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PubMed:17000699 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 641-648 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 690-697 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 641-648 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T2 690-697 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-105 Sentence denotes Clearance mechanism of a mannosylated antibody-enzyme fusion protein used in experimental cancer therapy.
TextSentencer_T2 106-219 Sentence denotes MFECP1 is a mannosylated antibody-enzyme fusion protein used in antibody-directed enzyme prodrug therapy (ADEPT).
TextSentencer_T3 220-326 Sentence denotes The antibody selectively targets tumor cells and the targeted enzyme converts a prodrug into a toxic drug.
TextSentencer_T4 327-422 Sentence denotes MFECP1 is obtained from expression in the yeast Pichia pastoris and produced to clinical grade.
TextSentencer_T5 423-548 Sentence denotes The P. pastoris-derived mannosylation of the fusion protein aids rapid normal tissue clearance required for successful ADEPT.
TextSentencer_T6 549-718 Sentence denotes The work presented provides evidence that MFECP1 is cleared by the endocytic and phagocytic mannose receptor (MR), which is known to bind to mannose-terminating glycans.
TextSentencer_T7 719-824 Sentence denotes MR-transfected fibroblast cells internalize MFECP1 as revealed by flow cytometry and confocal microscopy.
TextSentencer_T8 825-1014 Sentence denotes Immunofluorescence microscopy shows that in vivo clearance in mice occurs predominantly by MR on liver sinusoidal endothelial cells, although MR is also expressed on adjacent Kupffer cells.
TextSentencer_T9 1015-1182 Sentence denotes In the spleen, MFECP1 is taken up by MR-expressing macrophages residing in the red pulp and not by dendritic cells which are found in the marginal zone and white pulp.
TextSentencer_T10 1183-1294 Sentence denotes Clearance can be inhibited in vivo by the MR inhibitor mannan as shown by increased enzyme activities in blood.
TextSentencer_T11 1295-1560 Sentence denotes The work improves understanding of interactions of MFECP1 with normal tissue, shows that glycosylation can be exploited in the design of recombinant anticancer therapeutics and opens the ways for optimizing pharmacokinetics of mannosylated recombinant therapeutics.
T1 0-105 Sentence denotes Clearance mechanism of a mannosylated antibody-enzyme fusion protein used in experimental cancer therapy.
T2 106-219 Sentence denotes MFECP1 is a mannosylated antibody-enzyme fusion protein used in antibody-directed enzyme prodrug therapy (ADEPT).
T3 220-326 Sentence denotes The antibody selectively targets tumor cells and the targeted enzyme converts a prodrug into a toxic drug.
T4 327-422 Sentence denotes MFECP1 is obtained from expression in the yeast Pichia pastoris and produced to clinical grade.
T5 423-548 Sentence denotes The P. pastoris-derived mannosylation of the fusion protein aids rapid normal tissue clearance required for successful ADEPT.
T6 549-718 Sentence denotes The work presented provides evidence that MFECP1 is cleared by the endocytic and phagocytic mannose receptor (MR), which is known to bind to mannose-terminating glycans.
T7 719-824 Sentence denotes MR-transfected fibroblast cells internalize MFECP1 as revealed by flow cytometry and confocal microscopy.
T8 825-1014 Sentence denotes Immunofluorescence microscopy shows that in vivo clearance in mice occurs predominantly by MR on liver sinusoidal endothelial cells, although MR is also expressed on adjacent Kupffer cells.
T9 1015-1182 Sentence denotes In the spleen, MFECP1 is taken up by MR-expressing macrophages residing in the red pulp and not by dendritic cells which are found in the marginal zone and white pulp.
T10 1183-1294 Sentence denotes Clearance can be inhibited in vivo by the MR inhibitor mannan as shown by increased enzyme activities in blood.
T11 1295-1560 Sentence denotes The work improves understanding of interactions of MFECP1 with normal tissue, shows that glycosylation can be exploited in the design of recombinant anticancer therapeutics and opens the ways for optimizing pharmacokinetics of mannosylated recombinant therapeutics.
T1 0-105 Sentence denotes Clearance mechanism of a mannosylated antibody-enzyme fusion protein used in experimental cancer therapy.
T2 106-219 Sentence denotes MFECP1 is a mannosylated antibody-enzyme fusion protein used in antibody-directed enzyme prodrug therapy (ADEPT).
T3 220-326 Sentence denotes The antibody selectively targets tumor cells and the targeted enzyme converts a prodrug into a toxic drug.
T4 327-422 Sentence denotes MFECP1 is obtained from expression in the yeast Pichia pastoris and produced to clinical grade.
T5 423-548 Sentence denotes The P. pastoris-derived mannosylation of the fusion protein aids rapid normal tissue clearance required for successful ADEPT.
T6 549-718 Sentence denotes The work presented provides evidence that MFECP1 is cleared by the endocytic and phagocytic mannose receptor (MR), which is known to bind to mannose-terminating glycans.
T7 719-824 Sentence denotes MR-transfected fibroblast cells internalize MFECP1 as revealed by flow cytometry and confocal microscopy.
T8 825-1014 Sentence denotes Immunofluorescence microscopy shows that in vivo clearance in mice occurs predominantly by MR on liver sinusoidal endothelial cells, although MR is also expressed on adjacent Kupffer cells.
T9 1015-1182 Sentence denotes In the spleen, MFECP1 is taken up by MR-expressing macrophages residing in the red pulp and not by dendritic cells which are found in the marginal zone and white pulp.
T10 1183-1294 Sentence denotes Clearance can be inhibited in vivo by the MR inhibitor mannan as shown by increased enzyme activities in blood.
T11 1295-1560 Sentence denotes The work improves understanding of interactions of MFECP1 with normal tissue, shows that glycosylation can be exploited in the design of recombinant anticancer therapeutics and opens the ways for optimizing pharmacokinetics of mannosylated recombinant therapeutics.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 641-648 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 690-697 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 922-927 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T2 1022-1028 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen
T3 1288-1293 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T4 1288-1293 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 253-258 HP_0002664 denotes tumor

uniprot-human

Id Subject Object Predicate Lexical cue
T1 659-661 http://www.uniprot.org/uniprot/P08235 denotes MR
T2 719-721 http://www.uniprot.org/uniprot/P08235 denotes MR
T3 916-918 http://www.uniprot.org/uniprot/P08235 denotes MR
T4 967-969 http://www.uniprot.org/uniprot/P08235 denotes MR
T5 1052-1054 http://www.uniprot.org/uniprot/P08235 denotes MR
T6 1225-1227 http://www.uniprot.org/uniprot/P08235 denotes MR

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 659-661 http://www.uniprot.org/uniprot/Q8VII8 denotes MR
T2 719-721 http://www.uniprot.org/uniprot/Q8VII8 denotes MR
T3 916-918 http://www.uniprot.org/uniprot/Q8VII8 denotes MR
T4 967-969 http://www.uniprot.org/uniprot/Q8VII8 denotes MR
T5 1052-1054 http://www.uniprot.org/uniprot/Q8VII8 denotes MR
T6 1225-1227 http://www.uniprot.org/uniprot/Q8VII8 denotes MR

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 10-19 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanism
T2 90-96 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T3 259-264 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T4 375-381 http://purl.bioontology.org/ontology/NCBITAXON/1365831 denotes Pichia
T5 501-507 http://purl.bioontology.org/ontology/STY/T024 denotes tissue
T6 649-661 http://purl.bioontology.org/ontology/STY/T192 denotes receptor (MR
T7 745-750 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T8 951-956 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T9 1008-1013 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T10 1124-1129 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T11 1365-1371 http://purl.bioontology.org/ontology/STY/T024 denotes tissue

GO-BP

Id Subject Object Predicate Lexical cue
T1 25-37 http://purl.obolibrary.org/obo/GO_0097502 denotes mannosylated
T2 118-130 http://purl.obolibrary.org/obo/GO_0097502 denotes mannosylated
T3 447-460 http://purl.obolibrary.org/obo/GO_0097502 denotes mannosylation
T4 1267-1284 http://purl.obolibrary.org/obo/GO_0003824 denotes enzyme activities
T5 1384-1397 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation

GO-MF

Id Subject Object Predicate Lexical cue
T1 38-46 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T2 131-139 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T3 170-178 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T4 224-232 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T5 682-686 http://purl.obolibrary.org/obo/GO_0070026 denotes bind
T6 682-686 http://purl.obolibrary.org/obo/GO_0003680 denotes bind
T7 682-686 http://purl.obolibrary.org/obo/GO_0017091 denotes bind
T8 682-686 http://purl.obolibrary.org/obo/GO_0005488 denotes bind
T9 682-697 http://purl.obolibrary.org/obo/GO_0005537 denotes bind to mannose

GO-CC

Id Subject Object Predicate Lexical cue
T1 259-264 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 745-750 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 951-956 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4 1008-1013 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 1124-1129 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6 745-762 http://purl.obolibrary.org/obo/GO_0005622 denotes cells internalize
T7 1114-1123 http://purl.obolibrary.org/obo/GO_0030425 denotes dendritic

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 501-507 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T2 1365-1371 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T3 922-927 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T4 928-938 http://purl.obolibrary.org/obo/UBERON_0003909 denotes sinusoidal
T5 1022-1028 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
T6 1288-1293 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 922-927 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T2 1022-1028 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen
T3 1288-1293 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T4 1288-1293 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1288-1293 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T2 922-927 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T3 501-507 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T4 1365-1371 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T5 928-938 http://purl.obolibrary.org/obo/UBERON_0003909 denotes sinusoidal
PD-UBERON-AE-B_T6 1022-1028 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 90-96 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T2 253-258 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 922-927 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T2 1022-1028 Body_part denotes spleen http://purl.obolibrary.org/obo/MAT_0000085
T3 1288-1293 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-105 Sentence denotes Clearance mechanism of a mannosylated antibody-enzyme fusion protein used in experimental cancer therapy.
T2 106-219 Sentence denotes MFECP1 is a mannosylated antibody-enzyme fusion protein used in antibody-directed enzyme prodrug therapy (ADEPT).
T3 220-326 Sentence denotes The antibody selectively targets tumor cells and the targeted enzyme converts a prodrug into a toxic drug.
T4 327-422 Sentence denotes MFECP1 is obtained from expression in the yeast Pichia pastoris and produced to clinical grade.
T5 423-548 Sentence denotes The P. pastoris-derived mannosylation of the fusion protein aids rapid normal tissue clearance required for successful ADEPT.
T6 549-718 Sentence denotes The work presented provides evidence that MFECP1 is cleared by the endocytic and phagocytic mannose receptor (MR), which is known to bind to mannose-terminating glycans.
T7 719-824 Sentence denotes MR-transfected fibroblast cells internalize MFECP1 as revealed by flow cytometry and confocal microscopy.
T8 825-1014 Sentence denotes Immunofluorescence microscopy shows that in vivo clearance in mice occurs predominantly by MR on liver sinusoidal endothelial cells, although MR is also expressed on adjacent Kupffer cells.
T9 1015-1182 Sentence denotes In the spleen, MFECP1 is taken up by MR-expressing macrophages residing in the red pulp and not by dendritic cells which are found in the marginal zone and white pulp.
T10 1183-1294 Sentence denotes Clearance can be inhibited in vivo by the MR inhibitor mannan as shown by increased enzyme activities in blood.
T11 1295-1560 Sentence denotes The work improves understanding of interactions of MFECP1 with normal tissue, shows that glycosylation can be exploited in the design of recombinant anticancer therapeutics and opens the ways for optimizing pharmacokinetics of mannosylated recombinant therapeutics.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 375-390 OrganismTaxon denotes Pichia pastoris 4922
T2 887-891 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 501-507 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T2 734-744 Body_part denotes fibroblast http://purl.obolibrary.org/obo/CL_0000057
T3 922-956 Body_part denotes liver sinusoidal endothelial cells http://purl.obolibrary.org/obo/CL_1000398
T4 1022-1028 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T5 1066-1077 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T6 1094-1102 Body_part denotes red pulp http://purl.obolibrary.org/obo/UBERON_0001250
T7 1114-1129 Body_part denotes dendritic cells http://purl.obolibrary.org/obo/CL_0000451
T8 1153-1166 Body_part denotes marginal zone http://purl.obolibrary.org/obo/UBERON_0001251|http://purl.obolibrary.org/obo/UBERON_0004879|http://purl.obolibrary.org/obo/UBERON_0014935
T11 1171-1181 Body_part denotes white pulp http://purl.obolibrary.org/obo/UBERON_0001959
T12 1288-1293 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T13 1365-1371 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 90-96 Phenotype denotes cancer HP:0002664
T2 253-258 Phenotype denotes tumor HP:0002664

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 253-264 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063
T2 630-640 Cell denotes phagocytic http://purl.obolibrary.org/obo/CL:0000234
T3 734-744 Cell denotes fibroblast http://purl.obolibrary.org/obo/CL:0000057
T4 922-956 Cell denotes liver sinusoidal endothelial cells http://purl.obolibrary.org/obo/CL:1000398
T5 1000-1013 Cell denotes Kupffer cells http://purl.obolibrary.org/obo/CL:0000091
T6 1066-1077 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T8 1114-1129 Cell denotes dendritic cells http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056