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LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 634-638 OrganismTaxon denotes Rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T4 765-769 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T7 829-833 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T10 1033-1037 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T13 1403-1412 OrganismTaxon denotes scavenger NCBItxid:30848
T14 1503-1507 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T17 1553-1557 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T20 1712-1716 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T23 1756-1760 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T26 1843-1847 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T29 1919-1923 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-93 Sentence denotes Mechanisms of hypertension induced by nitric oxide (NO) deficiency: focus on venous function.
T2 94-199 Sentence denotes Loss of endothelial cell-derived nitric oxide (NO) in hypertension is a hallmark of arterial dysfunction.
T3 200-340 Sentence denotes Experimental hypertension created by the removal of NO, however, involves mechanisms in addition to decreased arterial vasodilator activity.
T4 341-478 Sentence denotes These include augmented endothelin-1 (ET-1) release, increased sympathetic nervous system activity, and elevated tissue oxidative stress.
T5 479-633 Sentence denotes We hypothesized that increased venous smooth muscle (venomotor) tone plays a role in Nomega-nitro-L-arginine (LNNA) hypertension through these mechanisms.
T6 634-728 Sentence denotes Rats were treated with the NO synthase inhibitor LNNA (0.5 g/L in drinking water) for 2 weeks.
T7 729-843 Sentence denotes Mean arterial pressure of conscious rats was 119 +/- 2 mm Hg in control and 194 +/- 5 mm Hg in LNNA rats (P<0.05).
T8 844-929 Sentence denotes Carotid arteries and vena cava were removed for measurement of isometric contraction.
T9 930-1118 Sentence denotes Maximal contraction to norepinephrine was modestly reduced in arteries from LNNA compared with control rats whereas the maximum contraction to ET-1 was significantly reduced (54% control).
T10 1119-1248 Sentence denotes Maximum contraction of vena cava to norepinephrine (37% control) also was reduced but no change in response to ET-1 was observed.
T11 1249-1387 Sentence denotes Mean circulatory filling pressure, an in vivo measure of venomotor tone, was not elevated in LNNA hypertension at 1 or 2 weeks after LNNA.
T12 1388-1604 Sentence denotes The superoxide scavenger tempol (30, 100, and 300 micromol kg(-1), IV) did not change arterial pressure in control rats but caused a dose-dependent decrease in LNNA rats (-18 +/- 8, -26 +/- 15, and -54 +/- 11 mm Hg).
T13 1605-1779 Sentence denotes Similarly, ganglionic blockade with hexamethonium caused a significantly greater fall in LNNA hypertensive rats (76 +/- 9 mm Hg) compared with control rats (35 +/- 10 mm Hg).
T14 1780-1924 Sentence denotes Carotid arteries, vena cava, and sympathetic ganglia from LNNA rats had higher basal levels of superoxide compared with those from control rats.
T15 1925-2142 Sentence denotes These data suggest that while NO deficiency increases oxidative stress and sympathetic activity in both arterial and venous vessels, the impact on veins does not make a major contribution to this form of hypertension.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
3067 14-26 DiseaseOrPhenotypicFeature denotes hypertension MESH:D006973
3068 38-50 ChemicalEntity denotes nitric oxide MESH:D009569
3069 52-54 ChemicalEntity denotes NO MESH:D009569
3070 127-139 ChemicalEntity denotes nitric oxide MESH:D009569
3071 141-143 ChemicalEntity denotes NO MESH:D009569
3072 148-160 DiseaseOrPhenotypicFeature denotes hypertension MESH:D006973
3073 178-198 DiseaseOrPhenotypicFeature denotes arterial dysfunction MESH:D018754
3074 213-225 DiseaseOrPhenotypicFeature denotes hypertension MESH:D006973
3075 252-254 ChemicalEntity denotes NO MESH:D009569
3076 365-377 GeneOrGeneProduct denotes endothelin-1 NCBIGene:24323
3077 379-383 GeneOrGeneProduct denotes ET-1 NCBIGene:24323
3078 564-587 ChemicalEntity denotes Nomega-nitro-L-arginine MESH:D019335
3079 589-593 ChemicalEntity denotes LNNA MESH:D019335
3080 595-607 DiseaseOrPhenotypicFeature denotes hypertension MESH:D006973
3081 634-638 OrganismTaxon denotes Rats NCBITaxon:10116
3082 661-672 GeneOrGeneProduct denotes NO synthase NCBIGene:24598
3083 683-687 ChemicalEntity denotes LNNA MESH:D019335
3084 765-769 OrganismTaxon denotes rats NCBITaxon:10116
3085 824-828 ChemicalEntity denotes LNNA MESH:D019335
3086 829-833 OrganismTaxon denotes rats NCBITaxon:10116
3087 953-967 ChemicalEntity denotes norepinephrine MESH:D009638
3088 1006-1010 ChemicalEntity denotes LNNA MESH:D019335
3089 1033-1037 OrganismTaxon denotes rats NCBITaxon:10116
3090 1073-1077 GeneOrGeneProduct denotes ET-1 NCBIGene:24323
3091 1155-1169 ChemicalEntity denotes norepinephrine MESH:D009638
3092 1230-1234 GeneOrGeneProduct denotes ET-1 NCBIGene:24323
3093 1342-1346 ChemicalEntity denotes LNNA MESH:D019335
3094 1347-1359 DiseaseOrPhenotypicFeature denotes hypertension MESH:D006973
3095 1382-1386 ChemicalEntity denotes LNNA MESH:D019335
3096 1392-1402 ChemicalEntity denotes superoxide MESH:D013481
3097 1413-1419 ChemicalEntity denotes tempol MESH:C001803
3098 1503-1507 OrganismTaxon denotes rats NCBITaxon:10116
3099 1548-1552 ChemicalEntity denotes LNNA MESH:D019335
3100 1553-1557 OrganismTaxon denotes rats NCBITaxon:10116
3101 1641-1654 ChemicalEntity denotes hexamethonium MESH:D018738
3102 1694-1698 ChemicalEntity denotes LNNA MESH:D019335
3103 1699-1711 DiseaseOrPhenotypicFeature denotes hypertensive MESH:D006973
3104 1712-1716 OrganismTaxon denotes rats NCBITaxon:10116
3105 1756-1760 OrganismTaxon denotes rats NCBITaxon:10116
3106 1838-1842 ChemicalEntity denotes LNNA MESH:D019335
3107 1843-1847 OrganismTaxon denotes rats NCBITaxon:10116
3108 1875-1885 ChemicalEntity denotes superoxide MESH:D013481
3109 1919-1923 OrganismTaxon denotes rats NCBITaxon:10116
3110 1955-1957 ChemicalEntity denotes NO MESH:D009569
3111 2129-2141 DiseaseOrPhenotypicFeature denotes hypertension MESH:D006973

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 102-113 DiseaseOrPhenotypicFeature denotes endothelial 0015292

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 14-26 GeneOrGeneProduct denotes hypertension
T2 27-34 GeneOrGeneProduct denotes induced
T3 102-113 GeneOrGeneProduct denotes endothelial
T4 114-118 GeneOrGeneProduct denotes cell
T5 148-160 GeneOrGeneProduct denotes hypertension
T6 213-225 GeneOrGeneProduct denotes hypertension
T7 226-233 GeneOrGeneProduct denotes created
T8 331-339 GeneOrGeneProduct denotes activity
T9 365-377 GeneOrGeneProduct denotes endothelin-1
T10 379-383 GeneOrGeneProduct denotes ET-1
T11 416-423 GeneOrGeneProduct denotes nervous
T12 431-439 GeneOrGeneProduct denotes activity
T13 517-530 GeneOrGeneProduct denotes smooth muscle
T14 595-607 GeneOrGeneProduct denotes hypertension
T15 661-672 GeneOrGeneProduct denotes NO synthase
T16 673-682 GeneOrGeneProduct denotes inhibitor
T17 865-869 GeneOrGeneProduct denotes vena
T18 870-874 GeneOrGeneProduct denotes cava
T19 981-988 GeneOrGeneProduct denotes reduced
T20 1073-1077 GeneOrGeneProduct denotes ET-1
T21 1096-1103 GeneOrGeneProduct denotes reduced
T22 1142-1146 GeneOrGeneProduct denotes vena
T23 1147-1151 GeneOrGeneProduct denotes cava
T24 1193-1200 GeneOrGeneProduct denotes reduced
T25 1230-1234 GeneOrGeneProduct denotes ET-1
T26 1266-1273 GeneOrGeneProduct denotes filling
T27 1347-1359 GeneOrGeneProduct denotes hypertension
T28 1360-1364 GeneOrGeneProduct denotes at 1
T29 1365-1369 GeneOrGeneProduct denotes or 2
T30 1571-1580 GeneOrGeneProduct denotes 26 +/- 15
T31 1605-1614 GeneOrGeneProduct denotes Similarly
T32 1699-1711 GeneOrGeneProduct denotes hypertensive
T33 1798-1802 GeneOrGeneProduct denotes vena
T34 1803-1807 GeneOrGeneProduct denotes cava
T35 2012-2020 GeneOrGeneProduct denotes activity
T36 2062-2068 GeneOrGeneProduct denotes impact
T37 2072-2077 GeneOrGeneProduct denotes veins
T38 2094-2099 GeneOrGeneProduct denotes major
T39 2129-2141 GeneOrGeneProduct denotes hypertension

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 14-26 GeneOrGeneProduct denotes hypertension
T2 102-113 GeneOrGeneProduct denotes endothelial
T3 114-118 GeneOrGeneProduct denotes cell
T4 148-160 GeneOrGeneProduct denotes hypertension
T5 213-225 GeneOrGeneProduct denotes hypertension
T6 365-377 GeneOrGeneProduct denotes endothelin-1
T7 379-383 GeneOrGeneProduct denotes ET-1
T8 416-423 GeneOrGeneProduct denotes nervous
T9 517-530 GeneOrGeneProduct denotes smooth muscle
T10 595-607 GeneOrGeneProduct denotes hypertension
T11 661-672 GeneOrGeneProduct denotes NO synthase
T12 673-682 GeneOrGeneProduct denotes inhibitor
T13 981-988 GeneOrGeneProduct denotes reduced
T14 1073-1077 GeneOrGeneProduct denotes ET-1
T15 1096-1103 GeneOrGeneProduct denotes reduced
T16 1193-1200 GeneOrGeneProduct denotes reduced
T17 1230-1234 GeneOrGeneProduct denotes ET-1
T18 1347-1359 GeneOrGeneProduct denotes hypertension
T19 1571-1580 GeneOrGeneProduct denotes 26 +/- 15
T20 2062-2068 GeneOrGeneProduct denotes impact
T21 2094-2099 GeneOrGeneProduct denotes major
T22 2129-2141 GeneOrGeneProduct denotes hypertension

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 14-26 DiseaseOrPhenotypicFeature denotes hypertension D006973
T2 148-160 DiseaseOrPhenotypicFeature denotes hypertension D006973
T3 213-225 DiseaseOrPhenotypicFeature denotes hypertension D006973
T4 595-607 DiseaseOrPhenotypicFeature denotes hypertension D006973
T5 1347-1359 DiseaseOrPhenotypicFeature denotes hypertension D006973
T6 1616-1626 DiseaseOrPhenotypicFeature denotes ganglionic D045888
T7 1699-1711 DiseaseOrPhenotypicFeature denotes hypertensive D006973
T8 2129-2141 DiseaseOrPhenotypicFeature denotes hypertension D006973

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 365-377 GeneOrGeneProduct denotes endothelin-1
T2 379-383 GeneOrGeneProduct denotes ET-1
T3 517-530 GeneOrGeneProduct denotes smooth muscle
T4 661-672 GeneOrGeneProduct denotes NO synthase
T5 1073-1077 GeneOrGeneProduct denotes ET-1
T6 1230-1234 GeneOrGeneProduct denotes ET-1
T7 1571-1580 GeneOrGeneProduct denotes 26 +/- 15

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 14-26 DiseaseOrPhenotypicFeature denotes hypertension 0005044
T2 148-160 DiseaseOrPhenotypicFeature denotes hypertension 0005044
T3 213-225 DiseaseOrPhenotypicFeature denotes hypertension 0005044
T4 379-381 DiseaseOrPhenotypicFeature denotes ET 0005029
T5 595-607 DiseaseOrPhenotypicFeature denotes hypertension 0005044
T6 1073-1075 DiseaseOrPhenotypicFeature denotes ET 0005029
T7 1230-1232 DiseaseOrPhenotypicFeature denotes ET 0005029
T8 1347-1359 DiseaseOrPhenotypicFeature denotes hypertension 0005044
T9 2129-2141 DiseaseOrPhenotypicFeature denotes hypertension 0005044

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 14-26 DiseaseOrPhenotypicFeature denotes hypertension D006973
T2 148-160 DiseaseOrPhenotypicFeature denotes hypertension D006973
T3 178-198 DiseaseOrPhenotypicFeature denotes arterial dysfunction DISEASE
T4 213-225 DiseaseOrPhenotypicFeature denotes hypertension D006973
T5 595-607 DiseaseOrPhenotypicFeature denotes hypertension D006973
T6 1347-1359 DiseaseOrPhenotypicFeature denotes hypertension D006973
T7 2129-2141 DiseaseOrPhenotypicFeature denotes hypertension D006973

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 14-26 DiseaseOrPhenotypicFeature denotes hypertension D006973
T2 148-160 DiseaseOrPhenotypicFeature denotes hypertension D006973
T3 178-198 DiseaseOrPhenotypicFeature denotes arterial dysfunction DISEASE
T4 213-225 DiseaseOrPhenotypicFeature denotes hypertension D006973
T5 595-607 DiseaseOrPhenotypicFeature denotes hypertension D006973
T6 1347-1359 DiseaseOrPhenotypicFeature denotes hypertension D006973
T7 2129-2141 DiseaseOrPhenotypicFeature denotes hypertension D006973

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 38-50 ChemicalEntity denotes nitric oxide D009569|http://purl.obolibrary.org/obo/CHEBI_16480
T3 127-139 ChemicalEntity denotes nitric oxide D009569|http://purl.obolibrary.org/obo/CHEBI_16480
T5 365-377 ChemicalEntity denotes endothelin-1 http://purl.obolibrary.org/obo/CHEBI_80240
T6 571-576 ChemicalEntity denotes nitro http://purl.obolibrary.org/obo/CHEBI_29785
T7 577-587 ChemicalEntity denotes L-arginine http://purl.obolibrary.org/obo/CHEBI_32682|http://purl.obolibrary.org/obo/CHEBI_29952|http://purl.obolibrary.org/obo/CHEBI_16467
T10 589-593 ChemicalEntity denotes LNNA http://purl.obolibrary.org/obo/CHEBI_32682
T11 661-672 ChemicalEntity denotes NO synthase D019001
T12 683-687 ChemicalEntity denotes LNNA http://purl.obolibrary.org/obo/CHEBI_32682
T13 700-714 ChemicalEntity denotes drinking water D060766
T14 824-828 ChemicalEntity denotes LNNA http://purl.obolibrary.org/obo/CHEBI_32682
T15 953-967 ChemicalEntity denotes norepinephrine D009638|http://purl.obolibrary.org/obo/CHEBI_33569|http://purl.obolibrary.org/obo/CHEBI_18357
T18 1006-1010 ChemicalEntity denotes LNNA http://purl.obolibrary.org/obo/CHEBI_32682
T19 1155-1169 ChemicalEntity denotes norepinephrine D009638|http://purl.obolibrary.org/obo/CHEBI_33569|http://purl.obolibrary.org/obo/CHEBI_18357
T22 1342-1346 ChemicalEntity denotes LNNA http://purl.obolibrary.org/obo/CHEBI_32682
T23 1382-1386 ChemicalEntity denotes LNNA http://purl.obolibrary.org/obo/CHEBI_32682
T24 1392-1402 ChemicalEntity denotes superoxide D013481|http://purl.obolibrary.org/obo/CHEBI_18421
T26 1413-1419 ChemicalEntity denotes tempol C001803|ChemicalEntity
T28 1548-1552 ChemicalEntity denotes LNNA http://purl.obolibrary.org/obo/CHEBI_32682
T29 1641-1654 ChemicalEntity denotes hexamethonium D018738
T30 1694-1698 ChemicalEntity denotes LNNA http://purl.obolibrary.org/obo/CHEBI_32682
T31 1838-1842 ChemicalEntity denotes LNNA http://purl.obolibrary.org/obo/CHEBI_32682
T32 1875-1885 ChemicalEntity denotes superoxide D013481|http://purl.obolibrary.org/obo/CHEBI_18421

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 0-10 OrganismTaxon denotes Mechanisms
T2 634-638 OrganismTaxon denotes Rats
T3 765-769 OrganismTaxon denotes rats
T4 829-833 OrganismTaxon denotes rats
T5 1033-1037 OrganismTaxon denotes rats
T6 1403-1412 OrganismTaxon denotes scavenger
T7 1503-1507 OrganismTaxon denotes rats
T8 1553-1557 OrganismTaxon denotes rats
T9 1712-1716 OrganismTaxon denotes rats
T10 1756-1760 OrganismTaxon denotes rats
T11 1843-1847 OrganismTaxon denotes rats
T12 1919-1923 OrganismTaxon denotes rats

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T32 1875-1885 ChemicalEntity denotes superoxide http://purl.obolibrary.org/obo/CHEBI_18421|D013481
T31 1838-1842 ChemicalEntity denotes LNNA http://purl.obolibrary.org/obo/CHEBI_32682
T30 1694-1698 ChemicalEntity denotes LNNA http://purl.obolibrary.org/obo/CHEBI_32682
T29 1641-1654 ChemicalEntity denotes hexamethonium D018738
T28 1548-1552 ChemicalEntity denotes LNNA http://purl.obolibrary.org/obo/CHEBI_32682
T26 1413-1419 ChemicalEntity denotes tempol ChemicalEntity|C001803
T24 1392-1402 ChemicalEntity denotes superoxide http://purl.obolibrary.org/obo/CHEBI_18421|D013481
T23 1382-1386 ChemicalEntity denotes LNNA http://purl.obolibrary.org/obo/CHEBI_32682
T22 1342-1346 ChemicalEntity denotes LNNA http://purl.obolibrary.org/obo/CHEBI_32682
T19 1155-1169 ChemicalEntity denotes norepinephrine http://purl.obolibrary.org/obo/CHEBI_18357|http://purl.obolibrary.org/obo/CHEBI_33569|D009638
T18 1006-1010 ChemicalEntity denotes LNNA http://purl.obolibrary.org/obo/CHEBI_32682
T15 953-967 ChemicalEntity denotes norepinephrine http://purl.obolibrary.org/obo/CHEBI_18357|http://purl.obolibrary.org/obo/CHEBI_33569|D009638
T14 824-828 ChemicalEntity denotes LNNA http://purl.obolibrary.org/obo/CHEBI_32682
T13 700-714 ChemicalEntity denotes drinking water D060766
T12 683-687 ChemicalEntity denotes LNNA http://purl.obolibrary.org/obo/CHEBI_32682
T11 661-672 ChemicalEntity denotes NO synthase D019001
T10 589-593 ChemicalEntity denotes LNNA http://purl.obolibrary.org/obo/CHEBI_32682
T7 577-587 ChemicalEntity denotes L-arginine http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29952|http://purl.obolibrary.org/obo/CHEBI_32682
T6 571-576 ChemicalEntity denotes nitro http://purl.obolibrary.org/obo/CHEBI_29785
T5 365-377 ChemicalEntity denotes endothelin-1 http://purl.obolibrary.org/obo/CHEBI_80240
T3 127-139 ChemicalEntity denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480|D009569
T1 38-50 ChemicalEntity denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480|D009569
T8889 1571-1580 GeneOrGeneProduct denotes 26 +/- 15
T31362 1230-1234 GeneOrGeneProduct denotes ET-1
T41184 1073-1077 GeneOrGeneProduct denotes ET-1
T4 661-672 GeneOrGeneProduct denotes NO synthase
T99910 517-530 GeneOrGeneProduct denotes smooth muscle
T2 379-383 GeneOrGeneProduct denotes ET-1
T1842 365-377 GeneOrGeneProduct denotes endothelin-1
T7291 2129-2141 DiseaseOrPhenotypicFeature denotes hypertension D006973
T43459 1347-1359 DiseaseOrPhenotypicFeature denotes hypertension D006973
T32546 595-607 DiseaseOrPhenotypicFeature denotes hypertension D006973
T15697 213-225 DiseaseOrPhenotypicFeature denotes hypertension D006973
T79970 178-198 DiseaseOrPhenotypicFeature denotes arterial dysfunction DISEASE
T44855 148-160 DiseaseOrPhenotypicFeature denotes hypertension D006973
T33848 14-26 DiseaseOrPhenotypicFeature denotes hypertension D006973
T58971 1919-1923 OrganismTaxon denotes rats
T33574 1843-1847 OrganismTaxon denotes rats
T57872 1756-1760 OrganismTaxon denotes rats
T9 1712-1716 OrganismTaxon denotes rats
T8 1553-1557 OrganismTaxon denotes rats
T73726 1503-1507 OrganismTaxon denotes rats
T32699 1403-1412 OrganismTaxon denotes scavenger
T89176 1033-1037 OrganismTaxon denotes rats
T11049 829-833 OrganismTaxon denotes rats
T10011 765-769 OrganismTaxon denotes rats
T67116 634-638 OrganismTaxon denotes Rats
T77778 0-10 OrganismTaxon denotes Mechanisms