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PubMed:16801510 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes Drug-induced long QT syndrome in injection drug users receiving methadone: high frequency in hospitalized patients and risk factors.
T2 133-144 Sentence denotes BACKGROUND:
T3 145-210 Sentence denotes Drug-induced long QT syndrome is a serious adverse drug reaction.
T4 211-282 Sentence denotes Methadone prolongs the QT interval in vitro in a dose-dependent manner.
T5 283-476 Sentence denotes In the inpatient setting, the frequency of QT interval prolongation with methadone treatment, its dose dependence, and the importance of cofactors such as drug-drug interactions remain unknown.
T6 477-485 Sentence denotes METHODS:
T7 486-718 Sentence denotes We performed a systematic, retrospective study comparing active or former intravenous drug users receiving methadone and those not receiving methadone among all patients hospitalized over a 5-year period in a tertiary care hospital.
T8 719-886 Sentence denotes A total of 167 patients receiving methadone fulfilled the inclusion criteria and were compared with a control group of 80 injection drug users not receiving methadone.
T9 887-1038 Sentence denotes In addition to methadone dose, 15 demographic, biological, and pharmacological variables were considered as potential risk factors for QT prolongation.
T10 1039-1047 Sentence denotes RESULTS:
T11 1048-1207 Sentence denotes Among 167 methadone maintenance patients, the prevalence of QTc prolongation to 0.50 second((1/2)) or longer was 16.2% compared with 0% in 80 control subjects.
T12 1208-1281 Sentence denotes Six patients (3.6%) in the methadone group presented torsades de pointes.
T13 1282-1412 Sentence denotes QTc length was weakly but significantly associated with methadone daily dose (Spearman rank correlation coefficient, 0.20; P<.01).
T14 1413-1598 Sentence denotes Multivariate regression analysis allowed attribution of 31.8% of QTc variability to methadone dose, cytochrome P-450 3A4 drug-drug interactions, hypokalemia, and altered liver function.
T15 1599-1732 Sentence denotes CONCLUSIONS: QT interval prolongation in methadone maintenance patients hospitalized in a tertiary care center is a frequent finding.
T16 1733-1860 Sentence denotes Methadone dose, presence of cytochrome P-450 3A4 inhibitors, potassium level, and liver function contribute to QT prolongation.
T17 1861-1916 Sentence denotes Long QT syndrome can occur with low doses of methadone.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
3032 13-29 DiseaseOrPhenotypicFeature denotes long QT syndrome MESH:D008133
3033 64-73 ChemicalEntity denotes methadone MESH:D008691
3034 106-114 OrganismTaxon denotes patients NCBITaxon:9606
3035 158-174 DiseaseOrPhenotypicFeature denotes long QT syndrome MESH:D008133
3036 211-220 ChemicalEntity denotes Methadone MESH:D008691
3037 290-299 OrganismTaxon denotes inpatient NCBITaxon:9606
3038 326-350 DiseaseOrPhenotypicFeature denotes QT interval prolongation MESH:D008133
3039 356-365 ChemicalEntity denotes methadone MESH:D008691
3040 593-602 ChemicalEntity denotes methadone MESH:D008691
3041 627-636 ChemicalEntity denotes methadone MESH:D008691
3042 647-655 OrganismTaxon denotes patients NCBITaxon:9606
3043 734-742 OrganismTaxon denotes patients NCBITaxon:9606
3044 753-762 ChemicalEntity denotes methadone MESH:D008691
3045 876-885 ChemicalEntity denotes methadone MESH:D008691
3046 902-911 ChemicalEntity denotes methadone MESH:D008691
3047 1022-1037 DiseaseOrPhenotypicFeature denotes QT prolongation MESH:D008133
3048 1058-1067 ChemicalEntity denotes methadone MESH:D008691
3049 1080-1088 OrganismTaxon denotes patients NCBITaxon:9606
3050 1108-1124 DiseaseOrPhenotypicFeature denotes QTc prolongation MESH:D008133
3051 1212-1220 OrganismTaxon denotes patients NCBITaxon:9606
3052 1235-1244 ChemicalEntity denotes methadone MESH:D008691
3053 1261-1280 DiseaseOrPhenotypicFeature denotes torsades de pointes MESH:D016171
3054 1338-1347 ChemicalEntity denotes methadone MESH:D008691
3055 1497-1506 ChemicalEntity denotes methadone MESH:D008691
3056 1513-1533 GeneOrGeneProduct denotes cytochrome P-450 3A4 NCBIGene:1576
3057 1558-1569 DiseaseOrPhenotypicFeature denotes hypokalemia MESH:D007008
3058 1612-1636 DiseaseOrPhenotypicFeature denotes QT interval prolongation MESH:D008133
3059 1640-1649 ChemicalEntity denotes methadone MESH:D008691
3060 1662-1670 OrganismTaxon denotes patients NCBITaxon:9606
3061 1733-1742 ChemicalEntity denotes Methadone MESH:D008691
3062 1761-1792 ChemicalEntity denotes cytochrome P-450 3A4 inhibitors MESH:D065692
3063 1794-1803 ChemicalEntity denotes potassium MESH:D011188
3064 1844-1859 DiseaseOrPhenotypicFeature denotes QT prolongation MESH:D008133
3065 1861-1877 DiseaseOrPhenotypicFeature denotes Long QT syndrome MESH:D008133
3066 1906-1915 ChemicalEntity denotes methadone MESH:D008691

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 13-29 DiseaseOrPhenotypicFeature denotes long QT syndrome 0002442
T2 158-174 DiseaseOrPhenotypicFeature denotes long QT syndrome 0002442
T3 1261-1280 DiseaseOrPhenotypicFeature denotes torsades de pointes 0005478
T4 1861-1877 DiseaseOrPhenotypicFeature denotes Long QT syndrome 0002442

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 5-12 GeneOrGeneProduct denotes induced
T2 13-17 GeneOrGeneProduct denotes long
T3 21-29 GeneOrGeneProduct denotes syndrome
T4 75-79 GeneOrGeneProduct denotes high
T5 80-89 GeneOrGeneProduct denotes frequency
T6 124-131 GeneOrGeneProduct denotes factors
T7 150-157 GeneOrGeneProduct denotes induced
T8 158-162 GeneOrGeneProduct denotes long
T9 166-174 GeneOrGeneProduct denotes syndrome
T10 255-259 GeneOrGeneProduct denotes in a
T11 313-322 GeneOrGeneProduct denotes frequency
T12 468-475 GeneOrGeneProduct denotes unknown
T13 477-484 GeneOrGeneProduct denotes METHODS
T14 543-552 GeneOrGeneProduct denotes active or
T15 643-646 GeneOrGeneProduct denotes all
T16 674-677 GeneOrGeneProduct denotes a 5
T17 678-682 GeneOrGeneProduct denotes year
T18 683-689 GeneOrGeneProduct denotes period
T19 704-708 GeneOrGeneProduct denotes care
T20 721-726 GeneOrGeneProduct denotes total
T21 1010-1021 GeneOrGeneProduct denotes factors for
T22 1273-1280 GeneOrGeneProduct denotes pointes
T23 1297-1303 GeneOrGeneProduct denotes weakly
T24 1369-1373 GeneOrGeneProduct denotes rank
T25 1513-1529 GeneOrGeneProduct denotes cytochrome P-450
T26 1583-1588 GeneOrGeneProduct denotes liver
T27 1684-1688 GeneOrGeneProduct denotes in a
T28 1698-1702 GeneOrGeneProduct denotes care
T29 1724-1731 GeneOrGeneProduct denotes finding
T30 1761-1777 GeneOrGeneProduct denotes cytochrome P-450
T31 1782-1792 GeneOrGeneProduct denotes inhibitors
T32 1794-1809 GeneOrGeneProduct denotes potassium level
T33 1815-1820 GeneOrGeneProduct denotes liver
T34 1861-1865 GeneOrGeneProduct denotes Long
T35 1869-1877 GeneOrGeneProduct denotes syndrome

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 21-29 GeneOrGeneProduct denotes syndrome
T2 75-79 GeneOrGeneProduct denotes high
T3 80-89 GeneOrGeneProduct denotes frequency
T4 166-174 GeneOrGeneProduct denotes syndrome
T5 313-322 GeneOrGeneProduct denotes frequency
T6 468-475 GeneOrGeneProduct denotes unknown
T7 683-689 GeneOrGeneProduct denotes period
T8 1369-1373 GeneOrGeneProduct denotes rank
T9 1513-1529 GeneOrGeneProduct denotes cytochrome P-450
T10 1583-1588 GeneOrGeneProduct denotes liver
T11 1761-1777 GeneOrGeneProduct denotes cytochrome P-450
T12 1782-1792 GeneOrGeneProduct denotes inhibitors
T13 1794-1809 GeneOrGeneProduct denotes potassium level
T14 1815-1820 GeneOrGeneProduct denotes liver
T15 1869-1877 GeneOrGeneProduct denotes syndrome

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 13-29 DiseaseOrPhenotypicFeature denotes long QT syndrome D008133
T2 158-174 DiseaseOrPhenotypicFeature denotes long QT syndrome D008133
T3 188-209 DiseaseOrPhenotypicFeature denotes adverse drug reaction D064420
T4 1022-1037 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T5 1261-1280 DiseaseOrPhenotypicFeature denotes torsades de pointes D016171
T6 1558-1569 DiseaseOrPhenotypicFeature denotes hypokalemia D007008
T7 1844-1859 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T8 1861-1877 DiseaseOrPhenotypicFeature denotes Long QT syndrome D008133

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 683-689 GeneOrGeneProduct denotes period
T2 1369-1373 GeneOrGeneProduct denotes rank
T3 1513-1529 GeneOrGeneProduct denotes cytochrome P-450
T4 1761-1777 GeneOrGeneProduct denotes cytochrome P-450

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 13-29 DiseaseOrPhenotypicFeature denotes long QT syndrome 0002442
T2 158-174 DiseaseOrPhenotypicFeature denotes long QT syndrome 0002442
T3 386-396 DiseaseOrPhenotypicFeature denotes dependence 0004938
T4 1261-1280 DiseaseOrPhenotypicFeature denotes torsades de pointes 0005478
T5 1558-1569 DiseaseOrPhenotypicFeature denotes hypokalemia 0003019
T6 1861-1877 DiseaseOrPhenotypicFeature denotes Long QT syndrome 0002442
T7 1878-1881 DiseaseOrPhenotypicFeature denotes can 0012833

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 13-29 DiseaseOrPhenotypicFeature denotes long QT syndrome D008133
T2 158-174 DiseaseOrPhenotypicFeature denotes long QT syndrome D008133
T3 188-209 DiseaseOrPhenotypicFeature denotes adverse drug reaction D064420
T4 221-245 DiseaseOrPhenotypicFeature denotes prolongs the QT interval DISEASE
T5 326-350 DiseaseOrPhenotypicFeature denotes QT interval prolongation DISEASE
T6 1022-1037 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T7 1108-1124 DiseaseOrPhenotypicFeature denotes QTc prolongation DISEASE
T8 1261-1280 DiseaseOrPhenotypicFeature denotes torsades de pointes D016171
T9 1558-1569 DiseaseOrPhenotypicFeature denotes hypokalemia D007008
T10 1612-1636 DiseaseOrPhenotypicFeature denotes QT interval prolongation DISEASE
T11 1844-1859 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T12 1861-1877 DiseaseOrPhenotypicFeature denotes Long QT syndrome D008133

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 13-29 DiseaseOrPhenotypicFeature denotes long QT syndrome D008133
T2 158-174 DiseaseOrPhenotypicFeature denotes long QT syndrome D008133
T3 221-245 DiseaseOrPhenotypicFeature denotes prolongs the QT interval DISEASE
T4 326-350 DiseaseOrPhenotypicFeature denotes QT interval prolongation DISEASE
T5 1022-1037 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T6 1108-1124 DiseaseOrPhenotypicFeature denotes QTc prolongation DISEASE
T7 1261-1280 DiseaseOrPhenotypicFeature denotes torsades de pointes D016171
T8 1558-1569 DiseaseOrPhenotypicFeature denotes hypokalemia D007008
T9 1612-1636 DiseaseOrPhenotypicFeature denotes QT interval prolongation DISEASE
T10 1844-1859 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T11 1861-1877 DiseaseOrPhenotypicFeature denotes Long QT syndrome D008133

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 106-114 OrganismTaxon denotes patients
T2 647-655 OrganismTaxon denotes patients
T3 734-742 OrganismTaxon denotes patients
T4 1080-1088 OrganismTaxon denotes patients
T5 1212-1220 OrganismTaxon denotes patients
T6 1662-1670 OrganismTaxon denotes patients

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 64-73 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T3 211-220 ChemicalEntity denotes Methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T5 356-365 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T7 593-602 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T9 627-636 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T11 753-762 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T13 876-885 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T15 902-911 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T17 1058-1067 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T19 1235-1244 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T21 1338-1347 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T23 1497-1506 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T25 1513-1529 ChemicalEntity denotes cytochrome P-450 http://purl.obolibrary.org/obo/CHEBI_38559
T26 1640-1649 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T28 1733-1742 ChemicalEntity denotes Methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T30 1761-1777 ChemicalEntity denotes cytochrome P-450 http://purl.obolibrary.org/obo/CHEBI_38559
T31 1794-1803 ChemicalEntity denotes potassium D011188|http://purl.obolibrary.org/obo/CHEBI_26216
T33 1906-1915 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T33 1906-1915 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T31 1794-1803 ChemicalEntity denotes potassium http://purl.obolibrary.org/obo/CHEBI_26216|D011188
T30 1761-1777 ChemicalEntity denotes cytochrome P-450 http://purl.obolibrary.org/obo/CHEBI_38559
T28 1733-1742 ChemicalEntity denotes Methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T26 1640-1649 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T25 1513-1529 ChemicalEntity denotes cytochrome P-450 http://purl.obolibrary.org/obo/CHEBI_38559
T23 1497-1506 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T21 1338-1347 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T19 1235-1244 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T17 1058-1067 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T15 902-911 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T13 876-885 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T11 753-762 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T9 627-636 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T7 593-602 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T5 356-365 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T3 211-220 ChemicalEntity denotes Methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T1 64-73 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T4 1761-1777 GeneOrGeneProduct denotes cytochrome P-450
T77348 1513-1529 GeneOrGeneProduct denotes cytochrome P-450
T2 1369-1373 GeneOrGeneProduct denotes rank
T62344 683-689 GeneOrGeneProduct denotes period
T60521 1861-1877 DiseaseOrPhenotypicFeature denotes Long QT syndrome D008133
T10 1844-1859 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T19616 1612-1636 DiseaseOrPhenotypicFeature denotes QT interval prolongation DISEASE
T8 1558-1569 DiseaseOrPhenotypicFeature denotes hypokalemia D007008
T28034 1261-1280 DiseaseOrPhenotypicFeature denotes torsades de pointes D016171
T6 1108-1124 DiseaseOrPhenotypicFeature denotes QTc prolongation DISEASE
T418 1022-1037 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T66972 326-350 DiseaseOrPhenotypicFeature denotes QT interval prolongation DISEASE
T71138 221-245 DiseaseOrPhenotypicFeature denotes prolongs the QT interval DISEASE
T28259 158-174 DiseaseOrPhenotypicFeature denotes long QT syndrome D008133
T27970 13-29 DiseaseOrPhenotypicFeature denotes long QT syndrome D008133
T8982 1662-1670 OrganismTaxon denotes patients
T88625 1212-1220 OrganismTaxon denotes patients
T34022 1080-1088 OrganismTaxon denotes patients
T88880 734-742 OrganismTaxon denotes patients
T1479 647-655 OrganismTaxon denotes patients
T4697 106-114 OrganismTaxon denotes patients