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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients.
T2 120-124 Sentence denotes AIM:
T3 125-259 Sentence denotes Extrapyramidal syndrome (EPS) is most commonly affected by typical antipsychotic drugs that have a high affinity with the D2 receptor.
T4 260-525 Sentence denotes Recently, many research groups have reported on the positive relationship between the genetic variations in the DRD2 gene and the therapeutic response in schizophrenia patients as a result of the role of variations in the receptor in modulating receptor expression.
T5 526-629 Sentence denotes In this study, we evaluate the role DRD2 plays in chlorpromazine-induced EPS in schizophrenic patients.
T6 630-638 Sentence denotes METHODS:
T7 639-922 Sentence denotes We identified seven SNP(single nucleotide polymorphism) (-141Cins>del, TaqIB, TaqID, Ser311Cys, rs6275, rs6277 and TaqIA) in the DRD2 gene in 146 schizophrenic inpatients (59 with EPS and 87 without EPS according to the Simpson-Angus Scale) treated with chlorpromazine after 8 weeks.
T8 923-998 Sentence denotes The alleles of all loci were determined by PCR (polymerase chain reaction).
T9 999-1007 Sentence denotes RESULTS:
T10 1008-1120 Sentence denotes Polymorphisms TaqID, Ser311Cys and rs6277 were not polymorphic in the population recruited in the present study.
T11 1121-1348 Sentence denotes No statistical significance was found in the allele distribution of -141Cins>del, TaqIB, rs6275 and TaqIA or in the estimated haplotypes (constituted by TaqIB, rs6275 and TaqIA) in linkage disequilibrium between the two groups.
T12 1349-1360 Sentence denotes CONCLUSION:
T13 1361-1595 Sentence denotes Our results did not lend strong support to the view that the genetic variation of the DRD2 gene plays a major role in the individually variable adverse effect induced by chlorpromazine, at least in Chinese patients with schizophrenia.
T14 1596-1690 Sentence denotes Our results confirmed a previous study on the relationship between DRD2 and EPS in Caucasians.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
3315 15-19 GeneOrGeneProduct denotes DRD2 NCBIGene:1813
3316 38-52 ChemicalEntity denotes chlorpromazine MESH:D002746
3317 61-84 DiseaseOrPhenotypicFeature denotes extrapyramidal syndrome MESH:D001480
3318 96-109 DiseaseOrPhenotypicFeature denotes schizophrenic MESH:D012559
3319 110-118 OrganismTaxon denotes patients NCBITaxon:9606
3320 125-148 DiseaseOrPhenotypicFeature denotes Extrapyramidal syndrome MESH:D001480
3321 150-153 DiseaseOrPhenotypicFeature denotes EPS MESH:D001480
3322 192-211 ChemicalEntity denotes antipsychotic drugs MESH:D014150
3323 247-258 GeneOrGeneProduct denotes D2 receptor NCBIGene:1813
3324 372-376 GeneOrGeneProduct denotes DRD2 NCBIGene:1813
3325 414-427 DiseaseOrPhenotypicFeature denotes schizophrenia MESH:D012559
3326 428-436 OrganismTaxon denotes patients NCBITaxon:9606
3327 562-566 GeneOrGeneProduct denotes DRD2 NCBIGene:1813
3328 576-590 ChemicalEntity denotes chlorpromazine MESH:D002746
3329 599-602 DiseaseOrPhenotypicFeature denotes EPS MESH:D001480
3330 606-619 DiseaseOrPhenotypicFeature denotes schizophrenic MESH:D012559
3331 620-628 OrganismTaxon denotes patients NCBITaxon:9606
3332 696-708 SequenceVariant denotes -141Cins>del c|INDEL|0141|C
3333 724-733 SequenceVariant denotes Ser311Cys c|SUB|S|311|C
3334 735-741 SequenceVariant denotes rs6275 DBSNP:rs6275
3335 743-749 SequenceVariant denotes rs6277 DBSNP:rs6277
3336 768-772 GeneOrGeneProduct denotes DRD2 NCBIGene:1813
3337 785-798 DiseaseOrPhenotypicFeature denotes schizophrenic MESH:D012559
3338 799-809 OrganismTaxon denotes inpatients NCBITaxon:9606
3339 819-822 DiseaseOrPhenotypicFeature denotes EPS MESH:D001480
3340 838-841 DiseaseOrPhenotypicFeature denotes EPS MESH:D001480
3341 893-907 ChemicalEntity denotes chlorpromazine MESH:D002746
3342 1029-1038 SequenceVariant denotes Ser311Cys c|SUB|S|311|C
3343 1043-1049 SequenceVariant denotes rs6277 DBSNP:rs6277
3344 1189-1201 SequenceVariant denotes -141Cins>del c|INDEL|0141|C
3345 1210-1216 SequenceVariant denotes rs6275 DBSNP:rs6275
3346 1281-1287 SequenceVariant denotes rs6275 DBSNP:rs6275
3347 1447-1451 GeneOrGeneProduct denotes DRD2 NCBIGene:1813
3348 1531-1545 ChemicalEntity denotes chlorpromazine MESH:D002746
3349 1567-1575 OrganismTaxon denotes patients NCBITaxon:9606
3350 1581-1594 DiseaseOrPhenotypicFeature denotes schizophrenia MESH:D012559
3351 1663-1667 GeneOrGeneProduct denotes DRD2 NCBIGene:1813
3352 1672-1675 DiseaseOrPhenotypicFeature denotes EPS MESH:D001480

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 414-427 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T2 1581-1594 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 724-733 SequenceVariant denotes Ser311Cys
T2 735-741 SequenceVariant denotes rs6275
T3 743-749 SequenceVariant denotes rs6277
T4 1029-1038 SequenceVariant denotes Ser311Cys
T5 1043-1049 SequenceVariant denotes rs6277
T6 1210-1216 SequenceVariant denotes rs6275
T7 1281-1287 SequenceVariant denotes rs6275

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 15-19 GeneOrGeneProduct denotes DRD2
T2 53-60 GeneOrGeneProduct denotes induced
T3 76-84 GeneOrGeneProduct denotes syndrome
T4 140-148 GeneOrGeneProduct denotes syndrome
T5 224-228 GeneOrGeneProduct denotes high
T6 250-258 GeneOrGeneProduct denotes receptor
T7 270-274 GeneOrGeneProduct denotes many
T8 372-376 GeneOrGeneProduct denotes DRD2
T9 482-490 GeneOrGeneProduct denotes receptor
T10 505-513 GeneOrGeneProduct denotes receptor
T11 562-566 GeneOrGeneProduct denotes DRD2
T12 591-598 GeneOrGeneProduct denotes induced
T13 630-637 GeneOrGeneProduct denotes METHODS
T14 705-708 GeneOrGeneProduct denotes del
T15 768-772 GeneOrGeneProduct denotes DRD2
T16 938-941 GeneOrGeneProduct denotes all
T17 952-962 GeneOrGeneProduct denotes determined
T18 971-981 GeneOrGeneProduct denotes polymerase
T19 982-987 GeneOrGeneProduct denotes chain
T20 1198-1201 GeneOrGeneProduct denotes del
T21 1447-1451 GeneOrGeneProduct denotes DRD2
T22 1465-1470 GeneOrGeneProduct denotes major
T23 1520-1527 GeneOrGeneProduct denotes induced
T24 1663-1667 GeneOrGeneProduct denotes DRD2

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 15-19 GeneOrGeneProduct denotes DRD2
T2 76-84 GeneOrGeneProduct denotes syndrome
T3 140-148 GeneOrGeneProduct denotes syndrome
T4 224-228 GeneOrGeneProduct denotes high
T5 250-258 GeneOrGeneProduct denotes receptor
T6 372-376 GeneOrGeneProduct denotes DRD2
T7 482-490 GeneOrGeneProduct denotes receptor
T8 505-513 GeneOrGeneProduct denotes receptor
T9 562-566 GeneOrGeneProduct denotes DRD2
T10 768-772 GeneOrGeneProduct denotes DRD2
T11 971-981 GeneOrGeneProduct denotes polymerase
T12 982-987 GeneOrGeneProduct denotes chain
T13 1447-1451 GeneOrGeneProduct denotes DRD2
T14 1465-1470 GeneOrGeneProduct denotes major
T15 1663-1667 GeneOrGeneProduct denotes DRD2

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 76-84 DiseaseOrPhenotypicFeature denotes syndrome D013577
T2 96-109 DiseaseOrPhenotypicFeature denotes schizophrenic DISEASE
T3 140-148 DiseaseOrPhenotypicFeature denotes syndrome D013577
T4 414-427 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T5 606-619 DiseaseOrPhenotypicFeature denotes schizophrenic DISEASE
T6 785-798 DiseaseOrPhenotypicFeature denotes schizophrenic DISEASE
T7 1581-1594 DiseaseOrPhenotypicFeature denotes schizophrenia D012559

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 76-84 DiseaseOrPhenotypicFeature denotes syndrome 0002254
T2 140-148 DiseaseOrPhenotypicFeature denotes syndrome 0002254
T3 414-427 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T4 1581-1594 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 15-19 GeneOrGeneProduct denotes DRD2
T2 247-258 GeneOrGeneProduct denotes D2 receptor
T3 372-376 GeneOrGeneProduct denotes DRD2
T4 562-566 GeneOrGeneProduct denotes DRD2
T5 768-772 GeneOrGeneProduct denotes DRD2
T6 1447-1451 GeneOrGeneProduct denotes DRD2
T7 1663-1667 GeneOrGeneProduct denotes DRD2

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 76-84 DiseaseOrPhenotypicFeature denotes syndrome D013577
T2 96-109 DiseaseOrPhenotypicFeature denotes schizophrenic DISEASE
T3 140-148 DiseaseOrPhenotypicFeature denotes syndrome D013577
T4 150-153 DiseaseOrPhenotypicFeature denotes EPS DISEASE
T5 414-427 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T6 599-602 DiseaseOrPhenotypicFeature denotes EPS DISEASE
T7 606-619 DiseaseOrPhenotypicFeature denotes schizophrenic DISEASE
T8 785-798 DiseaseOrPhenotypicFeature denotes schizophrenic DISEASE
T9 819-822 DiseaseOrPhenotypicFeature denotes EPS DISEASE
T10 838-841 DiseaseOrPhenotypicFeature denotes EPS DISEASE
T11 1581-1594 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T12 1672-1675 DiseaseOrPhenotypicFeature denotes EPS DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 61-84 DiseaseOrPhenotypicFeature denotes extrapyramidal syndrome EisukeAdded
T2 96-109 DiseaseOrPhenotypicFeature denotes schizophrenic DISEASE
T3 125-148 DiseaseOrPhenotypicFeature denotes Extrapyramidal syndrome EisukeAdded
T4 150-153 DiseaseOrPhenotypicFeature denotes EPS DISEASE|EisukeAdded
T6 414-427 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T7 599-602 DiseaseOrPhenotypicFeature denotes EPS DISEASE|EisukeAdded
T9 606-619 DiseaseOrPhenotypicFeature denotes schizophrenic DISEASE
T10 785-798 DiseaseOrPhenotypicFeature denotes schizophrenic DISEASE
T11 819-822 DiseaseOrPhenotypicFeature denotes EPS DISEASE|EisukeAdded
T13 838-841 DiseaseOrPhenotypicFeature denotes EPS DISEASE|EisukeAdded
T15 1581-1594 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T16 1672-1675 DiseaseOrPhenotypicFeature denotes EPS DISEASE|EisukeAdded

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 110-118 OrganismTaxon denotes patients
T2 428-436 OrganismTaxon denotes patients
T3 620-628 OrganismTaxon denotes patients
T4 1567-1575 OrganismTaxon denotes patients

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 38-52 ChemicalEntity denotes chlorpromazine D002746|http://purl.obolibrary.org/obo/CHEBI_3647
T3 120-123 ChemicalEntity denotes AIM http://purl.obolibrary.org/obo/CHEBI_3416
T4 576-590 ChemicalEntity denotes chlorpromazine D002746|http://purl.obolibrary.org/obo/CHEBI_3647
T6 893-907 ChemicalEntity denotes chlorpromazine D002746|http://purl.obolibrary.org/obo/CHEBI_3647
T8 1531-1545 ChemicalEntity denotes chlorpromazine D002746|http://purl.obolibrary.org/obo/CHEBI_3647

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T8 1531-1545 ChemicalEntity denotes chlorpromazine http://purl.obolibrary.org/obo/CHEBI_3647|D002746
T6 893-907 ChemicalEntity denotes chlorpromazine http://purl.obolibrary.org/obo/CHEBI_3647|D002746
T4 576-590 ChemicalEntity denotes chlorpromazine http://purl.obolibrary.org/obo/CHEBI_3647|D002746
T3 120-123 ChemicalEntity denotes AIM http://purl.obolibrary.org/obo/CHEBI_3416
T1 38-52 ChemicalEntity denotes chlorpromazine http://purl.obolibrary.org/obo/CHEBI_3647|D002746
T7 1663-1667 GeneOrGeneProduct denotes DRD2
T96406 1447-1451 GeneOrGeneProduct denotes DRD2
T5 768-772 GeneOrGeneProduct denotes DRD2
T20069 562-566 GeneOrGeneProduct denotes DRD2
T14311 372-376 GeneOrGeneProduct denotes DRD2
T2 247-258 GeneOrGeneProduct denotes D2 receptor
T91332 15-19 GeneOrGeneProduct denotes DRD2
T16 1672-1675 DiseaseOrPhenotypicFeature denotes EPS EisukeAdded|DISEASE
T15 1581-1594 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T13 838-841 DiseaseOrPhenotypicFeature denotes EPS EisukeAdded|DISEASE
T11 819-822 DiseaseOrPhenotypicFeature denotes EPS EisukeAdded|DISEASE
T10 785-798 DiseaseOrPhenotypicFeature denotes schizophrenic DISEASE
T9 606-619 DiseaseOrPhenotypicFeature denotes schizophrenic DISEASE
T85049 599-602 DiseaseOrPhenotypicFeature denotes EPS EisukeAdded|DISEASE
T71831 414-427 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T22579 150-153 DiseaseOrPhenotypicFeature denotes EPS EisukeAdded|DISEASE
T80435 125-148 DiseaseOrPhenotypicFeature denotes Extrapyramidal syndrome EisukeAdded
T8275 96-109 DiseaseOrPhenotypicFeature denotes schizophrenic DISEASE
T13478 61-84 DiseaseOrPhenotypicFeature denotes extrapyramidal syndrome EisukeAdded
T69768 1567-1575 OrganismTaxon denotes patients
T21342 620-628 OrganismTaxon denotes patients
T23833 428-436 OrganismTaxon denotes patients
T4401 110-118 OrganismTaxon denotes patients
T51684 1281-1287 SequenceVariant denotes rs6275
T13030 1210-1216 SequenceVariant denotes rs6275
T54176 1043-1049 SequenceVariant denotes rs6277
T12677 1029-1038 SequenceVariant denotes Ser311Cys
T11303 743-749 SequenceVariant denotes rs6277
T38827 735-741 SequenceVariant denotes rs6275
T44931 724-733 SequenceVariant denotes Ser311Cys

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
16867246-4#104#110#geners6277 743-749 geners6277 denotes rs6277
16867246-4#180#183#diseaseC0221271 819-822 diseaseC0221271 denotes EPS
16867246-4#180#183#diseaseC1868684 819-822 diseaseC1868684 denotes EPS
16867246-4#199#202#diseaseC0221271 838-841 diseaseC0221271 denotes EPS
16867246-4#199#202#diseaseC1868684 838-841 diseaseC1868684 denotes EPS
104#110#geners6277180#183#diseaseC0221271 16867246-4#104#110#geners6277 16867246-4#180#183#diseaseC0221271 associated_with rs6277,EPS
104#110#geners6277180#183#diseaseC1868684 16867246-4#104#110#geners6277 16867246-4#180#183#diseaseC1868684 associated_with rs6277,EPS
104#110#geners6277199#202#diseaseC0221271 16867246-4#104#110#geners6277 16867246-4#199#202#diseaseC0221271 associated_with rs6277,EPS
104#110#geners6277199#202#diseaseC1868684 16867246-4#104#110#geners6277 16867246-4#199#202#diseaseC1868684 associated_with rs6277,EPS

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
16867246-0#15#19#gene1813 15-19 gene1813 denotes DRD2
16867246-0#61#84#diseaseC0015371 61-84 diseaseC0015371 denotes extrapyramidal syndrome
16867246-8#86#90#gene1813 1447-1451 gene1813 denotes DRD2
16867246-8#220#233#diseaseC0036341 1581-1594 diseaseC0036341 denotes schizophrenia
16867246-9#67#71#gene1813 1663-1667 gene1813 denotes DRD2
16867246-9#76#79#diseaseC0221271 1672-1675 diseaseC0221271 denotes EPS
16867246-9#76#79#diseaseC1868684 1672-1675 diseaseC1868684 denotes EPS
15#19#gene181361#84#diseaseC0015371 16867246-0#15#19#gene1813 16867246-0#61#84#diseaseC0015371 associated_with DRD2,extrapyramidal syndrome
86#90#gene1813220#233#diseaseC0036341 16867246-8#86#90#gene1813 16867246-8#220#233#diseaseC0036341 associated_with DRD2,schizophrenia
67#71#gene181376#79#diseaseC0221271 16867246-9#67#71#gene1813 16867246-9#76#79#diseaseC0221271 associated_with DRD2,EPS
67#71#gene181376#79#diseaseC1868684 16867246-9#67#71#gene1813 16867246-9#76#79#diseaseC1868684 associated_with DRD2,EPS

DisGeNET

Id Subject Object Predicate Lexical cue
T0 15-19 gene:1813 denotes DRD2
T1 61-84 disease:C0015371 denotes extrapyramidal syndrome
T2 562-566 gene:1813 denotes DRD2
T3 599-602 disease:C0015371 denotes EPS
T4 768-772 gene:1813 denotes DRD2
T5 819-822 disease:C0015371 denotes EPS
T6 768-772 gene:1813 denotes DRD2
T7 838-841 disease:C0015371 denotes EPS
T8 1447-1451 gene:1813 denotes DRD2
T9 1581-1594 disease:C0036341 denotes schizophrenia
T10 1663-1667 gene:1813 denotes DRD2
T11 1672-1675 disease:C0015371 denotes EPS
R1 T0 T1 associated_with DRD2,extrapyramidal syndrome
R2 T2 T3 associated_with DRD2,EPS
R3 T4 T5 associated_with DRD2,EPS
R4 T6 T7 associated_with DRD2,EPS
R5 T8 T9 associated_with DRD2,schizophrenia
R6 T10 T11 associated_with DRD2,EPS