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PubMed:17071632 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 56-66 gene:3091 denotes HIF-1alpha
T1 18-36 disease:C1519670 denotes tumor angiogenesis
T2 71-75 gene:7422 denotes VEGF
T3 18-36 disease:C1519670 denotes tumor angiogenesis
R1 T0 T1 associated_with HIF-1alpha,tumor angiogenesis
R2 T2 T3 associated_with VEGF,tumor angiogenesis

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 140-145 HP_0002664 denotes tumor
T2 302-316 HP_0100615 denotes ovarian cancer
T3 310-316 HP_0002664 denotes cancer
T4 494-499 HP_0002664 denotes tumor
T5 614-620 HP_0002664 denotes cancer
T6 725-730 HP_0002664 denotes tumor
T7 848-853 HP_0002664 denotes tumor
T8 921-926 HP_0002664 denotes tumor
T9 994-999 HP_0002664 denotes tumor
T1 140-145 HP_0002664 denotes tumor
T2 302-316 HP_0100615 denotes ovarian cancer
T3 310-316 HP_0002664 denotes cancer
T4 494-499 HP_0002664 denotes tumor
T5 614-620 HP_0002664 denotes cancer
T6 725-730 HP_0002664 denotes tumor
T7 848-853 HP_0002664 denotes tumor
T8 921-926 HP_0002664 denotes tumor
T9 994-999 HP_0002664 denotes tumor

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
17071632-0#56#66#gene3091 56-66 gene3091 denotes HIF-1alpha
17071632-0#71#75#gene7422 71-75 gene7422 denotes VEGF
17071632-0#18#36#diseaseC1519670 18-36 diseaseC1519670 denotes tumor angiogenesis
17071632-2#71#76#gene3091 229-234 gene3091 denotes HIF-1
17071632-2#71#76#gene29072 229-234 gene29072 denotes HIF-1
17071632-2#82#116#gene7422 240-274 gene7422 denotes vascular endothelial growth factor
17071632-2#118#122#gene7422 276-280 gene7422 denotes VEGF
17071632-2#144#158#diseaseC0029925 302-316 diseaseC0029925 denotes ovarian cancer
17071632-2#144#158#diseaseC1140680 302-316 diseaseC1140680 denotes ovarian cancer
17071632-2#144#158#diseaseC0029925 302-316 diseaseC0029925 denotes ovarian cancer
17071632-2#144#158#diseaseC1140680 302-316 diseaseC1140680 denotes ovarian cancer
17071632-2#144#158#diseaseC0029925 302-316 diseaseC0029925 denotes ovarian cancer
17071632-2#144#158#diseaseC1140680 302-316 diseaseC1140680 denotes ovarian cancer
17071632-2#144#158#diseaseC0029925 302-316 diseaseC0029925 denotes ovarian cancer
17071632-2#144#158#diseaseC1140680 302-316 diseaseC1140680 denotes ovarian cancer
17071632-8#85#90#gene29072 1021-1026 gene29072 denotes HIF-1
17071632-8#58#76#diseaseC1519670 994-1012 diseaseC1519670 denotes tumor angiogenesis
56#66#gene309118#36#diseaseC1519670 17071632-0#56#66#gene3091 17071632-0#18#36#diseaseC1519670 associated_with HIF-1alpha,tumor angiogenesis
71#75#gene742218#36#diseaseC1519670 17071632-0#71#75#gene7422 17071632-0#18#36#diseaseC1519670 associated_with VEGF,tumor angiogenesis
71#76#gene3091144#158#diseaseC0029925 17071632-2#71#76#gene3091 17071632-2#144#158#diseaseC0029925 associated_with HIF-1,ovarian cancer
71#76#gene3091144#158#diseaseC1140680 17071632-2#71#76#gene3091 17071632-2#144#158#diseaseC1140680 associated_with HIF-1,ovarian cancer
71#76#gene3091144#158#diseaseC0029925 17071632-2#71#76#gene3091 17071632-2#144#158#diseaseC0029925 associated_with HIF-1,ovarian cancer
71#76#gene3091144#158#diseaseC1140680 17071632-2#71#76#gene3091 17071632-2#144#158#diseaseC1140680 associated_with HIF-1,ovarian cancer
71#76#gene3091144#158#diseaseC0029925 17071632-2#71#76#gene3091 17071632-2#144#158#diseaseC0029925 associated_with HIF-1,ovarian cancer
71#76#gene3091144#158#diseaseC1140680 17071632-2#71#76#gene3091 17071632-2#144#158#diseaseC1140680 associated_with HIF-1,ovarian cancer
71#76#gene3091144#158#diseaseC0029925 17071632-2#71#76#gene3091 17071632-2#144#158#diseaseC0029925 associated_with HIF-1,ovarian cancer
71#76#gene3091144#158#diseaseC1140680 17071632-2#71#76#gene3091 17071632-2#144#158#diseaseC1140680 associated_with HIF-1,ovarian cancer
71#76#gene29072144#158#diseaseC0029925 17071632-2#71#76#gene29072 17071632-2#144#158#diseaseC0029925 associated_with HIF-1,ovarian cancer
71#76#gene29072144#158#diseaseC1140680 17071632-2#71#76#gene29072 17071632-2#144#158#diseaseC1140680 associated_with HIF-1,ovarian cancer
71#76#gene29072144#158#diseaseC0029925 17071632-2#71#76#gene29072 17071632-2#144#158#diseaseC0029925 associated_with HIF-1,ovarian cancer
71#76#gene29072144#158#diseaseC1140680 17071632-2#71#76#gene29072 17071632-2#144#158#diseaseC1140680 associated_with HIF-1,ovarian cancer
71#76#gene29072144#158#diseaseC0029925 17071632-2#71#76#gene29072 17071632-2#144#158#diseaseC0029925 associated_with HIF-1,ovarian cancer
71#76#gene29072144#158#diseaseC1140680 17071632-2#71#76#gene29072 17071632-2#144#158#diseaseC1140680 associated_with HIF-1,ovarian cancer
71#76#gene29072144#158#diseaseC0029925 17071632-2#71#76#gene29072 17071632-2#144#158#diseaseC0029925 associated_with HIF-1,ovarian cancer
71#76#gene29072144#158#diseaseC1140680 17071632-2#71#76#gene29072 17071632-2#144#158#diseaseC1140680 associated_with HIF-1,ovarian cancer
82#116#gene7422144#158#diseaseC0029925 17071632-2#82#116#gene7422 17071632-2#144#158#diseaseC0029925 associated_with vascular endothelial growth factor,ovarian cancer
82#116#gene7422144#158#diseaseC1140680 17071632-2#82#116#gene7422 17071632-2#144#158#diseaseC1140680 associated_with vascular endothelial growth factor,ovarian cancer
82#116#gene7422144#158#diseaseC0029925 17071632-2#82#116#gene7422 17071632-2#144#158#diseaseC0029925 associated_with vascular endothelial growth factor,ovarian cancer
82#116#gene7422144#158#diseaseC1140680 17071632-2#82#116#gene7422 17071632-2#144#158#diseaseC1140680 associated_with vascular endothelial growth factor,ovarian cancer
82#116#gene7422144#158#diseaseC0029925 17071632-2#82#116#gene7422 17071632-2#144#158#diseaseC0029925 associated_with vascular endothelial growth factor,ovarian cancer
82#116#gene7422144#158#diseaseC1140680 17071632-2#82#116#gene7422 17071632-2#144#158#diseaseC1140680 associated_with vascular endothelial growth factor,ovarian cancer
82#116#gene7422144#158#diseaseC0029925 17071632-2#82#116#gene7422 17071632-2#144#158#diseaseC0029925 associated_with vascular endothelial growth factor,ovarian cancer
82#116#gene7422144#158#diseaseC1140680 17071632-2#82#116#gene7422 17071632-2#144#158#diseaseC1140680 associated_with vascular endothelial growth factor,ovarian cancer
118#122#gene7422144#158#diseaseC0029925 17071632-2#118#122#gene7422 17071632-2#144#158#diseaseC0029925 associated_with VEGF,ovarian cancer
118#122#gene7422144#158#diseaseC1140680 17071632-2#118#122#gene7422 17071632-2#144#158#diseaseC1140680 associated_with VEGF,ovarian cancer
118#122#gene7422144#158#diseaseC0029925 17071632-2#118#122#gene7422 17071632-2#144#158#diseaseC0029925 associated_with VEGF,ovarian cancer
118#122#gene7422144#158#diseaseC1140680 17071632-2#118#122#gene7422 17071632-2#144#158#diseaseC1140680 associated_with VEGF,ovarian cancer
118#122#gene7422144#158#diseaseC0029925 17071632-2#118#122#gene7422 17071632-2#144#158#diseaseC0029925 associated_with VEGF,ovarian cancer
118#122#gene7422144#158#diseaseC1140680 17071632-2#118#122#gene7422 17071632-2#144#158#diseaseC1140680 associated_with VEGF,ovarian cancer
118#122#gene7422144#158#diseaseC0029925 17071632-2#118#122#gene7422 17071632-2#144#158#diseaseC0029925 associated_with VEGF,ovarian cancer
118#122#gene7422144#158#diseaseC1140680 17071632-2#118#122#gene7422 17071632-2#144#158#diseaseC1140680 associated_with VEGF,ovarian cancer
85#90#gene2907258#76#diseaseC1519670 17071632-8#85#90#gene29072 17071632-8#58#76#diseaseC1519670 associated_with HIF-1,tumor angiogenesis

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1007 229-234 gene:3091 denotes HIF-1
T1008 302-316 disease:C0029925 denotes ovarian cancer
T1009 240-274 gene:7422 denotes vascular endothelial growth factor
T1010 276-280 gene:7422 denotes VEGF
T1011 1021-1026 gene:29072 denotes HIF-1
T1012 994-1012 disease:C1519670 denotes tumor angiogenesis
R1 T1007 T1008 associated_with HIF-1,ovarian cancer
R2 T1007 T1008 associated_with HIF-1,ovarian cancer
R3 T1007 T1008 associated_with HIF-1,ovarian cancer
R4 T1007 T1008 associated_with HIF-1,ovarian cancer
R5 T1009 T1008 associated_with vascular endothelial growth factor,ovarian cancer
R6 T1009 T1008 associated_with vascular endothelial growth factor,ovarian cancer
R7 T1010 T1008 associated_with VEGF,ovarian cancer
R8 T1010 T1008 associated_with VEGF,ovarian cancer
R9 T1011 T1012 associated_with HIF-1,tumor angiogenesis

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-87 Sentence denotes Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression.
TextSentencer_T2 88-157 Sentence denotes Apigenin is a non-toxic dietary flavonoid with anti-tumor properties.
TextSentencer_T3 158-348 Sentence denotes We recently showed that apigenin-inhibited hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression in human ovarian cancer cells under normoxic condition.
TextSentencer_T4 349-422 Sentence denotes However, the effect of apigenin in angiogenesis remains to be elucidated.
TextSentencer_T5 423-522 Sentence denotes Angiogenesis is the formation of new blood vessels and is required for tumor growth and metastasis.
TextSentencer_T6 523-670 Sentence denotes In this study, we showed that apigenin-inhibited expression of HIF-1 and VEGF in different cancer cells under both normoxic and hypoxic conditions.
TextSentencer_T7 671-829 Sentence denotes We demonstrated that apigenin significantly inhibited tumor angiogenesis in vivo, by using both the chicken chorioallantoic membrane and Matrigel plug assays.
TextSentencer_T8 830-935 Sentence denotes The inhibition of tumor angiogenesis was associated with the decrease of HIF-1 and VEGF in tumor tissues.
TextSentencer_T9 936-1047 Sentence denotes Taken together, our results show that apigenin suppresses tumor angiogenesis through HIF-1 and VEGF expression.
T1 0-87 Sentence denotes Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression.
T2 88-157 Sentence denotes Apigenin is a non-toxic dietary flavonoid with anti-tumor properties.
T3 158-348 Sentence denotes We recently showed that apigenin-inhibited hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression in human ovarian cancer cells under normoxic condition.
T4 349-422 Sentence denotes However, the effect of apigenin in angiogenesis remains to be elucidated.
T5 423-522 Sentence denotes Angiogenesis is the formation of new blood vessels and is required for tumor growth and metastasis.
T6 523-670 Sentence denotes In this study, we showed that apigenin-inhibited expression of HIF-1 and VEGF in different cancer cells under both normoxic and hypoxic conditions.
T7 671-829 Sentence denotes We demonstrated that apigenin significantly inhibited tumor angiogenesis in vivo, by using both the chicken chorioallantoic membrane and Matrigel plug assays.
T8 830-935 Sentence denotes The inhibition of tumor angiogenesis was associated with the decrease of HIF-1 and VEGF in tumor tissues.
T9 936-1047 Sentence denotes Taken together, our results show that apigenin suppresses tumor angiogenesis through HIF-1 and VEGF expression.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 460-465 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T2 460-473 http://purl.obolibrary.org/obo/UBERON_0001981 denotes blood vessels
PD-UBERON-AE-B_T3 466-473 http://purl.obolibrary.org/obo/UBERON_0000055 denotes vessels
PD-UBERON-AE-B_T4 779-803 http://purl.obolibrary.org/obo/UBERON_0005335 denotes chorioallantoic membrane
PD-UBERON-AE-B_T5 927-934 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 460-465 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T2 927-934 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T3 460-473 http://purl.obolibrary.org/obo/UBERON_0001981 denotes blood vessels
PD-UBERON-AE-B_T4 466-473 http://purl.obolibrary.org/obo/UBERON_0000055 denotes vessels
PD-UBERON-AE-B_T5 779-803 http://purl.obolibrary.org/obo/UBERON_0005335 denotes chorioallantoic membrane