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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 0-10 Glycan_Motif denotes Hyaluronan https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T2 308-318 Glycan_Motif denotes hyaluronan https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T3 320-322 Glycan_Motif denotes HA https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T4 629-631 Glycan_Motif denotes HA https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T5 772-774 Glycan_Motif denotes HA https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T6 1099-1101 Glycan_Motif denotes HA https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T7 1273-1275 Glycan_Motif denotes HA https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T8 1509-1511 Glycan_Motif denotes HA https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T9 1706-1708 Glycan_Motif denotes HA https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T10 1978-1980 Glycan_Motif denotes HA https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-253 Sentence denotes Hyaluronan-CD44 interaction with neural Wiskott-Aldrich syndrome protein (N-WASP) promotes actin polymerization and ErbB2 activation leading to beta-catenin nuclear translocation, transcriptional up-regulation, and cell migration in ovarian tumor cells.
T2 254-510 Sentence denotes In this study we have investigated the interaction of hyaluronan (HA) and CD44 with the neuronal Wiskott-Aldrich syndrome protein (N-WASP) in regulating actin polymerization and ErbB2/beta-catenin signaling in human ovarian tumor cells (SK-OV-3.ipl cells).
T3 511-758 Sentence denotes Biochemical and immunological analyses indicate that N-WASP is expressed in SK-OV-3.ipl cells and that the binding of HA stimulates N-WASP association with CD44 and Arp2/Arp3 leading to filamentous actin formation and ovarian tumor cell migration.
T4 759-944 Sentence denotes In addition, HA binding promotes CD44-N-WASP association with ErbB2 and activates ErbB2 kinase activity that in turn increases phosphorylation of the cytoskeletal protein, beta-catenin.
T5 945-1090 Sentence denotes Subsequently, phosphorylated beta-catenin is transported into the nucleus leading to beta-catenin-mediated TCF/LEF-transcriptional co-activation.
T6 1091-1371 Sentence denotes Because HA-induced beta-catenin phosphorylation, nuclear translocation, and TCF/LEF transcriptional activation is effectively blocked by the ErbB2 inhibitor, AG825, we conclude that HA/CD44-N-WASP-associated ErbB2 activation is required for beta-catenin-mediated signaling events.
T7 1372-1638 Sentence denotes Transfection of SK-OV-3.ipl cells with N-WASP-VCA (verpolin homology, cofilin homology, and acidic domain) fragment cDNA not only blocks HA/CD44-induced N-WASP-Arp2/3 complex formation but also inhibits actin polymerization/F-actin assembly and tumor cell migration.
T8 1639-1884 Sentence denotes Overexpression of the N-WASP-VCA domain also significantly reduces HA-induced ErbB2 recruitment to CD44, diminishes beta-catenin phosphorylation/nuclear translocation, and abrogates TCF/LEF-specific transcriptional co-activation by beta-catenin.
T9 1885-2149 Sentence denotes Taken together, our findings strongly suggest that N-WASP plays a pivotal role in regulating HA-mediated CD44-ErbB2 interaction, beta-catenin signaling, and actin cytoskeleton functions that are required for tumor-specific behaviors and ovarian cancer progression.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 0-10 https://glytoucan.org/Structures/Glycans/G00017MO denotes Hyaluronan
T2 308-318 https://glytoucan.org/Structures/Glycans/G00017MO denotes hyaluronan

DisGeNET

Id Subject Object Predicate Lexical cue
T0 11-15 gene:960 denotes CD44
T1 233-246 disease:C0919267 denotes ovarian tumor
T2 116-121 gene:2064 denotes ErbB2
T3 233-246 disease:C0919267 denotes ovarian tumor
T4 328-332 gene:960 denotes CD44
T5 470-483 disease:C0919267 denotes ovarian tumor
T6 676-680 gene:10097 denotes Arp2
T7 729-742 disease:C0919267 denotes ovarian tumor
T8 676-680 gene:23452 denotes Arp2
T9 729-742 disease:C0919267 denotes ovarian tumor
T10 676-680 gene:57379 denotes Arp2
T11 729-742 disease:C0919267 denotes ovarian tumor
T12 667-671 gene:960 denotes CD44
T13 729-742 disease:C0919267 denotes ovarian tumor
T14 681-685 gene:10096 denotes Arp3
T15 729-742 disease:C0919267 denotes ovarian tumor
T16 681-685 gene:100913187 denotes Arp3
T17 729-742 disease:C0919267 denotes ovarian tumor
T18 681-685 gene:200315 denotes Arp3
T19 729-742 disease:C0919267 denotes ovarian tumor
T20 1532-1536 gene:23452 denotes Arp2
T21 1617-1637 disease:C0027627 denotes tumor cell migration
T22 1532-1536 gene:10097 denotes Arp2
T23 1617-1637 disease:C0027627 denotes tumor cell migration
T24 1512-1516 gene:960 denotes CD44
T25 1617-1637 disease:C0027627 denotes tumor cell migration
T26 1532-1536 gene:57379 denotes Arp2
T27 1617-1637 disease:C0027627 denotes tumor cell migration
T28 1995-2000 gene:2064 denotes ErbB2
T29 2122-2136 disease:C1140680 denotes ovarian cancer
T30 1995-2000 gene:2064 denotes ErbB2
T31 2122-2136 disease:C0029925 denotes ovarian cancer
R1 T0 T1 associated_with CD44,ovarian tumor
R2 T2 T3 associated_with ErbB2,ovarian tumor
R3 T4 T5 associated_with CD44,ovarian tumor
R4 T6 T7 associated_with Arp2,ovarian tumor
R5 T8 T9 associated_with Arp2,ovarian tumor
R6 T10 T11 associated_with Arp2,ovarian tumor
R7 T12 T13 associated_with CD44,ovarian tumor
R8 T14 T15 associated_with Arp3,ovarian tumor
R9 T16 T17 associated_with Arp3,ovarian tumor
R10 T18 T19 associated_with Arp3,ovarian tumor
R11 T20 T21 associated_with Arp2,tumor cell migration
R12 T22 T23 associated_with Arp2,tumor cell migration
R13 T24 T25 associated_with CD44,tumor cell migration
R14 T26 T27 associated_with Arp2,tumor cell migration
R15 T28 T29 associated_with ErbB2,ovarian cancer
R16 T30 T31 associated_with ErbB2,ovarian cancer

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 470-483 HP_0100615 denotes ovarian tumor
T2 478-483 HP_0002664 denotes tumor
T3 729-742 HP_0100615 denotes ovarian tumor
T4 737-742 HP_0002664 denotes tumor
T5 1617-1622 HP_0002664 denotes tumor
T6 2093-2098 HP_0002664 denotes tumor
T7 2122-2136 HP_0100615 denotes ovarian cancer
T8 2130-2136 HP_0002664 denotes cancer
T1 470-483 HP_0100615 denotes ovarian tumor
T2 478-483 HP_0002664 denotes tumor
T3 729-742 HP_0100615 denotes ovarian tumor
T4 737-742 HP_0002664 denotes tumor
T5 1617-1622 HP_0002664 denotes tumor
T6 2093-2098 HP_0002664 denotes tumor
T7 2122-2136 HP_0100615 denotes ovarian cancer
T8 2130-2136 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
17092940-0#11#15#gene960 11-15 gene960 denotes CD44
17092940-0#33#72#gene8976 33-72 gene8976 denotes neural Wiskott-Aldrich syndrome protein
17092940-0#116#121#gene2064 116-121 gene2064 denotes ErbB2
17092940-0#233#246#diseaseC0919267 233-246 diseaseC0919267 denotes ovarian tumor
17092940-2#165#169#gene10097 676-680 gene10097 denotes Arp2
17092940-2#165#169#gene57379 676-680 gene57379 denotes Arp2
17092940-2#165#169#gene23452 676-680 gene23452 denotes Arp2
17092940-2#170#174#gene10096 681-685 gene10096 denotes Arp3
17092940-2#170#174#gene200315 681-685 gene200315 denotes Arp3
17092940-2#170#174#gene100913187 681-685 gene100913187 denotes Arp3
17092940-2#218#231#diseaseC0919267 729-742 diseaseC0919267 denotes ovarian tumor
17092940-6#160#164#gene10097 1532-1536 gene10097 denotes Arp2
17092940-6#160#164#gene57379 1532-1536 gene57379 denotes Arp2
17092940-6#160#164#gene23452 1532-1536 gene23452 denotes Arp2
17092940-6#140#144#gene960 1512-1516 gene960 denotes CD44
17092940-6#245#265#diseaseC0027627 1617-1637 diseaseC0027627 denotes tumor cell migration
17092940-6#245#265#diseaseC0027627 1617-1637 diseaseC0027627 denotes tumor cell migration
17092940-8#105#109#gene960 1990-1994 gene960 denotes CD44
17092940-8#110#115#gene2064 1995-2000 gene2064 denotes ErbB2
17092940-8#237#251#diseaseC0029925 2122-2136 diseaseC0029925 denotes ovarian cancer
17092940-8#237#251#diseaseC1140680 2122-2136 diseaseC1140680 denotes ovarian cancer
17092940-8#237#251#diseaseC0029925 2122-2136 diseaseC0029925 denotes ovarian cancer
17092940-8#237#251#diseaseC1140680 2122-2136 diseaseC1140680 denotes ovarian cancer
11#15#gene960233#246#diseaseC0919267 17092940-0#11#15#gene960 17092940-0#233#246#diseaseC0919267 associated_with CD44,ovarian tumor
33#72#gene8976233#246#diseaseC0919267 17092940-0#33#72#gene8976 17092940-0#233#246#diseaseC0919267 associated_with neural Wiskott-Aldrich syndrome protein,ovarian tumor
116#121#gene2064233#246#diseaseC0919267 17092940-0#116#121#gene2064 17092940-0#233#246#diseaseC0919267 associated_with ErbB2,ovarian tumor
165#169#gene10097218#231#diseaseC0919267 17092940-2#165#169#gene10097 17092940-2#218#231#diseaseC0919267 associated_with Arp2,ovarian tumor
165#169#gene57379218#231#diseaseC0919267 17092940-2#165#169#gene57379 17092940-2#218#231#diseaseC0919267 associated_with Arp2,ovarian tumor
165#169#gene23452218#231#diseaseC0919267 17092940-2#165#169#gene23452 17092940-2#218#231#diseaseC0919267 associated_with Arp2,ovarian tumor
170#174#gene10096218#231#diseaseC0919267 17092940-2#170#174#gene10096 17092940-2#218#231#diseaseC0919267 associated_with Arp3,ovarian tumor
170#174#gene200315218#231#diseaseC0919267 17092940-2#170#174#gene200315 17092940-2#218#231#diseaseC0919267 associated_with Arp3,ovarian tumor
170#174#gene100913187218#231#diseaseC0919267 17092940-2#170#174#gene100913187 17092940-2#218#231#diseaseC0919267 associated_with Arp3,ovarian tumor
160#164#gene10097245#265#diseaseC0027627 17092940-6#160#164#gene10097 17092940-6#245#265#diseaseC0027627 associated_with Arp2,tumor cell migration
160#164#gene10097245#265#diseaseC0027627 17092940-6#160#164#gene10097 17092940-6#245#265#diseaseC0027627 associated_with Arp2,tumor cell migration
160#164#gene57379245#265#diseaseC0027627 17092940-6#160#164#gene57379 17092940-6#245#265#diseaseC0027627 associated_with Arp2,tumor cell migration
160#164#gene57379245#265#diseaseC0027627 17092940-6#160#164#gene57379 17092940-6#245#265#diseaseC0027627 associated_with Arp2,tumor cell migration
160#164#gene23452245#265#diseaseC0027627 17092940-6#160#164#gene23452 17092940-6#245#265#diseaseC0027627 associated_with Arp2,tumor cell migration
160#164#gene23452245#265#diseaseC0027627 17092940-6#160#164#gene23452 17092940-6#245#265#diseaseC0027627 associated_with Arp2,tumor cell migration
140#144#gene960245#265#diseaseC0027627 17092940-6#140#144#gene960 17092940-6#245#265#diseaseC0027627 associated_with CD44,tumor cell migration
140#144#gene960245#265#diseaseC0027627 17092940-6#140#144#gene960 17092940-6#245#265#diseaseC0027627 associated_with CD44,tumor cell migration
105#109#gene960237#251#diseaseC0029925 17092940-8#105#109#gene960 17092940-8#237#251#diseaseC0029925 associated_with CD44,ovarian cancer
105#109#gene960237#251#diseaseC1140680 17092940-8#105#109#gene960 17092940-8#237#251#diseaseC1140680 associated_with CD44,ovarian cancer
105#109#gene960237#251#diseaseC0029925 17092940-8#105#109#gene960 17092940-8#237#251#diseaseC0029925 associated_with CD44,ovarian cancer
105#109#gene960237#251#diseaseC1140680 17092940-8#105#109#gene960 17092940-8#237#251#diseaseC1140680 associated_with CD44,ovarian cancer
110#115#gene2064237#251#diseaseC0029925 17092940-8#110#115#gene2064 17092940-8#237#251#diseaseC0029925 associated_with ErbB2,ovarian cancer
110#115#gene2064237#251#diseaseC1140680 17092940-8#110#115#gene2064 17092940-8#237#251#diseaseC1140680 associated_with ErbB2,ovarian cancer
110#115#gene2064237#251#diseaseC0029925 17092940-8#110#115#gene2064 17092940-8#237#251#diseaseC0029925 associated_with ErbB2,ovarian cancer
110#115#gene2064237#251#diseaseC1140680 17092940-8#110#115#gene2064 17092940-8#237#251#diseaseC1140680 associated_with ErbB2,ovarian cancer

CoMAGC

Id Subject Object Predicate Lexical cue
T1 116-121 Gene denotes ErbB2
E2 122-132 Positive_regulation denotes activation
T2 233-246 ovarian cancer denotes ovarian tumor
R1 T1 E2 themeOf ErbB2,activation
R3 T1 T2 CGE-increased ErbB2,ovarian tumor
R4 T1 T2 CCS-normalTOcancer ErbB2,ovarian tumor
R5 T1 T2 PT-causality ErbB2,ovarian tumor
R3 T1 T2 IGE-unidentifiable ErbB2,ovarian tumor

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 40-64 Disease denotes Wiskott-Aldrich syndrome http://purl.obolibrary.org/obo/MONDO_0010518
T2 233-246 Disease denotes ovarian tumor http://purl.obolibrary.org/obo/MONDO_0021068
T3 351-375 Disease denotes Wiskott-Aldrich syndrome http://purl.obolibrary.org/obo/MONDO_0010518
T4 470-483 Disease denotes ovarian tumor http://purl.obolibrary.org/obo/MONDO_0021068
T5 729-742 Disease denotes ovarian tumor http://purl.obolibrary.org/obo/MONDO_0021068
T6 1617-1622 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T7 2093-2098 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T8 2122-2136 Disease denotes ovarian cancer http://purl.obolibrary.org/obo/MONDO_0008170

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 464-469 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1011-1018 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125
T3 2042-2060 Body_part denotes actin cytoskeleton http://purl.obolibrary.org/obo/GO_0015629

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 233-246 Phenotype denotes ovarian tumor HP:0100615
T2 470-483 Phenotype denotes ovarian tumor HP:0100615
T3 729-742 Phenotype denotes ovarian tumor HP:0100615
T4 1617-1622 Phenotype denotes tumor HP:0002664
T5 2093-2098 Phenotype denotes tumor HP:0002664
T6 2122-2136 Phenotype denotes ovarian cancer HP:0100615

Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 241-252 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063
T2 342-350 Cell denotes neuronal http://purl.obolibrary.org/obo/CL:0000540
T3 478-489 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063
T4 737-747 Cell denotes tumor cell http://purl.obolibrary.org/obo/CL:0001063
T5 1617-1627 Cell denotes tumor cell http://purl.obolibrary.org/obo/CL:0001063