 coref-ident AP-1 and NF-kappa B,other transcription factors
R18 C26 C18 coref-ident NF-AT,NF-AT
R19 C27 C8 coref-ident the antigen receptor,the T-cell antigen receptor
R20 C30 C26 coref-ident NF-AT,NF-AT
R21 C31 C20 coref-ident FK506 and cyclosporin A,cyclosporin A and FK506
R22 C32 C28 coref-ident the cytoplasmic component,a pre-existing cytoplasmic subunit
R23 C33 C29 coref-ident the nuclear subunit,a newly synthesized nuclear subunit of NF-AT

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-19 other_name denotes Nuclear association
T2 25-52 protein_family_or_group denotes T-cell transcription factor
T3 64-70 other_organic_compound denotes FK-506
T4 75-88 other_organic_compound denotes cyclosporin A
T5 90-103 other_organic_compound denotes Cyclosporin A
T6 108-113 other_organic_compound denotes FK506
T7 122-146 other_name denotes T- and B-cell activation
T8 183-208 other_name denotes effective immune response
T9 213-226 cell_type denotes T lymphocytes
T10 303-326 protein_family_or_group denotes T-cell antigen receptor
T11 330-344 DNA_family_or_group denotes cytokine genes
T12 365-380 other_name denotes immune response
T13 386-418 protein_family_or_group denotes putative intracellular receptors
T14 423-428 other_organic_compound denotes FK506
T15 433-444 other_organic_compound denotes cyclosporin
T16 449-476 other_organic_compound denotes cis-trans prolyl isomerases
T17 507-516 protein_family_or_group denotes isomerase
T18 550-556 other_name denotes prolyl
T19 557-566 protein_family_or_group denotes isomerase
T20 594-605 other_organic_compound denotes cyclosporin
T21 627-632 mono_cell denotes yeast
T22 702-720 protein_complex denotes inhibitory complex
T23 742-751 protein_family_or_group denotes isomerase
T24 780-789 protein_family_or_group denotes isomerase
T25 802-822 protein_family_or_group denotes transcription factor
T26 824-829 protein_molecule denotes NF-AT
T27 860-882 other_name denotes T-cell gene activation
T28 917-928 other_organic_compound denotes cyclosporin
T29 935-940 other_organic_compound denotes FK506
T30 956-969 other_name denotes transcription
T31 1009-1016 cell_type denotes T cells
T32 1077-1098 protein_family_or_group denotes transcription factors
T33 1107-1111 protein_molecule denotes AP-1
T34 1116-1126 protein_molecule denotes NF-kappa B
T35 1153-1158 protein_molecule denotes NF-AT
T36 1192-1208 protein_family_or_group denotes antigen receptor
T37 1338-1343 protein_molecule denotes NF-AT
T38 1345-1350 other_organic_compound denotes FK506
T39 1355-1368 other_organic_compound denotes cyclosporin A
T40 1396-1417 protein_domain_or_region denotes cytoplasmic component
T41 1453-1468 protein_subunit denotes nuclear subunit