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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 122-391 DRI_Background denotes Zinc-dependent histone deacetylases (HDACs) are a family of hydrolases first identified as components of transcriptional repressor complexes, where they act by deacetylating lysine residues at the N-terminal extensions of core histones, thereby affecting transcription.
T2 392-574 DRI_Approach denotes To get more insight into the biological functions of the individual HDAC family members, we have used RNA interference in combination with microarray analysis in Drosophila S2 cells.
T3 575-697 DRI_Background denotes Silencing of Drosophila HDAC1 (DHDAC1), but not of the other DHDAC family members, leads to increased histone acetylation.
T4 698-841 DRI_Background denotes Silencing of either DHDAC1 or DHDAC3 leads to cell growth inhibition and deregulated transcription of both common and distinct groups of genes.
T5 842-967 DRI_Background denotes Silencing DHDAC2 leads to increased tubulin acetylation levels but was not associated with a deregulation of gene expression.
T6 968-1091 DRI_Outcome denotes No growth of phenotype and no significant deregulation of gene expression was observed upon silencing of DHDAC4 and DHDACX.
T7 1092-1432 DRI_Approach denotes Loss of DHDAC1 or exposure of S2 cells to the small molecule HDAC inhibitor trichostatin both lead to a G(2) arrest and were associated with significantly overlapping gene expression signatures in which genes involved in nucleobase and lipid metabolism, DNA replication, cell cycle regulation, and signal transduction were over-represented.
T8 1673-1748 DRI_Approach denotes 1) DHDAC1 and -3 have distinct functions in the control of gene expression.
T9 1749-1856 DRI_Approach denotes 2) Under the tested conditions, DHDAC2, -4, and X have no detectable transcriptional functions in S2 cells.
T10 1857-1975 DRI_Background denotes 3) The anti-proliferative and transcriptional effects of trichostatin are largely recapitulated by the loss of DHDAC1.
T11 1976-2074 DRI_Background denotes 4) The deacetylase activity of DHDAC1 significantly contributes to the repressor function of SIN3.

sentences

Id Subject Object Predicate Lexical cue
T1 0-121 Sentence denotes Dissecting the biological functions of Drosophila histone deacetylases by RNA interference and transcriptional profiling.
T2 122-391 Sentence denotes Zinc-dependent histone deacetylases (HDACs) are a family of hydrolases first identified as components of transcriptional repressor complexes, where they act by deacetylating lysine residues at the N-terminal extensions of core histones, thereby affecting transcription.
T3 392-574 Sentence denotes To get more insight into the biological functions of the individual HDAC family members, we have used RNA interference in combination with microarray analysis in Drosophila S2 cells.
T4 575-697 Sentence denotes Silencing of Drosophila HDAC1 (DHDAC1), but not of the other DHDAC family members, leads to increased histone acetylation.
T5 698-841 Sentence denotes Silencing of either DHDAC1 or DHDAC3 leads to cell growth inhibition and deregulated transcription of both common and distinct groups of genes.
T6 842-967 Sentence denotes Silencing DHDAC2 leads to increased tubulin acetylation levels but was not associated with a deregulation of gene expression.
T7 968-1091 Sentence denotes No growth of phenotype and no significant deregulation of gene expression was observed upon silencing of DHDAC4 and DHDACX.
T8 1092-1432 Sentence denotes Loss of DHDAC1 or exposure of S2 cells to the small molecule HDAC inhibitor trichostatin both lead to a G(2) arrest and were associated with significantly overlapping gene expression signatures in which genes involved in nucleobase and lipid metabolism, DNA replication, cell cycle regulation, and signal transduction were over-represented.
T9 1433-1541 Sentence denotes A large number of these genes were shown to also be deregulated upon loss of the co-repressor SIN3 (Pile, L.
T10 1542-1558 Sentence denotes A., Spellman, P.
T11 1559-1579 Sentence denotes T., Katzenberger, R.
T12 1580-1601 Sentence denotes J., and Wassarman, D.
T13 1602-1614 Sentence denotes A. (2003) J.
T14 1615-1620 Sentence denotes Biol.
T15 1621-1626 Sentence denotes Chem.
T16 1627-1645 Sentence denotes 278, 37840-37848).
T17 1646-1672 Sentence denotes We conclude the following.
T18 1673-1748 Sentence denotes 1) DHDAC1 and -3 have distinct functions in the control of gene expression.
T19 1749-1856 Sentence denotes 2) Under the tested conditions, DHDAC2, -4, and X have no detectable transcriptional functions in S2 cells.
T20 1857-1975 Sentence denotes 3) The anti-proliferative and transcriptional effects of trichostatin are largely recapitulated by the loss of DHDAC1.
T21 1976-2074 Sentence denotes 4) The deacetylase activity of DHDAC1 significantly contributes to the repressor function of SIN3.

bionlp-st-epi-2011-training

Id Subject Object Predicate Lexical cue
T1 50-57 Protein denotes histone
T2 137-144 Protein denotes histone
T3 349-357 Protein denotes histones
T4 599-604 Protein denotes HDAC1
T5 607-612 Protein denotes HDAC1
T6 677-684 Protein denotes histone
T7 719-724 Protein denotes HDAC1
T8 729-734 Protein denotes HDAC3
T9 853-858 Protein denotes HDAC2
T10 1074-1079 Protein denotes HDAC4
T11 1085-1090 Protein denotes HDACX
T12 1101-1106 Protein denotes HDAC1
T13 1527-1531 Protein denotes SIN3
T14 1677-1682 Protein denotes HDAC1
T15 1687-1689 Protein denotes -3
T16 1782-1787 Protein denotes HDAC2
T17 1789-1791 Protein denotes -4
T18 1797-1798 Protein denotes X
T19 1969-1974 Protein denotes HDAC1
T20 2008-2013 Protein denotes HDAC1
T21 2069-2073 Protein denotes SIN3

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 39-49 OrganismTaxon denotes Drosophila 2081351|32281|7215
T4 554-564 OrganismTaxon denotes Drosophila 2081351|32281|7215
T7 588-598 OrganismTaxon denotes Drosophila 2081351|32281|7215

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 330-340 Body_part denotes extensions http://purl.obolibrary.org/obo/UBERON_2000106
T2 1363-1373 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098