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sentences

Id Subject Object Predicate Lexical cue
T1 0-137 Sentence denotes Biochemical characterization of a family of serine/threonine protein kinases regulated by tyrosine and serine/threonine phosphorylations.
T2 138-314 Sentence denotes Mitogen-activated protein kinase (p42mapk) becomes transiently activated after treatment of serum-starved murine Swiss 3T3 cells or EL4 thymocytes with a diversity of mitogens.
T3 315-454 Sentence denotes Similarly, a meiosis-activated protein kinase (p44mpk) becomes stimulated during maturation of sea star oocytes induced by 1-methyladenine.
T4 455-597 Sentence denotes Both p42mapk and p44mpk have been identified as protein-serine/threonine kinases that are activated as a consequence of their phosphorylation.
T5 598-768 Sentence denotes Because homologous protein kinases may play essential roles in both mitogenesis and oogenesis, we have compared in detail the biochemical properties of these two kinases.
T6 769-926 Sentence denotes We find that these kinases are highly related based on their in vitro substrate specificities, sensitivity to inhibitors, and immunological cross-reactivity.
T7 927-1064 Sentence denotes However, they differ in apparent molecular weight and can be separated chromatographically, indicating that the two enzymes are distinct.
T8 1065-1313 Sentence denotes Furthermore, in the course of this investigation, we have identified a 44-kDa protein kinase in mitogen-stimulated Swiss mouse 3T3 cells and EL4 thymocytes that co-purifies with p44mpk and thus appears to be a closer homolog of the sea star enzyme.
T9 1314-1500 Sentence denotes Analysis of these protein kinases clarifies the relationships between a set of tyrosine-phosphorylated 41-45-kDa proteins present in mitogen-stimulated cells (Martinez, R., Nakamura., K.
T10 1501-1518 Sentence denotes D., and Weber, M.
T11 1519-1533 Sentence denotes J. (1982) Mol.
T12 1534-1539 Sentence denotes Cell.
T13 1540-1545 Sentence denotes Biol.
T14 1546-1568 Sentence denotes 2, 653-655; Cooper, J.
T15 1569-1599 Sentence denotes A., and Hunter, T. (1984) Mol.
T16 1600-1605 Sentence denotes Cell.
T17 1606-1611 Sentence denotes Biol.
T18 1612-1732 Sentence denotes 4, 30-37), two myelin basic protein kinases identified in epidermal growth factor-treated Swiss mouse 3T3 cells (Ahn, N.
T19 1733-1746 Sentence denotes G., Weiel, J.
T20 1747-1759 Sentence denotes E., Chan, C.
T21 1760-1777 Sentence denotes P., and Krebs, E.
T22 1778-1790 Sentence denotes G. (1990) J.
T23 1791-1796 Sentence denotes Biol.
T24 1797-1802 Sentence denotes Chem.
T25 1803-1834 Sentence denotes 265, 11487-11494), and p42mapk.
T26 1835-2016 Sentence denotes Our work points to the existence of a group of related serine/threonine protein kinases, regulated by tyrosine phosphorylation and functioning at different stages of the cell cycle.
T1 0-137 Sentence denotes Biochemical characterization of a family of serine/threonine protein kinases regulated by tyrosine and serine/threonine phosphorylations.
T2 138-314 Sentence denotes Mitogen-activated protein kinase (p42mapk) becomes transiently activated after treatment of serum-starved murine Swiss 3T3 cells or EL4 thymocytes with a diversity of mitogens.
T3 315-454 Sentence denotes Similarly, a meiosis-activated protein kinase (p44mpk) becomes stimulated during maturation of sea star oocytes induced by 1-methyladenine.
T4 455-597 Sentence denotes Both p42mapk and p44mpk have been identified as protein-serine/threonine kinases that are activated as a consequence of their phosphorylation.
T5 598-768 Sentence denotes Because homologous protein kinases may play essential roles in both mitogenesis and oogenesis, we have compared in detail the biochemical properties of these two kinases.
T6 769-926 Sentence denotes We find that these kinases are highly related based on their in vitro substrate specificities, sensitivity to inhibitors, and immunological cross-reactivity.
T7 927-1064 Sentence denotes However, they differ in apparent molecular weight and can be separated chromatographically, indicating that the two enzymes are distinct.
T8 1065-1313 Sentence denotes Furthermore, in the course of this investigation, we have identified a 44-kDa protein kinase in mitogen-stimulated Swiss mouse 3T3 cells and EL4 thymocytes that co-purifies with p44mpk and thus appears to be a closer homolog of the sea star enzyme.
T9 1314-1500 Sentence denotes Analysis of these protein kinases clarifies the relationships between a set of tyrosine-phosphorylated 41-45-kDa proteins present in mitogen-stimulated cells (Martinez, R., Nakamura., K.
T10 1501-1518 Sentence denotes D., and Weber, M.
T11 1519-1533 Sentence denotes J. (1982) Mol.
T12 1534-1539 Sentence denotes Cell.
T13 1540-1545 Sentence denotes Biol.
T14 1546-1568 Sentence denotes 2, 653-655; Cooper, J.
T15 1569-1599 Sentence denotes A., and Hunter, T. (1984) Mol.
T16 1600-1605 Sentence denotes Cell.
T17 1606-1611 Sentence denotes Biol.
T18 1612-1732 Sentence denotes 4, 30-37), two myelin basic protein kinases identified in epidermal growth factor-treated Swiss mouse 3T3 cells (Ahn, N.
T19 1733-1746 Sentence denotes G., Weiel, J.
T20 1747-1759 Sentence denotes E., Chan, C.
T21 1760-1777 Sentence denotes P., and Krebs, E.
T22 1778-1790 Sentence denotes G. (1990) J.
T23 1791-1796 Sentence denotes Biol.
T24 1797-1802 Sentence denotes Chem.
T25 1803-1834 Sentence denotes 265, 11487-11494), and p42mapk.
T26 1835-2016 Sentence denotes Our work points to the existence of a group of related serine/threonine protein kinases, regulated by tyrosine phosphorylation and functioning at different stages of the cell cycle.

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1757-1761 Phenotype denotes C. P HP:0100021

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 410-418 OrganismTaxon denotes sea star 7588
T2 1186-1191 OrganismTaxon denotes mouse 10088|10090
T4 1297-1305 OrganismTaxon denotes sea star 7588
T5 1708-1713 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 274-284 Body_part denotes thymocytes http://purl.obolibrary.org/obo/CL_0000893
T2 1210-1220 Body_part denotes thymocytes http://purl.obolibrary.org/obo/CL_0000893
T3 1627-1633 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T4 1670-1686 Body_part denotes epidermal growth http://purl.obolibrary.org/obo/UBERON_0000021
T5 2005-2015 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 274-284 Cell denotes thymocytes http://purl.obolibrary.org/obo/CL:0000893
T2 419-426 Cell denotes oocytes http://purl.obolibrary.org/obo/CL:0000023
T3 1210-1220 Cell denotes thymocytes http://purl.obolibrary.org/obo/CL:0000893