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PubMed:16773443 JSONTXT

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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 163-167 HP_0000365 denotes dead

AnEM_abstracts

Id Subject Object Predicate Lexical cue
T15 1485-1492 Cell denotes neurons
T16 1611-1616 Cell denotes cells
T17 941-961 Pathological_formation denotes inflammation lesions
T18 1063-1075 Pathological_formation denotes inflammation
T19 1632-1644 Pathological_formation denotes inflammation
T20 1768-1777 Organism_substance denotes cytoplasm
T21 1781-1801 Cell denotes phagocytic microglia
T22 1802-1813 Cell denotes macrophages
T24 380-403 Cell denotes intraspinal macrophages
T25 547-555 Multi-tissue_structure denotes thoracic
T1 65-89 Multi-tissue_structure denotes spinal cord white matter
T2 177-184 Cell denotes neurons
T3 240-264 Multi-tissue_structure denotes spinal cord white matter
T4 571-591 Multi-tissue_structure denotes lateral white matter
T5 599-610 Organ denotes spinal cord
T6 670-681 Organ denotes spinal cord
T7 835-840 Cell denotes cells
T8 1007-1018 Organ denotes spinal cord
T9 979-999 Multi-tissue_structure denotes lateral white matter
T10 1042-1047 Cell denotes cells
T11 1309-1333 Multi-tissue_structure denotes spinal cord white matter
T12 1365-1385 Cell denotes phagocytic microglia
T13 1386-1397 Cell denotes macrophages
T14 1430-1448 Cell denotes inflammatory cells

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-90 Sentence denotes Fluoro-Jade B staining following zymosan microinjection into the spinal cord white matter.
T2 91-93 Sentence denotes 1.
T3 94-265 Sentence denotes The fluorescein derivate Fluoro-Jade B (FJB), which primarily labels dead or dying neurons, was used to study the acute focal inflammation in the spinal cord white matter.
T4 266-466 Sentence denotes Inflammation was induced by microinjection of the yeast particulate zymosan to evaluate the biological effects of intraspinal macrophages activation without the confounding effects of physical trauma.
T5 467-469 Sentence denotes 2.
T6 470-611 Sentence denotes A single bolus of zymosan (Sigma, 75 nL) was stereotaxically injected at the thoracic level into the lateral white matter of rat spinal cord.
T7 612-734 Sentence denotes A standard Fluoro-Jade B staining protocol was applied to spinal cord sections at 6, 12, 24 h and 2, 4 days postinjection.
T8 735-890 Sentence denotes Neutral Red, NADPH-diaphorase, Iba1-IR, and DAPI staining protocols accomplished examination of the cells participating in the acute inflammatory response.
T9 891-893 Sentence denotes 3.
T10 894-1019 Sentence denotes Zymosan caused formation of clearly delineated inflammation lesions localized in the lateral white matter of the spinal cord.
T11 1020-1221 Sentence denotes Fluoro-Jade B stained cells in the area of inflammation were not observed at 12 h postinjection while mild FJB staining appeared at 24 h and intense staining was observed at 2 and 4 days postinjection.
T12 1222-1224 Sentence denotes 4.
T13 1225-1449 Sentence denotes This study shows that the acute response to zymosan-induced inflammation in the rat spinal cord white matter causes a gradual appearance of phagocytic microglia/macrophages and delayed FJB staining of the inflammatory cells.
T14 1450-1452 Sentence denotes 5.
T15 1453-1543 Sentence denotes FJB, a reliable marker of dying neurons, is a more universal agent than formerly believed.
T16 1544-1814 Sentence denotes One possible explanation for the gradual appearance of FJB-stained cells in the area of inflammation is that specific time is required for sufficient levels of proteins and/or myelin debris of axonal origin to appear in the cytoplasm of phagocytic microglia/macrophages.
T1 0-90 Sentence denotes Fluoro-Jade B staining following zymosan microinjection into the spinal cord white matter.
T2 91-93 Sentence denotes 1.
T3 94-265 Sentence denotes The fluorescein derivate Fluoro-Jade B (FJB), which primarily labels dead or dying neurons, was used to study the acute focal inflammation in the spinal cord white matter.
T4 266-466 Sentence denotes Inflammation was induced by microinjection of the yeast particulate zymosan to evaluate the biological effects of intraspinal macrophages activation without the confounding effects of physical trauma.
T5 467-469 Sentence denotes 2.
T6 470-611 Sentence denotes A single bolus of zymosan (Sigma, 75 nL) was stereotaxically injected at the thoracic level into the lateral white matter of rat spinal cord.
T7 612-734 Sentence denotes A standard Fluoro-Jade B staining protocol was applied to spinal cord sections at 6, 12, 24 h and 2, 4 days postinjection.
T8 735-890 Sentence denotes Neutral Red, NADPH-diaphorase, Iba1-IR, and DAPI staining protocols accomplished examination of the cells participating in the acute inflammatory response.
T9 891-893 Sentence denotes 3.
T10 894-1019 Sentence denotes Zymosan caused formation of clearly delineated inflammation lesions localized in the lateral white matter of the spinal cord.
T11 1020-1221 Sentence denotes Fluoro-Jade B stained cells in the area of inflammation were not observed at 12 h postinjection while mild FJB staining appeared at 24 h and intense staining was observed at 2 and 4 days postinjection.
T12 1222-1224 Sentence denotes 4.
T13 1225-1449 Sentence denotes This study shows that the acute response to zymosan-induced inflammation in the rat spinal cord white matter causes a gradual appearance of phagocytic microglia/macrophages and delayed FJB staining of the inflammatory cells.
T14 1450-1452 Sentence denotes 5.
T15 1453-1543 Sentence denotes FJB, a reliable marker of dying neurons, is a more universal agent than formerly believed.
T16 1544-1814 Sentence denotes One possible explanation for the gradual appearance of FJB-stained cells in the area of inflammation is that specific time is required for sufficient levels of proteins and/or myelin debris of axonal origin to appear in the cytoplasm of phagocytic microglia/macrophages.