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PubMed:16682955 JSONTXT

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DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
16682955-0#24#28#gene10818 24-28 gene10818 denotes FRS2
16682955-0#83#86#gene27352 83-86 gene27352 denotes MAP
16682955-0#163#168#gene2246 163-168 gene2246 denotes FGF-1
16682955-0#178#194#diseaseC0678222 178-194 diseaseC0678222 denotes breast carcinoma
16682955-1#72#89#gene2099 274-291 gene2099 denotes estrogen receptor
16682955-1#141#154#diseaseC0006142 343-356 diseaseC0006142 denotes breast cancer
16682955-1#141#154#diseaseC0678222 343-356 diseaseC0678222 denotes breast cancer
16682955-3#32#37#gene6640 720-725 gene6640 denotes SNT-1
16682955-3#39#44#gene6640 727-732 gene6640 denotes SNT-1
16682955-3#83#99#diseaseC0678222 771-787 diseaseC0678222 denotes breast carcinoma
16682955-9#212#217#gene10818 2109-2114 gene10818 denotes SNT-1
16682955-9#212#217#gene6640 2109-2114 gene6640 denotes SNT-1
16682955-9#0#26#gene2246 1897-1923 gene2246 denotes Fibroblast growth factor-1
16682955-9#286#300#diseaseC0006142 2183-2197 diseaseC0006142 denotes breast cancers
16682955-9#286#300#diseaseC0006142 2183-2197 diseaseC0006142 denotes breast cancers
24#28#gene10818178#194#diseaseC0678222 16682955-0#24#28#gene10818 16682955-0#178#194#diseaseC0678222 associated_with FRS2,breast carcinoma
83#86#gene27352178#194#diseaseC0678222 16682955-0#83#86#gene27352 16682955-0#178#194#diseaseC0678222 associated_with MAP,breast carcinoma
163#168#gene2246178#194#diseaseC0678222 16682955-0#163#168#gene2246 16682955-0#178#194#diseaseC0678222 associated_with FGF-1,breast carcinoma
72#89#gene2099141#154#diseaseC0006142 16682955-1#72#89#gene2099 16682955-1#141#154#diseaseC0006142 associated_with estrogen receptor,breast cancer
72#89#gene2099141#154#diseaseC0678222 16682955-1#72#89#gene2099 16682955-1#141#154#diseaseC0678222 associated_with estrogen receptor,breast cancer
32#37#gene664083#99#diseaseC0678222 16682955-3#32#37#gene6640 16682955-3#83#99#diseaseC0678222 associated_with SNT-1,breast carcinoma
39#44#gene664083#99#diseaseC0678222 16682955-3#39#44#gene6640 16682955-3#83#99#diseaseC0678222 associated_with SNT-1,breast carcinoma
212#217#gene10818286#300#diseaseC0006142 16682955-9#212#217#gene10818 16682955-9#286#300#diseaseC0006142 associated_with SNT-1,breast cancers
212#217#gene10818286#300#diseaseC0006142 16682955-9#212#217#gene10818 16682955-9#286#300#diseaseC0006142 associated_with SNT-1,breast cancers
212#217#gene6640286#300#diseaseC0006142 16682955-9#212#217#gene6640 16682955-9#286#300#diseaseC0006142 associated_with SNT-1,breast cancers
212#217#gene6640286#300#diseaseC0006142 16682955-9#212#217#gene6640 16682955-9#286#300#diseaseC0006142 associated_with SNT-1,breast cancers
0#26#gene2246286#300#diseaseC0006142 16682955-9#0#26#gene2246 16682955-9#286#300#diseaseC0006142 associated_with Fibroblast growth factor-1,breast cancers
0#26#gene2246286#300#diseaseC0006142 16682955-9#0#26#gene2246 16682955-9#286#300#diseaseC0006142 associated_with Fibroblast growth factor-1,breast cancers

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T437 2109-2114 gene:10818 denotes SNT-1
T438 2183-2197 disease:C0006142 denotes breast cancers
T2547 274-291 gene:2099 denotes estrogen receptor
T2548 343-356 disease:C0006142 denotes breast cancer
R1 T437 T438 associated_with SNT-1,breast cancers
R2 T437 T438 associated_with SNT-1,breast cancers
R1 T2547 T2548 associated_with estrogen receptor,breast cancer
R2 T2547 T2548 associated_with estrogen receptor,breast cancer

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-201 Sentence denotes Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells.
TextSentencer_T2 202-363 Sentence denotes Fibroblast growth factor (FGF) signaling can bypass the requirement for estrogen receptor (ER) activation in the growth of ER-positive (ER+) breast cancer cells.
TextSentencer_T3 364-687 Sentence denotes Fibroblast growth factor-1 stimulation leads to phosphorylation of the adaptor protein Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target (SNT-1) on C-terminal tyrosine residues, whereas it is constitutively bound through its N-terminal phosphotyrosine-binding domain (PTB) to FGF receptors (FGFRs).
TextSentencer_T4 688-949 Sentence denotes By expressing the PTB domain of SNT-1 (SNT-1 PTB) in an inducible manner in an ER+ breast carcinoma line, ML20, we asked whether we could uncouple FGFR activation from its downstream signaling components and abrogate FGF-1-induced antiestrogen-resistant growth.
TextSentencer_T5 950-1230 Sentence denotes Induction of SNT-1 PTB resulted in a significant decrease of FGF-1-dependent tyrosine phosphorylation of endogenous SNT-1, strong inhibition of complex formation between SNT-1, Gab-1 and Sos-1, and reduced activation of Ras, mitogen-activated protein kinase (MAP kinase), and Akt.
TextSentencer_T6 1231-1375 Sentence denotes SNT-1 PTB also inhibited the phosphorylation of p70S6K on Thr421/Ser424 and Ser411, which may result from the abrogation of MAP kinase activity.
TextSentencer_T7 1376-1473 Sentence denotes Moreover, we also observed a decreased phosphorylation of the MAP kinase-independent site Thr389.
TextSentencer_T8 1474-1731 Sentence denotes This may reflect both inhibition of PI-3 kinase pathways and mammalian target of rapamycin (mTOR)-dependent signaling, as the phosphorylation of Thr389 site was sensitive to treatment with the PI3-K and mTOR inhibitors, LY294002 and rapamycin, respectively.
TextSentencer_T9 1732-1896 Sentence denotes Collectively these results suggest that SNT-1 plays a pivotal role in FGF-dependent activation of the Ras-MAP kinase, PI-3 kinase, and mTOR pathways in these cells.
TextSentencer_T10 1897-2198 Sentence denotes Fibroblast growth factor-1 dependent colony formation of ML20 cells in media containing the pure antiestrogen ICI 182,780 was also markedly inhibited upon induction of SNT-1 PTB, suggesting that blockade of FGFR-SNT-1 interactions might abrogate FGF-mediated antiestrogen resistance in breast cancers.
T1 0-201 Sentence denotes Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells.
T2 202-363 Sentence denotes Fibroblast growth factor (FGF) signaling can bypass the requirement for estrogen receptor (ER) activation in the growth of ER-positive (ER+) breast cancer cells.
T3 364-687 Sentence denotes Fibroblast growth factor-1 stimulation leads to phosphorylation of the adaptor protein Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target (SNT-1) on C-terminal tyrosine residues, whereas it is constitutively bound through its N-terminal phosphotyrosine-binding domain (PTB) to FGF receptors (FGFRs).
T4 688-949 Sentence denotes By expressing the PTB domain of SNT-1 (SNT-1 PTB) in an inducible manner in an ER+ breast carcinoma line, ML20, we asked whether we could uncouple FGFR activation from its downstream signaling components and abrogate FGF-1-induced antiestrogen-resistant growth.
T5 950-1230 Sentence denotes Induction of SNT-1 PTB resulted in a significant decrease of FGF-1-dependent tyrosine phosphorylation of endogenous SNT-1, strong inhibition of complex formation between SNT-1, Gab-1 and Sos-1, and reduced activation of Ras, mitogen-activated protein kinase (MAP kinase), and Akt.
T6 1231-1375 Sentence denotes SNT-1 PTB also inhibited the phosphorylation of p70S6K on Thr421/Ser424 and Ser411, which may result from the abrogation of MAP kinase activity.
T7 1376-1473 Sentence denotes Moreover, we also observed a decreased phosphorylation of the MAP kinase-independent site Thr389.
T8 1474-1731 Sentence denotes This may reflect both inhibition of PI-3 kinase pathways and mammalian target of rapamycin (mTOR)-dependent signaling, as the phosphorylation of Thr389 site was sensitive to treatment with the PI3-K and mTOR inhibitors, LY294002 and rapamycin, respectively.
T9 1732-1896 Sentence denotes Collectively these results suggest that SNT-1 plays a pivotal role in FGF-dependent activation of the Ras-MAP kinase, PI-3 kinase, and mTOR pathways in these cells.
T10 1897-2198 Sentence denotes Fibroblast growth factor-1 dependent colony formation of ML20 cells in media containing the pure antiestrogen ICI 182,780 was also markedly inhibited upon induction of SNT-1 PTB, suggesting that blockade of FGFR-SNT-1 interactions might abrogate FGF-mediated antiestrogen resistance in breast cancers.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 178-184 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 343-349 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 771-777 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 2183-2189 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 178-184 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 343-349 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 771-777 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 2183-2189 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

DisGeNET

Id Subject Object Predicate Lexical cue
T0 274-291 gene:2099 denotes estrogen receptor
T1 343-356 disease:C0678222 denotes breast cancer
T2 274-291 gene:2099 denotes estrogen receptor
T3 343-356 disease:C0006142 denotes breast cancer
T4 727-732 gene:10818 denotes SNT-1
T5 771-787 disease:C0678222 denotes breast carcinoma
T6 720-725 gene:6640 denotes SNT-1
T7 771-787 disease:C0678222 denotes breast carcinoma
T8 727-732 gene:10818 denotes SNT-1
T9 771-787 disease:C0006142 denotes breast carcinoma
T10 720-725 gene:6640 denotes SNT-1
T11 771-787 disease:C0006142 denotes breast carcinoma
T12 727-732 gene:6640 denotes SNT-1
T13 771-787 disease:C0006142 denotes breast carcinoma
T14 727-732 gene:6640 denotes SNT-1
T15 771-787 disease:C0678222 denotes breast carcinoma
T16 720-725 gene:10818 denotes SNT-1
T17 771-787 disease:C0678222 denotes breast carcinoma
T18 720-725 gene:10818 denotes SNT-1
T19 771-787 disease:C0006142 denotes breast carcinoma
R1 T0 T1 associated_with estrogen receptor,breast cancer
R2 T2 T3 associated_with estrogen receptor,breast cancer
R3 T4 T5 associated_with SNT-1,breast carcinoma
R4 T6 T7 associated_with SNT-1,breast carcinoma
R5 T8 T9 associated_with SNT-1,breast carcinoma
R6 T10 T11 associated_with SNT-1,breast carcinoma
R7 T12 T13 associated_with SNT-1,breast carcinoma
R8 T14 T15 associated_with SNT-1,breast carcinoma
R9 T16 T17 associated_with SNT-1,breast carcinoma
R10 T18 T19 associated_with SNT-1,breast carcinoma