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PubMed:16867021 JSONTXT

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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
3267 0-13 ChemicalEntity denotes Antipsychotic MESH:D014150
3268 30-42 ChemicalEntity denotes thioperamide MESH:C052075
3269 56-67 GeneOrGeneProduct denotes H3-receptor NCBIGene:99296
3270 82-86 OrganismTaxon denotes mice NCBITaxon:10090
3271 195-208 DiseaseOrPhenotypicFeature denotes schizophrenia MESH:D012559
3272 264-287 GeneOrGeneProduct denotes histamine H(3)-receptor NCBIGene:99296
3273 299-310 ChemicalEntity denotes neuroleptic MESH:D014150
3274 319-328 DiseaseOrPhenotypicFeature denotes catalepsy MESH:D002375
3275 330-341 ChemicalEntity denotes apomorphine MESH:D001058
3276 372-383 ChemicalEntity denotes amphetamine MESH:D000661
3277 416-420 OrganismTaxon denotes mice NCBITaxon:10090
3278 422-431 DiseaseOrPhenotypicFeature denotes Catalepsy MESH:D002375
3279 447-458 ChemicalEntity denotes haloperidol MESH:D006220
3280 481-492 ChemicalEntity denotes apomorphine MESH:D001058
3281 514-525 ChemicalEntity denotes amphetamine MESH:D000661
3282 622-647 ChemicalEntity denotes (R)-alpha-methylhistamine MESH:C069357
3283 649-653 ChemicalEntity denotes RAMH MESH:C069357
3284 677-689 ChemicalEntity denotes thioperamide MESH:C052075
3285 691-694 ChemicalEntity denotes THP MESH:C052075
3286 734-743 DiseaseOrPhenotypicFeature denotes catalepsy MESH:D002375
3287 763-766 ChemicalEntity denotes THP MESH:C052075
3288 810-821 ChemicalEntity denotes haloperidol MESH:D006220
3289 867-876 DiseaseOrPhenotypicFeature denotes catalepsy MESH:D002375
3290 922-926 ChemicalEntity denotes RAMH MESH:C069357
3291 968-971 ChemicalEntity denotes THP MESH:C052075
3292 989-993 ChemicalEntity denotes RAMH MESH:C069357
3293 1089-1092 ChemicalEntity denotes THP MESH:C052075
3294 1154-1165 ChemicalEntity denotes amphetamine MESH:D000661
3295 1174-1187 DiseaseOrPhenotypicFeature denotes hyperactivity MESH:D006948
3296 1189-1192 ChemicalEntity denotes THP MESH:C052075
3297 1309-1313 ChemicalEntity denotes RAMH MESH:C069357
3298 1372-1375 ChemicalEntity denotes THP MESH:C052075
3299 1424-1435 ChemicalEntity denotes apomorphine MESH:D001058
3300 1472-1475 ChemicalEntity denotes THP MESH:C052075
3301 1530-1534 ChemicalEntity denotes RAMH MESH:C069357
3302 1536-1539 ChemicalEntity denotes THP MESH:C052075
3303 1553-1566 ChemicalEntity denotes antipsychotic MESH:D014150
3304 1596-1607 ChemicalEntity denotes haloperidol MESH:D006220
3305 1616-1625 DiseaseOrPhenotypicFeature denotes catalepsy MESH:D002375
3306 1636-1647 ChemicalEntity denotes amphetamine MESH:D000661
3307 1656-1669 DiseaseOrPhenotypicFeature denotes hyperactivity MESH:D006948
3308 1683-1694 ChemicalEntity denotes apomorphine MESH:D001058
3309 1715-1719 OrganismTaxon denotes mice NCBITaxon:10090
3310 1737-1740 ChemicalEntity denotes THP MESH:C052075
3311 1758-1762 ChemicalEntity denotes RAMH MESH:C069357
3312 1793-1817 GeneOrGeneProduct denotes histamine H(3)-receptors NCBIGene:99296
3313 1852-1877 ChemicalEntity denotes H(3)-receptor antagonists MESH:D054828
3314 1915-1928 DiseaseOrPhenotypicFeature denotes schizophrenia MESH:D012559

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-87 Sentence denotes Antipsychotic-like profile of thioperamide, a selective H3-receptor antagonist in mice.
T2 88-209 Sentence denotes Experimental and clinical evidence points to a role of central histaminergic system in the pathogenesis of schizophrenia.
T3 210-421 Sentence denotes The present study was designed to study the effect of histamine H(3)-receptor ligands on neuroleptic-induced catalepsy, apomorphine-induced climbing behavior and amphetamine-induced locomotor activities in mice.
T4 422-744 Sentence denotes Catalepsy was induced by haloperidol (2 mg/kg p.o.), while apomorphine (1.5 mg/kg s.c.) and amphetamine (2 mg/kg s.c.) were used for studying climbing behavior and locomotor activities, respectively. (R)-alpha-methylhistamine (RAMH) (5 microg i.c.v.) and thioperamide (THP) (15 mg/kg i.p.), per se did not cause catalepsy.
T5 745-894 Sentence denotes Administration of THP (3.75, 7.5 and 15 mg/kg i.p.) 1 h prior to haloperidol resulted in a dose-dependent increase in the catalepsy times (P < 0.05).
T6 895-988 Sentence denotes However, pretreatment with RAMH significantly reversed such an effect of THP (15 mg/kg i.p.).
T7 989-1150 Sentence denotes RAMH per se showed significant reduction in locomotor time, distance traveled and average speed but THP (15 mg/kg i.p.) per se had no effect on these parameters.
T8 1151-1290 Sentence denotes On amphetamine-induced hyperactivity, THP (3.75 and 7.5 mg/kg i.p.) reduced locomotor time, distance traveled and average speed (P < 0.05).
T9 1291-1394 Sentence denotes Pretreatment with RAMH (5 microg i.c.v.) could partially reverse such effects of THP (3.75 mg/kg i.p.).
T10 1395-1476 Sentence denotes Climbing behavior induced by apomorphine was reduced in animals treated with THP.
T11 1477-1535 Sentence denotes Such an effect was, however, reversed in presence of RAMH.
T12 1536-1720 Sentence denotes THP exhibited an antipsychotic-like profile by potentiating haloperidol-induced catalepsy, reducing amphetamine-induced hyperactivity and reducing apomorphine-induced climbing in mice.
T13 1721-1818 Sentence denotes Such effects of THP were reversed by RAMH indicating the involvement of histamine H(3)-receptors.
T14 1819-1929 Sentence denotes Findings suggest a potential for H(3)-receptor antagonists in improving the refractory cases of schizophrenia.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 82-86 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T3 416-420 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T5 1715-1719 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 195-208 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T2 1915-1928 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 14-18 GeneOrGeneProduct denotes like
T2 59-67 GeneOrGeneProduct denotes receptor
T3 68-78 GeneOrGeneProduct denotes antagonist
T4 82-86 GeneOrGeneProduct denotes mice
T5 123-129 GeneOrGeneProduct denotes points
T6 279-287 GeneOrGeneProduct denotes receptor
T7 311-318 GeneOrGeneProduct denotes induced
T8 342-349 GeneOrGeneProduct denotes induced
T9 359-367 GeneOrGeneProduct denotes behavior
T10 384-391 GeneOrGeneProduct denotes induced
T11 402-412 GeneOrGeneProduct denotes activities
T12 416-420 GeneOrGeneProduct denotes mice
T13 436-443 GeneOrGeneProduct denotes induced
T14 462-464 GeneOrGeneProduct denotes mg
T15 498-500 GeneOrGeneProduct denotes mg
T16 529-531 GeneOrGeneProduct denotes mg
T17 573-581 GeneOrGeneProduct denotes behavior
T18 596-606 GeneOrGeneProduct denotes activities
T19 626-631 GeneOrGeneProduct denotes alpha
T20 700-702 GeneOrGeneProduct denotes mg
T21 713-716 GeneOrGeneProduct denotes per
T22 785-787 GeneOrGeneProduct denotes mg
T23 831-835 GeneOrGeneProduct denotes in a
T24 877-882 GeneOrGeneProduct denotes times
T25 976-978 GeneOrGeneProduct denotes mg
T26 994-997 GeneOrGeneProduct denotes per
T27 1043-1047 GeneOrGeneProduct denotes time
T28 1097-1099 GeneOrGeneProduct denotes mg
T29 1109-1112 GeneOrGeneProduct denotes per
T30 1166-1173 GeneOrGeneProduct denotes induced
T31 1207-1209 GeneOrGeneProduct denotes mg
T32 1219-1226 GeneOrGeneProduct denotes reduced
T33 1237-1241 GeneOrGeneProduct denotes time
T34 1382-1384 GeneOrGeneProduct denotes mg
T35 1404-1412 GeneOrGeneProduct denotes behavior
T36 1413-1420 GeneOrGeneProduct denotes induced
T37 1440-1447 GeneOrGeneProduct denotes reduced
T38 1567-1571 GeneOrGeneProduct denotes like
T39 1608-1615 GeneOrGeneProduct denotes induced
T40 1627-1635 GeneOrGeneProduct denotes reducing
T41 1648-1655 GeneOrGeneProduct denotes induced
T42 1674-1682 GeneOrGeneProduct denotes reducing
T43 1695-1702 GeneOrGeneProduct denotes induced
T44 1715-1719 GeneOrGeneProduct denotes mice
T45 1793-1817 GeneOrGeneProduct denotes histamine H(3)-receptors
T46 1819-1827 GeneOrGeneProduct denotes Findings
T47 1857-1865 GeneOrGeneProduct denotes receptor
T48 1866-1877 GeneOrGeneProduct denotes antagonists
T49 1906-1911 GeneOrGeneProduct denotes cases

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 14-18 GeneOrGeneProduct denotes like
T2 59-67 GeneOrGeneProduct denotes receptor
T3 279-287 GeneOrGeneProduct denotes receptor
T4 359-367 GeneOrGeneProduct denotes behavior
T5 573-581 GeneOrGeneProduct denotes behavior
T6 626-631 GeneOrGeneProduct denotes alpha
T7 1219-1226 GeneOrGeneProduct denotes reduced
T8 1404-1412 GeneOrGeneProduct denotes behavior
T9 1440-1447 GeneOrGeneProduct denotes reduced
T10 1567-1571 GeneOrGeneProduct denotes like
T11 1793-1817 GeneOrGeneProduct denotes histamine H(3)-receptors
T12 1857-1865 GeneOrGeneProduct denotes receptor

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 195-208 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T2 319-328 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T3 422-431 DiseaseOrPhenotypicFeature denotes Catalepsy D002375
T4 734-743 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T5 867-876 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T6 1174-1187 DiseaseOrPhenotypicFeature denotes hyperactivity DISEASE
T7 1616-1625 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T8 1656-1669 DiseaseOrPhenotypicFeature denotes hyperactivity DISEASE
T9 1915-1928 DiseaseOrPhenotypicFeature denotes schizophrenia D012559

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 195-208 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T2 1915-1928 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 264-287 GeneOrGeneProduct denotes histamine H(3)-receptor
T2 626-631 GeneOrGeneProduct denotes alpha
T3 1793-1817 GeneOrGeneProduct denotes histamine H(3)-receptors

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 195-208 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T2 319-328 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T3 422-431 DiseaseOrPhenotypicFeature denotes Catalepsy D002375
T4 734-743 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T5 867-876 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T6 1174-1187 DiseaseOrPhenotypicFeature denotes hyperactivity DISEASE
T7 1616-1625 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T8 1656-1669 DiseaseOrPhenotypicFeature denotes hyperactivity DISEASE
T9 1915-1928 DiseaseOrPhenotypicFeature denotes schizophrenia D012559

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 195-208 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T2 319-328 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T3 422-431 DiseaseOrPhenotypicFeature denotes Catalepsy D002375
T4 734-743 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T5 867-876 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T6 1174-1187 DiseaseOrPhenotypicFeature denotes hyperactivity DISEASE
T7 1616-1625 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T8 1656-1669 DiseaseOrPhenotypicFeature denotes hyperactivity DISEASE
T9 1915-1928 DiseaseOrPhenotypicFeature denotes schizophrenia D012559

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 82-86 OrganismTaxon denotes mice
T2 416-420 OrganismTaxon denotes mice
T3 1715-1719 OrganismTaxon denotes mice

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 30-42 ChemicalEntity denotes thioperamide C052075
T2 56-78 ChemicalEntity denotes H3-receptor antagonist ChemicalEntity
T3 264-273 ChemicalEntity denotes histamine D006632|http://purl.obolibrary.org/obo/CHEBI_58432|http://purl.obolibrary.org/obo/CHEBI_18295
T6 299-310 ChemicalEntity denotes neuroleptic ChemicalEntity
T7 330-341 ChemicalEntity denotes apomorphine D001058|http://purl.obolibrary.org/obo/CHEBI_48538
T9 372-383 ChemicalEntity denotes amphetamine D000661|http://purl.obolibrary.org/obo/CHEBI_2679
T11 447-458 ChemicalEntity denotes haloperidol D006220|http://purl.obolibrary.org/obo/CHEBI_5613
T13 481-492 ChemicalEntity denotes apomorphine D001058|http://purl.obolibrary.org/obo/CHEBI_48538
T15 514-525 ChemicalEntity denotes amphetamine D000661|http://purl.obolibrary.org/obo/CHEBI_2679
T17 622-647 ChemicalEntity denotes (R)-alpha-methylhistamine http://purl.obolibrary.org/obo/CHEBI_73337
T18 649-653 ChemicalEntity denotes RAMH ChemicalEntity
T19 677-689 ChemicalEntity denotes thioperamide C052075
T20 691-694 ChemicalEntity denotes THP http://purl.obolibrary.org/obo/CHEBI_46941|C052075
T22 763-766 ChemicalEntity denotes THP http://purl.obolibrary.org/obo/CHEBI_46941|C052075
T24 810-821 ChemicalEntity denotes haloperidol D006220|http://purl.obolibrary.org/obo/CHEBI_5613
T26 922-926 ChemicalEntity denotes RAMH ChemicalEntity
T27 968-971 ChemicalEntity denotes THP http://purl.obolibrary.org/obo/CHEBI_46941|C052075
T29 989-993 ChemicalEntity denotes RAMH ChemicalEntity
T30 1089-1092 ChemicalEntity denotes THP http://purl.obolibrary.org/obo/CHEBI_46941|C052075
T32 1154-1165 ChemicalEntity denotes amphetamine D000661|http://purl.obolibrary.org/obo/CHEBI_2679
T34 1189-1192 ChemicalEntity denotes THP http://purl.obolibrary.org/obo/CHEBI_46941|C052075
T36 1309-1313 ChemicalEntity denotes RAMH ChemicalEntity
T37 1372-1375 ChemicalEntity denotes THP http://purl.obolibrary.org/obo/CHEBI_46941|C052075
T39 1424-1435 ChemicalEntity denotes apomorphine D001058|http://purl.obolibrary.org/obo/CHEBI_48538
T41 1472-1475 ChemicalEntity denotes THP http://purl.obolibrary.org/obo/CHEBI_46941|C052075
T43 1530-1534 ChemicalEntity denotes RAMH ChemicalEntity
T44 1536-1539 ChemicalEntity denotes THP http://purl.obolibrary.org/obo/CHEBI_46941|C052075
T46 1596-1607 ChemicalEntity denotes haloperidol D006220|http://purl.obolibrary.org/obo/CHEBI_5613
T48 1636-1647 ChemicalEntity denotes amphetamine D000661|http://purl.obolibrary.org/obo/CHEBI_2679
T50 1683-1694 ChemicalEntity denotes apomorphine D001058|http://purl.obolibrary.org/obo/CHEBI_48538
T52 1737-1740 ChemicalEntity denotes THP http://purl.obolibrary.org/obo/CHEBI_46941|C052075
T54 1758-1762 ChemicalEntity denotes RAMH ChemicalEntity
T55 1793-1802 ChemicalEntity denotes histamine D006632|http://purl.obolibrary.org/obo/CHEBI_58432|http://purl.obolibrary.org/obo/CHEBI_18295
T58 1852-1877 ChemicalEntity denotes H(3)-receptor antagonists ChemicalEntity

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T58 1852-1877 ChemicalEntity denotes H(3)-receptor antagonists ChemicalEntity
T55 1793-1802 ChemicalEntity denotes histamine http://purl.obolibrary.org/obo/CHEBI_18295|http://purl.obolibrary.org/obo/CHEBI_58432|D006632
T54 1758-1762 ChemicalEntity denotes RAMH ChemicalEntity
T52 1737-1740 ChemicalEntity denotes THP C052075|http://purl.obolibrary.org/obo/CHEBI_46941
T50 1683-1694 ChemicalEntity denotes apomorphine http://purl.obolibrary.org/obo/CHEBI_48538|D001058
T48 1636-1647 ChemicalEntity denotes amphetamine http://purl.obolibrary.org/obo/CHEBI_2679|D000661
T46 1596-1607 ChemicalEntity denotes haloperidol http://purl.obolibrary.org/obo/CHEBI_5613|D006220
T44 1536-1539 ChemicalEntity denotes THP C052075|http://purl.obolibrary.org/obo/CHEBI_46941
T43 1530-1534 ChemicalEntity denotes RAMH ChemicalEntity
T41 1472-1475 ChemicalEntity denotes THP C052075|http://purl.obolibrary.org/obo/CHEBI_46941
T39 1424-1435 ChemicalEntity denotes apomorphine http://purl.obolibrary.org/obo/CHEBI_48538|D001058
T37 1372-1375 ChemicalEntity denotes THP C052075|http://purl.obolibrary.org/obo/CHEBI_46941
T36 1309-1313 ChemicalEntity denotes RAMH ChemicalEntity
T34 1189-1192 ChemicalEntity denotes THP http://purl.obolibrary.org/obo/CHEBI_46941|C052075
T32 1154-1165 ChemicalEntity denotes amphetamine http://purl.obolibrary.org/obo/CHEBI_2679|D000661
T30 1089-1092 ChemicalEntity denotes THP C052075|http://purl.obolibrary.org/obo/CHEBI_46941
T29 989-993 ChemicalEntity denotes RAMH ChemicalEntity
T27 968-971 ChemicalEntity denotes THP C052075|http://purl.obolibrary.org/obo/CHEBI_46941
T26 922-926 ChemicalEntity denotes RAMH ChemicalEntity
T24 810-821 ChemicalEntity denotes haloperidol http://purl.obolibrary.org/obo/CHEBI_5613|D006220
T22 763-766 ChemicalEntity denotes THP C052075|http://purl.obolibrary.org/obo/CHEBI_46941
T20 691-694 ChemicalEntity denotes THP C052075|http://purl.obolibrary.org/obo/CHEBI_46941
T19 677-689 ChemicalEntity denotes thioperamide C052075
T18 649-653 ChemicalEntity denotes RAMH ChemicalEntity
T17 622-647 ChemicalEntity denotes (R)-alpha-methylhistamine http://purl.obolibrary.org/obo/CHEBI_73337
T15 514-525 ChemicalEntity denotes amphetamine http://purl.obolibrary.org/obo/CHEBI_2679|D000661
T13 481-492 ChemicalEntity denotes apomorphine http://purl.obolibrary.org/obo/CHEBI_48538|D001058
T11 447-458 ChemicalEntity denotes haloperidol http://purl.obolibrary.org/obo/CHEBI_5613|D006220
T9 372-383 ChemicalEntity denotes amphetamine http://purl.obolibrary.org/obo/CHEBI_2679|D000661
T7 330-341 ChemicalEntity denotes apomorphine http://purl.obolibrary.org/obo/CHEBI_48538|D001058
T6 299-310 ChemicalEntity denotes neuroleptic ChemicalEntity
T3 264-273 ChemicalEntity denotes histamine http://purl.obolibrary.org/obo/CHEBI_18295|http://purl.obolibrary.org/obo/CHEBI_58432|D006632
T2 56-78 ChemicalEntity denotes H3-receptor antagonist ChemicalEntity
T1 30-42 ChemicalEntity denotes thioperamide C052075
T9085 1793-1817 GeneOrGeneProduct denotes histamine H(3)-receptors
T77199 626-631 GeneOrGeneProduct denotes alpha
T97230 264-287 GeneOrGeneProduct denotes histamine H(3)-receptor
T45745 1915-1928 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T8 1656-1669 DiseaseOrPhenotypicFeature denotes hyperactivity DISEASE
T42132 1616-1625 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T31972 1174-1187 DiseaseOrPhenotypicFeature denotes hyperactivity DISEASE
T5 867-876 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T4 734-743 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T53230 422-431 DiseaseOrPhenotypicFeature denotes Catalepsy D002375
T45840 319-328 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T30164 195-208 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T47111 1715-1719 OrganismTaxon denotes mice
T50167 416-420 OrganismTaxon denotes mice
T44926 82-86 OrganismTaxon denotes mice

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 195-208 HP_0100753 denotes schizophrenia
T2 1174-1187 HP_0000752 denotes hyperactivity
T3 1656-1669 HP_0000752 denotes hyperactivity
T4 1915-1928 HP_0100753 denotes schizophrenia