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PubMed:16611040 JSON TXT

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LitCoin-entities-OrganismTaxon-PD

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	1222-1229	OrganismTaxon	denotes	vectors	NCBItxid:29278

LitCoin-sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-78	Sentence	denotes	Gene therapy for cystic fibrosis airway disease- is clinical success imminent?
T2	79-310	Sentence	denotes	Cystic fibrosis (CF) was one of the first inherited disorders for which gene therapy was seriously considered as a realistic option for treatment, and as such, it has long provided a paradigm for gene therapy of inherited diseases.
T3	311-484	Sentence	denotes	However, despite the cloning of the cystic fibrosis transmembrane conductance regulator gene in 1989, over 15 years later a practical gene therapy for CF has not eventuated.
T4	485-760	Sentence	denotes	There are a number of reasons for this, and analysis of the specific issues that have delayed the successful development of gene therapy for CF also provides general insights into the practical complexities involved in the development of gene therapy for inherited disorders.
T5	761-1057	Sentence	denotes	The issues which have prevented the application of gene therapy for CF to date include the lack of suitable gene delivery technologies, the complexities of the interactions between the host and vector, the biology of the lung airways, and the nature of the pathology found in individuals with CF.
T6	1058-1589	Sentence	denotes	We will discuss the history of CF gene therapy with specific reference to these and other issues that pre-occupy the field at present: namely, the question of what vectors appear to be suitable for airway gene delivery in CF, what cells must be targeted, how airway epithelium defences can be overcome or eluded to allow efficient gene delivery, how to ensure safe and long-term transgene expression and the need to identify relevant surrogate success measures that can be used to assess the outcome of gene therapy in CF patients.

LitCoin-entities

Id	Subject	Object	Predicate	Lexical cue	db_id
2955	17-32	DiseaseOrPhenotypicFeature	denotes	cystic fibrosis	MESH:D003550
2956	79-94	DiseaseOrPhenotypicFeature	denotes	Cystic fibrosis	MESH:D003550
2957	96-98	DiseaseOrPhenotypicFeature	denotes	CF	MESH:D003550
2958	121-140	DiseaseOrPhenotypicFeature	denotes	inherited disorders	MESH:D030342
2959	291-309	DiseaseOrPhenotypicFeature	denotes	inherited diseases	MESH:D030342
2960	347-398	GeneOrGeneProduct	denotes	cystic fibrosis transmembrane conductance regulator	NCBIGene:1080
2961	462-464	DiseaseOrPhenotypicFeature	denotes	CF	MESH:D003550
2962	626-628	DiseaseOrPhenotypicFeature	denotes	CF	MESH:D003550
2963	740-759	DiseaseOrPhenotypicFeature	denotes	inherited disorders	MESH:D030342
2964	829-831	DiseaseOrPhenotypicFeature	denotes	CF	MESH:D003550
2965	1054-1056	DiseaseOrPhenotypicFeature	denotes	CF	MESH:D003550
2966	1089-1091	DiseaseOrPhenotypicFeature	denotes	CF	MESH:D003550
2967	1280-1282	DiseaseOrPhenotypicFeature	denotes	CF	MESH:D003550
2968	1577-1579	DiseaseOrPhenotypicFeature	denotes	CF	MESH:D003550
2969	1580-1588	OrganismTaxon	denotes	patients	NCBITaxon:9606

LitCoin_Mondo

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	17-32	DiseaseOrPhenotypicFeature	denotes	cystic fibrosis	0009061
T2	79-94	DiseaseOrPhenotypicFeature	denotes	Cystic fibrosis	0009061
T3	121-130	DiseaseOrPhenotypicFeature	denotes	inherited	0021152
T4	291-300	DiseaseOrPhenotypicFeature	denotes	inherited	0021152
T5	347-362	DiseaseOrPhenotypicFeature	denotes	cystic fibrosis	0009061
T6	740-749	DiseaseOrPhenotypicFeature	denotes	inherited	0021152

LitCoin-GeneOrGeneProduct-v2

Id	Subject	Object	Predicate	Lexical cue
T1	17-23	GeneOrGeneProduct	denotes	cystic
T2	79-85	GeneOrGeneProduct	denotes	Cystic
T3	347-398	GeneOrGeneProduct	denotes	cystic fibrosis transmembrane conductance regulator
T4	852-856	GeneOrGeneProduct	denotes	lack
T5	1142-1147	GeneOrGeneProduct	denotes	other
T6	1432-1436	GeneOrGeneProduct	denotes	term

LitCoin-GeneOrGeneProduct-v0

Id	Subject	Object	Predicate	Lexical cue
T1	17-23	GeneOrGeneProduct	denotes	cystic
T2	79-85	GeneOrGeneProduct	denotes	Cystic
T3	246-250	GeneOrGeneProduct	denotes	long
T4	332-339	GeneOrGeneProduct	denotes	cloning
T5	347-398	GeneOrGeneProduct	denotes	cystic fibrosis transmembrane conductance regulator
T6	421-426	GeneOrGeneProduct	denotes	years
T7	427-432	GeneOrGeneProduct	denotes	later
T8	852-856	GeneOrGeneProduct	denotes	lack
T9	982-986	GeneOrGeneProduct	denotes	lung
T10	1142-1147	GeneOrGeneProduct	denotes	other
T11	1289-1294	GeneOrGeneProduct	denotes	cells
T12	1427-1431	GeneOrGeneProduct	denotes	long
T13	1432-1436	GeneOrGeneProduct	denotes	term

LitCoin-Disease-MeSH

Id	Subject	Object	Predicate	Lexical cue	originalLabel
T1	17-32	DiseaseOrPhenotypicFeature	denotes	cystic fibrosis	D003550
T2	40-47	DiseaseOrPhenotypicFeature	denotes	disease	D004194
T3	79-94	DiseaseOrPhenotypicFeature	denotes	Cystic fibrosis	D003550
T4	96-98	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T5	121-140	DiseaseOrPhenotypicFeature	denotes	inherited disorders	DISEASE
T6	301-309	DiseaseOrPhenotypicFeature	denotes	diseases	D004194
T7	347-362	DiseaseOrPhenotypicFeature	denotes	cystic fibrosis	D003550
T8	462-464	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T9	626-628	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T10	740-759	DiseaseOrPhenotypicFeature	denotes	inherited disorders	DISEASE
T11	829-831	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T12	1054-1056	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T13	1089-1091	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T14	1280-1282	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T15	1577-1579	DiseaseOrPhenotypicFeature	denotes	CF	D003550

LitCoin-GeneOrGeneProduct-v3

Id	Subject	Object	Predicate	Lexical cue
T1	347-398	GeneOrGeneProduct	denotes	cystic fibrosis transmembrane conductance regulator

LitCoin_Mondo_095

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	17-32	DiseaseOrPhenotypicFeature	denotes	cystic fibrosis	0009061
T2	79-94	DiseaseOrPhenotypicFeature	denotes	Cystic fibrosis	0009061
T3	96-98	DiseaseOrPhenotypicFeature	denotes	CF	0009061
T4	291-309	DiseaseOrPhenotypicFeature	denotes	inherited diseases	0003847
T5	347-362	DiseaseOrPhenotypicFeature	denotes	cystic fibrosis	0009061
T6	462-464	DiseaseOrPhenotypicFeature	denotes	CF	0009061
T7	626-628	DiseaseOrPhenotypicFeature	denotes	CF	0009061
T8	829-831	DiseaseOrPhenotypicFeature	denotes	CF	0009061
T9	982-986	DiseaseOrPhenotypicFeature	denotes	lung	0021117
T10	1054-1056	DiseaseOrPhenotypicFeature	denotes	CF	0009061
T11	1089-1091	DiseaseOrPhenotypicFeature	denotes	CF	0009061
T12	1280-1282	DiseaseOrPhenotypicFeature	denotes	CF	0009061
T13	1344-1347	DiseaseOrPhenotypicFeature	denotes	can	0012833
T14	1524-1527	DiseaseOrPhenotypicFeature	denotes	can	0012833
T15	1577-1579	DiseaseOrPhenotypicFeature	denotes	CF	0009061

LitCoin-MeSH-Disease-2

Id	Subject	Object	Predicate	Lexical cue	ID:
T1	17-32	DiseaseOrPhenotypicFeature	denotes	cystic fibrosis	D003550
T2	40-47	DiseaseOrPhenotypicFeature	denotes	disease	D004194
T3	79-94	DiseaseOrPhenotypicFeature	denotes	Cystic fibrosis	D003550
T4	96-98	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T5	121-140	DiseaseOrPhenotypicFeature	denotes	inherited disorders	DISEASE
T6	301-309	DiseaseOrPhenotypicFeature	denotes	diseases	D004194
T7	347-362	DiseaseOrPhenotypicFeature	denotes	cystic fibrosis	D003550
T8	462-464	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T9	626-628	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T10	740-759	DiseaseOrPhenotypicFeature	denotes	inherited disorders	DISEASE
T11	829-831	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T12	1054-1056	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T13	1089-1091	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T14	1280-1282	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T15	1577-1579	DiseaseOrPhenotypicFeature	denotes	CF	D003550

LitCoin-MONDO_bioort2019

Id	Subject	Object	Predicate	Lexical cue	#label
T1	17-32	DiseaseOrPhenotypicFeature	denotes	cystic fibrosis	D003550
T2	79-94	DiseaseOrPhenotypicFeature	denotes	Cystic fibrosis	D003550
T3	96-98	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T4	121-140	DiseaseOrPhenotypicFeature	denotes	inherited disorders	DISEASE
T5	347-362	DiseaseOrPhenotypicFeature	denotes	cystic fibrosis	D003550
T6	462-464	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T7	626-628	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T8	740-759	DiseaseOrPhenotypicFeature	denotes	inherited disorders	DISEASE
T9	829-831	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T10	1054-1056	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T11	1089-1091	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T12	1280-1282	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T13	1577-1579	DiseaseOrPhenotypicFeature	denotes	CF	D003550

LitCoin-NCBITaxon-2

Id	Subject	Object	Predicate	Lexical cue
T1	1580-1588	OrganismTaxon	denotes	patients

LitCoin-training-merged

Id	Subject	Object	Predicate	Lexical cue	#label
T1	347-398	GeneOrGeneProduct	denotes	cystic fibrosis transmembrane conductance regulator
T13	1577-1579	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T12	1280-1282	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T11	1089-1091	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T10	1054-1056	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T9	829-831	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T8	740-759	DiseaseOrPhenotypicFeature	denotes	inherited disorders	DISEASE
T7	626-628	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T6	462-464	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T5	347-362	DiseaseOrPhenotypicFeature	denotes	cystic fibrosis	D003550
T4	121-140	DiseaseOrPhenotypicFeature	denotes	inherited disorders	DISEASE
T3	96-98	DiseaseOrPhenotypicFeature	denotes	CF	D003550
T2	79-94	DiseaseOrPhenotypicFeature	denotes	Cystic fibrosis	D003550
T37937	17-32	DiseaseOrPhenotypicFeature	denotes	cystic fibrosis	D003550
T50305	1580-1588	OrganismTaxon	denotes	patients