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c_corpus

Id Subject Object Predicate Lexical cue
T1 28-34 UBERON:0000310 denotes breast
T2 28-41 D001943 denotes breast cancer
T3 28-41 D001943 denotes breast cancer
T4 59-68 CHEBI:24621 denotes endocrine
T7 69-93 D002285 denotes ductal carcinoma-in-situ
T8 69-93 D002285 denotes ductal carcinoma-in-situ
T13 189-198 CHEBI:24621 denotes endocrine
T16 199-223 D002285 denotes ductal carcinoma-in-situ
T17 199-223 D002285 denotes ductal carcinoma-in-situ
T23 227-231 CVCL_5552 denotes DCIS
T22 227-231 D002285 denotes DCIS
T24 227-231 D002285 denotes DCIS
T25 261-267 UBERON:0000310 denotes breast
T26 261-274 D001943 denotes breast cancer
T27 261-274 D001943 denotes breast cancer
T29 294-298 CVCL_5552 denotes DCIS
T28 294-298 D002285 denotes DCIS
T30 294-298 D002285 denotes DCIS
T32 376-380 CVCL_5552 denotes DCIS
T31 376-380 D002285 denotes DCIS
T33 376-380 D002285 denotes DCIS
T34 501-506 D009369 denotes tumor
T35 501-506 D009369 denotes tumor
T36 588-601 P08247 denotes synaptophysin
T37 588-601 P20488 denotes synaptophysin
T39 588-601 PR:000015890 denotes synaptophysin
T40 588-601 Q5YJC1 denotes synaptophysin
T42 588-601 Q62277 denotes synaptophysin
T43 588-601 P07825 denotes synaptophysin
T38 588-601 D016708 denotes synaptophysin
T41 588-601 D016708 denotes synaptophysin
T44 606-612 CL:0000540 denotes neuron
T45 606-629 P17183 denotes neuron-specific enolase
T47 606-629 P09104 denotes neuron-specific enolase
T48 606-629 PR:000007081 denotes neuron-specific enolase
T49 606-629 P07323 denotes neuron-specific enolase
T46 606-629 D010751 denotes neuron-specific enolase
T882 643-647 CVCL_5552 denotes DCIS
T881 643-647 D002285 denotes DCIS
T883 643-647 D002285 denotes DCIS
T884 786-792 UBERON:0000310 denotes breast
T885 805-811 UBERON:0002030 denotes nipple
T887 841-845 CVCL_5552 denotes DCIS
T886 841-845 D002285 denotes DCIS
T888 841-845 D002285 denotes DCIS
T889 884-898 GO:0007150 denotes growth pattern
T890 884-898 GO:0040007 denotes growth pattern
T891 900-921 D018300 denotes Intraductal papilloma
T892 900-921 D018300 denotes Intraductal papilloma
T895 969-974 D009369 denotes tumor
T896 969-974 D009369 denotes tumor
T897 980-985 D009369 denotes tumor
T898 980-985 D009369 denotes tumor
T899 1008-1012 PR:P01012 denotes oval
T901 1016-1023 CVCL_E018 denotes spindle
T900 1016-1023 GO:0005819 denotes spindle
T902 1081-1090 GO:0005737 denotes cytoplasm
T903 1128-1134 CHEBI:33252 denotes nuclei
T904 1136-1149 GO:0005622 denotes Intracellular
T905 1153-1166 GO:0005576 denotes extracellular
T906 1167-1172 CHEBI:7010 denotes mucin
T907 1167-1172 D009077 denotes mucin
T908 1192-1205 D010504 denotes periodic acid
T909 1192-1205 D010504 denotes periodic acid
T910 1192-1205 CHEBI:29149 denotes periodic acid
T912 1206-1212 1046239 denotes Schiff
T913 1219-1227 D000681 denotes diastase
T914 1228-1237 GO:0007586 denotes digestion
T915 1242-1253 D000423 denotes alcian blue
T916 1242-1253 D000423 denotes alcian blue
T917 1254-1260 D004396 denotes stains
T918 1254-1260 D004396 denotes stains
T919 1267-1272 D009369 denotes tumor
T920 1267-1272 D009369 denotes tumor
T922 1394-1398 CVCL_5552 denotes DCIS
T921 1394-1398 D002285 denotes DCIS
T923 1394-1398 D002285 denotes DCIS
T924 1489-1493 PR:000001024 denotes CD56
T926 1584-1588 CVCL_5552 denotes DCIS
T925 1584-1588 D002285 denotes DCIS
T927 1584-1588 D002285 denotes DCIS
T929 1704-1708 CVCL_5552 denotes DCIS
T928 1704-1708 D002285 denotes DCIS
T930 1704-1708 D002285 denotes DCIS
T931 1727-1738 D006965 denotes hyperplasia
T932 1727-1738 D006965 denotes hyperplasia
T934 1755-1759 CVCL_5552 denotes DCIS
T933 1755-1759 D002285 denotes DCIS
T935 1755-1759 D002285 denotes DCIS
T937 1795-1799 CVCL_5552 denotes DCIS
T936 1795-1799 D002285 denotes DCIS
T938 1795-1799 D002285 denotes DCIS

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 199-223 HP_0030075 denotes ductal carcinoma-in-situ

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-95 DRI_Background denotes [Clinicopathologic study of breast cancer with features of endocrine ductal carcinoma-in-situ].
T2 101-233 DRI_Background denotes TIVE: To study the clinicopathologic features and differential diagnosis of 18 cases of endocrine ductal carcinoma-in-situ (E-DCIS).
T3 243-373 DRI_Background denotes Eighteen cases of breast cancer with features of E-DCIS were studied by light microscopy, histochemistry and immunohistochemistry.
T4 374-631 DRI_Approach denotes E-DCIS was diagnosed if the histologic patterns were compatible with those described in the literature and at least 50% of the tumor cells expressing two of the three neuroendocrine markers employed (chromogranin, synaptophysin and neuron-specific enolase).
T5 641-679 DRI_Background denotes E-DCIS tended to occur in older women.
T6 680-740 DRI_Approach denotes All the patients were over 61 years old (mean age=71 years).
T7 741-822 DRI_Background denotes The presenting symptoms were either palpable breast mass or had nipple discharge.
T8 823-899 DRI_Unspecified denotes Histologically, E-DCIS demonstrated an expansile intraductal growth pattern.
T9 900-975 DRI_Background denotes Intraductal papilloma was not uncommon at the peripheral area of the tumor.
T10 976-1135 DRI_Background denotes The tumor cells were polygonal, oval or spindle in shape and contained abundant eosinophilic to granular cytoplasm and mildly to moderately pleomorphic nuclei.
T11 1136-1261 DRI_Background denotes Intracellular or extracellular mucin was highlighted by periodic acid-Schiff (with diastase digestion) or alcian blue stains.
T12 1262-1315 DRI_Background denotes Some tumor cells assumed a signet-ring configuration.
T13 1316-1405 DRI_Approach denotes All the three neuroendocrine markers were expressed by more than 50% of the E-DCIS cells.
T14 1406-1488 DRI_Background denotes The neuroendocrine differentiation was further confirmed in some cases by CD57 and
T15 1489-1508 Token_Label.OUTSIDE denotes CD56 immunostaining
T16 1508-1509 DRI_Background denotes .
T17 1510-1660 DRI_Approach denotes Pagetoid spread into adjacent ductolobular units was frequently seen in E-DCIS, and the expanded lobules were often not rimmed by myoepithelial cells.
T18 1661-1739 DRI_Background denotes These two features helped to distinguish E-DCIS from usual ductal hyperplasia.
T19 1753-1871 DRI_Background denotes E-DCIS represents a subgroup of low-grade DCIS, which carries characteristic morphologic features and immunophenotype.
T20 1872-1938 DRI_Background denotes Conventional light microscopy usually permits a correct diagnosis.
T21 1939-2028 DRI_Background denotes Ancillary histochemical and immunohistochemical studies can be helpful in doubtful cases.

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 107-233 OBJECTIVE denotes To study the clinicopathologic features and differential diagnosis of 18 cases of endocrine ductal carcinoma-in-situ (E-DCIS).
T2 243-631 METHODS denotes Eighteen cases of breast cancer with features of E-DCIS were studied by light microscopy, histochemistry and immunohistochemistry. E-DCIS was diagnosed if the histologic patterns were compatible with those described in the literature and at least 50% of the tumor cells expressing two of the three neuroendocrine markers employed (chromogranin, synaptophysin and neuron-specific enolase).
T3 641-1739 RESULTS denotes E-DCIS tended to occur in older women. All the patients were over 61 years old (mean age=71 years). The presenting symptoms were either palpable breast mass or had nipple discharge. Histologically, E-DCIS demonstrated an expansile intraductal growth pattern. Intraductal papilloma was not uncommon at the peripheral area of the tumor. The tumor cells were polygonal, oval or spindle in shape and contained abundant eosinophilic to granular cytoplasm and mildly to moderately pleomorphic nuclei. Intracellular or extracellular mucin was highlighted by periodic acid-Schiff (with diastase digestion) or alcian blue stains. Some tumor cells assumed a signet-ring configuration. All the three neuroendocrine markers were expressed by more than 50% of the E-DCIS cells. The neuroendocrine differentiation was further confirmed in some cases by CD57 and CD56 immunostaining. Pagetoid spread into adjacent ductolobular units was frequently seen in E-DCIS, and the expanded lobules were often not rimmed by myoepithelial cells. These two features helped to distinguish E-DCIS from usual ductal hyperplasia.
T4 1753-2028 CONCLUSIONS denotes E-DCIS represents a subgroup of low-grade DCIS, which carries characteristic morphologic features and immunophenotype. Conventional light microscopy usually permits a correct diagnosis. Ancillary histochemical and immunohistochemical studies can be helpful in doubtful cases.