PubMed:17006639
Annnotations
GGDB-2020
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 149-157 | https://acgg.asia/db/ggdb/info/gg128 | denotes | (GnT)-IV |
| T2 | 149-157 | https://acgg.asia/db/ggdb/info/gg129 | denotes | (GnT)-IV |
| T3 | 292-298 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IV |
| T4 | 292-298 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IV |
| T5 | 309-316 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| T6 | 321-328 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
| T7 | 624-631 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
| T8 | 718-725 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| T9 | 747-754 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
| T10 | 871-878 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| T11 | 981-988 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| T12 | 993-1000 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
| T13 | 1606-1613 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
| T14 | 1674-1681 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| T15 | 1692-1699 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
| T16 | 1750-1757 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| T17 | 1778-1785 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| T18 | 1806-1813 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
ggdb-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 149-157 | https://acgg.asia/db/ggdb/info/gg129 | denotes | (GnT)-IV |
| T2 | 149-157 | https://acgg.asia/db/ggdb/info/gg128 | denotes | (GnT)-IV |
| T3 | 292-298 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IV |
| T4 | 292-298 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IV |
| T5 | 309-316 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| T6 | 321-328 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
| T7 | 624-631 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
| T8 | 718-725 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| T9 | 747-754 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
| T10 | 871-878 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| T11 | 981-988 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| T12 | 993-1000 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
| T13 | 1606-1613 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
| T14 | 1674-1681 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| T15 | 1692-1699 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
| T16 | 1750-1757 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| T17 | 1778-1785 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| T18 | 1806-1813 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-116 | Sentence | denotes | Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes. |
| TextSentencer_T2 | 117-281 | Sentence | denotes | N-acetylglucosaminyltransferase (GnT)-IV catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-glycans. |
| TextSentencer_T3 | 282-437 | Sentence | denotes | Two human GnT-IV isozymes (GnT-IVa and GnT-IVb) had been identified, which exhibit different expression profiles among human tissues and cancer cell lines. |
| TextSentencer_T4 | 438-604 | Sentence | denotes | To clarify the enzymatic properties of the respective enzymes, their kinetic parameters were determined using recombinant full-length enzymes expressed in COS7 cells. |
| TextSentencer_T5 | 605-726 | Sentence | denotes | The K (m) of human GnT-IVb for UDP-GlcNAc was estimated to be 0.24 mM, which is 2-fold higher than that of human GnT-IVa. |
| TextSentencer_T6 | 727-879 | Sentence | denotes | The K (m) values of GnT-IVb for pyridylaminated (PA) acceptor sugar chains with different branch numbers were 3- to 6-fold higher than those of GnT-IVa. |
| TextSentencer_T7 | 880-1027 | Sentence | denotes | To compare substrate specificities more precisely, we generated recombinant soluble enzymes of human GnT-IVa and GnT-IVb with N-terminal flag tags. |
| TextSentencer_T8 | 1028-1125 | Sentence | denotes | Both enzymes showed similar substrate specificities as determined using fourteen PA-sugar chains. |
| TextSentencer_T9 | 1126-1182 | Sentence | denotes | They preferred complex-type N-glycans over hybrid-types. |
| TextSentencer_T10 | 1183-1350 | Sentence | denotes | Among the complex-type N-glycans tested, the relative activities of both enzymes were increased in proportion to the number of GlcNAc branches on the Man alpha1-6 arm. |
| TextSentencer_T11 | 1351-1571 | Sentence | denotes | The Man alpha1-6 arm of the acceptors was not essential for their activities because a linear pentasaccharide lacking this arm, GlcNAcbeta1-2Manalpha1-3Manbeta1-4GlcNAcbeta1-4 GlcNAc-PA, was a substrate for both enzymes. |
| TextSentencer_T12 | 1572-1758 | Sentence | denotes | These results indicate that human GnT-IVb exhibits the same acceptor substrate specificities as human GnT-IVa, although GnT-IVb has lower affinities for donors or acceptors than GnT-IVa. |
| TextSentencer_T13 | 1759-1912 | Sentence | denotes | This suggests that GnT-IVa is more active than GnT-IVb under physiological conditions and that it primarily contributes to the biosynthesis of N-glycans. |
| T1 | 0-116 | Sentence | denotes | Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes. |
| T2 | 117-281 | Sentence | denotes | N-acetylglucosaminyltransferase (GnT)-IV catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-glycans. |
| T3 | 282-437 | Sentence | denotes | Two human GnT-IV isozymes (GnT-IVa and GnT-IVb) had been identified, which exhibit different expression profiles among human tissues and cancer cell lines. |
| T4 | 438-604 | Sentence | denotes | To clarify the enzymatic properties of the respective enzymes, their kinetic parameters were determined using recombinant full-length enzymes expressed in COS7 cells. |
| T5 | 605-726 | Sentence | denotes | The K (m) of human GnT-IVb for UDP-GlcNAc was estimated to be 0.24 mM, which is 2-fold higher than that of human GnT-IVa. |
| T6 | 727-879 | Sentence | denotes | The K (m) values of GnT-IVb for pyridylaminated (PA) acceptor sugar chains with different branch numbers were 3- to 6-fold higher than those of GnT-IVa. |
| T7 | 880-1027 | Sentence | denotes | To compare substrate specificities more precisely, we generated recombinant soluble enzymes of human GnT-IVa and GnT-IVb with N-terminal flag tags. |
| T8 | 1028-1125 | Sentence | denotes | Both enzymes showed similar substrate specificities as determined using fourteen PA-sugar chains. |
| T9 | 1126-1182 | Sentence | denotes | They preferred complex-type N-glycans over hybrid-types. |
| T10 | 1183-1350 | Sentence | denotes | Among the complex-type N-glycans tested, the relative activities of both enzymes were increased in proportion to the number of GlcNAc branches on the Man alpha1-6 arm. |
| T11 | 1351-1571 | Sentence | denotes | The Man alpha1-6 arm of the acceptors was not essential for their activities because a linear pentasaccharide lacking this arm, GlcNAcbeta1-2Manalpha1-3Manbeta1-4GlcNAcbeta1-4 GlcNAc-PA, was a substrate for both enzymes. |
| T12 | 1572-1758 | Sentence | denotes | These results indicate that human GnT-IVb exhibits the same acceptor substrate specificities as human GnT-IVa, although GnT-IVb has lower affinities for donors or acceptors than GnT-IVa. |
| T13 | 1759-1912 | Sentence | denotes | This suggests that GnT-IVa is more active than GnT-IVb under physiological conditions and that it primarily contributes to the biosynthesis of N-glycans. |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 419-425 | HP_0002664 | denotes | cancer |
glycogenes
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-GlycoGenes20190927-B_T1 | 292-298 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IV |
| PD-GlycoGenes20190927-B_T2 | 292-298 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IV |
| PD-GlycoGenes20190927-B_T3 | 309-316 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| PD-GlycoGenes20190927-B_T4 | 321-328 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
| PD-GlycoGenes20190927-B_T5 | 624-631 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
| PD-GlycoGenes20190927-B_T6 | 718-725 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| PD-GlycoGenes20190927-B_T7 | 747-754 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
| PD-GlycoGenes20190927-B_T8 | 871-878 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| PD-GlycoGenes20190927-B_T9 | 981-988 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| PD-GlycoGenes20190927-B_T10 | 993-1000 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
| PD-GlycoGenes20190927-B_T11 | 1606-1613 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
| PD-GlycoGenes20190927-B_T12 | 1674-1681 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| PD-GlycoGenes20190927-B_T13 | 1692-1699 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
| PD-GlycoGenes20190927-B_T14 | 1700-1703 | https://acgg.asia/db/ggdb/info/gg135 | denotes | has |
| PD-GlycoGenes20190927-B_T15 | 1750-1757 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| PD-GlycoGenes20190927-B_T16 | 1778-1785 | https://acgg.asia/db/ggdb/info/gg128 | denotes | GnT-IVa |
| PD-GlycoGenes20190927-B_T17 | 1806-1813 | https://acgg.asia/db/ggdb/info/gg129 | denotes | GnT-IVb |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T1 | 640-646 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T2 | 1310-1316 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T3 | 1527-1533 | chem:24139 | denotes | GlcNAc |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 419-425 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 419-425 | Phenotype | denotes | cancer | HP:0002664 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 66-71 | OrganismTaxon | denotes | human | 9606 |
| T2 | 286-291 | OrganismTaxon | denotes | human | 9606 |
| T3 | 401-406 | OrganismTaxon | denotes | human | 9606 |
| T4 | 618-623 | OrganismTaxon | denotes | human | 9606 |
| T5 | 712-717 | OrganismTaxon | denotes | human | 9606 |
| T6 | 975-980 | OrganismTaxon | denotes | human | 9606 |
| T7 | 1600-1605 | OrganismTaxon | denotes | human | 9606 |
| T8 | 1668-1673 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 242-245 | Body_part | denotes | arm | http://purl.obolibrary.org/obo/UBERON_0001460|http://purl.obolibrary.org/obo/UBERON_0003822 |
| T3 | 1346-1349 | Body_part | denotes | arm | http://purl.obolibrary.org/obo/UBERON_0001460|http://purl.obolibrary.org/obo/UBERON_0003822 |
| T5 | 1368-1371 | Body_part | denotes | arm | http://purl.obolibrary.org/obo/UBERON_0001460|http://purl.obolibrary.org/obo/UBERON_0003822 |
| T7 | 1474-1477 | Body_part | denotes | arm | http://purl.obolibrary.org/obo/UBERON_0001460|http://purl.obolibrary.org/obo/UBERON_0003822 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 419-430 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |