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Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 150-155 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-71 Sentence denotes Screening a series of sialyltransferases for possible BACE1 substrates.
TextSentencer_T2 72-211 Sentence denotes Deposition of amyloid beta-peptide (Abeta) and neurofibrillary tangles in the brain are hallmarks of Alzheimer's disease (AD) pathogenesis.
TextSentencer_T3 212-383 Sentence denotes BACE1, a membrane-bound aspartic protease that cleaves amyloid precursor protein (APP) to produce Abeta, has been implicated in triggering the pathogenesis of the disease.
TextSentencer_T4 384-532 Sentence denotes We previously reported that BACE1 also cleaved alpha2,6-sialyltransferase (ST6Gal I) in the Golgi apparatus and induced its secretion from the cell.
TextSentencer_T5 533-724 Sentence denotes Since most glycosyltransferases show Golgi localization and many of these are cleaved and secreted from the cell, we hypothesized that other glycosyltransferases may also be BACE1 substrates.
TextSentencer_T6 725-811 Sentence denotes Here, we focused on a series of sialyltransferases as candidates for BACE1 substrates.
TextSentencer_T7 812-887 Sentence denotes We found that BACE1 cleaved polysialyltransferase ST8Sia IV (PST) in vitro.
TextSentencer_T8 888-1065 Sentence denotes We further found that BACE1 overexpression in COS cells enhanced the secretion of ST3Gal I, II, III and IV, although these sialyltransferases were not cleaved by BACE1 in vitro.
TextSentencer_T9 1066-1269 Sentence denotes These results suggest that BACE1 expression affects glycosylation not only by directly cleaving glycosyltransferases but also by modifying the secretion of glycosyltransferases via some other mechanisms.
T1 0-71 Sentence denotes Screening a series of sialyltransferases for possible BACE1 substrates.
T2 72-211 Sentence denotes Deposition of amyloid beta-peptide (Abeta) and neurofibrillary tangles in the brain are hallmarks of Alzheimer's disease (AD) pathogenesis.
T3 212-383 Sentence denotes BACE1, a membrane-bound aspartic protease that cleaves amyloid precursor protein (APP) to produce Abeta, has been implicated in triggering the pathogenesis of the disease.
T4 384-532 Sentence denotes We previously reported that BACE1 also cleaved alpha2,6-sialyltransferase (ST6Gal I) in the Golgi apparatus and induced its secretion from the cell.
T5 533-724 Sentence denotes Since most glycosyltransferases show Golgi localization and many of these are cleaved and secreted from the cell, we hypothesized that other glycosyltransferases may also be BACE1 substrates.
T6 725-811 Sentence denotes Here, we focused on a series of sialyltransferases as candidates for BACE1 substrates.
T7 812-887 Sentence denotes We found that BACE1 cleaved polysialyltransferase ST8Sia IV (PST) in vitro.
T8 888-1065 Sentence denotes We further found that BACE1 overexpression in COS cells enhanced the secretion of ST3Gal I, II, III and IV, although these sialyltransferases were not cleaved by BACE1 in vitro.
T9 1066-1269 Sentence denotes These results suggest that BACE1 expression affects glycosylation not only by directly cleaving glycosyltransferases but also by modifying the secretion of glycosyltransferases via some other mechanisms.

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 150-155 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 119-142 Phenotype denotes neurofibrillary tangles HP:0002185
T2 173-192 Phenotype denotes Alzheimer's disease HP:0002511
T3 194-196 Phenotype denotes AD HP:0002511

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 86-93 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T2 173-192 Disease denotes Alzheimer's disease http://purl.obolibrary.org/obo/MONDO_0004975
T3 194-196 Disease denotes AD http://purl.obolibrary.org/obo/MONDO_0004975
T4 267-274 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 150-155 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T3 221-229 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T6 476-491 Body_part denotes Golgi apparatus http://purl.obolibrary.org/obo/GO_0005794
T7 570-575 Body_part denotes Golgi http://purl.obolibrary.org/obo/GO_0005794