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PubMed:16807236 JSON TXT

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CL-cell

Id	Subject	Object	Predicate	Lexical cue	cl_id
T1	32-39	Cell	denotes	T cells	http://purl.obolibrary.org/obo/CL:0000084
T2	150-156	Cell	denotes	T cell	http://purl.obolibrary.org/obo/CL:0000084
T3	238-244	Cell	denotes	T cell	http://purl.obolibrary.org/obo/CL:0000084
T4	453-459	Cell	denotes	T cell	http://purl.obolibrary.org/obo/CL:0000084
T5	530-537	Cell	denotes	T cells	http://purl.obolibrary.org/obo/CL:0000084
T6	710-714	Cell	denotes	poly	http://purl.obolibrary.org/obo/CL:0000096\|http://purl.obolibrary.org/obo/CL:0000775
T8	1854-1861	Cell	denotes	T cells	http://purl.obolibrary.org/obo/CL:0000084

GlyCosmos15-Species

Id	Subject	Object	Predicate	Lexical cue	db_id
69	447-452	Species	denotes	human	9606
72	499-504	Species	denotes	human	9606

GlyCosmos6-Glycan-Motif-Image

Id	Subject	Object	Predicate	Lexical cue	image
T1	1188-1195	Glycan_Motif	denotes	heparin	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T3	1200-1211	Glycan_Motif	denotes	chondroitin	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT

sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-40	Sentence	denotes	CCL5-CCR5-mediated apoptosis in T cells:
T2	41-104	Sentence	denotes	Requirement for glycosaminoglycan binding and CCL5 aggregation.
T3	105-256	Sentence	denotes	CCL5 (RANTES (regulated on activation normal T cell expressed and secreted)) and its cognate receptor, CCR5, have been implicated in T cell activation.
T4	257-423	Sentence	denotes	CCL5 binding to glycosaminoglycans (GAGs) on the cell surface or in extracellular matrix sequesters CCL5, thereby immobilizing CCL5 to provide the directional signal.
T5	424-590	Sentence	denotes	In two CCR5-expressing human T cell lines, PM1.CCR5 and MOLT4.CCR5, and in human peripheral blood-derived T cells, micromolar concentrations of CCL5 induce apoptosis.
T6	591-747	Sentence	denotes	CCL5-induced cell death involves the cytosolic release of cytochrome c, the activation of caspase-9 and caspase-3, and poly(ADP-ribose) polymerase cleavage.
T7	748-888	Sentence	denotes	CCL5-induced apoptosis is CCR5-dependent, since native PM1 and MOLT4 cells lacking CCR5 expression are resistant to CCL5-induced cell death.
T8	889-1077	Sentence	denotes	Furthermore, we implicate tyrosine 339 as a critical residue involved in CCL5-induced apoptosis, since PM1 cells expressing a tyrosine mutant receptor, CCR5Y339F, do not undergo apoptosis.
T9	1078-1161	Sentence	denotes	We show that CCL5-CCR5-mediated apoptosis is dependent on cell surface GAG binding.
T10	1162-1289	Sentence	denotes	The addition of exogenous heparin and chondroitin sulfate and GAG digestion from the cell surface protect cells from apoptosis.
T11	1290-1372	Sentence	denotes	Moreover, the non-GAG binding variant, (44AANA47)-CCL5, fails to induce apoptosis.
T12	1373-1564	Sentence	denotes	To address the role of aggregation in CCL5-mediated apoptosis, nonaggregating CCL5 mutant E66S, which forms dimers, and E26A, which form tetramers at micromolar concentrations, were utilized.
T13	1565-1737	Sentence	denotes	Unlike native CCL5, the E66S mutant fails to induce apoptosis, suggesting that tetramers are the minimal higher ordered CCL5 aggregates required for CCL5-induced apoptosis.
T14	1738-1918	Sentence	denotes	Viewed altogether, these data suggest that CCL5-GAG binding and CCL5 aggregation are important for CCL5 activity in T cells, specifically in the context of CCR5-mediated apoptosis.

GlyCosmos6-Glycan-Motif-Structure

Id	Subject	Object	Predicate	Lexical cue
T1	1188-1195	https://glytoucan.org/Structures/Glycans/G00021MO	denotes	heparin
T2	1188-1195	https://glytoucan.org/Structures/Glycans/G54161DR	denotes	heparin
T3	1200-1211	https://glytoucan.org/Structures/Glycans/G43702JT	denotes	chondroitin

Glycosmos6-GlycoEpitope

Id	Subject	Object	Predicate	Lexical cue	glyco_epitope_db_id
T1	1200-1211	GlycoEpitope	denotes	chondroitin	http://www.glycoepitope.jp/epitopes/EP0081

Glycosmos6-MAT

Id	Subject	Object	Predicate	Lexical cue
T1	516-521	http://purl.obolibrary.org/obo/MAT_0000083	denotes	blood
T2	516-521	http://purl.obolibrary.org/obo/MAT_0000315	denotes	blood

GlyCosmos15-Glycan

Id	Subject	Object	Predicate	Lexical cue	image
T1	1200-1211	Glycan	denotes	chondroitin	https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT

Anatomy-MAT

Id	Subject	Object	Predicate	Lexical cue	mat_id
T1	516-521	Body_part	denotes	blood	http://purl.obolibrary.org/obo/MAT_0000083\|http://purl.obolibrary.org/obo/MAT_0000315

Glycan-GlyCosmos

Id	Subject	Object	Predicate	Lexical cue	image
T1	1200-1211	Glycan	denotes	chondroitin	https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT

GlyCosmos-GlycoEpitope

Id	Subject	Object	Predicate	Lexical cue	glycoepitope_id
T1	1200-1211	http://purl.jp/bio/12/glyco/glycan#Glycan_epitope	denotes	chondroitin	http://www.glycoepitope.jp/epitopes/EP0081

GlyCosmos15-NCBITAXON

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	447-452	OrganismTaxon	denotes	human	9606
T2	499-504	OrganismTaxon	denotes	human	9606

GlyCosmos15-CL

Id	Subject	Object	Predicate	Lexical cue	cl_id
T1	32-39	Cell	denotes	T cells	http://purl.obolibrary.org/obo/CL:0000084
T2	150-156	Cell	denotes	T cell	http://purl.obolibrary.org/obo/CL:0000084
T3	238-244	Cell	denotes	T cell	http://purl.obolibrary.org/obo/CL:0000084
T4	453-459	Cell	denotes	T cell	http://purl.obolibrary.org/obo/CL:0000084
T5	530-537	Cell	denotes	T cells	http://purl.obolibrary.org/obo/CL:0000084
T6	710-714	Cell	denotes	poly	http://purl.obolibrary.org/obo/CL:0000096\|http://purl.obolibrary.org/obo/CL:0000775
T8	1854-1861	Cell	denotes	T cells	http://purl.obolibrary.org/obo/CL:0000084

GlyCosmos15-UBERON

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T1	150-156	Body_part	denotes	T cell	http://purl.obolibrary.org/obo/CL_0000084
T2	238-244	Body_part	denotes	T cell	http://purl.obolibrary.org/obo/CL_0000084
T3	325-345	Body_part	denotes	extracellular matrix	http://purl.obolibrary.org/obo/GO_0031012
T4	453-459	Body_part	denotes	T cell	http://purl.obolibrary.org/obo/CL_0000084
T5	516-521	Body_part	denotes	blood	http://purl.obolibrary.org/obo/UBERON_0000178

GlyCosmos15-GlycoEpitope

Id	Subject	Object	Predicate	Lexical cue	glycoepitope_id
T1	1200-1211	http://purl.jp/bio/12/glyco/glycan#Glycan_epitope	denotes	chondroitin	http://www.glycoepitope.jp/epitopes/EP0081

GlyCosmos15-Sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-40	Sentence	denotes	CCL5-CCR5-mediated apoptosis in T cells:
T2	41-104	Sentence	denotes	Requirement for glycosaminoglycan binding and CCL5 aggregation.
T3	105-256	Sentence	denotes	CCL5 (RANTES (regulated on activation normal T cell expressed and secreted)) and its cognate receptor, CCR5, have been implicated in T cell activation.
T4	257-423	Sentence	denotes	CCL5 binding to glycosaminoglycans (GAGs) on the cell surface or in extracellular matrix sequesters CCL5, thereby immobilizing CCL5 to provide the directional signal.
T5	424-590	Sentence	denotes	In two CCR5-expressing human T cell lines, PM1.CCR5 and MOLT4.CCR5, and in human peripheral blood-derived T cells, micromolar concentrations of CCL5 induce apoptosis.
T6	591-747	Sentence	denotes	CCL5-induced cell death involves the cytosolic release of cytochrome c, the activation of caspase-9 and caspase-3, and poly(ADP-ribose) polymerase cleavage.
T7	748-888	Sentence	denotes	CCL5-induced apoptosis is CCR5-dependent, since native PM1 and MOLT4 cells lacking CCR5 expression are resistant to CCL5-induced cell death.
T8	889-1077	Sentence	denotes	Furthermore, we implicate tyrosine 339 as a critical residue involved in CCL5-induced apoptosis, since PM1 cells expressing a tyrosine mutant receptor, CCR5Y339F, do not undergo apoptosis.
T9	1078-1161	Sentence	denotes	We show that CCL5-CCR5-mediated apoptosis is dependent on cell surface GAG binding.
T10	1162-1289	Sentence	denotes	The addition of exogenous heparin and chondroitin sulfate and GAG digestion from the cell surface protect cells from apoptosis.
T11	1290-1372	Sentence	denotes	Moreover, the non-GAG binding variant, (44AANA47)-CCL5, fails to induce apoptosis.
T12	1373-1564	Sentence	denotes	To address the role of aggregation in CCL5-mediated apoptosis, nonaggregating CCL5 mutant E66S, which forms dimers, and E26A, which form tetramers at micromolar concentrations, were utilized.
T13	1565-1737	Sentence	denotes	Unlike native CCL5, the E66S mutant fails to induce apoptosis, suggesting that tetramers are the minimal higher ordered CCL5 aggregates required for CCL5-induced apoptosis.
T14	1738-1918	Sentence	denotes	Viewed altogether, these data suggest that CCL5-GAG binding and CCL5 aggregation are important for CCL5 activity in T cells, specifically in the context of CCR5-mediated apoptosis.

GlyCosmos15-FMA

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	306-318	Body_part	denotes	cell surface	FMA:67653
T2	325-345	Body_part	denotes	extracellular matrix	FMA:9672
T3	516-521	Body_part	denotes	blood	FMA:9670
T4	628-637	Body_part	denotes	cytosolic	FMA:66836
T5	1136-1148	Body_part	denotes	cell surface	FMA:67653
T6	1247-1259	Body_part	denotes	cell surface	FMA:67653

GlyCosmos15-MAT

Id	Subject	Object	Predicate	Lexical cue	mat_id
T1	516-521	Body_part	denotes	blood	http://purl.obolibrary.org/obo/MAT_0000315

NCBITAXON

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	447-452	OrganismTaxon	denotes	human	9606
T2	499-504	OrganismTaxon	denotes	human	9606

Anatomy-UBERON

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T1	150-156	Body_part	denotes	T cell	http://purl.obolibrary.org/obo/CL_0000084
T2	238-244	Body_part	denotes	T cell	http://purl.obolibrary.org/obo/CL_0000084
T3	325-345	Body_part	denotes	extracellular matrix	http://purl.obolibrary.org/obo/GO_0031012
T4	453-459	Body_part	denotes	T cell	http://purl.obolibrary.org/obo/CL_0000084
T5	516-521	Body_part	denotes	blood	http://purl.obolibrary.org/obo/UBERON_0000178