PubMed:1683740 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/1683740","sourcedb":"PubMed","sourceid":"1683740","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/1683740","text":"Changes of lymphocyte subsets in leukemia patients who received allogenic bone marrow transplantation.\nProportional changes of lymphocyte subsets in the peripheral blood were monitored by two-color flow-cytometry in seven leukemia patients who had received allogenic bone marrow transplantation (BMT). Lymphocyte counts, and proportions of T and B-cells returned to normal ranges between the 2nd and 12th months after BMT. Activated T-cells prominently increased after BMT, and the values gradually returned toward normal. As to lymphocyte subsets, the proportions of CD 4+ cells had remained low, while those of CD 8+ cells high for a whole observation period after BMT. The changes of CD 4+ cells were caused by the decrease of suppressor-inducer T-cells (CD 4+ Leu 8+). High proportion of CD 8+ cells was mainly associated with increased suppressor T-cells (CD 8+ CD 11+). Among natural killer (NK) cells, highly active NK cells (CD 16+ CD 57-) markedly increased shortly after BMT, and gradually returned to normal. CD 16 -CD 57+ NK cells increased beyond normal ranges after the 2nd month. The incidence or degree of acute and chronic graft-versus-host diseases (GVHD) did not correlate with the changes of any lymphocyte subsets. The present results suggest that the increase of activated T-cells shortly after BMT reflects lymphocyte reconstitution. The prolonged immune deficiency after BMT might be related to either deficient expression of homing receptor (Leu 8 antigen) on CD 4+ cells or increased suppressor T-cells (CD 8+ CD 11+). In addition, the early increase of NK cells after BMT may compensate for the immune deficiency in BMT patients.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":222,"end":230},"obj":"HP_0001909"},{"id":"T2","span":{"begin":1371,"end":1388},"obj":"HP_0002721"},{"id":"T3","span":{"begin":1622,"end":1639},"obj":"HP_0002721"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"}]},{"project":"AnEM_abstracts","denotations":[{"id":"T1","span":{"begin":11,"end":21},"obj":"Cell"},{"id":"T2","span":{"begin":74,"end":85},"obj":"Multi-tissue_structure"},{"id":"T3","span":{"begin":127,"end":137},"obj":"Cell"},{"id":"T4","span":{"begin":153,"end":169},"obj":"Organism_substance"},{"id":"T5","span":{"begin":267,"end":278},"obj":"Multi-tissue_structure"},{"id":"T6","span":{"begin":302,"end":312},"obj":"Cell"},{"id":"T7","span":{"begin":340,"end":341},"obj":"Cell"},{"id":"T8","span":{"begin":346,"end":353},"obj":"Cell"},{"id":"T9","span":{"begin":433,"end":440},"obj":"Cell"},{"id":"T10","span":{"begin":529,"end":539},"obj":"Cell"},{"id":"T11","span":{"begin":568,"end":579},"obj":"Cell"},{"id":"T12","span":{"begin":613,"end":624},"obj":"Cell"},{"id":"T13","span":{"begin":687,"end":698},"obj":"Cell"},{"id":"T14","span":{"begin":730,"end":756},"obj":"Cell"},{"id":"T15","span":{"begin":792,"end":803},"obj":"Cell"},{"id":"T16","span":{"begin":841,"end":859},"obj":"Cell"},{"id":"T17","span":{"begin":882,"end":907},"obj":"Cell"},{"id":"T18","span":{"begin":923,"end":931},"obj":"Cell"},{"id":"T19","span":{"begin":1020,"end":1042},"obj":"Cell"},{"id":"T20","span":{"begin":1216,"end":1226},"obj":"Cell"},{"id":"T21","span":{"begin":1295,"end":1302},"obj":"Cell"},{"id":"T22","span":{"begin":1330,"end":1340},"obj":"Cell"},{"id":"T23","span":{"begin":1485,"end":1496},"obj":"Cell"},{"id":"T24","span":{"begin":1510,"end":1528},"obj":"Cell"},{"id":"T25","span":{"begin":1580,"end":1588},"obj":"Cell"},{"id":"T26","span":{"begin":1140,"end":1145},"obj":"Multi-tissue_structure"}],"attributes":[{"subj":"T1","pred":"source","obj":"AnEM_abstracts"},{"subj":"T2","pred":"source","obj":"AnEM_abstracts"},{"subj":"T3","pred":"source","obj":"AnEM_abstracts"},{"subj":"T4","pred":"source","obj":"AnEM_abstracts"},{"subj":"T5","pred":"source","obj":"AnEM_abstracts"},{"subj":"T6","pred":"source","obj":"AnEM_abstracts"},{"subj":"T7","pred":"source","obj":"AnEM_abstracts"},{"subj":"T8","pred":"source","obj":"AnEM_abstracts"},{"subj":"T9","pred":"source","obj":"AnEM_abstracts"},{"subj":"T10","pred":"source","obj":"AnEM_abstracts"},{"subj":"T11","pred":"source","obj":"AnEM_abstracts"},{"subj":"T12","pred":"source","obj":"AnEM_abstracts"},{"subj":"T13","pred":"source","obj":"AnEM_abstracts"},{"subj":"T14","pred":"source","obj":"AnEM_abstracts"},{"subj":"T15","pred":"source","obj":"AnEM_abstracts"},{"subj":"T16","pred":"source","obj":"AnEM_abstracts"},{"subj":"T17","pred":"source","obj":"AnEM_abstracts"},{"subj":"T18","pred":"source","obj":"AnEM_abstracts"},{"subj":"T19","pred":"source","obj":"AnEM_abstracts"},{"subj":"T20","pred":"source","obj":"AnEM_abstracts"},{"subj":"T21","pred":"source","obj":"AnEM_abstracts"},{"subj":"T22","pred":"source","obj":"AnEM_abstracts"},{"subj":"T23","pred":"source","obj":"AnEM_abstracts"},{"subj":"T24","pred":"source","obj":"AnEM_abstracts"},{"subj":"T25","pred":"source","obj":"AnEM_abstracts"},{"subj":"T26","pred":"source","obj":"AnEM_abstracts"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#ec9a93","default":true},{"id":"AnEM_abstracts","color":"#93a5ec"}]}]}}