PubMed:16574813 / 465-875 JSONTXT

{"project":"PubmedHPO","denotations":[{"id":"T3","span":{"begin":143,"end":148},"obj":"HP_0002664"}],"text":"Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein."}

{"project":"uniprot-human","denotations":[{"id":"T2","span":{"begin":217,"end":221},"obj":"http://www.uniprot.org/uniprot/P60484"},{"id":"T7","span":{"begin":160,"end":190},"obj":"http://www.uniprot.org/uniprot/P60484"},{"id":"T29","span":{"begin":303,"end":305},"obj":"http://www.uniprot.org/uniprot/Q86U18"},{"id":"T34","span":{"begin":303,"end":305},"obj":"http://www.uniprot.org/uniprot/P01298"},{"id":"T38","span":{"begin":29,"end":33},"obj":"http://www.uniprot.org/uniprot/Q13301"},{"id":"T39","span":{"begin":348,"end":352},"obj":"http://www.uniprot.org/uniprot/Q13301"},{"id":"T40","span":{"begin":397,"end":401},"obj":"http://www.uniprot.org/uniprot/Q13301"}],"text":"Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein."}

{"project":"uniprot-mouse","denotations":[{"id":"T19","span":{"begin":160,"end":190},"obj":"http://www.uniprot.org/uniprot/O08586"}],"text":"Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein."}

{"project":"GlycoBiology-NCBITAXON","denotations":[{"id":"T4","span":{"begin":127,"end":137},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/127244"}],"text":"Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein."}

{"project":"GO-BP","denotations":[{"id":"T2","span":{"begin":143,"end":159},"obj":"http://purl.obolibrary.org/obo/GO_0051726"},{"id":"T14","span":{"begin":160,"end":171},"obj":"http://purl.obolibrary.org/obo/GO_0016791"},{"id":"T15","span":{"begin":243,"end":254},"obj":"http://purl.obolibrary.org/obo/GO_0016791"},{"id":"T16","span":{"begin":310,"end":323},"obj":"http://purl.obolibrary.org/obo/GO_0043491"},{"id":"T19","span":{"begin":314,"end":323},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein."}

{"project":"GO-CC","denotations":[{"id":"T8","span":{"begin":160,"end":190},"obj":"http://purl.obolibrary.org/obo/GO_1990455"},{"id":"T9","span":{"begin":202,"end":212},"obj":"http://purl.obolibrary.org/obo/GO_0005694"}],"text":"Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein."}

{"project":"EDAM-topics","denotations":[{"id":"T9","span":{"begin":9,"end":16},"obj":"http://edamontology.org/topic_3678"},{"id":"T10","span":{"begin":202,"end":212},"obj":"http://edamontology.org/topic_0624"},{"id":"T11","span":{"begin":202,"end":212},"obj":"http://edamontology.org/topic_0654"},{"id":"T12","span":{"begin":402,"end":409},"obj":"http://edamontology.org/topic_0078"}],"text":"Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein."}

{"project":"EDAM-DFO","denotations":[{"id":"T2","span":{"begin":402,"end":409},"obj":"http://edamontology.org/data_1467"},{"id":"T3","span":{"begin":402,"end":409},"obj":"http://edamontology.org/format_1208"}],"text":"Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"16574813-3#29#33#gene4193","span":{"begin":29,"end":33},"obj":"gene4193"},{"id":"16574813-3#66#79#diseaseC0596263","span":{"begin":66,"end":79},"obj":"diseaseC0596263"}],"relations":[{"id":"29#33#gene419366#79#diseaseC0596263","pred":"associated_with","subj":"16574813-3#29#33#gene4193","obj":"16574813-3#66#79#diseaseC0596263"}],"text":"Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T4","span":{"begin":0,"end":410},"obj":"Sentence"},{"id":"T4","span":{"begin":0,"end":410},"obj":"Sentence"},{"id":"T4","span":{"begin":0,"end":410},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":29,"end":33},"obj":"gene:4193"},{"id":"T1","span":{"begin":66,"end":79},"obj":"disease:C0596263"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein."}

{"project":"mondo_disease","denotations":[{"id":"T4","span":{"begin":143,"end":148},"obj":"Disease"}],"attributes":[{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"}],"text":"Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein."}

{"project":"GlyCosmos15-HP","denotations":[{"id":"T4","span":{"begin":143,"end":148},"obj":"Phenotype"}],"attributes":[{"id":"A4","pred":"hp_id","subj":"T4","obj":"HP:0002664"}],"text":"Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein."}

{"project":"GlyCosmos15-MONDO","denotations":[{"id":"T4","span":{"begin":143,"end":148},"obj":"Disease"}],"attributes":[{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"}],"text":"Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein."}

{"project":"GlyCosmos15-UBERON","denotations":[{"id":"T2","span":{"begin":202,"end":212},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/GO_0005694"}],"text":"Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T4","span":{"begin":0,"end":410},"obj":"Sentence"},{"id":"T4","span":{"begin":0,"end":410},"obj":"Sentence"},{"id":"T4","span":{"begin":0,"end":410},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein."}

{"project":"GlyCosmos15-Sentences","blocks":[{"id":"T4","span":{"begin":0,"end":410},"obj":"Sentence"}],"text":"Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T2","span":{"begin":202,"end":212},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/GO_0005694"}],"text":"Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein."}

{"project":"HP-phenotype","denotations":[{"id":"T4","span":{"begin":143,"end":148},"obj":"Phenotype"}],"attributes":[{"id":"A4","pred":"hp_id","subj":"T4","obj":"HP:0002664"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}],"text":"Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein."}