PubMed:17106921 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/17106921","sourcedb":"PubMed","sourceid":"17106921","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/17106921","text":"Crohn's disease: innate immunodeficiency?\nIn the past, Crohn's disease (CD) has been understood primarily as an immunologic disorder characterized by an abnormal T-cell response. Recent in vitro and in vivo data suggests that CD may instead be precipitated by innate immune dysfunction resulting from a combination of genetic and environmental factors. Some reports have demonstrated a defective immune response in a variety of other cellular components, including neutrophils, monocytes and dendritic cells. Recent studies of granulocyte-macrophage colony-stimulating factor (GM-CSF) in CD, aiming to stimulate the innate immune system with the conception that an innate immune defect underlies the development of the disease, have been demonstrated a clinical benefit and reinforce this evolving understanding of the disease.","tracks":[]}