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PubMed:16931514 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-107 Sentence denotes Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver.
T2 108-210 Sentence denotes The RNA-binding protein CUGBP1 regulates translation of proteins in a variety of biological processes.
T3 211-367 Sentence denotes In this study, we show that aging liver increases CUGBP1 translational activities by induction of a high molecular weight protein-protein complex of CUGBP1.
T4 368-547 Sentence denotes The complex contains CUGBP1, subunits alpha, beta, and gamma of the initiation translation factor eIF2, and four proteins of the endoplasmic reticulum, eR90, CRT, eR60, and Grp78.
T5 548-777 Sentence denotes The induction of the CUGBP1-eIF2 complex in old livers is associated with the elevation of protein levels of CUGBP1 and with the hyper-phosphorylation of CUGBP1 by a cyclin D3-cdk4 kinase, activity of which is increased with age.
T6 778-1066 Sentence denotes We have examined the role of the elevation of CUGBP1 and the role of cyclin D3-cdk4-mediated phosphorylation of CUGBP1 in the formation of the CUGBP1-eIF2 complex by using CUGBP1 transgenic mice and young animals expressing high levels of cyclin D3 after injection with cyclin D3 plasmid.
T7 1067-1251 Sentence denotes These studies showed that both the increased levels of CUGBP1 and cdk4-mediated hyper-phosphorylation of CUGBP1 are involved in the age-associated induction of the CUGBP1-eIF2 complex.
T8 1252-1461 Sentence denotes The CUGBP1-eIF2 complex is bound to C/EBPbeta mRNA in the liver of old animals, and this binding correlates with the increased amounts of liver-enriched activator protein and liver-enriched inhibitory protein.
T9 1462-1718 Sentence denotes Consistent with these observations, the purified CUGBP1-eIF2 complex binds to the 5' region of C/EBPbeta mRNA and significantly increases translation of the three isoforms of C/EBPbeta in a cell-free translation system, in cultured cells, and in the liver.
T10 1719-1854 Sentence denotes Thus, these studies demonstrated that age-mediated induction of the CUGBP1-eIF2 complex changes translation of C/EBPbeta in old livers.
T1 0-107 Sentence denotes Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver.
T2 108-210 Sentence denotes The RNA-binding protein CUGBP1 regulates translation of proteins in a variety of biological processes.
T3 211-367 Sentence denotes In this study, we show that aging liver increases CUGBP1 translational activities by induction of a high molecular weight protein-protein complex of CUGBP1.
T4 368-547 Sentence denotes The complex contains CUGBP1, subunits alpha, beta, and gamma of the initiation translation factor eIF2, and four proteins of the endoplasmic reticulum, eR90, CRT, eR60, and Grp78.
T5 548-777 Sentence denotes The induction of the CUGBP1-eIF2 complex in old livers is associated with the elevation of protein levels of CUGBP1 and with the hyper-phosphorylation of CUGBP1 by a cyclin D3-cdk4 kinase, activity of which is increased with age.
T6 778-1066 Sentence denotes We have examined the role of the elevation of CUGBP1 and the role of cyclin D3-cdk4-mediated phosphorylation of CUGBP1 in the formation of the CUGBP1-eIF2 complex by using CUGBP1 transgenic mice and young animals expressing high levels of cyclin D3 after injection with cyclin D3 plasmid.
T7 1067-1251 Sentence denotes These studies showed that both the increased levels of CUGBP1 and cdk4-mediated hyper-phosphorylation of CUGBP1 are involved in the age-associated induction of the CUGBP1-eIF2 complex.
T8 1252-1461 Sentence denotes The CUGBP1-eIF2 complex is bound to C/EBPbeta mRNA in the liver of old animals, and this binding correlates with the increased amounts of liver-enriched activator protein and liver-enriched inhibitory protein.
T9 1462-1718 Sentence denotes Consistent with these observations, the purified CUGBP1-eIF2 complex binds to the 5' region of C/EBPbeta mRNA and significantly increases translation of the three isoforms of C/EBPbeta in a cell-free translation system, in cultured cells, and in the liver.
T10 1719-1854 Sentence denotes Thus, these studies demonstrated that age-mediated induction of the CUGBP1-eIF2 complex changes translation of C/EBPbeta in old livers.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 101-106 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T2 245-250 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T3 596-602 http://purl.obolibrary.org/obo/MAT_0000097 denotes livers
T4 1310-1315 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T5 1390-1395 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T6 1427-1432 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T7 1712-1717 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T8 1847-1853 http://purl.obolibrary.org/obo/MAT_0000097 denotes livers

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 101-106 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T2 245-250 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T3 596-602 Body_part denotes livers http://purl.obolibrary.org/obo/MAT_0000097
T4 1310-1315 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T5 1390-1395 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T6 1427-1432 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T7 1712-1717 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T8 1847-1853 Body_part denotes livers http://purl.obolibrary.org/obo/MAT_0000097

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 968-972 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 101-106 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T2 245-250 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T3 509-518 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T4 1310-1315 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T5 1390-1395 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T6 1427-1432 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T7 1712-1717 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 1685-1699 Cell denotes cultured cells http://purl.obolibrary.org/obo/CL:0000010