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c_corpus

Id Subject Object Predicate Lexical cue
T1 0-14 SO:0000289 denotes Microsatellite
T2 0-26 D053842 denotes Microsatellite instability
T3 0-26 D053842 denotes Microsatellite instability
T4 37-52 GO:0006298 denotes mismatch repair
T5 53-57 SO:0000704 denotes gene
T6 129-146 D015179 denotes colorectal cancer
T7 129-146 D015179 denotes colorectal cancer
T8 184-201 D015179 denotes colorectal cancer
T9 184-201 D015179 denotes colorectal cancer
T10 258-275 D015179 denotes colorectal cancer
T11 258-275 D015179 denotes colorectal cancer
T12 304-318 SO:0000289 denotes Microsatellite
T13 304-330 D053842 denotes Microsatellite instability
T14 304-330 D053842 denotes Microsatellite instability
T15 332-335 PR:000006870 denotes MSI
T16 332-335 PR:P70245 denotes MSI
T17 350-358 SO:0000109 denotes mutation
T20 373-376 SO:0000352 denotes DNA
T19 373-376 CHEBI:16991 denotes DNA
T21 373-376 D004247 denotes DNA
T18 373-376 GO:0005574 denotes DNA
T22 377-392 GO:0006298 denotes mismatch repair
T23 394-397 GO:0006298 denotes MMR
T24 394-397 CVCL_E779 denotes MMR
T25 394-397 P22897 denotes MMR
T26 394-397 PR:000002972 denotes MMR
T27 394-397 Q61830 denotes MMR
T30 530-533 P22897 denotes MMR
T31 530-533 PR:000002972 denotes MMR
T32 530-533 Q61830 denotes MMR
T29 530-533 CVCL_E779 denotes MMR
T28 530-533 GO:0006298 denotes MMR
T33 534-538 SO:0000704 denotes gene
T34 539-547 SO:0000109 denotes mutation
T37 826-829 P22897 denotes MMR
T38 826-829 PR:000002972 denotes MMR
T39 826-829 Q61830 denotes MMR
T36 826-829 CVCL_E779 denotes MMR
T35 826-829 GO:0006298 denotes MMR
T40 830-834 SO:0000704 denotes gene
T41 835-843 SO:0000109 denotes mutation
T44 965-968 P22897 denotes MMR
T45 965-968 PR:000002972 denotes MMR
T46 965-968 Q61830 denotes MMR
T43 965-968 CVCL_E779 denotes MMR
T42 965-968 GO:0006298 denotes MMR
T47 969-973 SO:0000704 denotes gene
T48 974-982 SO:0000109 denotes mutation
T49 1000-1003 PR:000006870 denotes MSI
T50 1000-1003 PR:P70245 denotes MSI
T51 1158-1161 PR:000006870 denotes MSI
T52 1158-1161 PR:P70245 denotes MSI
T55 1221-1227 CVCL_E025 denotes Cancer
T53 1221-1227 D009369 denotes Cancer
T54 1221-1227 D009369 denotes Cancer
T56 1251-1254 PR:000037413 denotes D2S
T57 1267-1270 Q63276 denotes BAT
T58 1267-1270 PR:000004614 denotes BAT
T60 1267-1270 Q14032 denotes BAT
T61 1267-1270 Q91X34 denotes BAT
T59 1267-1270 UBERON:0001348 denotes BAT
T62 1275-1278 Q63276 denotes BAT
T63 1275-1278 PR:000004614 denotes BAT
T65 1275-1278 Q14032 denotes BAT
T66 1275-1278 Q91X34 denotes BAT
T64 1275-1278 UBERON:0001348 denotes BAT
T67 1286-1289 Q63276 denotes BAT
T68 1286-1289 PR:000004614 denotes BAT
T70 1286-1289 Q14032 denotes BAT
T71 1286-1289 Q91X34 denotes BAT
T69 1286-1289 UBERON:0001348 denotes BAT
T72 1297-1300 Q41249 denotes PCR
T73 1297-1300 O66148 denotes PCR
T74 1297-1300 Q59987 denotes PCR
T75 1297-1300 Q01289 denotes PCR
T76 1297-1300 O80333 denotes PCR
T77 1297-1300 P15904 denotes PCR
T78 1297-1300 Q9SDT1 denotes PCR
T79 1297-1300 Q39617 denotes PCR
T80 1310-1315 D009369 denotes tumor
T81 1310-1315 D009369 denotes tumor
T82 1327-1333 UBERON:0000479 denotes tissue
T84 1335-1338 CHEBI:16768 denotes MSH
T88 1335-1338 D009074 denotes MSH
T89 1335-1338 D009074 denotes MSH
T90 1335-1339 PR:000010666 denotes MSH2
T91 1335-1339 PR:P25847 denotes MSH2
T92 1335-1339 PR:P43246 denotes MSH2
T93 1335-1339 P22711 denotes MSH2
T94 1335-1339 PR:P22711 denotes MSH2
T95 1335-1339 PR:P54275 denotes MSH2
T96 1335-1339 PR:O74773 denotes MSH2
T97 1335-1339 PR:P43247 denotes MSH2
T98 1335-1339 PR:Q553L4 denotes MSH2
T99 1335-1339 PR:O24617 denotes MSH2
T101 1341-1344 CHEBI:16768 denotes MSH
T105 1341-1344 D009074 denotes MSH
T106 1341-1344 D009074 denotes MSH
T107 1341-1345 PR:P52701 denotes MSH6
T108 1341-1345 PR:P54276 denotes MSH6
T109 1341-1345 PR:Q9VUM0 denotes MSH6
T110 1341-1345 PR:Q55GU9 denotes MSH6
T111 1341-1345 PR:O04716 denotes MSH6
T112 1341-1345 PR:Q03834 denotes MSH6
T113 1341-1345 PR:O74502 denotes MSH6
T114 1341-1345 PR:000010670 denotes MSH6
T115 1350-1354 PR:Q9ZRV4 denotes MLH1
T116 1350-1354 PR:P38920 denotes MLH1
T117 1350-1354 PR:Q54KD8 denotes MLH1
T119 1350-1354 PR:Q9JK91 denotes MLH1
T120 1350-1354 PR:P97679 denotes MLH1
T121 1350-1354 PR:Q9P7W6 denotes MLH1
T122 1350-1354 PR:000010442 denotes MLH1
T123 1350-1354 PR:P40692 denotes MLH1
T118 1350-1354 CVCL_G669 denotes MLH1
T125 1431-1434 CHEBI:16768 denotes MSH
T129 1431-1434 D009074 denotes MSH
T130 1431-1434 D009074 denotes MSH
T131 1431-1435 PR:000010666 denotes MSH2
T132 1431-1435 PR:P25847 denotes MSH2
T133 1431-1435 PR:P43246 denotes MSH2
T134 1431-1435 P22711 denotes MSH2
T135 1431-1435 PR:P22711 denotes MSH2
T136 1431-1435 PR:P54275 denotes MSH2
T137 1431-1435 PR:O74773 denotes MSH2
T138 1431-1435 PR:P43247 denotes MSH2
T139 1431-1435 PR:Q553L4 denotes MSH2
T140 1431-1435 PR:O24617 denotes MSH2
T141 1440-1444 PR:Q9ZRV4 denotes MLH1
T142 1440-1444 PR:P38920 denotes MLH1
T143 1440-1444 PR:Q54KD8 denotes MLH1
T145 1440-1444 PR:Q9JK91 denotes MLH1
T146 1440-1444 PR:P97679 denotes MLH1
T147 1440-1444 PR:Q9P7W6 denotes MLH1
T148 1440-1444 PR:000010442 denotes MLH1
T149 1440-1444 PR:P40692 denotes MLH1
T144 1440-1444 CVCL_G669 denotes MLH1
T150 1462-1465 Q41249 denotes PCR
T151 1462-1465 O66148 denotes PCR
T152 1462-1465 Q59987 denotes PCR
T153 1462-1465 Q01289 denotes PCR
T154 1462-1465 O80333 denotes PCR
T155 1462-1465 P15904 denotes PCR
T156 1462-1465 Q9SDT1 denotes PCR
T157 1462-1465 Q39617 denotes PCR
T159 1466-1470 SO:0001236 denotes base
T158 1466-1470 CHEBI:22695 denotes base
T160 1511-1519 SO:0000159 denotes deletion
T162 1549-1552 CHEBI:16768 denotes MSH
T166 1549-1552 D009074 denotes MSH
T167 1549-1552 D009074 denotes MSH
T168 1549-1553 PR:000010666 denotes MSH2
T169 1549-1553 PR:P25847 denotes MSH2
T170 1549-1553 PR:P43246 denotes MSH2
T171 1549-1553 P22711 denotes MSH2
T172 1549-1553 PR:P22711 denotes MSH2
T173 1549-1553 PR:P54275 denotes MSH2
T174 1549-1553 PR:O74773 denotes MSH2
T175 1549-1553 PR:P43247 denotes MSH2
T176 1549-1553 PR:Q553L4 denotes MSH2
T177 1549-1553 PR:O24617 denotes MSH2
T186 1565-1573 SO:0000159 denotes deletion
T187 1584-1588 PR:P33696 denotes exon
T188 1584-1588 SO:0000147 denotes exon
T189 1595-1599 PR:Q9ZRV4 denotes MLH1
T190 1595-1599 PR:P38920 denotes MLH1
T191 1595-1599 PR:Q54KD8 denotes MLH1
T193 1595-1599 PR:Q9JK91 denotes MLH1
T194 1595-1599 PR:P97679 denotes MLH1
T195 1595-1599 PR:Q9P7W6 denotes MLH1
T196 1595-1599 PR:000010442 denotes MLH1
T197 1595-1599 PR:P40692 denotes MLH1
T192 1595-1599 CVCL_G669 denotes MLH1
T198 1644-1647 CHEBI:32644 denotes met
T200 1668-1673 PR:Q9SE50 denotes BG) 1
T201 1668-1673 PR:000003655 denotes BG) 1
T202 1668-1673 PR:Q9M2M0 denotes BG) 1
T199 1668-1673 CVCL_6570 denotes BG) 1
T203 1682-1685 CHEBI:32644 denotes met
T204 1686-1689 PR:F4J270 denotes BG3
T205 1721-1736 D003110 denotes colonic cancers
T206 1721-1736 D003110 denotes colonic cancers
T209 1742-1756 D013274 denotes gastric cancer
T210 1742-1756 D013274 denotes gastric cancer
T211 1822-1828 D009369 denotes tumors
T212 1822-1828 D009369 denotes tumors
T213 1864-1878 SO:0000289 denotes microsatellite
T214 1864-1890 D053842 denotes microsatellite instability
T215 1864-1890 D053842 denotes microsatellite instability
T216 1892-1895 PR:000006870 denotes MSI
T217 1892-1895 PR:P70245 denotes MSI
T218 1919-1933 SO:0000289 denotes microsatellite
T219 1942-1945 PR:000011146 denotes MSS
T220 1942-1945 Q9JMH3 denotes MSS
T221 1942-1945 D013132 denotes MSS
T222 1973-1976 PR:000006870 denotes MSI
T223 1973-1976 PR:P70245 denotes MSI
T224 1979-1985 D009369 denotes tumors
T225 1979-1985 D009369 denotes tumors
T226 2012-2016 PR:Q9ZRV4 denotes MLH1
T227 2012-2016 PR:P38920 denotes MLH1
T228 2012-2016 PR:Q54KD8 denotes MLH1
T230 2012-2016 PR:Q9JK91 denotes MLH1
T231 2012-2016 PR:P97679 denotes MLH1
T232 2012-2016 PR:Q9P7W6 denotes MLH1
T233 2012-2016 PR:000010442 denotes MLH1
T234 2012-2016 PR:P40692 denotes MLH1
T229 2012-2016 CVCL_G669 denotes MLH1
T236 2024-2027 CHEBI:16768 denotes MSH
T240 2024-2027 D009074 denotes MSH
T241 2024-2027 D009074 denotes MSH
T242 2024-2028 PR:000010666 denotes MSH2
T243 2024-2028 PR:P25847 denotes MSH2
T244 2024-2028 PR:P43246 denotes MSH2
T245 2024-2028 P22711 denotes MSH2
T246 2024-2028 PR:P22711 denotes MSH2
T247 2024-2028 PR:P54275 denotes MSH2
T248 2024-2028 PR:O74773 denotes MSH2
T249 2024-2028 PR:P43247 denotes MSH2
T250 2024-2028 PR:Q553L4 denotes MSH2
T251 2024-2028 PR:O24617 denotes MSH2
T256 2029-2036 SO:0000104 denotes protein
T253 2029-2036 CHEBI:36080 denotes protein
T254 2029-2036 CHEBI:11122 denotes protein
T255 2029-2036 PR:000000001 denotes protein
T252 2029-2036 GO:0003675 denotes protein
T257 2044-2047 PR:000006870 denotes MSI
T258 2044-2047 PR:P70245 denotes MSI
T259 2050-2056 D009369 denotes tumors
T260 2050-2056 D009369 denotes tumors
T261 2070-2073 PR:000011146 denotes MSS
T262 2070-2073 Q9JMH3 denotes MSS
T263 2070-2073 D013132 denotes MSS
T264 2074-2080 D009369 denotes tumors
T265 2074-2080 D009369 denotes tumors
T268 2123-2126 P22897 denotes MMR
T269 2123-2126 PR:000002972 denotes MMR
T270 2123-2126 Q61830 denotes MMR
T267 2123-2126 CVCL_E779 denotes MMR
T266 2123-2126 GO:0006298 denotes MMR
T271 2127-2135 CHEBI:36080 denotes proteins
T272 2137-2140 PR:Q9JLR5 denotes Out
T273 2137-2140 PR:000016181 denotes Out
T274 2165-2168 PR:000006870 denotes MSI
T275 2165-2168 PR:P70245 denotes MSI
T276 2171-2177 D009369 denotes tumors
T277 2171-2177 D009369 denotes tumors
T278 2235-2239 PR:Q9ZRV4 denotes MLH1
T279 2235-2239 PR:P38920 denotes MLH1
T280 2235-2239 PR:Q54KD8 denotes MLH1
T282 2235-2239 PR:Q9JK91 denotes MLH1
T283 2235-2239 PR:P97679 denotes MLH1
T284 2235-2239 PR:Q9P7W6 denotes MLH1
T285 2235-2239 PR:000010442 denotes MLH1
T286 2235-2239 PR:P40692 denotes MLH1
T281 2235-2239 CVCL_G669 denotes MLH1
T288 2251-2254 CHEBI:16768 denotes MSH
T292 2251-2254 D009074 denotes MSH
T293 2251-2254 D009074 denotes MSH
T294 2251-2255 PR:000010666 denotes MSH2
T295 2251-2255 PR:P25847 denotes MSH2
T296 2251-2255 PR:P43246 denotes MSH2
T297 2251-2255 P22711 denotes MSH2
T298 2251-2255 PR:P22711 denotes MSH2
T299 2251-2255 PR:P54275 denotes MSH2
T300 2251-2255 PR:O74773 denotes MSH2
T301 2251-2255 PR:P43247 denotes MSH2
T302 2251-2255 PR:Q553L4 denotes MSH2
T303 2251-2255 PR:O24617 denotes MSH2
T304 2309-2312 CVCL_H613 denotes H22
T305 2309-2312 CVCL_1E32 denotes H22
T306 2314-2317 1134437 denotes H17
T307 2369-2373 PR:P0ADH1 denotes insA
T310 2384-2403 SO:1000065 denotes frameshift mutation
T312 2411-2415 PR:Q9ZRV4 denotes MLH1
T313 2411-2415 PR:P38920 denotes MLH1
T314 2411-2415 PR:Q54KD8 denotes MLH1
T316 2411-2415 PR:Q9JK91 denotes MLH1
T317 2411-2415 PR:P97679 denotes MLH1
T318 2411-2415 PR:Q9P7W6 denotes MLH1
T319 2411-2415 PR:000010442 denotes MLH1
T320 2411-2415 PR:P40692 denotes MLH1
T315 2411-2415 CVCL_G669 denotes MLH1
T321 2416-2420 SO:0000704 denotes gene
T323 2454-2457 CHEBI:16768 denotes MSH
T327 2454-2457 D009074 denotes MSH
T328 2454-2457 D009074 denotes MSH
T329 2454-2458 PR:000010666 denotes MSH2
T330 2454-2458 PR:P25847 denotes MSH2
T331 2454-2458 PR:P43246 denotes MSH2
T332 2454-2458 P22711 denotes MSH2
T333 2454-2458 PR:P22711 denotes MSH2
T334 2454-2458 PR:P54275 denotes MSH2
T335 2454-2458 PR:O74773 denotes MSH2
T336 2454-2458 PR:P43247 denotes MSH2
T337 2454-2458 PR:Q553L4 denotes MSH2
T338 2454-2458 PR:O24617 denotes MSH2
T339 2459-2463 SO:0000704 denotes gene
T340 2477-2487 SO:0000865 denotes frameshift
T341 2477-2487 SO:0001589 denotes frameshift
T342 2511-2526 SO:0001421 denotes splice junction
T343 2518-2526 UBERON:0007651 denotes junction
T346 2547-2551 SO:0000147 denotes Exon
T345 2547-2551 PR:P33696 denotes Exon
T347 2555-2563 SO:0000109 denotes mutation
T348 2621-2629 SO:0000109 denotes mutation
T349 2642-2645 GO:0006298 denotes MMR
T351 2642-2645 P22897 denotes MMR
T352 2642-2645 PR:000002972 denotes MMR
T353 2642-2645 Q61830 denotes MMR
T350 2642-2645 CVCL_E779 denotes MMR
T354 2776-2779 GO:0006298 denotes MMR
T356 2776-2779 P22897 denotes MMR
T357 2776-2779 PR:000002972 denotes MMR
T358 2776-2779 Q61830 denotes MMR
T355 2776-2779 CVCL_E779 denotes MMR
T359 2780-2784 SO:0000704 denotes gene
T360 2785-2793 SO:0000109 denotes mutation

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 174-194 HP_0200063 denotes polyposis colorectal
T2 195-201 HP_0002664 denotes cancer
T3 269-275 HP_0002664 denotes cancer

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-147 DRI_Background denotes Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with hereditary non-polyposis colorectal cancer.
T2 159-303 DRI_Background denotes Hereditary non-polyposis colorectal cancer (HNPCC) syndrome is the most common cause of hereditary colorectal cancer with an early age of onset.
T3 304-525 DRI_Challenge denotes Microsatellite instability (MSI) and germline mutation in one of the DNA mismatch repair (MMR) genes are found in the majority of HNPCC families and provide an opportunity for genetic diagnosis and prophylactic screening.
T4 526-673 DRI_Background denotes The MMR gene mutation spectrum may vary across different populations and be influenced by founder mutations that prevail in specific ethnic groups.
T5 674-823 DRI_Background denotes China is a big and ancient nation with enormous genetic diversity, which is especially notable between the northern and southern Chinese populations.
T6 824-940 DRI_Background denotes A MMR gene mutation database for the southern Chinese population based in Hong Kong has been previously established.
T7 941-1067 DRI_Background denotes This study compares the MMR gene mutation spectrum and the MSI of HNPCC between the northern and southern Chinese populations.
T8 1077-1153 DRI_Unspecified denotes Twenty-five HNPCC families from northern China were systematically analyzed.
T9 1154-1334 DRI_Approach denotes The MSI analysis was performed using five loci in the USA National Cancer Institute (NCI) panel (D2S123, D5S346, BAT-25, BAT-26 and BAT-40) by PCR from the tumor and normal tissue.
T10 1335-1405 DRI_Background denotes MSH2, MSH6 and MLH1 were performed using immunohistochemical staining.
T11 1406-1601 DRI_Background denotes Two founder mutations of MSH2 and MLH1 were examined by PCR base analyses using primers flanking the two deletion sites (c.1452_1455delAATG in MSH2 and 1.8 kb deletion involving exon 11 of MLH1).
T12 1611-1690 DRI_Unspecified denotes Of the 25 families collected, 19 met Bethesda guideline (BG) 1 and six met BG3.
T13 1691-1811 DRI_Background denotes Twenty-two (15.7%) were extra-colonic cancers with gastric cancer (in seven patients) being the most common cancer type.
T14 1812-1947 DRI_Outcome denotes Of the 25 tumors analyzed, 21 (84%) were high level microsatellite instability (MSI-H) and four (16%) were microsatellite stable (MSS).
T15 1948-2037 DRI_Background denotes Eighteen (86%) of the 21 MSI-H tumors showed loss of either the MLH1 or the MSH2 protein.
T16 2038-2136 DRI_Outcome denotes Three MSI-H tumors and all four MSS tumors showed no loss of expression of the three MMR proteins.
T17 2137-2264 DRI_Approach denotes Out of the 21 patients with MSI-H tumors, 12 (57%) showed pathogenic germline mutations in either MLH1 (n = 8) or MSH2 (n = 4).
T18 2265-2348 DRI_Approach denotes Overall, three novel mutations (in patients H22, H17 and H29) have been identified.
T19 2349-2421 DRI_Approach denotes One of them, c.503_4insA, caused a frameshift mutation in the MLH1 gene.
T20 2422-2564 DRI_Approach denotes The other two were found in the MSH2 gene, including a frameshift (c.899_890insAT) and a splice junction (IVS7-1G-->A, SA of Exon 8) mutation.
T21 2578-2858 DRI_Background denotes The results suggest a distinctly different mutation spectrum of MMR genes between northern and southern Chinese populations and call for a systematic, nationwide study to facilitate the design of a MMR gene mutation detection strategy tailored for individual populations in China.