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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-185 Sentence denotes Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma.
T2 186-434 Sentence denotes Type 2 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) is a multi-functional enzyme that possesses 3alpha-, 17beta- and 20alpha-HSD, as well as prostaglandin (PG) F synthase activities and catalyzes androgen, estrogen, progestin and PG metabolism.
T3 435-563 Sentence denotes Type 2 3alpha-HSD was cloned from human prostate, is a member of the aldo-keto reductase (AKR) superfamily and was named AKR1C3.
T4 564-810 Sentence denotes In androgen target tissues such as the prostate, AKR1C3 catalyzes the conversion of Delta(4)-androstene-3,17-dione to testosterone, 5alpha-dihydrotestosterone to 5alpha-androstane-3alpha,17beta-diol (3alpha-diol), and 3alpha-diol to androsterone.
T5 811-930 Sentence denotes Thus AKR1C3 may regulate the balance of androgens and hence trans-activation of the androgen receptor in these tissues.
T6 931-1031 Sentence denotes Tissue distribution studies indicate that AKR1C3 transcripts are highly expressed in human prostate.
T7 1032-1171 Sentence denotes To measure AKR1C3 protein expression and its distribution in the prostate, we raised a monoclonal antibody specifically recognizing AKR1C3.
T8 1172-1268 Sentence denotes This antibody allowed us to distinguish AKR1C3 from other AKR1C family members in human tissues.
T9 1269-1442 Sentence denotes Immunoblot analysis showed that this monoclonal antibody binds to one species of protein in primary cultures of prostate epithelial cells and in LNCaP prostate cancer cells.
T10 1443-1659 Sentence denotes Immunohistochemistry with this antibody on human prostate detected strong nuclear immunoreactivity in normal stromal and smooth muscle cells, perineurial cells, urothelial (transitional) cells, and endothelial cells.
T11 1660-1738 Sentence denotes Normal prostate epithelial cells were only faintly immunoreactive or negative.
T12 1739-1835 Sentence denotes Positive immunoreactivity was demonstrated in primary prostatic adenocarcinoma in 9 of 11 cases.
T13 1836-2036 Sentence denotes Variable increases in immunoreactivity for AKR1C3 was also demonstrated in non-neoplastic changes in the prostate including chronic inflammation, atrophy and urothelial (transitional) cell metaplasia.
T14 2037-2129 Sentence denotes We conclude that elevated expression of AKR1C3 is highly associated with prostate carcinoma.
T15 2130-2327 Sentence denotes Although the biological significance of elevated AKR1C3 in prostatic carcinoma is uncertain, AKR1C3 may be responsible for the trophic effects of androgens and/or PGs on prostatic epithelial cells.
T1 0-185 Sentence denotes Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma.
T2 186-434 Sentence denotes Type 2 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) is a multi-functional enzyme that possesses 3alpha-, 17beta- and 20alpha-HSD, as well as prostaglandin (PG) F synthase activities and catalyzes androgen, estrogen, progestin and PG metabolism.
T3 435-563 Sentence denotes Type 2 3alpha-HSD was cloned from human prostate, is a member of the aldo-keto reductase (AKR) superfamily and was named AKR1C3.
T4 564-810 Sentence denotes In androgen target tissues such as the prostate, AKR1C3 catalyzes the conversion of Delta(4)-androstene-3,17-dione to testosterone, 5alpha-dihydrotestosterone to 5alpha-androstane-3alpha,17beta-diol (3alpha-diol), and 3alpha-diol to androsterone.
T5 811-930 Sentence denotes Thus AKR1C3 may regulate the balance of androgens and hence trans-activation of the androgen receptor in these tissues.
T6 931-1031 Sentence denotes Tissue distribution studies indicate that AKR1C3 transcripts are highly expressed in human prostate.
T7 1032-1171 Sentence denotes To measure AKR1C3 protein expression and its distribution in the prostate, we raised a monoclonal antibody specifically recognizing AKR1C3.
T8 1172-1268 Sentence denotes This antibody allowed us to distinguish AKR1C3 from other AKR1C family members in human tissues.
T9 1269-1442 Sentence denotes Immunoblot analysis showed that this monoclonal antibody binds to one species of protein in primary cultures of prostate epithelial cells and in LNCaP prostate cancer cells.
T10 1443-1659 Sentence denotes Immunohistochemistry with this antibody on human prostate detected strong nuclear immunoreactivity in normal stromal and smooth muscle cells, perineurial cells, urothelial (transitional) cells, and endothelial cells.
T11 1660-1738 Sentence denotes Normal prostate epithelial cells were only faintly immunoreactive or negative.
T12 1739-1835 Sentence denotes Positive immunoreactivity was demonstrated in primary prostatic adenocarcinoma in 9 of 11 cases.
T13 1836-2036 Sentence denotes Variable increases in immunoreactivity for AKR1C3 was also demonstrated in non-neoplastic changes in the prostate including chronic inflammation, atrophy and urothelial (transitional) cell metaplasia.
T14 2037-2129 Sentence denotes We conclude that elevated expression of AKR1C3 is highly associated with prostate carcinoma.
T15 2130-2327 Sentence denotes Although the biological significance of elevated AKR1C3 in prostatic carcinoma is uncertain, AKR1C3 may be responsible for the trophic effects of androgens and/or PGs on prostatic epithelial cells.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1420-1435 HP_0012125 denotes prostate cancer
T2 1429-1435 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
16601286-0#74#109#gene51478 74-109 gene51478 denotes 17beta-hydroxysteroid dehydrogenase
16601286-0#111#117#gene8644 111-117 gene8644 denotes AKR1C3
16601286-0#145#162#gene367 145-162 gene367 denotes androgen receptor
16601286-0#166#184#diseaseC0600139 166-184 diseaseC0600139 denotes prostate carcinoma
16601286-12#43#49#gene8644 1879-1885 gene8644 denotes AKR1C3
16601286-12#75#89#diseaseC1709246 1911-1925 diseaseC1709246 denotes non-neoplastic
74#109#gene51478166#184#diseaseC0600139 16601286-0#74#109#gene51478 16601286-0#166#184#diseaseC0600139 associated_with 17beta-hydroxysteroid dehydrogenase,prostate carcinoma
111#117#gene8644166#184#diseaseC0600139 16601286-0#111#117#gene8644 16601286-0#166#184#diseaseC0600139 associated_with AKR1C3,prostate carcinoma
145#162#gene367166#184#diseaseC0600139 16601286-0#145#162#gene367 16601286-0#166#184#diseaseC0600139 associated_with androgen receptor,prostate carcinoma
43#49#gene864475#89#diseaseC1709246 16601286-12#43#49#gene8644 16601286-12#75#89#diseaseC1709246 associated_with AKR1C3,non-neoplastic

CoMAGC

Id Subject Object Predicate Lexical cue
T1 2077-2083 Gene denotes AKR1C3
E1 2063-2073 Gene_expression denotes expression
E2 2054-2062 Positive_regulation denotes elevated
T2 2110-2128 prostate cancer denotes prostate carcinoma
R1 T1 E1 themeOf AKR1C3,expression
R2 E1 E2 themeOf expression,elevated
R3 T1 T2 CGE-increased AKR1C3,prostate carcinoma
R4 T1 T2 CCS-normalTOcancer AKR1C3,prostate carcinoma
R5 T1 T2 PT-observation AKR1C3,prostate carcinoma
R3 T1 T2 IGE-unchanged AKR1C3,prostate carcinoma

DisGeNET

Id Subject Object Predicate Lexical cue
T0 2179-2185 gene:8644 denotes AKR1C3
T1 2189-2208 disease:C0600139 denotes prostatic carcinoma
T2 2223-2229 gene:8644 denotes AKR1C3
T3 2189-2208 disease:C0600139 denotes prostatic carcinoma
R1 T0 T1 associated_with AKR1C3,prostatic carcinoma
R2 T2 T3 associated_with AKR1C3,prostatic carcinoma