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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-104 Sentence denotes Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy.
T2 105-269 Sentence denotes Chloroacetaldehyde (CAA) is a metabolite of the alkylating agent ifosfamide (IFO) and putatively responsible for renal damage following anti-tumor therapy with IFO.
T3 270-371 Sentence denotes Depletion of sulfhydryl (SH) groups has been reported from cell culture, animal and clinical studies.
T4 372-479 Sentence denotes In this work the effect of CAA on human proximal tubule cells in primary culture (hRPTEC) was investigated.
T5 480-608 Sentence denotes Toxicity of CAA was determined by protein content, cell number, LDH release, trypan blue exclusion assay and caspase-3 activity.
T6 609-659 Sentence denotes Free thiols were measured by the method of Ellman.
T7 660-784 Sentence denotes CAA reduced hRPTEC cell number and protein, induced a loss in free intracellular thiols and an increase in necrosis markers.
T8 785-876 Sentence denotes CAA but not acrolein inhibited the cysteine proteases caspase-3, caspase-8 and cathepsin B.
T9 877-930 Sentence denotes Caspase activation by cisplatin was inhibited by CAA.
T10 931-1055 Sentence denotes In cells stained with fluorescent dyes targeting lysosomes, CAA induced an increase in lysosomal size and lysosomal leakage.
T11 1056-1153 Sentence denotes The effects of CAA on cysteine protease activities and thiols could be reproduced in cell lysate.
T12 1154-1343 Sentence denotes Acidification, which slowed the reaction of CAA with thiol donors, could also attenuate effects of CAA on necrosis markers, thiol depletion and cysteine protease inhibition in living cells.
T13 1344-1449 Sentence denotes Thus, CAA directly reacts with cellular protein and non-protein thiols, mediating its toxicity on hRPTEC.
T14 1450-1494 Sentence denotes This effect can be reduced by acidification.
T15 1495-1586 Sentence denotes Therefore, urinary acidification could be an option to prevent IFO nephropathy in patients.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 406-411 OrganismTaxon denotes human NCBItxid:9606

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
3476 0-18 ChemicalEntity denotes Chloroacetaldehyde MESH:C004656
3477 24-42 ChemicalEntity denotes sulfhydryl reagent MESH:D013439
3478 65-70 ChemicalEntity denotes thiol MESH:D013438
3479 81-91 ChemicalEntity denotes ifosfamide MESH:D007069
3480 92-103 DiseaseOrPhenotypicFeature denotes nephropathy MESH:D007674
3481 105-123 ChemicalEntity denotes Chloroacetaldehyde MESH:C004656
3482 125-128 ChemicalEntity denotes CAA MESH:C004656
3483 153-169 ChemicalEntity denotes alkylating agent MESH:D000477
3484 170-180 ChemicalEntity denotes ifosfamide MESH:D007069
3485 182-185 ChemicalEntity denotes IFO MESH:D007069
3486 218-230 DiseaseOrPhenotypicFeature denotes renal damage MESH:D007674
3487 246-251 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369
3488 265-268 ChemicalEntity denotes IFO MESH:D007069
3489 283-293 ChemicalEntity denotes sulfhydryl MESH:D013439
3490 295-297 ChemicalEntity denotes SH MESH:D013439
3491 399-402 ChemicalEntity denotes CAA MESH:C004656
3492 406-411 OrganismTaxon denotes human NCBITaxon:9606
3493 454-460 CellLine denotes hRPTEC NCBITaxon:9606
3494 480-488 DiseaseOrPhenotypicFeature denotes Toxicity MESH:D064420
3495 492-495 ChemicalEntity denotes CAA MESH:C004656
3496 544-547 ChemicalEntity denotes LDH MESH:D007770
3497 557-568 ChemicalEntity denotes trypan blue MESH:D014343
3498 589-598 GeneOrGeneProduct denotes caspase-3 NCBIGene:836
3499 614-620 ChemicalEntity denotes thiols MESH:D013438
3500 660-663 ChemicalEntity denotes CAA MESH:C004656
3501 672-678 CellLine denotes hRPTEC NCBITaxon:9606
3502 741-747 ChemicalEntity denotes thiols MESH:D013438
3503 767-775 DiseaseOrPhenotypicFeature denotes necrosis MESH:D009336
3504 785-788 ChemicalEntity denotes CAA MESH:C004656
3505 797-805 ChemicalEntity denotes acrolein MESH:D000171
3506 820-838 GeneOrGeneProduct denotes cysteine proteases NCBIGene:1508|NCBIGene:836|NCBIGene:841
3507 839-848 GeneOrGeneProduct denotes caspase-3 NCBIGene:836
3508 850-859 GeneOrGeneProduct denotes caspase-8 NCBIGene:841
3509 864-875 GeneOrGeneProduct denotes cathepsin B NCBIGene:1508
3510 877-884 GeneOrGeneProduct denotes Caspase NCBIGene:836|NCBIGene:841
3511 899-908 ChemicalEntity denotes cisplatin MESH:D002945
3512 926-929 ChemicalEntity denotes CAA MESH:C004656
3513 991-994 ChemicalEntity denotes CAA MESH:C004656
3514 1071-1074 ChemicalEntity denotes CAA MESH:C004656
3515 1078-1095 GeneOrGeneProduct denotes cysteine protease NCBIGene:1508|NCBIGene:836|NCBIGene:841
3516 1111-1117 ChemicalEntity denotes thiols MESH:D013438
3517 1198-1201 ChemicalEntity denotes CAA MESH:C004656
3518 1207-1212 ChemicalEntity denotes thiol MESH:D013438
3519 1253-1256 ChemicalEntity denotes CAA MESH:C004656
3520 1260-1268 DiseaseOrPhenotypicFeature denotes necrosis MESH:D009336
3521 1278-1283 ChemicalEntity denotes thiol MESH:D013438
3522 1298-1315 GeneOrGeneProduct denotes cysteine protease NCBIGene:1508|NCBIGene:836|NCBIGene:841
3523 1350-1353 ChemicalEntity denotes CAA MESH:C004656
3524 1408-1414 ChemicalEntity denotes thiols MESH:D013438
3525 1430-1438 DiseaseOrPhenotypicFeature denotes toxicity MESH:D064420
3526 1442-1448 CellLine denotes hRPTEC NCBITaxon:9606
3527 1558-1561 ChemicalEntity denotes IFO MESH:D007069
3528 1562-1573 DiseaseOrPhenotypicFeature denotes nephropathy MESH:D007674
3529 1577-1585 OrganismTaxon denotes patients NCBITaxon:9606

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 65-70 GeneOrGeneProduct denotes thiol
T2 329-333 GeneOrGeneProduct denotes cell
T3 421-427 GeneOrGeneProduct denotes tubule
T4 514-521 GeneOrGeneProduct denotes protein
T5 531-535 GeneOrGeneProduct denotes cell
T6 564-568 GeneOrGeneProduct denotes blue
T7 589-598 GeneOrGeneProduct denotes caspase-3
T8 642-648 GeneOrGeneProduct denotes method
T9 664-671 GeneOrGeneProduct denotes reduced
T10 679-683 GeneOrGeneProduct denotes cell
T11 695-702 GeneOrGeneProduct denotes protein
T12 820-838 GeneOrGeneProduct denotes cysteine proteases
T13 839-848 GeneOrGeneProduct denotes caspase-3
T14 850-859 GeneOrGeneProduct denotes caspase-8
T15 864-875 GeneOrGeneProduct denotes cathepsin B
T16 877-884 GeneOrGeneProduct denotes Caspase
T17 899-908 GeneOrGeneProduct denotes cisplatin
T18 1078-1095 GeneOrGeneProduct denotes cysteine protease
T19 1141-1145 GeneOrGeneProduct denotes cell
T20 1207-1212 GeneOrGeneProduct denotes thiol
T21 1278-1283 GeneOrGeneProduct denotes thiol
T22 1298-1315 GeneOrGeneProduct denotes cysteine protease
T23 1375-1391 GeneOrGeneProduct denotes cellular protein
T24 1400-1407 GeneOrGeneProduct denotes protein
T25 1469-1476 GeneOrGeneProduct denotes reduced

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 65-70 GeneOrGeneProduct denotes thiol
T2 191-201 GeneOrGeneProduct denotes putatively
T3 224-230 GeneOrGeneProduct denotes damage
T4 246-251 GeneOrGeneProduct denotes tumor
T5 270-279 GeneOrGeneProduct denotes Depletion
T6 329-333 GeneOrGeneProduct denotes cell
T7 421-427 GeneOrGeneProduct denotes tubule
T8 428-433 GeneOrGeneProduct denotes cells
T9 500-510 GeneOrGeneProduct denotes determined
T10 514-521 GeneOrGeneProduct denotes protein
T11 531-535 GeneOrGeneProduct denotes cell
T12 564-568 GeneOrGeneProduct denotes blue
T13 589-598 GeneOrGeneProduct denotes caspase-3
T14 599-607 GeneOrGeneProduct denotes activity
T15 614-620 GeneOrGeneProduct denotes thiols
T16 642-648 GeneOrGeneProduct denotes method
T17 664-671 GeneOrGeneProduct denotes reduced
T18 679-683 GeneOrGeneProduct denotes cell
T19 695-702 GeneOrGeneProduct denotes protein
T20 704-711 GeneOrGeneProduct denotes induced
T21 741-747 GeneOrGeneProduct denotes thiols
T22 820-838 GeneOrGeneProduct denotes cysteine proteases
T23 839-848 GeneOrGeneProduct denotes caspase-3
T24 850-859 GeneOrGeneProduct denotes caspase-8
T25 864-875 GeneOrGeneProduct denotes cathepsin B
T26 877-884 GeneOrGeneProduct denotes Caspase
T27 885-895 GeneOrGeneProduct denotes activation
T28 899-908 GeneOrGeneProduct denotes cisplatin
T29 934-939 GeneOrGeneProduct denotes cells
T30 995-1002 GeneOrGeneProduct denotes induced
T31 1028-1032 GeneOrGeneProduct denotes size
T32 1078-1095 GeneOrGeneProduct denotes cysteine protease
T33 1096-1106 GeneOrGeneProduct denotes activities
T34 1111-1117 GeneOrGeneProduct denotes thiols
T35 1141-1145 GeneOrGeneProduct denotes cell
T36 1175-1181 GeneOrGeneProduct denotes slowed
T37 1207-1212 GeneOrGeneProduct denotes thiol
T38 1232-1241 GeneOrGeneProduct denotes attenuate
T39 1278-1283 GeneOrGeneProduct denotes thiol
T40 1284-1293 GeneOrGeneProduct denotes depletion
T41 1298-1315 GeneOrGeneProduct denotes cysteine protease
T42 1337-1342 GeneOrGeneProduct denotes cells
T43 1375-1391 GeneOrGeneProduct denotes cellular protein
T44 1400-1407 GeneOrGeneProduct denotes protein
T45 1408-1414 GeneOrGeneProduct denotes thiols
T46 1416-1425 GeneOrGeneProduct denotes mediating
T47 1469-1476 GeneOrGeneProduct denotes reduced

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 92-103 DiseaseOrPhenotypicFeature denotes nephropathy DISEASE
T2 218-230 DiseaseOrPhenotypicFeature denotes renal damage DISEASE
T3 246-251 DiseaseOrPhenotypicFeature denotes tumor D009369
T4 480-488 DiseaseOrPhenotypicFeature denotes Toxicity DISEASE
T5 767-775 DiseaseOrPhenotypicFeature denotes necrosis D009336
T6 1260-1268 DiseaseOrPhenotypicFeature denotes necrosis D009336
T7 1430-1438 DiseaseOrPhenotypicFeature denotes toxicity DISEASE
T8 1562-1573 DiseaseOrPhenotypicFeature denotes nephropathy DISEASE

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 421-427 GeneOrGeneProduct denotes tubule
T2 514-529 GeneOrGeneProduct denotes protein content
T3 589-598 GeneOrGeneProduct denotes caspase-3
T4 820-838 GeneOrGeneProduct denotes cysteine proteases
T5 839-848 GeneOrGeneProduct denotes caspase-3
T6 850-859 GeneOrGeneProduct denotes caspase-8
T7 864-875 GeneOrGeneProduct denotes cathepsin B
T8 877-884 GeneOrGeneProduct denotes Caspase
T9 1078-1095 GeneOrGeneProduct denotes cysteine protease
T10 1298-1315 GeneOrGeneProduct denotes cysteine protease
T11 1375-1391 GeneOrGeneProduct denotes cellular protein

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 92-103 DiseaseOrPhenotypicFeature denotes nephropathy 0005240
T2 125-128 DiseaseOrPhenotypicFeature denotes CAA 0011921
T3 246-251 DiseaseOrPhenotypicFeature denotes tumor 0005070
T4 399-402 DiseaseOrPhenotypicFeature denotes CAA 0011921
T5 492-495 DiseaseOrPhenotypicFeature denotes CAA 0011921
T6 660-663 DiseaseOrPhenotypicFeature denotes CAA 0011921
T7 785-788 DiseaseOrPhenotypicFeature denotes CAA 0011921
T8 926-929 DiseaseOrPhenotypicFeature denotes CAA 0011921
T9 991-994 DiseaseOrPhenotypicFeature denotes CAA 0011921
T10 1071-1074 DiseaseOrPhenotypicFeature denotes CAA 0011921
T11 1198-1201 DiseaseOrPhenotypicFeature denotes CAA 0011921
T12 1253-1256 DiseaseOrPhenotypicFeature denotes CAA 0011921
T13 1350-1353 DiseaseOrPhenotypicFeature denotes CAA 0011921
T14 1462-1465 DiseaseOrPhenotypicFeature denotes can 0012833
T15 1562-1573 DiseaseOrPhenotypicFeature denotes nephropathy 0005240

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 92-103 DiseaseOrPhenotypicFeature denotes nephropathy DISEASE
T2 218-230 DiseaseOrPhenotypicFeature denotes renal damage DISEASE
T3 246-251 DiseaseOrPhenotypicFeature denotes tumor D009369
T4 480-488 DiseaseOrPhenotypicFeature denotes Toxicity DISEASE
T5 767-775 DiseaseOrPhenotypicFeature denotes necrosis D009336
T6 1260-1268 DiseaseOrPhenotypicFeature denotes necrosis D009336
T7 1430-1438 DiseaseOrPhenotypicFeature denotes toxicity DISEASE
T8 1562-1573 DiseaseOrPhenotypicFeature denotes nephropathy DISEASE

LitCoin_CellLine

Id Subject Object Predicate Lexical cue cellosaurus_accession_id
T1 454-460 CellLine denotes hRPTEC AddedByYayamamo
T2 672-678 CellLine denotes hRPTEC AddedByYayamamo
T3 1442-1448 CellLine denotes hRPTEC AddedByYayamamo

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 92-103 DiseaseOrPhenotypicFeature denotes nephropathy DISEASE
T2 218-230 DiseaseOrPhenotypicFeature denotes renal damage DISEASE
T3 246-251 DiseaseOrPhenotypicFeature denotes tumor D009369
T4 480-488 DiseaseOrPhenotypicFeature denotes Toxicity DISEASE
T5 1430-1438 DiseaseOrPhenotypicFeature denotes toxicity DISEASE
T6 1562-1573 DiseaseOrPhenotypicFeature denotes nephropathy DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 0-18 ChemicalEntity denotes Chloroacetaldehyde http://purl.obolibrary.org/obo/CHEBI_27871
T2 24-42 ChemicalEntity denotes sulfhydryl reagent ChemicalEntity
T3 65-70 ChemicalEntity denotes thiol D013438|http://purl.obolibrary.org/obo/CHEBI_29917|http://purl.obolibrary.org/obo/CHEBI_29256
T6 81-91 ChemicalEntity denotes ifosfamide D007069|http://purl.obolibrary.org/obo/CHEBI_5864
T8 105-123 ChemicalEntity denotes Chloroacetaldehyde http://purl.obolibrary.org/obo/CHEBI_27871
T9 125-128 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27869|http://purl.obolibrary.org/obo/CHEBI_27871
T11 153-169 ChemicalEntity denotes alkylating agent ChemicalEntity
T12 170-180 ChemicalEntity denotes ifosfamide D007069|http://purl.obolibrary.org/obo/CHEBI_5864
T14 182-185 ChemicalEntity denotes IFO ChemicalEntity|D007069
T16 265-268 ChemicalEntity denotes IFO ChemicalEntity|D007069
T18 283-293 ChemicalEntity denotes sulfhydryl ChemicalEntity
T19 295-297 ChemicalEntity denotes SH ChemicalEntity
T20 399-402 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27869|http://purl.obolibrary.org/obo/CHEBI_27871
T22 492-495 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27869|http://purl.obolibrary.org/obo/CHEBI_27871
T24 544-547 ChemicalEntity denotes LDH ChemicalEntity
T25 557-568 ChemicalEntity denotes trypan blue D014343|http://purl.obolibrary.org/obo/CHEBI_78897
T27 614-620 ChemicalEntity denotes thiols D013438|http://purl.obolibrary.org/obo/CHEBI_29256
T29 660-663 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27869|http://purl.obolibrary.org/obo/CHEBI_27871
T31 741-747 ChemicalEntity denotes thiols D013438|http://purl.obolibrary.org/obo/CHEBI_29256
T33 785-788 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27869|http://purl.obolibrary.org/obo/CHEBI_27871
T35 797-805 ChemicalEntity denotes acrolein D000171|http://purl.obolibrary.org/obo/CHEBI_15368
T37 820-838 ChemicalEntity denotes cysteine proteases D057056
T38 864-875 ChemicalEntity denotes cathepsin B D002401
T39 899-908 ChemicalEntity denotes cisplatin D002945|http://purl.obolibrary.org/obo/CHEBI_27899
T41 926-929 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27869|http://purl.obolibrary.org/obo/CHEBI_27871
T43 991-994 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27869|http://purl.obolibrary.org/obo/CHEBI_27871
T45 1071-1074 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27869|http://purl.obolibrary.org/obo/CHEBI_27871
T47 1078-1095 ChemicalEntity denotes cysteine protease D057056
T48 1111-1117 ChemicalEntity denotes thiols D013438|http://purl.obolibrary.org/obo/CHEBI_29256
T50 1198-1201 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27869|http://purl.obolibrary.org/obo/CHEBI_27871
T52 1207-1212 ChemicalEntity denotes thiol D013438|http://purl.obolibrary.org/obo/CHEBI_29917|http://purl.obolibrary.org/obo/CHEBI_29256
T55 1253-1256 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27869|http://purl.obolibrary.org/obo/CHEBI_27871
T57 1278-1283 ChemicalEntity denotes thiol D013438|http://purl.obolibrary.org/obo/CHEBI_29917|http://purl.obolibrary.org/obo/CHEBI_29256
T60 1298-1315 ChemicalEntity denotes cysteine protease D057056
T61 1350-1353 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27869|http://purl.obolibrary.org/obo/CHEBI_27871
T63 1408-1414 ChemicalEntity denotes thiols D013438|http://purl.obolibrary.org/obo/CHEBI_29256
T65 1558-1561 ChemicalEntity denotes IFO ChemicalEntity|D007069

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 406-411 OrganismTaxon denotes human
T2 1577-1585 OrganismTaxon denotes patients

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID: cellosaurus_accession_id
T3 1442-1448 CellLine denotes hRPTEC AddedByYayamamo
T2 672-678 CellLine denotes hRPTEC AddedByYayamamo
T1 454-460 CellLine denotes hRPTEC AddedByYayamamo
T65 1558-1561 ChemicalEntity denotes IFO D007069|ChemicalEntity
T63 1408-1414 ChemicalEntity denotes thiols http://purl.obolibrary.org/obo/CHEBI_29256|D013438
T61 1350-1353 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27871|http://purl.obolibrary.org/obo/CHEBI_27869
T60 1298-1315 ChemicalEntity denotes cysteine protease D057056
T57 1278-1283 ChemicalEntity denotes thiol http://purl.obolibrary.org/obo/CHEBI_29256|http://purl.obolibrary.org/obo/CHEBI_29917|D013438
T55 1253-1256 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27871|http://purl.obolibrary.org/obo/CHEBI_27869
T52 1207-1212 ChemicalEntity denotes thiol http://purl.obolibrary.org/obo/CHEBI_29256|http://purl.obolibrary.org/obo/CHEBI_29917|D013438
T50 1198-1201 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27871|http://purl.obolibrary.org/obo/CHEBI_27869
T48 1111-1117 ChemicalEntity denotes thiols http://purl.obolibrary.org/obo/CHEBI_29256|D013438
T47 1078-1095 ChemicalEntity denotes cysteine protease D057056
T45 1071-1074 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27871|http://purl.obolibrary.org/obo/CHEBI_27869
T43 991-994 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27871|http://purl.obolibrary.org/obo/CHEBI_27869
T41 926-929 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27871|http://purl.obolibrary.org/obo/CHEBI_27869
T39 899-908 ChemicalEntity denotes cisplatin http://purl.obolibrary.org/obo/CHEBI_27899|D002945
T38 864-875 ChemicalEntity denotes cathepsin B D002401
T37 820-838 ChemicalEntity denotes cysteine proteases D057056
T35 797-805 ChemicalEntity denotes acrolein http://purl.obolibrary.org/obo/CHEBI_15368|D000171
T33 785-788 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27871|http://purl.obolibrary.org/obo/CHEBI_27869
T31 741-747 ChemicalEntity denotes thiols http://purl.obolibrary.org/obo/CHEBI_29256|D013438
T29 660-663 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27871|http://purl.obolibrary.org/obo/CHEBI_27869
T27 614-620 ChemicalEntity denotes thiols http://purl.obolibrary.org/obo/CHEBI_29256|D013438
T25 557-568 ChemicalEntity denotes trypan blue http://purl.obolibrary.org/obo/CHEBI_78897|D014343
T24 544-547 ChemicalEntity denotes LDH ChemicalEntity
T22 492-495 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27871|http://purl.obolibrary.org/obo/CHEBI_27869
T20 399-402 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27871|http://purl.obolibrary.org/obo/CHEBI_27869
T19 295-297 ChemicalEntity denotes SH ChemicalEntity
T18 283-293 ChemicalEntity denotes sulfhydryl ChemicalEntity
T16 265-268 ChemicalEntity denotes IFO D007069|ChemicalEntity
T14 182-185 ChemicalEntity denotes IFO D007069|ChemicalEntity
T12 170-180 ChemicalEntity denotes ifosfamide http://purl.obolibrary.org/obo/CHEBI_5864|D007069
T11 153-169 ChemicalEntity denotes alkylating agent ChemicalEntity
T9 125-128 ChemicalEntity denotes CAA http://purl.obolibrary.org/obo/CHEBI_27871|http://purl.obolibrary.org/obo/CHEBI_27869
T8 105-123 ChemicalEntity denotes Chloroacetaldehyde http://purl.obolibrary.org/obo/CHEBI_27871
T6 81-91 ChemicalEntity denotes ifosfamide http://purl.obolibrary.org/obo/CHEBI_5864|D007069
T7021 65-70 ChemicalEntity denotes thiol http://purl.obolibrary.org/obo/CHEBI_29256|http://purl.obolibrary.org/obo/CHEBI_29917|D013438
T54356 24-42 ChemicalEntity denotes sulfhydryl reagent ChemicalEntity
T66550 0-18 ChemicalEntity denotes Chloroacetaldehyde http://purl.obolibrary.org/obo/CHEBI_27871
T86529 1375-1391 GeneOrGeneProduct denotes cellular protein
T10 1298-1315 GeneOrGeneProduct denotes cysteine protease
T67388 1078-1095 GeneOrGeneProduct denotes cysteine protease
T99515 877-884 GeneOrGeneProduct denotes Caspase
T7 864-875 GeneOrGeneProduct denotes cathepsin B
T42236 850-859 GeneOrGeneProduct denotes caspase-8
T5 839-848 GeneOrGeneProduct denotes caspase-3
T4 820-838 GeneOrGeneProduct denotes cysteine proteases
T44498 589-598 GeneOrGeneProduct denotes caspase-3
T4398 514-529 GeneOrGeneProduct denotes protein content
T1313 421-427 GeneOrGeneProduct denotes tubule
T63890 1562-1573 DiseaseOrPhenotypicFeature denotes nephropathy DISEASE
T62693 1430-1438 DiseaseOrPhenotypicFeature denotes toxicity DISEASE
T49495 480-488 DiseaseOrPhenotypicFeature denotes Toxicity DISEASE
T2827 246-251 DiseaseOrPhenotypicFeature denotes tumor D009369
T91271 218-230 DiseaseOrPhenotypicFeature denotes renal damage DISEASE
T68882 92-103 DiseaseOrPhenotypicFeature denotes nephropathy DISEASE
T21690 1577-1585 OrganismTaxon denotes patients
T42707 406-411 OrganismTaxon denotes human

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 246-251 HP_0002664 denotes tumor
T2 1562-1573 HP_0000112 denotes nephropathy