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PubMed:16840830 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-85 Sentence denotes Two novel mutations in the MEN1 gene in subjects with multiple endocrine neoplasia-1.
T2 86-258 Sentence denotes Multiple endocrine neoplasia type 1 (MEN1) is characterized by parathyroid, enteropancreatic endocrine and pituitary adenomas as well as germline mutation of the MEN1 gene.
T3 259-330 Sentence denotes We describe 2 families with MEN1 with novel mutations in the MEN1 gene.
T4 331-477 Sentence denotes One family was of Turkish origin, and the index patient had primary hyperparathyroidism (PHPT) plus a prolactinoma; three relatives had PHPT only.
T5 478-574 Sentence denotes The index patient in the second family was a 46-yr-old woman of Chinese origin living in Taiwan.
T6 575-789 Sentence denotes This patient presented with a complaint of epigastric pain and watery diarrhea over the past 3 months, and had undergone subtotal parathyroidectomy and enucleation of pancreatic islet cell tumor about 10 yr before.
T7 790-820 Sentence denotes There was also a prolactinoma.
T8 821-932 Sentence denotes Sequence analysis of the MEN1 gene from leukocyte genomic DNA revealed heterozygous mutations in both probands.
T9 933-1122 Sentence denotes The Turkish patient and her affected relatives all had a heterozygous A to G transition at codon 557 (AAG-->GAG) of exon 10 of MEN1 that results in a replacement of lysine by glutamic acid.
T10 1123-1296 Sentence denotes The Chinese index patient and one of her siblings had a heterozygous mutation at codon 418 of exon 9 (GAC-->TAT) that results in a substitution of aspartic acid by tyrosine.
T11 1297-1375 Sentence denotes In conclusion, we have identified 2 novel missense mutations in the MEN1 gene.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 529-538 OrganismTaxon denotes old woman NCBItxid:333954
T2 1024-1029 OrganismTaxon denotes codon NCBItxid:79338
T3 1204-1209 OrganismTaxon denotes codon NCBItxid:79338

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
3178 27-31 GeneOrGeneProduct denotes MEN1 NCBIGene:4221
3179 54-84 DiseaseOrPhenotypicFeature denotes multiple endocrine neoplasia-1 MESH:D018761
3180 86-121 DiseaseOrPhenotypicFeature denotes Multiple endocrine neoplasia type 1 MESH:D018761
3181 123-127 DiseaseOrPhenotypicFeature denotes MEN1 MESH:D018761
3182 162-211 DiseaseOrPhenotypicFeature denotes enteropancreatic endocrine and pituitary adenomas MESH:C535650|MESH:D010911
3183 248-252 GeneOrGeneProduct denotes MEN1 NCBIGene:4221
3184 287-291 GeneOrGeneProduct denotes MEN1 NCBIGene:4221
3185 320-324 GeneOrGeneProduct denotes MEN1 NCBIGene:4221
3186 379-386 OrganismTaxon denotes patient NCBITaxon:9606
3187 391-418 DiseaseOrPhenotypicFeature denotes primary hyperparathyroidism MESH:D049950
3188 420-424 DiseaseOrPhenotypicFeature denotes PHPT MESH:D049950
3189 433-445 DiseaseOrPhenotypicFeature denotes prolactinoma MESH:D015175
3190 467-471 DiseaseOrPhenotypicFeature denotes PHPT MESH:D049950
3191 488-495 OrganismTaxon denotes patient NCBITaxon:9606
3192 533-538 OrganismTaxon denotes woman NCBITaxon:9606
3193 580-587 OrganismTaxon denotes patient NCBITaxon:9606
3194 629-633 DiseaseOrPhenotypicFeature denotes pain MESH:D010146
3195 645-653 DiseaseOrPhenotypicFeature denotes diarrhea MESH:D003967
3196 742-769 DiseaseOrPhenotypicFeature denotes pancreatic islet cell tumor MESH:D007516
3197 807-819 DiseaseOrPhenotypicFeature denotes prolactinoma MESH:D015175
3198 846-850 GeneOrGeneProduct denotes MEN1 NCBIGene:4221
3199 945-952 OrganismTaxon denotes patient NCBITaxon:9606
3200 1003-1045 SequenceVariant denotes A to G transition at codon 557 (AAG-->GAG) p|SUB|K|557|E
3201 1060-1064 GeneOrGeneProduct denotes MEN1 NCBIGene:4221
3202 1098-1121 SequenceVariant denotes lysine by glutamic acid p|SUB|K||E
3203 1141-1148 OrganismTaxon denotes patient NCBITaxon:9606
3204 1192-1235 SequenceVariant denotes mutation at codon 418 of exon 9 (GAC-->TAT) p|SUB|D|418|Y
3205 1270-1295 SequenceVariant denotes aspartic acid by tyrosine p|SUB|D||Y
3206 1365-1369 GeneOrGeneProduct denotes MEN1 NCBIGene:4221

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 54-82 DiseaseOrPhenotypicFeature denotes multiple endocrine neoplasia 0017169
T2 86-121 DiseaseOrPhenotypicFeature denotes Multiple endocrine neoplasia type 1 0007540
T3 203-211 DiseaseOrPhenotypicFeature denotes adenomas 0004972
T4 391-418 DiseaseOrPhenotypicFeature denotes primary hyperparathyroidism 0010837
T5 399-418 DiseaseOrPhenotypicFeature denotes hyperparathyroidism 0001741
T6 742-752 DiseaseOrPhenotypicFeature denotes pancreatic 0004982

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 4-9 GeneOrGeneProduct denotes novel
T2 10-19 GeneOrGeneProduct denotes mutations
T3 27-31 GeneOrGeneProduct denotes MEN1
T4 54-62 GeneOrGeneProduct denotes multiple
T5 63-82 GeneOrGeneProduct denotes endocrine neoplasia
T6 95-114 GeneOrGeneProduct denotes endocrine neoplasia
T7 123-127 GeneOrGeneProduct denotes MEN1
T8 232-240 GeneOrGeneProduct denotes mutation
T9 248-252 GeneOrGeneProduct denotes MEN1
T10 287-291 GeneOrGeneProduct denotes MEN1
T11 297-302 GeneOrGeneProduct denotes novel
T12 303-312 GeneOrGeneProduct denotes mutations
T13 320-324 GeneOrGeneProduct denotes MEN1
T14 629-633 GeneOrGeneProduct denotes pain
T15 663-667 GeneOrGeneProduct denotes past
T16 753-758 GeneOrGeneProduct denotes islet
T17 759-763 GeneOrGeneProduct denotes cell
T18 764-769 GeneOrGeneProduct denotes tumor
T19 846-850 GeneOrGeneProduct denotes MEN1
T20 905-914 GeneOrGeneProduct denotes mutations
T21 980-983 GeneOrGeneProduct denotes all
T22 984-989 GeneOrGeneProduct denotes had a
T23 1060-1064 GeneOrGeneProduct denotes MEN1
T24 1078-1082 GeneOrGeneProduct denotes in a
T25 1098-1104 GeneOrGeneProduct denotes lysine
T26 1108-1116 GeneOrGeneProduct denotes glutamic
T27 1117-1121 GeneOrGeneProduct denotes acid
T28 1173-1178 GeneOrGeneProduct denotes had a
T29 1192-1200 GeneOrGeneProduct denotes mutation
T30 1231-1234 GeneOrGeneProduct denotes TAT
T31 1249-1253 GeneOrGeneProduct denotes in a
T32 1270-1278 GeneOrGeneProduct denotes aspartic
T33 1279-1283 GeneOrGeneProduct denotes acid
T34 1287-1295 GeneOrGeneProduct denotes tyrosine
T35 1333-1338 GeneOrGeneProduct denotes novel
T36 1339-1347 GeneOrGeneProduct denotes missense
T37 1348-1357 GeneOrGeneProduct denotes mutations
T38 1365-1369 GeneOrGeneProduct denotes MEN1

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 4-9 GeneOrGeneProduct denotes novel
T2 27-31 GeneOrGeneProduct denotes MEN1
T3 54-62 GeneOrGeneProduct denotes multiple
T4 63-82 GeneOrGeneProduct denotes endocrine neoplasia
T5 95-114 GeneOrGeneProduct denotes endocrine neoplasia
T6 123-127 GeneOrGeneProduct denotes MEN1
T7 248-252 GeneOrGeneProduct denotes MEN1
T8 287-291 GeneOrGeneProduct denotes MEN1
T9 297-302 GeneOrGeneProduct denotes novel
T10 320-324 GeneOrGeneProduct denotes MEN1
T11 629-633 GeneOrGeneProduct denotes pain
T12 663-667 GeneOrGeneProduct denotes past
T13 753-758 GeneOrGeneProduct denotes islet
T14 759-763 GeneOrGeneProduct denotes cell
T15 846-850 GeneOrGeneProduct denotes MEN1
T16 1060-1064 GeneOrGeneProduct denotes MEN1
T17 1098-1104 GeneOrGeneProduct denotes lysine
T18 1117-1121 GeneOrGeneProduct denotes acid
T19 1231-1234 GeneOrGeneProduct denotes TAT
T20 1279-1283 GeneOrGeneProduct denotes acid
T21 1287-1295 GeneOrGeneProduct denotes tyrosine
T22 1333-1338 GeneOrGeneProduct denotes novel
T23 1365-1369 GeneOrGeneProduct denotes MEN1

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 54-82 DiseaseOrPhenotypicFeature denotes multiple endocrine neoplasia D009377
T2 86-121 DiseaseOrPhenotypicFeature denotes Multiple endocrine neoplasia type 1 D018761
T3 193-211 DiseaseOrPhenotypicFeature denotes pituitary adenomas D010911
T4 391-418 DiseaseOrPhenotypicFeature denotes primary hyperparathyroidism D049950
T5 420-424 DiseaseOrPhenotypicFeature denotes PHPT D049950
T6 433-445 DiseaseOrPhenotypicFeature denotes prolactinoma D015175
T7 467-471 DiseaseOrPhenotypicFeature denotes PHPT D049950
T8 629-633 DiseaseOrPhenotypicFeature denotes pain D010146
T9 645-653 DiseaseOrPhenotypicFeature denotes diarrhea D003967
T10 753-769 DiseaseOrPhenotypicFeature denotes islet cell tumor D007516
T11 807-819 DiseaseOrPhenotypicFeature denotes prolactinoma D015175

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 27-31 GeneOrGeneProduct denotes MEN1
T2 54-84 GeneOrGeneProduct denotes multiple endocrine neoplasia-1
T3 86-121 GeneOrGeneProduct denotes Multiple endocrine neoplasia type 1
T4 123-127 GeneOrGeneProduct denotes MEN1
T5 248-252 GeneOrGeneProduct denotes MEN1
T6 287-291 GeneOrGeneProduct denotes MEN1
T7 320-324 GeneOrGeneProduct denotes MEN1
T8 663-667 GeneOrGeneProduct denotes past
T9 753-758 GeneOrGeneProduct denotes islet
T10 846-850 GeneOrGeneProduct denotes MEN1
T11 1060-1064 GeneOrGeneProduct denotes MEN1
T12 1231-1234 GeneOrGeneProduct denotes TAT
T13 1365-1369 GeneOrGeneProduct denotes MEN1

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 27-31 DiseaseOrPhenotypicFeature denotes MEN1 0007540
T2 54-82 DiseaseOrPhenotypicFeature denotes multiple endocrine neoplasia 0017169
T3 86-121 DiseaseOrPhenotypicFeature denotes Multiple endocrine neoplasia type 1 0007540
T4 123-127 DiseaseOrPhenotypicFeature denotes MEN1 0007540
T5 193-202 DiseaseOrPhenotypicFeature denotes pituitary 0021156
T6 203-211 DiseaseOrPhenotypicFeature denotes adenomas 0004972
T7 248-252 DiseaseOrPhenotypicFeature denotes MEN1 0007540
T8 287-291 DiseaseOrPhenotypicFeature denotes MEN1 0007540
T9 320-324 DiseaseOrPhenotypicFeature denotes MEN1 0007540
T10 391-418 DiseaseOrPhenotypicFeature denotes primary hyperparathyroidism 0010837
T11 420-424 DiseaseOrPhenotypicFeature denotes PHPT 0010837
T12 433-445 DiseaseOrPhenotypicFeature denotes prolactinoma 0010911
T13 467-471 DiseaseOrPhenotypicFeature denotes PHPT 0010837
T14 645-653 DiseaseOrPhenotypicFeature denotes diarrhea 0001673
T15 753-769 DiseaseOrPhenotypicFeature denotes islet cell tumor 0019954|0005815
T17 807-819 DiseaseOrPhenotypicFeature denotes prolactinoma 0010911
T18 846-850 DiseaseOrPhenotypicFeature denotes MEN1 0007540
T19 1060-1064 DiseaseOrPhenotypicFeature denotes MEN1 0007540
T20 1365-1369 DiseaseOrPhenotypicFeature denotes MEN1 0007540

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 27-31 DiseaseOrPhenotypicFeature denotes MEN1 DISEASE
T2 54-82 DiseaseOrPhenotypicFeature denotes multiple endocrine neoplasia D009377
T3 86-121 DiseaseOrPhenotypicFeature denotes Multiple endocrine neoplasia type 1 D018761
T4 123-127 DiseaseOrPhenotypicFeature denotes MEN1 DISEASE
T5 162-211 DiseaseOrPhenotypicFeature denotes enteropancreatic endocrine and pituitary adenomas DISEASE
T6 248-252 DiseaseOrPhenotypicFeature denotes MEN1 DISEASE
T7 287-291 DiseaseOrPhenotypicFeature denotes MEN1 DISEASE
T8 320-324 DiseaseOrPhenotypicFeature denotes MEN1 DISEASE
T9 391-418 DiseaseOrPhenotypicFeature denotes primary hyperparathyroidism D049950
T10 420-424 DiseaseOrPhenotypicFeature denotes PHPT D049950
T11 433-445 DiseaseOrPhenotypicFeature denotes prolactinoma D015175
T12 467-471 DiseaseOrPhenotypicFeature denotes PHPT D049950
T13 629-633 DiseaseOrPhenotypicFeature denotes pain D010146
T14 645-653 DiseaseOrPhenotypicFeature denotes diarrhea D003967
T15 753-769 DiseaseOrPhenotypicFeature denotes islet cell tumor D007516
T16 807-819 DiseaseOrPhenotypicFeature denotes prolactinoma D015175
T17 846-850 DiseaseOrPhenotypicFeature denotes MEN1 DISEASE
T18 1060-1064 DiseaseOrPhenotypicFeature denotes MEN1 DISEASE
T19 1365-1369 DiseaseOrPhenotypicFeature denotes MEN1 DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 54-82 DiseaseOrPhenotypicFeature denotes multiple endocrine neoplasia D009377
T2 86-121 DiseaseOrPhenotypicFeature denotes Multiple endocrine neoplasia type 1 D018761
T3 162-211 DiseaseOrPhenotypicFeature denotes enteropancreatic endocrine and pituitary adenomas DISEASE
T4 391-418 DiseaseOrPhenotypicFeature denotes primary hyperparathyroidism D049950
T5 420-424 DiseaseOrPhenotypicFeature denotes PHPT D049950
T6 433-445 DiseaseOrPhenotypicFeature denotes prolactinoma D015175
T7 467-471 DiseaseOrPhenotypicFeature denotes PHPT D049950
T8 629-633 DiseaseOrPhenotypicFeature denotes pain D010146
T9 645-653 DiseaseOrPhenotypicFeature denotes diarrhea D003967
T10 753-769 DiseaseOrPhenotypicFeature denotes islet cell tumor D007516
T11 807-819 DiseaseOrPhenotypicFeature denotes prolactinoma D015175

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 1035-1038 ChemicalEntity denotes AAG http://purl.obolibrary.org/obo/CHEBI_73318
T2 1041-1044 ChemicalEntity denotes GAG http://purl.obolibrary.org/obo/CHEBI_143889
T3 1098-1104 ChemicalEntity denotes lysine http://purl.obolibrary.org/obo/CHEBI_25094|http://purl.obolibrary.org/obo/CHEBI_18019
T5 1108-1121 ChemicalEntity denotes glutamic acid http://purl.obolibrary.org/obo/CHEBI_18237|http://purl.obolibrary.org/obo/CHEBI_16015
T7 1270-1283 ChemicalEntity denotes aspartic acid http://purl.obolibrary.org/obo/CHEBI_22660
T8 1287-1295 ChemicalEntity denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 379-386 OrganismTaxon denotes patient
T2 488-495 OrganismTaxon denotes patient
T3 529-538 OrganismTaxon denotes old woman
T4 580-587 OrganismTaxon denotes patient
T5 945-952 OrganismTaxon denotes patient
T6 1041-1044 OrganismTaxon denotes GAG
T7 1141-1148 OrganismTaxon denotes patient

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T8 1287-1295 ChemicalEntity denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T7 1270-1283 ChemicalEntity denotes aspartic acid http://purl.obolibrary.org/obo/CHEBI_22660
T5 1108-1121 ChemicalEntity denotes glutamic acid http://purl.obolibrary.org/obo/CHEBI_16015|http://purl.obolibrary.org/obo/CHEBI_18237
T3 1098-1104 ChemicalEntity denotes lysine http://purl.obolibrary.org/obo/CHEBI_18019|http://purl.obolibrary.org/obo/CHEBI_25094
T2 1041-1044 ChemicalEntity denotes GAG http://purl.obolibrary.org/obo/CHEBI_143889
T1 1035-1038 ChemicalEntity denotes AAG http://purl.obolibrary.org/obo/CHEBI_73318
T13 1365-1369 GeneOrGeneProduct denotes MEN1
T12 1231-1234 GeneOrGeneProduct denotes TAT
T11 1060-1064 GeneOrGeneProduct denotes MEN1
T10 846-850 GeneOrGeneProduct denotes MEN1
T9 753-758 GeneOrGeneProduct denotes islet
T54664 663-667 GeneOrGeneProduct denotes past
T67075 320-324 GeneOrGeneProduct denotes MEN1
T6 287-291 GeneOrGeneProduct denotes MEN1
T78633 248-252 GeneOrGeneProduct denotes MEN1
T4 123-127 GeneOrGeneProduct denotes MEN1
T80403 86-121 GeneOrGeneProduct denotes Multiple endocrine neoplasia type 1
T75791 54-84 GeneOrGeneProduct denotes multiple endocrine neoplasia-1
T69123 27-31 GeneOrGeneProduct denotes MEN1
T7678 807-819 DiseaseOrPhenotypicFeature denotes prolactinoma D015175
T56288 753-769 DiseaseOrPhenotypicFeature denotes islet cell tumor D007516
T77597 645-653 DiseaseOrPhenotypicFeature denotes diarrhea D003967
T50180 629-633 DiseaseOrPhenotypicFeature denotes pain D010146
T15258 467-471 DiseaseOrPhenotypicFeature denotes PHPT D049950
T61606 433-445 DiseaseOrPhenotypicFeature denotes prolactinoma D015175
T14986 420-424 DiseaseOrPhenotypicFeature denotes PHPT D049950
T1161 391-418 DiseaseOrPhenotypicFeature denotes primary hyperparathyroidism D049950
T18563 162-211 DiseaseOrPhenotypicFeature denotes enteropancreatic endocrine and pituitary adenomas DISEASE
T84619 86-121 DiseaseOrPhenotypicFeature denotes Multiple endocrine neoplasia type 1 D018761
T13023 54-82 DiseaseOrPhenotypicFeature denotes multiple endocrine neoplasia D009377
T42361 1141-1148 OrganismTaxon denotes patient
T9085 1041-1044 OrganismTaxon denotes GAG
T70774 945-952 OrganismTaxon denotes patient
T37490 580-587 OrganismTaxon denotes patient
T5396 529-538 OrganismTaxon denotes old woman
T71124 488-495 OrganismTaxon denotes patient
T53208 379-386 OrganismTaxon denotes patient

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 95-114 HP_0100568 denotes endocrine neoplasia
T2 105-114 HP_0002664 denotes neoplasia
T3 193-211 HP_0002893 denotes pituitary adenomas
T4 391-418 HP_0008200 denotes primary hyperparathyroidism
T5 399-418 HP_0000843 denotes hyperparathyroidism
T6 629-633 HP_0012531 denotes pain
T7 645-653 HP_0002014 denotes diarrhea
T8 764-769 HP_0002664 denotes tumor

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
16840830-1#162#166#gene4221 248-252 gene4221 denotes MEN1
16840830-1#0#35#diseaseC0025267 86-121 diseaseC0025267 denotes Multiple endocrine neoplasia type 1
16840830-1#107#125#diseaseC0032000 193-211 diseaseC0032000 denotes pituitary adenomas
162#166#gene42210#35#diseaseC0025267 16840830-1#162#166#gene4221 16840830-1#0#35#diseaseC0025267 associated_with MEN1,Multiple endocrine neoplasia type 1
162#166#gene4221107#125#diseaseC0032000 16840830-1#162#166#gene4221 16840830-1#107#125#diseaseC0032000 associated_with MEN1,pituitary adenomas

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 1035-1044 DNAMutation:|SUB|AAG||GAG denotes AAG-->GAG
T2 1225-1234 DNAMutation:|SUB|GAC||TAT denotes GAC-->TAT