PubMed:16608396 JSONTXT

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":279,"end":292},"obj":"HP_0003002"},{"id":"T2","span":{"begin":279,"end":292},"obj":"HP_0100013"},{"id":"T3","span":{"begin":286,"end":292},"obj":"HP_0002664"},{"id":"T4","span":{"begin":512,"end":525},"obj":"HP_0003002"},{"id":"T5","span":{"begin":512,"end":525},"obj":"HP_0100013"},{"id":"T6","span":{"begin":519,"end":525},"obj":"HP_0002664"}],"text":"Multilocus genotypes spanning estrogen metabolism associated with breast cancer and fibroadenoma.\nWe investigated inherited polymorphic variation in genes spanning estrogen metabolism (10 SNPs [single nucleotide polymorphism]) to distinguish multilocus genotypes associated with breast cancer (n = 393), benign breast lesions (n = 154), and low risk (n = 1936). Three latent classification GoM extreme type groups represented the data: (a) fibroadenoma, and infrequent SRD5A2 and VDR alleles; (b) postmenopausal breast cancer, and infrequent CYP1A1-1 and CYP1A1-2 alleles (both over-represented infrequent alleles for CYP17, CYP19-3, and COMT); and (c) women at intrinsically low risk. Carriage of the respective multilocus genotypes increased risk 25-fold. We conclude that GoM latent classification may be useful to identify genetic risk sets and estimate risk for individuals."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"16608396-2#118#121#gene7421","span":{"begin":480,"end":483},"obj":"gene7421"},{"id":"16608396-2#150#163#diseaseC0006142","span":{"begin":512,"end":525},"obj":"diseaseC0006142"},{"id":"16608396-2#150#163#diseaseC0678222","span":{"begin":512,"end":525},"obj":"diseaseC0678222"}],"relations":[{"id":"118#121#gene7421150#163#diseaseC0006142","pred":"associated_with","subj":"16608396-2#118#121#gene7421","obj":"16608396-2#150#163#diseaseC0006142"},{"id":"118#121#gene7421150#163#diseaseC0678222","pred":"associated_with","subj":"16608396-2#118#121#gene7421","obj":"16608396-2#150#163#diseaseC0678222"}],"text":"Multilocus genotypes spanning estrogen metabolism associated with breast cancer and fibroadenoma.\nWe investigated inherited polymorphic variation in genes spanning estrogen metabolism (10 SNPs [single nucleotide polymorphism]) to distinguish multilocus genotypes associated with breast cancer (n = 393), benign breast lesions (n = 154), and low risk (n = 1936). Three latent classification GoM extreme type groups represented the data: (a) fibroadenoma, and infrequent SRD5A2 and VDR alleles; (b) postmenopausal breast cancer, and infrequent CYP1A1-1 and CYP1A1-2 alleles (both over-represented infrequent alleles for CYP17, CYP19-3, and COMT); and (c) women at intrinsically low risk. Carriage of the respective multilocus genotypes increased risk 25-fold. We conclude that GoM latent classification may be useful to identify genetic risk sets and estimate risk for individuals."}

{"project":"DisGeNet-2017-sample","denotations":[{"id":"T1177","span":{"begin":480,"end":483},"obj":"gene:7421"},{"id":"T1178","span":{"begin":512,"end":525},"obj":"disease:C0006142"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T1177","obj":"T1178"},{"id":"R2","pred":"associated_with","subj":"T1177","obj":"T1178"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Multilocus genotypes spanning estrogen metabolism associated with breast cancer and fibroadenoma.\nWe investigated inherited polymorphic variation in genes spanning estrogen metabolism (10 SNPs [single nucleotide polymorphism]) to distinguish multilocus genotypes associated with breast cancer (n = 393), benign breast lesions (n = 154), and low risk (n = 1936). Three latent classification GoM extreme type groups represented the data: (a) fibroadenoma, and infrequent SRD5A2 and VDR alleles; (b) postmenopausal breast cancer, and infrequent CYP1A1-1 and CYP1A1-2 alleles (both over-represented infrequent alleles for CYP17, CYP19-3, and COMT); and (c) women at intrinsically low risk. Carriage of the respective multilocus genotypes increased risk 25-fold. We conclude that GoM latent classification may be useful to identify genetic risk sets and estimate risk for individuals."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":97},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":98,"end":361},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":362,"end":685},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":686,"end":757},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":758,"end":879},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":97},"obj":"Sentence"},{"id":"T2","span":{"begin":98,"end":361},"obj":"Sentence"},{"id":"T3","span":{"begin":362,"end":685},"obj":"Sentence"},{"id":"T4","span":{"begin":686,"end":757},"obj":"Sentence"},{"id":"T5","span":{"begin":758,"end":879},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Multilocus genotypes spanning estrogen metabolism associated with breast cancer and fibroadenoma.\nWe investigated inherited polymorphic variation in genes spanning estrogen metabolism (10 SNPs [single nucleotide polymorphism]) to distinguish multilocus genotypes associated with breast cancer (n = 393), benign breast lesions (n = 154), and low risk (n = 1936). Three latent classification GoM extreme type groups represented the data: (a) fibroadenoma, and infrequent SRD5A2 and VDR alleles; (b) postmenopausal breast cancer, and infrequent CYP1A1-1 and CYP1A1-2 alleles (both over-represented infrequent alleles for CYP17, CYP19-3, and COMT); and (c) women at intrinsically low risk. Carriage of the respective multilocus genotypes increased risk 25-fold. We conclude that GoM latent classification may be useful to identify genetic risk sets and estimate risk for individuals."}

{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":66,"end":72},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":279,"end":285},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":311,"end":317},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":512,"end":518},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"}],"text":"Multilocus genotypes spanning estrogen metabolism associated with breast cancer and fibroadenoma.\nWe investigated inherited polymorphic variation in genes spanning estrogen metabolism (10 SNPs [single nucleotide polymorphism]) to distinguish multilocus genotypes associated with breast cancer (n = 393), benign breast lesions (n = 154), and low risk (n = 1936). Three latent classification GoM extreme type groups represented the data: (a) fibroadenoma, and infrequent SRD5A2 and VDR alleles; (b) postmenopausal breast cancer, and infrequent CYP1A1-1 and CYP1A1-2 alleles (both over-represented infrequent alleles for CYP17, CYP19-3, and COMT); and (c) women at intrinsically low risk. Carriage of the respective multilocus genotypes increased risk 25-fold. We conclude that GoM latent classification may be useful to identify genetic risk sets and estimate risk for individuals."}

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":66,"end":72},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":279,"end":285},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":311,"end":317},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":512,"end":518},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"}],"text":"Multilocus genotypes spanning estrogen metabolism associated with breast cancer and fibroadenoma.\nWe investigated inherited polymorphic variation in genes spanning estrogen metabolism (10 SNPs [single nucleotide polymorphism]) to distinguish multilocus genotypes associated with breast cancer (n = 393), benign breast lesions (n = 154), and low risk (n = 1936). Three latent classification GoM extreme type groups represented the data: (a) fibroadenoma, and infrequent SRD5A2 and VDR alleles; (b) postmenopausal breast cancer, and infrequent CYP1A1-1 and CYP1A1-2 alleles (both over-represented infrequent alleles for CYP17, CYP19-3, and COMT); and (c) women at intrinsically low risk. Carriage of the respective multilocus genotypes increased risk 25-fold. We conclude that GoM latent classification may be useful to identify genetic risk sets and estimate risk for individuals."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":469,"end":475},"obj":"gene:6716"},{"id":"T1","span":{"begin":512,"end":525},"obj":"disease:C0006142"},{"id":"T2","span":{"begin":469,"end":475},"obj":"gene:6716"},{"id":"T3","span":{"begin":512,"end":525},"obj":"disease:C0678222"},{"id":"T4","span":{"begin":480,"end":483},"obj":"gene:1594"},{"id":"T5","span":{"begin":512,"end":525},"obj":"disease:C0006142"},{"id":"T6","span":{"begin":480,"end":483},"obj":"gene:1594"},{"id":"T7","span":{"begin":512,"end":525},"obj":"disease:C0678222"},{"id":"T8","span":{"begin":480,"end":483},"obj":"gene:7421"},{"id":"T9","span":{"begin":512,"end":525},"obj":"disease:C0006142"},{"id":"T10","span":{"begin":480,"end":483},"obj":"gene:7421"},{"id":"T11","span":{"begin":512,"end":525},"obj":"disease:C0678222"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"},{"id":"R6","pred":"associated_with","subj":"T10","obj":"T11"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Multilocus genotypes spanning estrogen metabolism associated with breast cancer and fibroadenoma.\nWe investigated inherited polymorphic variation in genes spanning estrogen metabolism (10 SNPs [single nucleotide polymorphism]) to distinguish multilocus genotypes associated with breast cancer (n = 393), benign breast lesions (n = 154), and low risk (n = 1936). Three latent classification GoM extreme type groups represented the data: (a) fibroadenoma, and infrequent SRD5A2 and VDR alleles; (b) postmenopausal breast cancer, and infrequent CYP1A1-1 and CYP1A1-2 alleles (both over-represented infrequent alleles for CYP17, CYP19-3, and COMT); and (c) women at intrinsically low risk. Carriage of the respective multilocus genotypes increased risk 25-fold. We conclude that GoM latent classification may be useful to identify genetic risk sets and estimate risk for individuals."}