PubMed:17070086 JSONTXT

{"project":"QFMC_MEDLINE","denotations":[{"id":"T1","span":{"begin":108,"end":128},"obj":"PROC"},{"id":"T1c","span":{"begin":108,"end":128},"obj":"UMLS:C0015915"},{"id":"T2","span":{"begin":108,"end":119},"obj":"PROC"},{"id":"T2c","span":{"begin":108,"end":119},"obj":"UMLS:C0015914"},{"id":"T3","span":{"begin":132,"end":137},"obj":"CHEM"},{"id":"T3c","span":{"begin":132,"end":137},"obj":"UMLS:C0040329"},{"id":"T4","span":{"begin":153,"end":164},"obj":"PROC"},{"id":"T4c","span":{"begin":153,"end":164},"obj":"UMLS:C0202363"},{"id":"T5","span":{"begin":173,"end":182},"obj":"DEVI"},{"id":"T5c","span":{"begin":173,"end":182},"obj":"UMLS:C0179038"},{"id":"T6","span":{"begin":186,"end":205},"obj":"CHEM"},{"id":"T6c","span":{"begin":186,"end":205},"obj":"UMLS:C0007018"}],"relations":[{"id":"#1","pred":"Normalization","subj":"T1","obj":"T1c"},{"id":"#2","pred":"Normalization","subj":"T2","obj":"T2c"},{"id":"#3","pred":"Normalization","subj":"T3","obj":"T3c"},{"id":"#4","pred":"Normalization","subj":"T4","obj":"T4c"},{"id":"#5","pred":"Normalization","subj":"T5","obj":"T5c"},{"id":"#6","pred":"Normalization","subj":"T6","obj":"T6c"}],"namespaces":[{"prefix":"UMLS","uri":"https://uts.nlm.nih.gov/metathesaurus.html#"}],"text":"[In vitro fertilization and smoking: use of urinary cotinine and expired air carbon monoxide measurements].\nFécondation in vitro et tabac: intérêt de la cotininurie et de l'analyseur de monoxyde de carbone expiré.\nOBJECTIVE: To study the correlation between expired air carbon (EACO) and urinary cotinine, and to determine the impact of tobacco smoking on in vitro fertilization (IVF) results.\nPATIENTS AND METHODS: We studied prospectively 221 patients in our ART center from October 2002 to October 2004: 51 active smokers, 85 passive smokers, and 85 non-smokers. Patients were classified into active, passive smokers, or non-smokers, based on a questionnaire. We measured urinary cotinine and EACO on the embryo transfer day and we recorded the IVF parameters.\nRESULTS: Two hundred and twenty-one patients were included. We observed a 17.2% reduction of estradiolemy (P=0.05), a 1.5% reduction of pregnancies (NS), a 7.8% reduction of infants born alive (NS), a 28.5% reduction of twin pregnancies (P=0.06), as well as a 10% increase of miscarriages (NS) in the active smokers in comparison with non-smokers (the same trends were observed between active and passive smokers). EACO and urinary cotinine were well correlated. There was a negative correlation between estradiolemy and urinary cotinine (R=-0.15, P=0.02).\nDISCUSSION AND CONCLUSION: Tobacco smoking intensity may be dilatory on IVF results. There is a high correlation between EACO and urinary cotinine. Other larger studies would probably obtain results more statistically significant."}