PubMed:17003780 JSONTXT

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":169,"end":175},"obj":"HP_0002664"},{"id":"T2","span":{"begin":251,"end":257},"obj":"HP_0002664"},{"id":"T3","span":{"begin":419,"end":428},"obj":"HP_0002664"},{"id":"T4","span":{"begin":1585,"end":1600},"obj":"HP_0012125"},{"id":"T5","span":{"begin":1594,"end":1600},"obj":"HP_0002664"},{"id":"T1","span":{"begin":169,"end":175},"obj":"HP_0002664"},{"id":"T2","span":{"begin":251,"end":257},"obj":"HP_0002664"},{"id":"T3","span":{"begin":419,"end":428},"obj":"HP_0002664"},{"id":"T4","span":{"begin":1585,"end":1600},"obj":"HP_0012125"},{"id":"T5","span":{"begin":1594,"end":1600},"obj":"HP_0002664"}],"text":"Prognostic relevance of Tiam1 protein expression in prostate carcinomas.\nThe Rac-specific guanine nucleotide exchange factor, Tiam1, plays a major role in oncogenicity, tumour invasion and metastasis but its usefulness as a prognostic marker in human cancer has not been tested yet. In the present study, Tiam1 expression was analysed in benign secretory epithelium, pre-neoplastic high-grade prostatic intraepithelium neoplasia (HG-PIN) and prostate carcinomas of 60 R0-resected radical prostatectomy specimens by semiquantitative immunohistochemistry. Tiam1 proved significantly overexpressed in both HG-PIN (P\u003c0.001) and prostate carcinomas (P\u003c0.001) when compared to benign secretory epithelium. Strong Tiam1 overexpression (i.e. \u003e or =3.5-fold) in prostate carcinomas relative to the respective benign prostatic epithelium was statistically significantly associated with disease recurrence (P=0.016), the presence of lymph vessel invasion (P=0.031) and high Gleason scores (GS) (i.e. \u003e or =7) (P=0.044). Univariate analysis showed a statistically significant association of strong Tiam1 overexpression with decreased disease-free survival (DFS) (P=0.03). This prognostic effect of strong Tiam1 overexpression remained significant in multivariate analysis including preoperative prostate-specific antigen levels, pT stage, and GS (relative risk= 3.75, 95% confidence interval=1.06-13.16; P=0.04). Together, our data suggest that strong Tiam1 overexpression relative to the corresponding benign epithelial cells is a new and independent predictor of decreased DFS for patients with prostate cancer."}

{"project":"CoMAGC","denotations":[{"id":"T1","span":{"begin":1440,"end":1445},"obj":"Gene"},{"id":"E1","span":{"begin":1446,"end":1460},"obj":"Gene_expression"},{"id":"E2","span":{"begin":1446,"end":1460},"obj":"Positive_regulation"},{"id":"T2","span":{"begin":1585,"end":1600},"obj":"prostate cancer"}],"relations":[{"id":"R1","pred":"themeOf","subj":"T1","obj":"E1"},{"id":"R2","pred":"themeOf","subj":"E1","obj":"E2"},{"id":"R3","pred":"CGE-increased","subj":"T1","obj":"T2"},{"id":"R4","pred":"CCS-unidentifiable","subj":"T1","obj":"T2"},{"id":"R5","pred":"PT-","subj":"T1","obj":"T2"},{"id":"R3","pred":"IGE-","subj":"T1","obj":"T2"}],"text":"Prognostic relevance of Tiam1 protein expression in prostate carcinomas.\nThe Rac-specific guanine nucleotide exchange factor, Tiam1, plays a major role in oncogenicity, tumour invasion and metastasis but its usefulness as a prognostic marker in human cancer has not been tested yet. In the present study, Tiam1 expression was analysed in benign secretory epithelium, pre-neoplastic high-grade prostatic intraepithelium neoplasia (HG-PIN) and prostate carcinomas of 60 R0-resected radical prostatectomy specimens by semiquantitative immunohistochemistry. Tiam1 proved significantly overexpressed in both HG-PIN (P\u003c0.001) and prostate carcinomas (P\u003c0.001) when compared to benign secretory epithelium. Strong Tiam1 overexpression (i.e. \u003e or =3.5-fold) in prostate carcinomas relative to the respective benign prostatic epithelium was statistically significantly associated with disease recurrence (P=0.016), the presence of lymph vessel invasion (P=0.031) and high Gleason scores (GS) (i.e. \u003e or =7) (P=0.044). Univariate analysis showed a statistically significant association of strong Tiam1 overexpression with decreased disease-free survival (DFS) (P=0.03). This prognostic effect of strong Tiam1 overexpression remained significant in multivariate analysis including preoperative prostate-specific antigen levels, pT stage, and GS (relative risk= 3.75, 95% confidence interval=1.06-13.16; P=0.04). Together, our data suggest that strong Tiam1 overexpression relative to the corresponding benign epithelial cells is a new and independent predictor of decreased DFS for patients with prostate cancer."}