
PubMed:16720068
Annnotations
LitCoin-entities-OrganismTaxon-PD
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 119-122 | OrganismTaxon | denotes | man | NCBItxid:9606 |
LitCoin-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-104 | Sentence | denotes | Possible neuroleptic malignant syndrome related to concomitant treatment with paroxetine and alprazolam. |
T2 | 105-248 | Sentence | denotes | A 74-year-old man with depressive symptoms was admitted to a psychiatric hospital due to insomnia, loss of appetite, exhaustion, and agitation. |
T3 | 249-339 | Sentence | denotes | Medical treatment was initiated at a daily dose of 20 mg paroxetine and 1.2 mg alprazolam. |
T4 | 340-506 | Sentence | denotes | On the 10th day of paroxetine and alprazolam treatment, the patient exhibited marked psychomotor retardation, disorientation, and severe muscle rigidity with tremors. |
T5 | 507-649 | Sentence | denotes | The patient had a fever (38.2 degrees C), fluctuating blood pressure (between 165/90 and 130/70 mg mm Hg), and severe extrapyramidal symptoms. |
T6 | 650-829 | Sentence | denotes | Laboratory tests showed an elevation of creatine phosphokinase (2218 IU/L), aspartate aminotransferase (134 IU/L), alanine aminotransferase (78 IU/L), and BUN (27.9 mg/ml) levels. |
T7 | 830-900 | Sentence | denotes | The patient received bromocriptine and diazepam to treat his symptoms. |
T8 | 901-999 | Sentence | denotes | 7 days later, the fever disappeared and the patient's serum CPK levels were normalized (175 IU/L). |
T9 | 1000-1181 | Sentence | denotes | This patient presented with symptoms of neuroleptic malignant syndrome (NMS), thus demonstrating that NMS-like symptoms can occur after combined paroxetine and alprazolam treatment. |
T10 | 1182-1395 | Sentence | denotes | The adverse drug reaction score obtained by the Naranjo algorithm was 6 in our case, indicating a probable relationship between the patient's NMS-like adverse symptoms and the combined treatment used in this case. |
T11 | 1396-1492 | Sentence | denotes | The involvement of physiologic and environmental aspects specific to this patient was suspected. |
T12 | 1493-1651 | Sentence | denotes | Several risk factors for NMS should be noted in elderly depressive patients whose symptoms often include dehydration, agitation, malnutrition, and exhaustion. |
T13 | 1652-1761 | Sentence | denotes | Careful therapeutic intervention is necessary in cases involving elderly patients who suffer from depression. |
LitCoin-entities
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
2970 | 9-39 | DiseaseOrPhenotypicFeature | denotes | neuroleptic malignant syndrome | MESH:D009459 |
2971 | 78-88 | ChemicalEntity | denotes | paroxetine | MESH:D017374 |
2972 | 93-103 | ChemicalEntity | denotes | alprazolam | MESH:D000525 |
2973 | 119-122 | OrganismTaxon | denotes | man | NCBITaxon:9606 |
2974 | 128-147 | DiseaseOrPhenotypicFeature | denotes | depressive symptoms | MESH:D003866 |
2975 | 166-177 | DiseaseOrPhenotypicFeature | denotes | psychiatric | MESH:D001523 |
2976 | 194-202 | DiseaseOrPhenotypicFeature | denotes | insomnia | MESH:D007319 |
2977 | 204-220 | DiseaseOrPhenotypicFeature | denotes | loss of appetite | MESH:D001068 |
2978 | 238-247 | DiseaseOrPhenotypicFeature | denotes | agitation | MESH:D011595 |
2979 | 306-316 | ChemicalEntity | denotes | paroxetine | MESH:D017374 |
2980 | 328-338 | ChemicalEntity | denotes | alprazolam | MESH:D000525 |
2981 | 359-369 | ChemicalEntity | denotes | paroxetine | MESH:D017374 |
2982 | 374-384 | ChemicalEntity | denotes | alprazolam | MESH:D000525 |
2983 | 400-407 | OrganismTaxon | denotes | patient | NCBITaxon:9606 |
2984 | 425-448 | DiseaseOrPhenotypicFeature | denotes | psychomotor retardation | MESH:D011596 |
2985 | 477-492 | DiseaseOrPhenotypicFeature | denotes | muscle rigidity | MESH:D009127 |
2986 | 498-505 | DiseaseOrPhenotypicFeature | denotes | tremors | MESH:D014202 |
2987 | 511-518 | OrganismTaxon | denotes | patient | NCBITaxon:9606 |
2988 | 525-530 | DiseaseOrPhenotypicFeature | denotes | fever | MESH:D005334 |
2989 | 625-648 | DiseaseOrPhenotypicFeature | denotes | extrapyramidal symptoms | MESH:D001480 |
2990 | 690-712 | ChemicalEntity | denotes | creatine phosphokinase | MESH:D003402 |
2991 | 726-752 | ChemicalEntity | denotes | aspartate aminotransferase | MESH:D001219 |
2992 | 765-789 | ChemicalEntity | denotes | alanine aminotransferase | MESH:D000410 |
2993 | 834-841 | OrganismTaxon | denotes | patient | NCBITaxon:9606 |
2994 | 851-864 | ChemicalEntity | denotes | bromocriptine | MESH:D001971 |
2995 | 869-877 | ChemicalEntity | denotes | diazepam | MESH:D003975 |
2996 | 919-924 | DiseaseOrPhenotypicFeature | denotes | fever | MESH:D005334 |
2997 | 945-952 | OrganismTaxon | denotes | patient | NCBITaxon:9606 |
2998 | 961-964 | ChemicalEntity | denotes | CPK | MESH:D003402 |
2999 | 1005-1012 | OrganismTaxon | denotes | patient | NCBITaxon:9606 |
3000 | 1040-1070 | DiseaseOrPhenotypicFeature | denotes | neuroleptic malignant syndrome | MESH:D009459 |
3001 | 1072-1075 | DiseaseOrPhenotypicFeature | denotes | NMS | MESH:D009459 |
3002 | 1102-1105 | DiseaseOrPhenotypicFeature | denotes | NMS | MESH:D009459 |
3003 | 1145-1155 | ChemicalEntity | denotes | paroxetine | MESH:D017374 |
3004 | 1160-1170 | ChemicalEntity | denotes | alprazolam | MESH:D000525 |
3005 | 1314-1321 | OrganismTaxon | denotes | patient | NCBITaxon:9606 |
3006 | 1324-1327 | DiseaseOrPhenotypicFeature | denotes | NMS | MESH:D009459 |
3007 | 1470-1477 | OrganismTaxon | denotes | patient | NCBITaxon:9606 |
3008 | 1518-1521 | DiseaseOrPhenotypicFeature | denotes | NMS | MESH:D009459 |
3009 | 1549-1559 | DiseaseOrPhenotypicFeature | denotes | depressive | MESH:D003866 |
3010 | 1560-1568 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
3011 | 1598-1609 | DiseaseOrPhenotypicFeature | denotes | dehydration | MESH:D003681 |
3012 | 1611-1620 | DiseaseOrPhenotypicFeature | denotes | agitation | MESH:D011595 |
3013 | 1622-1634 | DiseaseOrPhenotypicFeature | denotes | malnutrition | MESH:D044342 |
3014 | 1725-1733 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
3015 | 1750-1760 | DiseaseOrPhenotypicFeature | denotes | depression | MESH:D003866 |
LitCoin_Mondo
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 9-39 | DiseaseOrPhenotypicFeature | denotes | neuroleptic malignant syndrome | 0019790 |
T2 | 194-202 | DiseaseOrPhenotypicFeature | denotes | insomnia | 0013600 |
T3 | 1040-1070 | DiseaseOrPhenotypicFeature | denotes | neuroleptic malignant syndrome | 0019790 |
LitCoin-GeneOrGeneProduct-v0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 31-39 | GeneOrGeneProduct | denotes | syndrome |
T2 | 110-114 | GeneOrGeneProduct | denotes | year |
T3 | 128-138 | GeneOrGeneProduct | denotes | depressive |
T4 | 271-280 | GeneOrGeneProduct | denotes | initiated |
T5 | 303-305 | GeneOrGeneProduct | denotes | mg |
T6 | 325-327 | GeneOrGeneProduct | denotes | mg |
T7 | 418-424 | GeneOrGeneProduct | denotes | marked |
T8 | 477-483 | GeneOrGeneProduct | denotes | muscle |
T9 | 484-492 | GeneOrGeneProduct | denotes | rigidity |
T10 | 498-505 | GeneOrGeneProduct | denotes | tremors |
T11 | 519-524 | GeneOrGeneProduct | denotes | had a |
T12 | 603-605 | GeneOrGeneProduct | denotes | mg |
T13 | 661-666 | GeneOrGeneProduct | denotes | tests |
T14 | 726-752 | GeneOrGeneProduct | denotes | aspartate aminotransferase |
T15 | 765-789 | GeneOrGeneProduct | denotes | alanine aminotransferase |
T16 | 815-817 | GeneOrGeneProduct | denotes | mg |
T17 | 818-820 | GeneOrGeneProduct | denotes | ml |
T18 | 908-913 | GeneOrGeneProduct | denotes | later |
T19 | 1062-1070 | GeneOrGeneProduct | denotes | syndrome |
T20 | 1106-1110 | GeneOrGeneProduct | denotes | like |
T21 | 1248-1256 | GeneOrGeneProduct | denotes | was 6 in |
T22 | 1261-1265 | GeneOrGeneProduct | denotes | case |
T23 | 1280-1288 | GeneOrGeneProduct | denotes | probable |
T24 | 1328-1332 | GeneOrGeneProduct | denotes | like |
T25 | 1390-1394 | GeneOrGeneProduct | denotes | case |
T26 | 1506-1517 | GeneOrGeneProduct | denotes | factors for |
T27 | 1549-1559 | GeneOrGeneProduct | denotes | depressive |
T28 | 1652-1659 | GeneOrGeneProduct | denotes | Careful |
T29 | 1701-1706 | GeneOrGeneProduct | denotes | cases |
T30 | 1750-1760 | GeneOrGeneProduct | denotes | depression |
LitCoin-GeneOrGeneProduct-v2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 31-39 | GeneOrGeneProduct | denotes | syndrome |
T2 | 477-483 | GeneOrGeneProduct | denotes | muscle |
T3 | 726-752 | GeneOrGeneProduct | denotes | aspartate aminotransferase |
T4 | 765-789 | GeneOrGeneProduct | denotes | alanine aminotransferase |
T5 | 1062-1070 | GeneOrGeneProduct | denotes | syndrome |
T6 | 1106-1110 | GeneOrGeneProduct | denotes | like |
T7 | 1280-1288 | GeneOrGeneProduct | denotes | probable |
T8 | 1328-1332 | GeneOrGeneProduct | denotes | like |
LitCoin-Disease-MeSH
Id | Subject | Object | Predicate | Lexical cue | originalLabel |
---|---|---|---|---|---|
T1 | 9-39 | DiseaseOrPhenotypicFeature | denotes | neuroleptic malignant syndrome | D009459 |
T2 | 128-138 | DiseaseOrPhenotypicFeature | denotes | depressive | DISEASE |
T3 | 194-202 | DiseaseOrPhenotypicFeature | denotes | insomnia | D007319 |
T4 | 425-448 | DiseaseOrPhenotypicFeature | denotes | psychomotor retardation | DISEASE |
T5 | 450-464 | DiseaseOrPhenotypicFeature | denotes | disorientation | D003221 |
T6 | 477-492 | DiseaseOrPhenotypicFeature | denotes | muscle rigidity | D009127 |
T7 | 498-505 | DiseaseOrPhenotypicFeature | denotes | tremors | D014202 |
T8 | 525-530 | DiseaseOrPhenotypicFeature | denotes | fever | D005334 |
T9 | 919-924 | DiseaseOrPhenotypicFeature | denotes | fever | D005334 |
T10 | 1040-1070 | DiseaseOrPhenotypicFeature | denotes | neuroleptic malignant syndrome | D009459 |
T11 | 1186-1207 | DiseaseOrPhenotypicFeature | denotes | adverse drug reaction | D064420 |
T12 | 1549-1559 | DiseaseOrPhenotypicFeature | denotes | depressive | DISEASE |
T13 | 1598-1609 | DiseaseOrPhenotypicFeature | denotes | dehydration | D003681 |
T14 | 1622-1634 | DiseaseOrPhenotypicFeature | denotes | malnutrition | D044342 |
T15 | 1750-1760 | DiseaseOrPhenotypicFeature | denotes | depression | DISEASE |
LitCoin-GeneOrGeneProduct-v3
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 726-752 | GeneOrGeneProduct | denotes | aspartate aminotransferase |
T2 | 765-789 | GeneOrGeneProduct | denotes | alanine aminotransferase |
T3 | 1280-1288 | GeneOrGeneProduct | denotes | probable |
LitCoin_Mondo_095
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 9-39 | DiseaseOrPhenotypicFeature | denotes | neuroleptic malignant syndrome | 0019790 |
T2 | 194-202 | DiseaseOrPhenotypicFeature | denotes | insomnia | 0013600 |
T3 | 719-721 | DiseaseOrPhenotypicFeature | denotes | IU | 0006806 |
T4 | 758-760 | DiseaseOrPhenotypicFeature | denotes | IU | 0006806 |
T5 | 794-796 | DiseaseOrPhenotypicFeature | denotes | IU | 0006806 |
T6 | 993-995 | DiseaseOrPhenotypicFeature | denotes | IU | 0006806 |
T7 | 1040-1070 | DiseaseOrPhenotypicFeature | denotes | neuroleptic malignant syndrome | 0019790 |
T8 | 1072-1075 | DiseaseOrPhenotypicFeature | denotes | NMS | 0019790 |
T9 | 1102-1105 | DiseaseOrPhenotypicFeature | denotes | NMS | 0019790 |
T10 | 1120-1123 | DiseaseOrPhenotypicFeature | denotes | can | 0012833 |
T11 | 1324-1327 | DiseaseOrPhenotypicFeature | denotes | NMS | 0019790 |
T12 | 1518-1521 | DiseaseOrPhenotypicFeature | denotes | NMS | 0019790 |
T13 | 1622-1634 | DiseaseOrPhenotypicFeature | denotes | malnutrition | 0006873 |
T14 | 1750-1760 | DiseaseOrPhenotypicFeature | denotes | depression | 0002050 |
LitCoin-MeSH-Disease-2
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 9-39 | DiseaseOrPhenotypicFeature | denotes | neuroleptic malignant syndrome | D009459 |
T2 | 128-147 | DiseaseOrPhenotypicFeature | denotes | depressive symptoms | DISEASE |
T3 | 166-177 | DiseaseOrPhenotypicFeature | denotes | psychiatric | DISEASE |
T4 | 194-202 | DiseaseOrPhenotypicFeature | denotes | insomnia | D007319 |
T5 | 204-220 | DiseaseOrPhenotypicFeature | denotes | loss of appetite | DISEASE |
T6 | 238-247 | DiseaseOrPhenotypicFeature | denotes | agitation | DISEASE |
T7 | 425-448 | DiseaseOrPhenotypicFeature | denotes | psychomotor retardation | DISEASE |
T8 | 450-464 | DiseaseOrPhenotypicFeature | denotes | disorientation | D003221 |
T9 | 477-492 | DiseaseOrPhenotypicFeature | denotes | muscle rigidity | D009127 |
T10 | 498-505 | DiseaseOrPhenotypicFeature | denotes | tremors | D014202 |
T11 | 525-530 | DiseaseOrPhenotypicFeature | denotes | fever | D005334 |
T12 | 625-648 | DiseaseOrPhenotypicFeature | denotes | extrapyramidal symptoms | DISEASE |
T13 | 919-924 | DiseaseOrPhenotypicFeature | denotes | fever | D005334 |
T14 | 1040-1070 | DiseaseOrPhenotypicFeature | denotes | neuroleptic malignant syndrome | D009459 |
T15 | 1072-1075 | DiseaseOrPhenotypicFeature | denotes | NMS | DISEASE|D009459 |
T17 | 1102-1105 | DiseaseOrPhenotypicFeature | denotes | NMS | DISEASE|D009459 |
T19 | 1186-1207 | DiseaseOrPhenotypicFeature | denotes | adverse drug reaction | D064420 |
T20 | 1324-1327 | DiseaseOrPhenotypicFeature | denotes | NMS | DISEASE|D009459 |
T22 | 1518-1521 | DiseaseOrPhenotypicFeature | denotes | NMS | DISEASE|D009459 |
T24 | 1549-1559 | DiseaseOrPhenotypicFeature | denotes | depressive | DISEASE |
T25 | 1598-1609 | DiseaseOrPhenotypicFeature | denotes | dehydration | D003681 |
T26 | 1611-1620 | DiseaseOrPhenotypicFeature | denotes | agitation | DISEASE |
T27 | 1622-1634 | DiseaseOrPhenotypicFeature | denotes | malnutrition | D044342 |
T28 | 1750-1760 | DiseaseOrPhenotypicFeature | denotes | depression | DISEASE |
LitCoin-MONDO_bioort2019
Id | Subject | Object | Predicate | Lexical cue | #label |
---|---|---|---|---|---|
T1 | 9-39 | DiseaseOrPhenotypicFeature | denotes | neuroleptic malignant syndrome | D009459 |
T2 | 128-147 | DiseaseOrPhenotypicFeature | denotes | depressive symptoms | DISEASE |
T3 | 166-177 | DiseaseOrPhenotypicFeature | denotes | psychiatric | DISEASE |
T4 | 194-202 | DiseaseOrPhenotypicFeature | denotes | insomnia | D007319 |
T5 | 204-220 | DiseaseOrPhenotypicFeature | denotes | loss of appetite | DISEASE |
T6 | 238-247 | DiseaseOrPhenotypicFeature | denotes | agitation | DISEASE |
T7 | 425-448 | DiseaseOrPhenotypicFeature | denotes | psychomotor retardation | DISEASE |
T8 | 450-464 | DiseaseOrPhenotypicFeature | denotes | disorientation | D003221 |
T9 | 477-492 | DiseaseOrPhenotypicFeature | denotes | muscle rigidity | D009127 |
T10 | 498-505 | DiseaseOrPhenotypicFeature | denotes | tremors | D014202 |
T11 | 525-530 | DiseaseOrPhenotypicFeature | denotes | fever | D005334 |
T12 | 625-648 | DiseaseOrPhenotypicFeature | denotes | extrapyramidal symptoms | DISEASE |
T13 | 919-924 | DiseaseOrPhenotypicFeature | denotes | fever | D005334 |
T14 | 1040-1070 | DiseaseOrPhenotypicFeature | denotes | neuroleptic malignant syndrome | D009459 |
T15 | 1072-1075 | DiseaseOrPhenotypicFeature | denotes | NMS | DISEASE|D009459 |
T17 | 1102-1105 | DiseaseOrPhenotypicFeature | denotes | NMS | DISEASE|D009459 |
T19 | 1324-1327 | DiseaseOrPhenotypicFeature | denotes | NMS | DISEASE|D009459 |
T21 | 1518-1521 | DiseaseOrPhenotypicFeature | denotes | NMS | DISEASE|D009459 |
T23 | 1549-1559 | DiseaseOrPhenotypicFeature | denotes | depressive | DISEASE |
T24 | 1598-1609 | DiseaseOrPhenotypicFeature | denotes | dehydration | D003681 |
T25 | 1611-1620 | DiseaseOrPhenotypicFeature | denotes | agitation | DISEASE |
T26 | 1622-1634 | DiseaseOrPhenotypicFeature | denotes | malnutrition | D044342 |
T27 | 1750-1760 | DiseaseOrPhenotypicFeature | denotes | depression | DISEASE |
LitCoin-NCBITaxon-2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 119-122 | OrganismTaxon | denotes | man |
T2 | 400-407 | OrganismTaxon | denotes | patient |
T3 | 511-518 | OrganismTaxon | denotes | patient |
T4 | 834-841 | OrganismTaxon | denotes | patient |
T5 | 1005-1012 | OrganismTaxon | denotes | patient |
T6 | 1470-1477 | OrganismTaxon | denotes | patient |
T7 | 1560-1568 | OrganismTaxon | denotes | patients |
T8 | 1725-1733 | OrganismTaxon | denotes | patients |
LitCoin-Chemical-MeSH-CHEBI
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 9-20 | ChemicalEntity | denotes | neuroleptic | ChemicalEntity |
T2 | 78-88 | ChemicalEntity | denotes | paroxetine | D017374|http://purl.obolibrary.org/obo/CHEBI_7936 |
T4 | 93-103 | ChemicalEntity | denotes | alprazolam | D000525|http://purl.obolibrary.org/obo/CHEBI_2611 |
T6 | 306-316 | ChemicalEntity | denotes | paroxetine | D017374|http://purl.obolibrary.org/obo/CHEBI_7936 |
T8 | 328-338 | ChemicalEntity | denotes | alprazolam | D000525|http://purl.obolibrary.org/obo/CHEBI_2611 |
T10 | 359-369 | ChemicalEntity | denotes | paroxetine | D017374|http://purl.obolibrary.org/obo/CHEBI_7936 |
T12 | 374-384 | ChemicalEntity | denotes | alprazolam | D000525|http://purl.obolibrary.org/obo/CHEBI_2611 |
T14 | 690-712 | ChemicalEntity | denotes | creatine phosphokinase | D003402 |
T15 | 726-752 | ChemicalEntity | denotes | aspartate aminotransferase | D001219 |
T16 | 765-789 | ChemicalEntity | denotes | alanine aminotransferase | D000410 |
T17 | 851-864 | ChemicalEntity | denotes | bromocriptine | D001971|http://purl.obolibrary.org/obo/CHEBI_3181 |
T19 | 869-877 | ChemicalEntity | denotes | diazepam | D003975|http://purl.obolibrary.org/obo/CHEBI_49575 |
T21 | 961-964 | ChemicalEntity | denotes | CPK | ChemicalEntity |
T22 | 1040-1051 | ChemicalEntity | denotes | neuroleptic | ChemicalEntity |
T23 | 1145-1155 | ChemicalEntity | denotes | paroxetine | D017374|http://purl.obolibrary.org/obo/CHEBI_7936 |
T25 | 1160-1170 | ChemicalEntity | denotes | alprazolam | D000525|http://purl.obolibrary.org/obo/CHEBI_2611 |
LitCoin-training-merged
Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
---|---|---|---|---|---|---|
T25 | 1160-1170 | ChemicalEntity | denotes | alprazolam | http://purl.obolibrary.org/obo/CHEBI_2611|D000525 | |
T23 | 1145-1155 | ChemicalEntity | denotes | paroxetine | http://purl.obolibrary.org/obo/CHEBI_7936|D017374 | |
T22 | 1040-1051 | ChemicalEntity | denotes | neuroleptic | ChemicalEntity | |
T21 | 961-964 | ChemicalEntity | denotes | CPK | ChemicalEntity | |
T19 | 869-877 | ChemicalEntity | denotes | diazepam | http://purl.obolibrary.org/obo/CHEBI_49575|D003975 | |
T17 | 851-864 | ChemicalEntity | denotes | bromocriptine | http://purl.obolibrary.org/obo/CHEBI_3181|D001971 | |
T16 | 765-789 | ChemicalEntity | denotes | alanine aminotransferase | D000410 | |
T15 | 726-752 | ChemicalEntity | denotes | aspartate aminotransferase | D001219 | |
T14 | 690-712 | ChemicalEntity | denotes | creatine phosphokinase | D003402 | |
T12 | 374-384 | ChemicalEntity | denotes | alprazolam | http://purl.obolibrary.org/obo/CHEBI_2611|D000525 | |
T10 | 359-369 | ChemicalEntity | denotes | paroxetine | http://purl.obolibrary.org/obo/CHEBI_7936|D017374 | |
T8 | 328-338 | ChemicalEntity | denotes | alprazolam | http://purl.obolibrary.org/obo/CHEBI_2611|D000525 | |
T6 | 306-316 | ChemicalEntity | denotes | paroxetine | http://purl.obolibrary.org/obo/CHEBI_7936|D017374 | |
T4 | 93-103 | ChemicalEntity | denotes | alprazolam | http://purl.obolibrary.org/obo/CHEBI_2611|D000525 | |
T2 | 78-88 | ChemicalEntity | denotes | paroxetine | http://purl.obolibrary.org/obo/CHEBI_7936|D017374 | |
T1 | 9-20 | ChemicalEntity | denotes | neuroleptic | ChemicalEntity | |
T3 | 1280-1288 | GeneOrGeneProduct | denotes | probable | ||
T32572 | 765-789 | GeneOrGeneProduct | denotes | alanine aminotransferase | ||
T25222 | 726-752 | GeneOrGeneProduct | denotes | aspartate aminotransferase | ||
T27 | 1750-1760 | DiseaseOrPhenotypicFeature | denotes | depression | DISEASE | |
T26 | 1622-1634 | DiseaseOrPhenotypicFeature | denotes | malnutrition | D044342 | |
T84255 | 1611-1620 | DiseaseOrPhenotypicFeature | denotes | agitation | DISEASE | |
T24 | 1598-1609 | DiseaseOrPhenotypicFeature | denotes | dehydration | D003681 | |
T79548 | 1549-1559 | DiseaseOrPhenotypicFeature | denotes | depressive | DISEASE | |
T85198 | 1518-1521 | DiseaseOrPhenotypicFeature | denotes | NMS | D009459|DISEASE | |
T26589 | 1324-1327 | DiseaseOrPhenotypicFeature | denotes | NMS | D009459|DISEASE | |
T11865 | 1102-1105 | DiseaseOrPhenotypicFeature | denotes | NMS | D009459|DISEASE | |
T34125 | 1072-1075 | DiseaseOrPhenotypicFeature | denotes | NMS | D009459|DISEASE | |
T19169 | 1040-1070 | DiseaseOrPhenotypicFeature | denotes | neuroleptic malignant syndrome | D009459 | |
T13 | 919-924 | DiseaseOrPhenotypicFeature | denotes | fever | D005334 | |
T61844 | 625-648 | DiseaseOrPhenotypicFeature | denotes | extrapyramidal symptoms | DISEASE | |
T11 | 525-530 | DiseaseOrPhenotypicFeature | denotes | fever | D005334 | |
T38641 | 498-505 | DiseaseOrPhenotypicFeature | denotes | tremors | D014202 | |
T9 | 477-492 | DiseaseOrPhenotypicFeature | denotes | muscle rigidity | D009127 | |
T64274 | 450-464 | DiseaseOrPhenotypicFeature | denotes | disorientation | D003221 | |
T7 | 425-448 | DiseaseOrPhenotypicFeature | denotes | psychomotor retardation | DISEASE | |
T52166 | 238-247 | DiseaseOrPhenotypicFeature | denotes | agitation | DISEASE | |
T5 | 204-220 | DiseaseOrPhenotypicFeature | denotes | loss of appetite | DISEASE | |
T11520 | 194-202 | DiseaseOrPhenotypicFeature | denotes | insomnia | D007319 | |
T13588 | 166-177 | DiseaseOrPhenotypicFeature | denotes | psychiatric | DISEASE | |
T9421 | 128-147 | DiseaseOrPhenotypicFeature | denotes | depressive symptoms | DISEASE | |
T89746 | 9-39 | DiseaseOrPhenotypicFeature | denotes | neuroleptic malignant syndrome | D009459 | |
T65943 | 1725-1733 | OrganismTaxon | denotes | patients | ||
T26138 | 1560-1568 | OrganismTaxon | denotes | patients | ||
T61529 | 1470-1477 | OrganismTaxon | denotes | patient | ||
T80804 | 1005-1012 | OrganismTaxon | denotes | patient | ||
T97887 | 834-841 | OrganismTaxon | denotes | patient | ||
T47905 | 511-518 | OrganismTaxon | denotes | patient | ||
T13054 | 400-407 | OrganismTaxon | denotes | patient | ||
T75712 | 119-122 | OrganismTaxon | denotes | man |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 128-138 | HP_0000716 | denotes | depressive |
T2 | 194-202 | HP_0100785 | denotes | insomnia |
T3 | 238-247 | HP_0000713 | denotes | agitation |
T4 | 425-448 | HP_0001263 | denotes | psychomotor retardation |
T5 | 450-464 | HP_0001289 | denotes | disorientation |
T6 | 477-492 | HP_0002063 | denotes | muscle rigidity |
T7 | 484-492 | HP_0002063 | denotes | rigidity |
T8 | 498-505 | HP_0001337 | denotes | tremors |
T9 | 525-530 | HP_0001945 | denotes | fever |
T10 | 625-648 | HP_0002071 | denotes | extrapyramidal symptoms |
T11 | 919-924 | HP_0001945 | denotes | fever |
T12 | 1549-1559 | HP_0000716 | denotes | depressive |
T13 | 1598-1609 | HP_0001944 | denotes | dehydration |
T14 | 1611-1620 | HP_0000713 | denotes | agitation |
T15 | 1622-1634 | HP_0004395 | denotes | malnutrition |
T16 | 1750-1760 | HP_0000716 | denotes | depression |
PubCasesHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
AB1 | 194-202 | HP:0100785 | denotes | insomnia |
AB2 | 238-247 | HP:0000713 | denotes | agitation |
AB3 | 484-492 | HP:0002063 | denotes | rigidity |
AB4 | 498-505 | HP:0001337 | denotes | tremors |
AB5 | 525-530 | HP:0001945 | denotes | fever |
AB6 | 919-924 | HP:0001945 | denotes | fever |
AB7 | 1598-1609 | HP:0001944 | denotes | dehydration |
AB8 | 1611-1620 | HP:0000713 | denotes | agitation |
AB9 | 1622-1634 | HP:0004395 | denotes | malnutrition |
AB10 | 1750-1760 | HP:0000716 | denotes | depression |
PubCasesORDO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TI1 | 9-39 | ORDO:94093 | denotes | neuroleptic malignant syndrome |
AB1 | 1040-1070 | ORDO:94093 | denotes | neuroleptic malignant syndrome |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-104 | Sentence | denotes | Possible neuroleptic malignant syndrome related to concomitant treatment with paroxetine and alprazolam. |
TextSentencer_T2 | 105-248 | Sentence | denotes | A 74-year-old man with depressive symptoms was admitted to a psychiatric hospital due to insomnia, loss of appetite, exhaustion, and agitation. |
TextSentencer_T3 | 249-339 | Sentence | denotes | Medical treatment was initiated at a daily dose of 20 mg paroxetine and 1.2 mg alprazolam. |
TextSentencer_T4 | 340-506 | Sentence | denotes | On the 10th day of paroxetine and alprazolam treatment, the patient exhibited marked psychomotor retardation, disorientation, and severe muscle rigidity with tremors. |
TextSentencer_T5 | 507-649 | Sentence | denotes | The patient had a fever (38.2 degrees C), fluctuating blood pressure (between 165/90 and 130/70 mg mm Hg), and severe extrapyramidal symptoms. |
TextSentencer_T6 | 650-829 | Sentence | denotes | Laboratory tests showed an elevation of creatine phosphokinase (2218 IU/L), aspartate aminotransferase (134 IU/L), alanine aminotransferase (78 IU/L), and BUN (27.9 mg/ml) levels. |
TextSentencer_T7 | 830-900 | Sentence | denotes | The patient received bromocriptine and diazepam to treat his symptoms. |
TextSentencer_T8 | 901-999 | Sentence | denotes | 7 days later, the fever disappeared and the patient's serum CPK levels were normalized (175 IU/L). |
TextSentencer_T9 | 1000-1181 | Sentence | denotes | This patient presented with symptoms of neuroleptic malignant syndrome (NMS), thus demonstrating that NMS-like symptoms can occur after combined paroxetine and alprazolam treatment. |
TextSentencer_T10 | 1182-1395 | Sentence | denotes | The adverse drug reaction score obtained by the Naranjo algorithm was 6 in our case, indicating a probable relationship between the patient's NMS-like adverse symptoms and the combined treatment used in this case. |
TextSentencer_T11 | 1396-1492 | Sentence | denotes | The involvement of physiologic and environmental aspects specific to this patient was suspected. |
TextSentencer_T12 | 1493-1651 | Sentence | denotes | Several risk factors for NMS should be noted in elderly depressive patients whose symptoms often include dehydration, agitation, malnutrition, and exhaustion. |
TextSentencer_T13 | 1652-1761 | Sentence | denotes | Careful therapeutic intervention is necessary in cases involving elderly patients who suffer from depression. |
T1 | 0-104 | Sentence | denotes | Possible neuroleptic malignant syndrome related to concomitant treatment with paroxetine and alprazolam. |
T2 | 105-248 | Sentence | denotes | A 74-year-old man with depressive symptoms was admitted to a psychiatric hospital due to insomnia, loss of appetite, exhaustion, and agitation. |
T3 | 249-339 | Sentence | denotes | Medical treatment was initiated at a daily dose of 20 mg paroxetine and 1.2 mg alprazolam. |
T4 | 340-506 | Sentence | denotes | On the 10th day of paroxetine and alprazolam treatment, the patient exhibited marked psychomotor retardation, disorientation, and severe muscle rigidity with tremors. |
T5 | 507-649 | Sentence | denotes | The patient had a fever (38.2 degrees C), fluctuating blood pressure (between 165/90 and 130/70 mg mm Hg), and severe extrapyramidal symptoms. |
T6 | 650-829 | Sentence | denotes | Laboratory tests showed an elevation of creatine phosphokinase (2218 IU/L), aspartate aminotransferase (134 IU/L), alanine aminotransferase (78 IU/L), and BUN (27.9 mg/ml) levels. |
T7 | 830-900 | Sentence | denotes | The patient received bromocriptine and diazepam to treat his symptoms. |
T8 | 901-999 | Sentence | denotes | 7 days later, the fever disappeared and the patient's serum CPK levels were normalized (175 IU/L). |
T9 | 1000-1181 | Sentence | denotes | This patient presented with symptoms of neuroleptic malignant syndrome (NMS), thus demonstrating that NMS-like symptoms can occur after combined paroxetine and alprazolam treatment. |
T10 | 1182-1395 | Sentence | denotes | The adverse drug reaction score obtained by the Naranjo algorithm was 6 in our case, indicating a probable relationship between the patient's NMS-like adverse symptoms and the combined treatment used in this case. |
T11 | 1396-1492 | Sentence | denotes | The involvement of physiologic and environmental aspects specific to this patient was suspected. |
T12 | 1493-1651 | Sentence | denotes | Several risk factors for NMS should be noted in elderly depressive patients whose symptoms often include dehydration, agitation, malnutrition, and exhaustion. |
T13 | 1652-1761 | Sentence | denotes | Careful therapeutic intervention is necessary in cases involving elderly patients who suffer from depression. |
performance-test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-UBERON-AE-B_T1 | 955-960 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
PD-UBERON-AE-B_T2 | 561-566 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |