PubMed:16596970 JSONTXT

{"project":"LitCoin-entities-OrganismTaxon-PD","denotations":[{"id":"T1","span":{"begin":505,"end":509},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":756,"end":760},"obj":"OrganismTaxon"},{"id":"T7","span":{"begin":810,"end":814},"obj":"OrganismTaxon"},{"id":"T10","span":{"begin":911,"end":915},"obj":"OrganismTaxon"},{"id":"T13","span":{"begin":987,"end":991},"obj":"OrganismTaxon"},{"id":"T16","span":{"begin":1099,"end":1103},"obj":"OrganismTaxon"},{"id":"T19","span":{"begin":1207,"end":1210},"obj":"OrganismTaxon"},{"id":"T21","span":{"begin":1371,"end":1377},"obj":"OrganismTaxon"}],"attributes":[{"id":"A13","pred":"db_id","subj":"T13","obj":"NCBItxid:10118"},{"id":"A14","pred":"db_id","subj":"T13","obj":"NCBItxid:10116"},{"id":"A15","pred":"db_id","subj":"T13","obj":"NCBItxid:10114"},{"id":"A10","pred":"db_id","subj":"T10","obj":"NCBItxid:10118"},{"id":"A11","pred":"db_id","subj":"T10","obj":"NCBItxid:10116"},{"id":"A12","pred":"db_id","subj":"T10","obj":"NCBItxid:10114"},{"id":"A19","pred":"db_id","subj":"T19","obj":"NCBItxid:10116"},{"id":"A20","pred":"db_id","subj":"T19","obj":"NCBItxid:10114"},{"id":"A1","pred":"db_id","subj":"T1","obj":"NCBItxid:10118"},{"id":"A2","pred":"db_id","subj":"T1","obj":"NCBItxid:10116"},{"id":"A3","pred":"db_id","subj":"T1","obj":"NCBItxid:10114"},{"id":"A16","pred":"db_id","subj":"T16","obj":"NCBItxid:10118"},{"id":"A17","pred":"db_id","subj":"T16","obj":"NCBItxid:10116"},{"id":"A18","pred":"db_id","subj":"T16","obj":"NCBItxid:10114"},{"id":"A7","pred":"db_id","subj":"T7","obj":"NCBItxid:10118"},{"id":"A8","pred":"db_id","subj":"T7","obj":"NCBItxid:10116"},{"id":"A9","pred":"db_id","subj":"T7","obj":"NCBItxid:10114"},{"id":"A4","pred":"db_id","subj":"T4","obj":"NCBItxid:10118"},{"id":"A5","pred":"db_id","subj":"T4","obj":"NCBItxid:10116"},{"id":"A6","pred":"db_id","subj":"T4","obj":"NCBItxid:10114"},{"id":"A21","pred":"db_id","subj":"T21","obj":"NCBItxid:9605"}],"text":"Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.\nChildren who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was used to evaluate this question using an animal model of status epilepticus. Male Sprague-Dawley rats were injected with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilepticus; status epilepticus at P45 resulted in CA3 cell loss and spontaneous seizures, whereas P20 rats had no cell loss or spontaneous seizures. Mature rats were trained with sound-source location and sound-silence discriminations. Control (saline P20) rats acquired both discriminations immediately. In status epilepticus (P20) rats, acquisition of the sound-source location discrimination was moderately impaired. Status epilepticus (P45) rats failed to acquire either sound-source location or sound-silence discriminations. Status epilepticus in rat causes an age-dependent, long-term impairment in auditory discrimination. This impairment may explain one cause of impaired auditory location discrimination in humans."}

{"project":"LitCoin-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":88},"obj":"Sentence"},{"id":"T2","span":{"begin":89,"end":255},"obj":"Sentence"},{"id":"T3","span":{"begin":256,"end":349},"obj":"Sentence"},{"id":"T4","span":{"begin":350,"end":484},"obj":"Sentence"},{"id":"T5","span":{"begin":485,"end":611},"obj":"Sentence"},{"id":"T6","span":{"begin":612,"end":802},"obj":"Sentence"},{"id":"T7","span":{"begin":803,"end":889},"obj":"Sentence"},{"id":"T8","span":{"begin":890,"end":958},"obj":"Sentence"},{"id":"T9","span":{"begin":959,"end":1073},"obj":"Sentence"},{"id":"T10","span":{"begin":1074,"end":1184},"obj":"Sentence"},{"id":"T11","span":{"begin":1185,"end":1284},"obj":"Sentence"},{"id":"T12","span":{"begin":1285,"end":1378},"obj":"Sentence"}],"text":"Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.\nChildren who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was used to evaluate this question using an animal model of status epilepticus. Male Sprague-Dawley rats were injected with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilepticus; status epilepticus at P45 resulted in CA3 cell loss and spontaneous seizures, whereas P20 rats had no cell loss or spontaneous seizures. Mature rats were trained with sound-source location and sound-silence discriminations. Control (saline P20) rats acquired both discriminations immediately. In status epilepticus (P20) rats, acquisition of the sound-source location discrimination was moderately impaired. Status epilepticus (P45) rats failed to acquire either sound-source location or sound-silence discriminations. Status epilepticus in rat causes an age-dependent, long-term impairment in auditory discrimination. This impairment may explain one cause of impaired auditory location discrimination in humans."}

{"project":"LitCoin-entities","denotations":[{"id":"2927","span":{"begin":0,"end":11},"obj":"ChemicalEntity"},{"id":"2928","span":{"begin":12,"end":20},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2929","span":{"begin":41,"end":87},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2930","span":{"begin":107,"end":125},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2931","span":{"begin":163,"end":171},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2932","span":{"begin":276,"end":294},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2933","span":{"begin":302,"end":337},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2934","span":{"begin":465,"end":483},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2935","span":{"begin":505,"end":509},"obj":"OrganismTaxon"},{"id":"2936","span":{"begin":585,"end":596},"obj":"ChemicalEntity"},{"id":"2937","span":{"begin":612,"end":623},"obj":"ChemicalEntity"},{"id":"2938","span":{"begin":646,"end":664},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2939","span":{"begin":666,"end":684},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2940","span":{"begin":704,"end":707},"obj":"CellLine"},{"id":"2941","span":{"begin":734,"end":742},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2942","span":{"begin":756,"end":760},"obj":"OrganismTaxon"},{"id":"2943","span":{"begin":793,"end":801},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2944","span":{"begin":810,"end":814},"obj":"OrganismTaxon"},{"id":"2945","span":{"begin":911,"end":915},"obj":"OrganismTaxon"},{"id":"2946","span":{"begin":962,"end":980},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2947","span":{"begin":987,"end":991},"obj":"OrganismTaxon"},{"id":"2948","span":{"begin":1074,"end":1092},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2949","span":{"begin":1099,"end":1103},"obj":"OrganismTaxon"},{"id":"2950","span":{"begin":1185,"end":1203},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2951","span":{"begin":1207,"end":1210},"obj":"OrganismTaxon"},{"id":"2952","span":{"begin":1246,"end":1283},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2953","span":{"begin":1326,"end":1367},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2954","span":{"begin":1371,"end":1377},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"2927","obj":"MESH:D010862"},{"id":"A2","pred":"db_id","subj":"2928","obj":"MESH:D012640"},{"id":"A3","pred":"db_id","subj":"2929","obj":"MESH:D001308"},{"id":"A4","pred":"db_id","subj":"2930","obj":"MESH:D013226"},{"id":"A5","pred":"db_id","subj":"2931","obj":"MESH:D012640"},{"id":"A6","pred":"db_id","subj":"2932","obj":"MESH:D013226"},{"id":"A7","pred":"db_id","subj":"2933","obj":"MESH:D001308"},{"id":"A8","pred":"db_id","subj":"2934","obj":"MESH:D013226"},{"id":"A9","pred":"db_id","subj":"2935","obj":"NCBITaxon:10116"},{"id":"A10","pred":"db_id","subj":"2936","obj":"MESH:D010862"},{"id":"A11","pred":"db_id","subj":"2937","obj":"MESH:D010862"},{"id":"A12","pred":"db_id","subj":"2938","obj":"MESH:D013226"},{"id":"A13","pred":"db_id","subj":"2939","obj":"MESH:D013226"},{"id":"A14","pred":"db_id","subj":"2940","obj":"NCBITaxon:10090"},{"id":"A15","pred":"db_id","subj":"2941","obj":"MESH:D012640"},{"id":"A16","pred":"db_id","subj":"2942","obj":"NCBITaxon:10116"},{"id":"A17","pred":"db_id","subj":"2943","obj":"MESH:D012640"},{"id":"A18","pred":"db_id","subj":"2944","obj":"NCBITaxon:10116"},{"id":"A19","pred":"db_id","subj":"2945","obj":"NCBITaxon:10116"},{"id":"A20","pred":"db_id","subj":"2946","obj":"MESH:D013226"},{"id":"A21","pred":"db_id","subj":"2947","obj":"NCBITaxon:10116"},{"id":"A22","pred":"db_id","subj":"2948","obj":"MESH:D013226"},{"id":"A23","pred":"db_id","subj":"2949","obj":"NCBITaxon:10116"},{"id":"A24","pred":"db_id","subj":"2950","obj":"MESH:D013226"},{"id":"A25","pred":"db_id","subj":"2951","obj":"NCBITaxon:10116"},{"id":"A26","pred":"db_id","subj":"2952","obj":"MESH:D001308"},{"id":"A27","pred":"db_id","subj":"2953","obj":"MESH:D001308"},{"id":"A28","pred":"db_id","subj":"2954","obj":"NCBITaxon:9606"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}],"text":"Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.\nChildren who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was used to evaluate this question using an animal model of status epilepticus. Male Sprague-Dawley rats were injected with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilepticus; status epilepticus at P45 resulted in CA3 cell loss and spontaneous seizures, whereas P20 rats had no cell loss or spontaneous seizures. Mature rats were trained with sound-source location and sound-silence discriminations. Control (saline P20) rats acquired both discriminations immediately. In status epilepticus (P20) rats, acquisition of the sound-source location discrimination was moderately impaired. Status epilepticus (P45) rats failed to acquire either sound-source location or sound-silence discriminations. Status epilepticus in rat causes an age-dependent, long-term impairment in auditory discrimination. This impairment may explain one cause of impaired auditory location discrimination in humans."}

{"project":"LitCoin_Mondo","denotations":[{"id":"T1","span":{"begin":107,"end":125},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":276,"end":294},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":465,"end":483},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":646,"end":664},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":666,"end":684},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":916,"end":924},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":962,"end":980},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1074,"end":1092},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1114,"end":1121},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":1185,"end":1203},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0002125"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0021141"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0002125"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0002125"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0021141"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0002125"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0002125"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0002125"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0002125"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"0002125"}],"text":"Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.\nChildren who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was used to evaluate this question using an animal model of status epilepticus. Male Sprague-Dawley rats were injected with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilepticus; status epilepticus at P45 resulted in CA3 cell loss and spontaneous seizures, whereas P20 rats had no cell loss or spontaneous seizures. Mature rats were trained with sound-source location and sound-silence discriminations. Control (saline P20) rats acquired both discriminations immediately. In status epilepticus (P20) rats, acquisition of the sound-source location discrimination was moderately impaired. Status epilepticus (P45) rats failed to acquire either sound-source location or sound-silence discriminations. Status epilepticus in rat causes an age-dependent, long-term impairment in auditory discrimination. This impairment may explain one cause of impaired auditory location discrimination in humans."}

{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T1","span":{"begin":12,"end":20},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":163,"end":171},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":236,"end":241},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":246,"end":254},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":341,"end":348},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":398,"end":404},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":704,"end":707},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":708,"end":712},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":722,"end":742},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":768,"end":772},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":781,"end":801},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":1241,"end":1245},"obj":"GeneOrGeneProduct"}],"text":"Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.\nChildren who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was used to evaluate this question using an animal model of status epilepticus. Male Sprague-Dawley rats were injected with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilepticus; status epilepticus at P45 resulted in CA3 cell loss and spontaneous seizures, whereas P20 rats had no cell loss or spontaneous seizures. Mature rats were trained with sound-source location and sound-silence discriminations. Control (saline P20) rats acquired both discriminations immediately. In status epilepticus (P20) rats, acquisition of the sound-source location discrimination was moderately impaired. Status epilepticus (P45) rats failed to acquire either sound-source location or sound-silence discriminations. Status epilepticus in rat causes an age-dependent, long-term impairment in auditory discrimination. This impairment may explain one cause of impaired auditory location discrimination in humans."}

{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T1","span":{"begin":12,"end":20},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":163,"end":171},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":220,"end":224},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":236,"end":241},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":246,"end":254},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":341,"end":348},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":398,"end":404},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":485,"end":489},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":557,"end":563},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":638,"end":645},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":704,"end":707},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":708,"end":712},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":722,"end":742},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":768,"end":772},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":781,"end":801},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":803,"end":809},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":833,"end":838},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":859,"end":864},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":1012,"end":1017},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":1129,"end":1134},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":1154,"end":1159},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":1236,"end":1240},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":1241,"end":1245},"obj":"GeneOrGeneProduct"}],"text":"Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.\nChildren who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was used to evaluate this question using an animal model of status epilepticus. Male Sprague-Dawley rats were injected with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilepticus; status epilepticus at P45 resulted in CA3 cell loss and spontaneous seizures, whereas P20 rats had no cell loss or spontaneous seizures. Mature rats were trained with sound-source location and sound-silence discriminations. Control (saline P20) rats acquired both discriminations immediately. In status epilepticus (P20) rats, acquisition of the sound-source location discrimination was moderately impaired. Status epilepticus (P45) rats failed to acquire either sound-source location or sound-silence discriminations. Status epilepticus in rat causes an age-dependent, long-term impairment in auditory discrimination. This impairment may explain one cause of impaired auditory location discrimination in humans."}

{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T1","span":{"begin":12,"end":20},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":107,"end":125},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":163,"end":171},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":276,"end":294},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":465,"end":483},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":646,"end":664},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":666,"end":684},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":734,"end":742},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":793,"end":801},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":962,"end":980},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":1074,"end":1092},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":1185,"end":1203},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A3","pred":"originalLabel","subj":"T3","obj":"D012640"},{"id":"A11","pred":"originalLabel","subj":"T11","obj":"D013226"},{"id":"A8","pred":"originalLabel","subj":"T8","obj":"D012640"},{"id":"A1","pred":"originalLabel","subj":"T1","obj":"D012640"},{"id":"A7","pred":"originalLabel","subj":"T7","obj":"D013226"},{"id":"A12","pred":"originalLabel","subj":"T12","obj":"D013226"},{"id":"A9","pred":"originalLabel","subj":"T9","obj":"D012640"},{"id":"A2","pred":"originalLabel","subj":"T2","obj":"D013226"},{"id":"A4","pred":"originalLabel","subj":"T4","obj":"D013226"},{"id":"A5","pred":"originalLabel","subj":"T5","obj":"D013226"},{"id":"A10","pred":"originalLabel","subj":"T10","obj":"D013226"},{"id":"A6","pred":"originalLabel","subj":"T6","obj":"D013226"}],"text":"Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.\nChildren who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was used to evaluate this question using an animal model of status epilepticus. Male Sprague-Dawley rats were injected with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilepticus; status epilepticus at P45 resulted in CA3 cell loss and spontaneous seizures, whereas P20 rats had no cell loss or spontaneous seizures. Mature rats were trained with sound-source location and sound-silence discriminations. Control (saline P20) rats acquired both discriminations immediately. In status epilepticus (P20) rats, acquisition of the sound-source location discrimination was moderately impaired. Status epilepticus (P45) rats failed to acquire either sound-source location or sound-silence discriminations. Status epilepticus in rat causes an age-dependent, long-term impairment in auditory discrimination. This impairment may explain one cause of impaired auditory location discrimination in humans."}

{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T1","span":{"begin":704,"end":707},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":722,"end":742},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":781,"end":801},"obj":"GeneOrGeneProduct"}],"text":"Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.\nChildren who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was used to evaluate this question using an animal model of status epilepticus. Male Sprague-Dawley rats were injected with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilepticus; status epilepticus at P45 resulted in CA3 cell loss and spontaneous seizures, whereas P20 rats had no cell loss or spontaneous seizures. Mature rats were trained with sound-source location and sound-silence discriminations. Control (saline P20) rats acquired both discriminations immediately. In status epilepticus (P20) rats, acquisition of the sound-source location discrimination was moderately impaired. Status epilepticus (P45) rats failed to acquire either sound-source location or sound-silence discriminations. Status epilepticus in rat causes an age-dependent, long-term impairment in auditory discrimination. This impairment may explain one cause of impaired auditory location discrimination in humans."}

{"project":"LitCoin_Mondo_095","denotations":[{"id":"T1","span":{"begin":107,"end":125},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":276,"end":294},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":465,"end":483},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":646,"end":664},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":666,"end":684},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":962,"end":980},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1074,"end":1092},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1185,"end":1203},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0002125"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0002125"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0002125"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0002125"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0002125"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0002125"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0002125"},{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0002125"}],"text":"Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.\nChildren who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was used to evaluate this question using an animal model of status epilepticus. Male Sprague-Dawley rats were injected with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilepticus; status epilepticus at P45 resulted in CA3 cell loss and spontaneous seizures, whereas P20 rats had no cell loss or spontaneous seizures. Mature rats were trained with sound-source location and sound-silence discriminations. Control (saline P20) rats acquired both discriminations immediately. In status epilepticus (P20) rats, acquisition of the sound-source location discrimination was moderately impaired. Status epilepticus (P45) rats failed to acquire either sound-source location or sound-silence discriminations. Status epilepticus in rat causes an age-dependent, long-term impairment in auditory discrimination. This impairment may explain one cause of impaired auditory location discrimination in humans."}

{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T1","span":{"begin":12,"end":20},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":41,"end":87},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":107,"end":125},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":163,"end":171},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":276,"end":294},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":302,"end":337},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":465,"end":483},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":646,"end":664},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":666,"end":684},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":734,"end":742},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":793,"end":801},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":962,"end":980},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":1074,"end":1092},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":1185,"end":1203},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T15","span":{"begin":1246,"end":1283},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T16","span":{"begin":1326,"end":1367},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A2","pred":"ID:","subj":"T2","obj":"DISEASE"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D013226"},{"id":"A12","pred":"ID:","subj":"T12","obj":"D013226"},{"id":"A9","pred":"ID:","subj":"T9","obj":"D013226"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D013226"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D012640"},{"id":"A5","pred":"ID:","subj":"T5","obj":"D013226"},{"id":"A15","pred":"ID:","subj":"T15","obj":"DISEASE"},{"id":"A6","pred":"ID:","subj":"T6","obj":"DISEASE"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D013226"},{"id":"A13","pred":"ID:","subj":"T13","obj":"D013226"},{"id":"A16","pred":"ID:","subj":"T16","obj":"DISEASE"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D012640"},{"id":"A10","pred":"ID:","subj":"T10","obj":"D012640"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D012640"},{"id":"A14","pred":"ID:","subj":"T14","obj":"D013226"}],"text":"Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.\nChildren who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was used to evaluate this question using an animal model of status epilepticus. Male Sprague-Dawley rats were injected with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilepticus; status epilepticus at P45 resulted in CA3 cell loss and spontaneous seizures, whereas P20 rats had no cell loss or spontaneous seizures. Mature rats were trained with sound-source location and sound-silence discriminations. Control (saline P20) rats acquired both discriminations immediately. In status epilepticus (P20) rats, acquisition of the sound-source location discrimination was moderately impaired. Status epilepticus (P45) rats failed to acquire either sound-source location or sound-silence discriminations. Status epilepticus in rat causes an age-dependent, long-term impairment in auditory discrimination. This impairment may explain one cause of impaired auditory location discrimination in humans."}

{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T1","span":{"begin":12,"end":20},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":41,"end":87},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":107,"end":125},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":163,"end":171},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":276,"end":294},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":302,"end":337},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":465,"end":483},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":646,"end":664},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":666,"end":684},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":734,"end":742},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":793,"end":801},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":962,"end":980},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":1074,"end":1092},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":1185,"end":1203},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T15","span":{"begin":1246,"end":1283},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T16","span":{"begin":1326,"end":1367},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A10","pred":"#label","subj":"T10","obj":"D012640"},{"id":"A1","pred":"#label","subj":"T1","obj":"D012640"},{"id":"A5","pred":"#label","subj":"T5","obj":"D013226"},{"id":"A3","pred":"#label","subj":"T3","obj":"D013226"},{"id":"A6","pred":"#label","subj":"T6","obj":"DISEASE"},{"id":"A11","pred":"#label","subj":"T11","obj":"D012640"},{"id":"A12","pred":"#label","subj":"T12","obj":"D013226"},{"id":"A7","pred":"#label","subj":"T7","obj":"D013226"},{"id":"A9","pred":"#label","subj":"T9","obj":"D013226"},{"id":"A4","pred":"#label","subj":"T4","obj":"D012640"},{"id":"A16","pred":"#label","subj":"T16","obj":"DISEASE"},{"id":"A8","pred":"#label","subj":"T8","obj":"D013226"},{"id":"A2","pred":"#label","subj":"T2","obj":"DISEASE"},{"id":"A15","pred":"#label","subj":"T15","obj":"DISEASE"},{"id":"A14","pred":"#label","subj":"T14","obj":"D013226"},{"id":"A13","pred":"#label","subj":"T13","obj":"D013226"}],"text":"Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.\nChildren who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was used to evaluate this question using an animal model of status epilepticus. Male Sprague-Dawley rats were injected with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilepticus; status epilepticus at P45 resulted in CA3 cell loss and spontaneous seizures, whereas P20 rats had no cell loss or spontaneous seizures. Mature rats were trained with sound-source location and sound-silence discriminations. Control (saline P20) rats acquired both discriminations immediately. In status epilepticus (P20) rats, acquisition of the sound-source location discrimination was moderately impaired. Status epilepticus (P45) rats failed to acquire either sound-source location or sound-silence discriminations. Status epilepticus in rat causes an age-dependent, long-term impairment in auditory discrimination. This impairment may explain one cause of impaired auditory location discrimination in humans."}

{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":0,"end":11},"obj":"ChemicalEntity"},{"id":"T2","span":{"begin":585,"end":596},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":612,"end":623},"obj":"ChemicalEntity"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_8207"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D010862"},{"id":"A3","pred":"ID:","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_39462"},{"id":"A4","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_8207"}],"text":"Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.\nChildren who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was used to evaluate this question using an animal model of status epilepticus. Male Sprague-Dawley rats were injected with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilepticus; status epilepticus at P45 resulted in CA3 cell loss and spontaneous seizures, whereas P20 rats had no cell loss or spontaneous seizures. Mature rats were trained with sound-source location and sound-silence discriminations. Control (saline P20) rats acquired both discriminations immediately. In status epilepticus (P20) rats, acquisition of the sound-source location discrimination was moderately impaired. Status epilepticus (P45) rats failed to acquire either sound-source location or sound-silence discriminations. Status epilepticus in rat causes an age-dependent, long-term impairment in auditory discrimination. This impairment may explain one cause of impaired auditory location discrimination in humans."}

{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T1","span":{"begin":505,"end":509},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":756,"end":760},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":810,"end":814},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":911,"end":915},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":987,"end":991},"obj":"OrganismTaxon"},{"id":"T6","span":{"begin":1099,"end":1103},"obj":"OrganismTaxon"},{"id":"T7","span":{"begin":1207,"end":1210},"obj":"OrganismTaxon"},{"id":"T8","span":{"begin":1371,"end":1377},"obj":"OrganismTaxon"}],"text":"Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.\nChildren who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was used to evaluate this question using an animal model of status epilepticus. Male Sprague-Dawley rats were injected with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilepticus; status epilepticus at P45 resulted in CA3 cell loss and spontaneous seizures, whereas P20 rats had no cell loss or spontaneous seizures. Mature rats were trained with sound-source location and sound-silence discriminations. Control (saline P20) rats acquired both discriminations immediately. In status epilepticus (P20) rats, acquisition of the sound-source location discrimination was moderately impaired. Status epilepticus (P45) rats failed to acquire either sound-source location or sound-silence discriminations. Status epilepticus in rat causes an age-dependent, long-term impairment in auditory discrimination. This impairment may explain one cause of impaired auditory location discrimination in humans."}

{"project":"LitCoin-training-merged","denotations":[{"id":"T4","span":{"begin":612,"end":623},"obj":"ChemicalEntity"},{"id":"T2","span":{"begin":585,"end":596},"obj":"ChemicalEntity"},{"id":"T1","span":{"begin":0,"end":11},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":781,"end":801},"obj":"GeneOrGeneProduct"},{"id":"T86940","span":{"begin":722,"end":742},"obj":"GeneOrGeneProduct"},{"id":"T54782","span":{"begin":704,"end":707},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":1326,"end":1367},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T15","span":{"begin":1246,"end":1283},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":1185,"end":1203},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":1074,"end":1092},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":962,"end":980},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":793,"end":801},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":734,"end":742},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":666,"end":684},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":646,"end":664},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":465,"end":483},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":302,"end":337},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":276,"end":294},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T25477","span":{"begin":163,"end":171},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T70735","span":{"begin":107,"end":125},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T71660","span":{"begin":41,"end":87},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T29434","span":{"begin":12,"end":20},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T87228","span":{"begin":1371,"end":1377},"obj":"OrganismTaxon"},{"id":"T8310","span":{"begin":1207,"end":1210},"obj":"OrganismTaxon"},{"id":"T44360","span":{"begin":1099,"end":1103},"obj":"OrganismTaxon"},{"id":"T55999","span":{"begin":987,"end":991},"obj":"OrganismTaxon"},{"id":"T37006","span":{"begin":911,"end":915},"obj":"OrganismTaxon"},{"id":"T33463","span":{"begin":810,"end":814},"obj":"OrganismTaxon"},{"id":"T46808","span":{"begin":756,"end":760},"obj":"OrganismTaxon"},{"id":"T36849","span":{"begin":505,"end":509},"obj":"OrganismTaxon"}],"attributes":[{"id":"A4","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_8207"},{"id":"A3","pred":"ID:","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_39462"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D010862"},{"id":"A1","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_8207"},{"id":"A16","pred":"#label","subj":"T16","obj":"DISEASE"},{"id":"A15","pred":"#label","subj":"T15","obj":"DISEASE"},{"id":"A14","pred":"#label","subj":"T14","obj":"D013226"},{"id":"A13","pred":"#label","subj":"T13","obj":"D013226"},{"id":"A12","pred":"#label","subj":"T12","obj":"D013226"},{"id":"A11","pred":"#label","subj":"T11","obj":"D012640"},{"id":"A10","pred":"#label","subj":"T10","obj":"D012640"},{"id":"A9","pred":"#label","subj":"T9","obj":"D013226"},{"id":"A8","pred":"#label","subj":"T8","obj":"D013226"},{"id":"A7","pred":"#label","subj":"T7","obj":"D013226"},{"id":"A6","pred":"#label","subj":"T6","obj":"DISEASE"},{"id":"A5","pred":"#label","subj":"T5","obj":"D013226"},{"id":"A30723","pred":"#label","subj":"T25477","obj":"D012640"},{"id":"A99517","pred":"#label","subj":"T70735","obj":"D013226"},{"id":"A15959","pred":"#label","subj":"T71660","obj":"DISEASE"},{"id":"A52173","pred":"#label","subj":"T29434","obj":"D012640"}],"text":"Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.\nChildren who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was used to evaluate this question using an animal model of status epilepticus. Male Sprague-Dawley rats were injected with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilepticus; status epilepticus at P45 resulted in CA3 cell loss and spontaneous seizures, whereas P20 rats had no cell loss or spontaneous seizures. Mature rats were trained with sound-source location and sound-silence discriminations. Control (saline P20) rats acquired both discriminations immediately. In status epilepticus (P20) rats, acquisition of the sound-source location discrimination was moderately impaired. Status epilepticus (P45) rats failed to acquire either sound-source location or sound-silence discriminations. Status epilepticus in rat causes an age-dependent, long-term impairment in auditory discrimination. This impairment may explain one cause of impaired auditory location discrimination in humans."}