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PubMed:16949912 JSONTXT

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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 238-267 HP_0005202 denotes Helicobacter pylori infection
T2 269-274 HP_0002664 denotes tumor
T3 449-464 HP_0012126 denotes gastric cancers
T4 457-464 HP_0002664 denotes cancers
T5 789-794 HP_0002664 denotes Tumor
T6 1505-1510 HP_0002664 denotes tumor

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
16949912-0#11#16#gene4513 11-16 gene4513 denotes COX-2
16949912-0#11#16#gene5743 11-16 gene5743 denotes COX-2
16949912-0#64#79#diseaseC0024623 64-79 diseaseC0024623 denotes gastric cancers
16949912-2#111#123#diseaseC0032927 475-487 diseaseC0032927 denotes premalignant
16949912-7#111#116#gene5743 1423-1428 gene5743 denotes COX-2
16949912-7#291#296#gene5743 1603-1608 gene5743 denotes COX-2
16949912-7#375#380#gene5743 1687-1692 gene5743 denotes COX-2
16949912-7#470#475#gene1786 1782-1787 gene1786 denotes DNMT1
16949912-7#220#238#diseaseC0850666 1532-1550 diseaseC0850666 denotes H pylori infection
16949912-7#77#79#diseaseC0024623 1389-1391 diseaseC0024623 denotes GC
16949912-7#171#173#diseaseC0024623 1483-1485 diseaseC0024623 denotes GC
16949912-7#220#238#diseaseC0850666 1532-1550 diseaseC0850666 denotes H pylori infection
16949912-7#401#403#diseaseC0024623 1713-1715 diseaseC0024623 denotes GC
11#16#gene451364#79#diseaseC0024623 16949912-0#11#16#gene4513 16949912-0#64#79#diseaseC0024623 associated_with COX-2,gastric cancers
11#16#gene574364#79#diseaseC0024623 16949912-0#11#16#gene5743 16949912-0#64#79#diseaseC0024623 associated_with COX-2,gastric cancers
111#116#gene5743220#238#diseaseC0850666 16949912-7#111#116#gene5743 16949912-7#220#238#diseaseC0850666 associated_with COX-2,H pylori infection
111#116#gene574377#79#diseaseC0024623 16949912-7#111#116#gene5743 16949912-7#77#79#diseaseC0024623 associated_with COX-2,GC
111#116#gene5743171#173#diseaseC0024623 16949912-7#111#116#gene5743 16949912-7#171#173#diseaseC0024623 associated_with COX-2,GC
111#116#gene5743220#238#diseaseC0850666 16949912-7#111#116#gene5743 16949912-7#220#238#diseaseC0850666 associated_with COX-2,H pylori infection
111#116#gene5743401#403#diseaseC0024623 16949912-7#111#116#gene5743 16949912-7#401#403#diseaseC0024623 associated_with COX-2,GC
291#296#gene5743220#238#diseaseC0850666 16949912-7#291#296#gene5743 16949912-7#220#238#diseaseC0850666 associated_with COX-2,H pylori infection
291#296#gene574377#79#diseaseC0024623 16949912-7#291#296#gene5743 16949912-7#77#79#diseaseC0024623 associated_with COX-2,GC
291#296#gene5743171#173#diseaseC0024623 16949912-7#291#296#gene5743 16949912-7#171#173#diseaseC0024623 associated_with COX-2,GC
291#296#gene5743220#238#diseaseC0850666 16949912-7#291#296#gene5743 16949912-7#220#238#diseaseC0850666 associated_with COX-2,H pylori infection
291#296#gene5743401#403#diseaseC0024623 16949912-7#291#296#gene5743 16949912-7#401#403#diseaseC0024623 associated_with COX-2,GC
375#380#gene5743220#238#diseaseC0850666 16949912-7#375#380#gene5743 16949912-7#220#238#diseaseC0850666 associated_with COX-2,H pylori infection
375#380#gene574377#79#diseaseC0024623 16949912-7#375#380#gene5743 16949912-7#77#79#diseaseC0024623 associated_with COX-2,GC
375#380#gene5743171#173#diseaseC0024623 16949912-7#375#380#gene5743 16949912-7#171#173#diseaseC0024623 associated_with COX-2,GC
375#380#gene5743220#238#diseaseC0850666 16949912-7#375#380#gene5743 16949912-7#220#238#diseaseC0850666 associated_with COX-2,H pylori infection
375#380#gene5743401#403#diseaseC0024623 16949912-7#375#380#gene5743 16949912-7#401#403#diseaseC0024623 associated_with COX-2,GC
470#475#gene1786220#238#diseaseC0850666 16949912-7#470#475#gene1786 16949912-7#220#238#diseaseC0850666 associated_with DNMT1,H pylori infection
470#475#gene178677#79#diseaseC0024623 16949912-7#470#475#gene1786 16949912-7#77#79#diseaseC0024623 associated_with DNMT1,GC
470#475#gene1786171#173#diseaseC0024623 16949912-7#470#475#gene1786 16949912-7#171#173#diseaseC0024623 associated_with DNMT1,GC
470#475#gene1786220#238#diseaseC0850666 16949912-7#470#475#gene1786 16949912-7#220#238#diseaseC0850666 associated_with DNMT1,H pylori infection
470#475#gene1786401#403#diseaseC0024623 16949912-7#470#475#gene1786 16949912-7#401#403#diseaseC0024623 associated_with DNMT1,GC

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 525-531 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
PD-UBERON-AE-B_T2 488-495 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T3 973-979 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1437 11-16 gene:4513 denotes COX-2
T1438 64-79 disease:C0024623 denotes gastric cancers
R1 T1437 T1438 associated_with COX-2,gastric cancers
R2 T1437 T1438 associated_with COX-2,gastric cancers

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-97 Sentence denotes Infrequent COX-2 expression due to promoter hypermethylation in gastric cancers in Dalian, China.
TextSentencer_T2 98-363 Sentence denotes Cyclooxygenase-2 (COX-2) has been shown to play oncogenic roles during stepwise gastrocarcinogenesis, and its expression is correlated with Helicobacter pylori infection, tumor necrosis factor alpha-mediated nuclear factor (NF)-kappaB activation, and Wnt signaling.
TextSentencer_T3 364-564 Sentence denotes To examine COX-2 expression and the status of its regulatory factors, we examined 49 gastric cancers (GCs), 21 premalignant tissues, and 10 noncancerous gastric mucosa from residents of Dalian, China.
TextSentencer_T4 565-727 Sentence denotes Unexpectedly, it was found that COX-2 expression was infrequent in the gastric samples (18.8%, 15/80) regardless of the type of lesion or morphological phenotype.
TextSentencer_T5 728-788 Sentence denotes H pylori infection was detected in 19 of 35 tested GC cases.
TextSentencer_T6 789-1002 Sentence denotes Tumor necrosis factor alpha expression, NF-kappaB nuclear translocation, or Wnt2 overexpression was observed in 56 (82.3%) of 68, 40 (50.0%) of 80, and 62 (77.5%) of 80 of the gastric tissue samples, respectively.
TextSentencer_T7 1003-1311 Sentence denotes Methylation-sensitive restriction enzyme digestion followed by polymerase chain reaction of COX-2 promoter regions revealed a remarkably high hypermethylation rate (100%, 20/20) among the COX-2-negative GCs, which was associated with the overexpression of DNA methyltransferase (DNMT) 1 (r = 0.587, P < .01).
TextSentencer_T8 1312-1789 Sentence denotes These results indicate that (1) in contrast to previous findings using other GC sources, our results show that COX-2 activity may not be a critical molecular event during GC formation, (2) the tumor-promoting effects of H pylori infection and Wnt and NF-kappaB activities may be mediated by COX-2-independent pathways, and (3) promoter hypermethylation is the major cause of COX-2 silencing in Dalian GCs, apparently because of increased expression of DNMTs (especially DNMT1).
TextSentencer_T9 1790-1888 Sentence denotes Consequently, a COX-2-oriented preventive or therapeutic strategy is not practical for Dalian GCs.
TextSentencer_T10 1889-2012 Sentence denotes The frequent COX-2 hypermethylation observed in Dalian GCs could have insightful epigenetic and epidemiologic implications.
T1 0-97 Sentence denotes Infrequent COX-2 expression due to promoter hypermethylation in gastric cancers in Dalian, China.
T2 98-363 Sentence denotes Cyclooxygenase-2 (COX-2) has been shown to play oncogenic roles during stepwise gastrocarcinogenesis, and its expression is correlated with Helicobacter pylori infection, tumor necrosis factor alpha-mediated nuclear factor (NF)-kappaB activation, and Wnt signaling.
T3 364-564 Sentence denotes To examine COX-2 expression and the status of its regulatory factors, we examined 49 gastric cancers (GCs), 21 premalignant tissues, and 10 noncancerous gastric mucosa from residents of Dalian, China.
T4 565-727 Sentence denotes Unexpectedly, it was found that COX-2 expression was infrequent in the gastric samples (18.8%, 15/80) regardless of the type of lesion or morphological phenotype.
T5 728-788 Sentence denotes H pylori infection was detected in 19 of 35 tested GC cases.
T6 789-1002 Sentence denotes Tumor necrosis factor alpha expression, NF-kappaB nuclear translocation, or Wnt2 overexpression was observed in 56 (82.3%) of 68, 40 (50.0%) of 80, and 62 (77.5%) of 80 of the gastric tissue samples, respectively.
T7 1003-1311 Sentence denotes Methylation-sensitive restriction enzyme digestion followed by polymerase chain reaction of COX-2 promoter regions revealed a remarkably high hypermethylation rate (100%, 20/20) among the COX-2-negative GCs, which was associated with the overexpression of DNA methyltransferase (DNMT) 1 (r = 0.587, P < .01).
T8 1312-1789 Sentence denotes These results indicate that (1) in contrast to previous findings using other GC sources, our results show that COX-2 activity may not be a critical molecular event during GC formation, (2) the tumor-promoting effects of H pylori infection and Wnt and NF-kappaB activities may be mediated by COX-2-independent pathways, and (3) promoter hypermethylation is the major cause of COX-2 silencing in Dalian GCs, apparently because of increased expression of DNMTs (especially DNMT1).
T9 1790-1888 Sentence denotes Consequently, a COX-2-oriented preventive or therapeutic strategy is not practical for Dalian GCs.
T10 1889-2012 Sentence denotes The frequent COX-2 hypermethylation observed in Dalian GCs could have insightful epigenetic and epidemiologic implications.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 488-495 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T2 973-979 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T3 525-531 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa

DisGeNET

Id Subject Object Predicate Lexical cue
T0 11-16 gene:5743 denotes COX-2
T1 64-79 disease:C0024623 denotes gastric cancers
T2 11-16 gene:4513 denotes COX-2
T3 64-79 disease:C0024623 denotes gastric cancers
T4 116-121 gene:5743 denotes COX-2
T5 238-267 disease:C0850666 denotes Helicobacter pylori infection
T6 98-114 gene:5743 denotes Cyclooxygenase-2
T7 238-267 disease:C0850666 denotes Helicobacter pylori infection
T8 375-380 gene:5743 denotes COX-2
T9 449-464 disease:C0024623 denotes gastric cancers
T10 375-380 gene:5743 denotes COX-2
T11 466-469 disease:C0024623 denotes GCs
T12 1191-1196 gene:5743 denotes COX-2
T13 1206-1209 disease:C0024623 denotes GCs
T14 1095-1100 gene:5743 denotes COX-2
T15 1206-1209 disease:C0024623 denotes GCs
T16 1687-1692 gene:5743 denotes COX-2
T17 1713-1716 disease:C0024623 denotes GCs
T18 1782-1787 gene:1786 denotes DNMT1
T19 1532-1550 disease:C0850666 denotes H pylori infection
T20 1902-1907 gene:5743 denotes COX-2
T21 1944-1947 disease:C0024623 denotes GCs
R1 T0 T1 associated_with COX-2,gastric cancers
R2 T2 T3 associated_with COX-2,gastric cancers
R3 T4 T5 associated_with COX-2,Helicobacter pylori infection
R4 T6 T7 associated_with Cyclooxygenase-2,Helicobacter pylori infection
R5 T8 T9 associated_with COX-2,gastric cancers
R6 T10 T11 associated_with COX-2,GCs
R7 T12 T13 associated_with COX-2,GCs
R8 T14 T15 associated_with COX-2,GCs
R9 T16 T17 associated_with COX-2,GCs
R10 T18 T19 associated_with DNMT1,H pylori infection
R11 T20 T21 associated_with COX-2,GCs