PubMed:16574813
Annnotations
Glycan-Motif
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 12-15 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T2 | 12-15 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T3 | 193-196 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T4 | 193-196 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T5 | 329-332 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T6 | 329-332 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T7 | 917-920 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T8 | 917-920 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T9 | 1220-1223 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T10 | 1220-1223 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T11 | 1465-1468 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T12 | 1465-1468 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T13 | 1653-1656 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T14 | 1653-1656 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T15 | 1976-1979 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T16 | 1976-1979 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T17 | 2020-2023 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T18 | 2020-2023 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T19 | 2151-2154 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T20 | 2151-2154 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 12-15 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T3 | 193-196 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T5 | 329-332 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T7 | 917-920 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T9 | 1220-1223 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T11 | 1465-1468 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T13 | 1653-1656 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T15 | 1976-1979 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T17 | 2020-2023 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T19 | 2151-2154 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 12-15 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T2 | 12-15 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T3 | 193-196 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T4 | 193-196 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T5 | 329-332 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T6 | 329-332 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T7 | 917-920 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T8 | 917-920 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T9 | 1220-1223 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T10 | 1220-1223 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T11 | 1465-1468 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T12 | 1465-1468 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T13 | 1653-1656 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T14 | 1653-1656 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T15 | 1976-1979 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T16 | 1976-1979 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T17 | 2020-2023 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T18 | 2020-2023 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T19 | 2151-2154 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T20 | 2151-2154 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1144-1149 | http://purl.obolibrary.org/obo/MAT_0000526 | denotes | colon |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 279-285 | HP_0002664 | denotes | cancer |
| T2 | 361-367 | HP_0002664 | denotes | cancer |
| T3 | 608-613 | HP_0002664 | denotes | tumor |
| T4 | 1144-1156 | HP_0003003 | denotes | colon cancer |
| T5 | 1144-1156 | HP_0100273 | denotes | colon cancer |
| T6 | 1150-1156 | HP_0002664 | denotes | cancer |
| T7 | 2181-2187 | HP_0002664 | denotes | cancer |
| T8 | 2252-2258 | HP_0002664 | denotes | cancer |
uniprot-human
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 43-47 | http://www.uniprot.org/uniprot/P60484 | denotes | PTEN |
| T2 | 682-686 | http://www.uniprot.org/uniprot/P60484 | denotes | PTEN |
| T3 | 1068-1072 | http://www.uniprot.org/uniprot/P60484 | denotes | PTEN |
| T4 | 1518-1522 | http://www.uniprot.org/uniprot/P60484 | denotes | PTEN |
| T5 | 1766-1770 | http://www.uniprot.org/uniprot/P60484 | denotes | PTEN |
| T6 | 1923-1927 | http://www.uniprot.org/uniprot/P60484 | denotes | PTEN |
| T7 | 625-655 | http://www.uniprot.org/uniprot/P60484 | denotes | phosphatase and tensin homolog |
| T8 | 110-113 | http://www.uniprot.org/uniprot/P38936 | denotes | p21 |
| T9 | 1000-1003 | http://www.uniprot.org/uniprot/P38936 | denotes | p21 |
| T10 | 1274-1277 | http://www.uniprot.org/uniprot/P38936 | denotes | p21 |
| T11 | 1305-1308 | http://www.uniprot.org/uniprot/P38936 | denotes | p21 |
| T12 | 1372-1375 | http://www.uniprot.org/uniprot/P38936 | denotes | p21 |
| T13 | 114-118 | http://www.uniprot.org/uniprot/P38936 | denotes | WAF1 |
| T14 | 1004-1008 | http://www.uniprot.org/uniprot/P38936 | denotes | WAF1 |
| T15 | 1278-1282 | http://www.uniprot.org/uniprot/P38936 | denotes | WAF1 |
| T16 | 1309-1313 | http://www.uniprot.org/uniprot/P38936 | denotes | WAF1 |
| T17 | 1376-1380 | http://www.uniprot.org/uniprot/P38936 | denotes | WAF1 |
| T18 | 1852-1856 | http://www.uniprot.org/uniprot/P38936 | denotes | WAF1 |
| T19 | 124-127 | http://www.uniprot.org/uniprot/Q13177 | denotes | p27 |
| T20 | 1496-1499 | http://www.uniprot.org/uniprot/Q13177 | denotes | p27 |
| T21 | 1878-1881 | http://www.uniprot.org/uniprot/Q13177 | denotes | p27 |
| T22 | 124-127 | http://www.uniprot.org/uniprot/Q9Y3B3 | denotes | p27 |
| T23 | 1496-1499 | http://www.uniprot.org/uniprot/Q9Y3B3 | denotes | p27 |
| T24 | 1878-1881 | http://www.uniprot.org/uniprot/Q9Y3B3 | denotes | p27 |
| T25 | 124-127 | http://www.uniprot.org/uniprot/P40305 | denotes | p27 |
| T26 | 1496-1499 | http://www.uniprot.org/uniprot/P40305 | denotes | p27 |
| T27 | 1878-1881 | http://www.uniprot.org/uniprot/P40305 | denotes | p27 |
| T28 | 151-153 | http://www.uniprot.org/uniprot/Q86U18 | denotes | PI |
| T29 | 768-770 | http://www.uniprot.org/uniprot/Q86U18 | denotes | PI |
| T30 | 1100-1102 | http://www.uniprot.org/uniprot/Q86U18 | denotes | PI |
| T31 | 1550-1552 | http://www.uniprot.org/uniprot/Q86U18 | denotes | PI |
| T32 | 1931-1933 | http://www.uniprot.org/uniprot/Q86U18 | denotes | PI |
| T33 | 151-153 | http://www.uniprot.org/uniprot/P01298 | denotes | PI |
| T34 | 768-770 | http://www.uniprot.org/uniprot/P01298 | denotes | PI |
| T35 | 1100-1102 | http://www.uniprot.org/uniprot/P01298 | denotes | PI |
| T36 | 1550-1552 | http://www.uniprot.org/uniprot/P01298 | denotes | PI |
| T37 | 1931-1933 | http://www.uniprot.org/uniprot/P01298 | denotes | PI |
| T38 | 494-498 | http://www.uniprot.org/uniprot/Q13301 | denotes | MDM2 |
| T39 | 813-817 | http://www.uniprot.org/uniprot/Q13301 | denotes | MDM2 |
| T40 | 862-866 | http://www.uniprot.org/uniprot/Q13301 | denotes | MDM2 |
| T41 | 1110-1114 | http://www.uniprot.org/uniprot/Q13301 | denotes | MDM2 |
| T42 | 954-960 | http://www.uniprot.org/uniprot/P12004 | denotes | cyclin |
| T43 | 1611-1617 | http://www.uniprot.org/uniprot/P12004 | denotes | cyclin |
| T44 | 1706-1712 | http://www.uniprot.org/uniprot/P12004 | denotes | cyclin |
| T45 | 995-998 | http://www.uniprot.org/uniprot/P35790 | denotes | CKI |
| T46 | 1492-1495 | http://www.uniprot.org/uniprot/P35790 | denotes | CKI |
| T47 | 1624-1628 | http://www.uniprot.org/uniprot/P24941 | denotes | CDK2 |
| T48 | 1720-1724 | http://www.uniprot.org/uniprot/P11802 | denotes | CDK4 |
| T49 | 2061-2091 | http://www.uniprot.org/uniprot/P18754 | denotes | cell cycle regulatory proteins |
| T50 | 2061-2082 | http://www.uniprot.org/uniprot/O60934 | denotes | cell cycle regulatory |
uniprot-mouse
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 110-113 | http://www.uniprot.org/uniprot/P63028 | denotes | p21 |
| T2 | 1000-1003 | http://www.uniprot.org/uniprot/P63028 | denotes | p21 |
| T3 | 1274-1277 | http://www.uniprot.org/uniprot/P63028 | denotes | p21 |
| T4 | 1305-1308 | http://www.uniprot.org/uniprot/P63028 | denotes | p21 |
| T5 | 1372-1375 | http://www.uniprot.org/uniprot/P63028 | denotes | p21 |
| T6 | 1848-1851 | http://www.uniprot.org/uniprot/P63028 | denotes | p21 |
| T7 | 110-113 | http://www.uniprot.org/uniprot/Q62092 | denotes | p21 |
| T8 | 1000-1003 | http://www.uniprot.org/uniprot/Q62092 | denotes | p21 |
| T9 | 1274-1277 | http://www.uniprot.org/uniprot/Q62092 | denotes | p21 |
| T10 | 1305-1308 | http://www.uniprot.org/uniprot/Q62092 | denotes | p21 |
| T11 | 1372-1375 | http://www.uniprot.org/uniprot/Q62092 | denotes | p21 |
| T12 | 1848-1851 | http://www.uniprot.org/uniprot/Q62092 | denotes | p21 |
| T13 | 110-113 | http://www.uniprot.org/uniprot/P39689 | denotes | p21 |
| T14 | 1000-1003 | http://www.uniprot.org/uniprot/P39689 | denotes | p21 |
| T15 | 1274-1277 | http://www.uniprot.org/uniprot/P39689 | denotes | p21 |
| T16 | 1305-1308 | http://www.uniprot.org/uniprot/P39689 | denotes | p21 |
| T17 | 1372-1375 | http://www.uniprot.org/uniprot/P39689 | denotes | p21 |
| T18 | 1848-1851 | http://www.uniprot.org/uniprot/P39689 | denotes | p21 |
| T19 | 625-655 | http://www.uniprot.org/uniprot/O08586 | denotes | phosphatase and tensin homolog |
| T20 | 954-960 | http://www.uniprot.org/uniprot/P17918 | denotes | cyclin |
| T21 | 1611-1617 | http://www.uniprot.org/uniprot/P17918 | denotes | cyclin |
| T22 | 1706-1712 | http://www.uniprot.org/uniprot/P17918 | denotes | cyclin |
GlycoBiology-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 279-285 | http://purl.bioontology.org/ontology/NCBITAXON/6754 | denotes | cancer |
| T2 | 361-367 | http://purl.bioontology.org/ontology/NCBITAXON/6754 | denotes | cancer |
| T3 | 398-407 | http://purl.bioontology.org/ontology/NCBITAXON/127244 | denotes | mechanism |
| T4 | 592-602 | http://purl.bioontology.org/ontology/NCBITAXON/127244 | denotes | mechanisms |
| T5 | 1150-1156 | http://purl.bioontology.org/ontology/NCBITAXON/6754 | denotes | cancer |
| T6 | 1157-1162 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T7 | 1672-1677 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T8 | 2181-2187 | http://purl.bioontology.org/ontology/NCBITAXON/6754 | denotes | cancer |
| T9 | 2252-2258 | http://purl.bioontology.org/ontology/NCBITAXON/6754 | denotes | cancer |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 26-42 | http://purl.obolibrary.org/obo/GO_0051726 | denotes | tumor suppressor |
| T2 | 608-624 | http://purl.obolibrary.org/obo/GO_0051726 | denotes | tumor suppressor |
| T3 | 57-67 | http://purl.obolibrary.org/obo/GO_0007049 | denotes | cell cycle |
| T4 | 2061-2071 | http://purl.obolibrary.org/obo/GO_0007049 | denotes | cell cycle |
| T5 | 57-79 | http://purl.obolibrary.org/obo/GO_0051726 | denotes | cell cycle progression |
| T6 | 2051-2071 | http://purl.obolibrary.org/obo/GO_0051726 | denotes | modulates cell cycle |
| T7 | 57-79 | http://purl.obolibrary.org/obo/GO_0007050 | denotes | cell cycle progression |
| T8 | 81-96 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcriptional |
| T9 | 1246-1261 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcriptional |
| T10 | 307-316 | http://purl.obolibrary.org/obo/GO_0042638 | denotes | exogenous |
| T11 | 368-386 | http://purl.obolibrary.org/obo/GO_0008283 | denotes | cell proliferation |
| T12 | 429-447 | http://purl.obolibrary.org/obo/GO_0008283 | denotes | cell proliferation |
| T13 | 2188-2206 | http://purl.obolibrary.org/obo/GO_0008283 | denotes | cell proliferation |
| T14 | 625-636 | http://purl.obolibrary.org/obo/GO_0016791 | denotes | phosphatase |
| T15 | 708-719 | http://purl.obolibrary.org/obo/GO_0016791 | denotes | phosphatase |
| T16 | 775-788 | http://purl.obolibrary.org/obo/GO_0043491 | denotes | AKT signaling |
| T17 | 1556-1569 | http://purl.obolibrary.org/obo/GO_0043491 | denotes | AKT signaling |
| T18 | 1937-1950 | http://purl.obolibrary.org/obo/GO_0043491 | denotes | AKT signaling |
| T19 | 779-788 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T20 | 1124-1133 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T21 | 1560-1569 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T22 | 1941-1950 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T23 | 954-960 | http://purl.obolibrary.org/obo/GO_0016538 | denotes | cyclin |
| T24 | 1611-1617 | http://purl.obolibrary.org/obo/GO_0016538 | denotes | cyclin |
| T25 | 1706-1712 | http://purl.obolibrary.org/obo/GO_0016538 | denotes | cyclin |
| T26 | 979-982 | http://purl.obolibrary.org/obo/GO_0004693 | denotes | CDK |
| T27 | 979-993 | http://purl.obolibrary.org/obo/GO_0004861 | denotes | CDK) inhibitor |
| T28 | 979-993 | http://purl.obolibrary.org/obo/GO_0045736 | denotes | CDK) inhibitor |
| T29 | 1236-1270 | http://purl.obolibrary.org/obo/GO_0045893 | denotes | dependent transcriptional activity |
| T30 | 1236-1270 | http://purl.obolibrary.org/obo/GO_1900622 | denotes | dependent transcriptional activity |
| T31 | 1593-1603 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
| T32 | 1692-1702 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
| T33 | 1781-1797 | http://purl.obolibrary.org/obo/GO_0016246 | denotes | RNA interference |
| T34 | 2051-2071 | http://purl.obolibrary.org/obo/GO_0051445 | denotes | modulates cell cycle |
| T35 | 2051-2071 | http://purl.obolibrary.org/obo/GO_0007346 | denotes | modulates cell cycle |
| T36 | 2098-2120 | http://purl.obolibrary.org/obo/GO_0051514 | denotes | inhibiting cell growth |
| T37 | 2098-2120 | http://purl.obolibrary.org/obo/GO_0030308 | denotes | inhibiting cell growth |
| T38 | 2098-2120 | http://purl.obolibrary.org/obo/GO_0051511 | denotes | inhibiting cell growth |
| T39 | 2098-2120 | http://purl.obolibrary.org/obo/GO_0051517 | denotes | inhibiting cell growth |
| T40 | 2109-2120 | http://purl.obolibrary.org/obo/GO_0016049 | denotes | cell growth |
| T41 | 2114-2120 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
GO-MF
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1419-1430 | http://purl.obolibrary.org/obo/GO_0002039 | denotes | p53-binding |
| T2 | 1423-1430 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
| T3 | 1423-1430 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
| T4 | 1423-1430 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
| T5 | 1423-1430 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 57-61 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T2 | 368-372 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T3 | 429-433 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T4 | 2061-2065 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T5 | 2109-2113 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T6 | 1157-1162 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T7 | 1672-1677 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T8 | 625-655 | http://purl.obolibrary.org/obo/GO_1990455 | denotes | phosphatase and tensin homolog |
| T9 | 667-677 | http://purl.obolibrary.org/obo/GO_0005694 | denotes | chromosome |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1144-1149 | http://purl.obolibrary.org/obo/UBERON_0001155 | denotes | colon |
EDAM-topics
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 57-67 | http://edamontology.org/topic_0612 | denotes | cell cycle |
| T2 | 81-96 | http://edamontology.org/topic_0110 | denotes | transcriptional |
| T3 | 81-96 | http://edamontology.org/topic_3512 | denotes | transcriptional |
| T4 | 81-96 | http://edamontology.org/topic_0203 | denotes | transcriptional |
| T5 | 81-96 | http://edamontology.org/topic_3308 | denotes | transcriptional |
| T6 | 161-168 | http://edamontology.org/topic_0602 | denotes | pathway |
| T7 | 279-285 | http://edamontology.org/topic_2640 | denotes | cancer |
| T8 | 361-367 | http://edamontology.org/topic_2640 | denotes | cancer |
| T9 | 474-481 | http://edamontology.org/topic_3678 | denotes | studies |
| T10 | 667-677 | http://edamontology.org/topic_0624 | denotes | chromosome |
| T11 | 667-677 | http://edamontology.org/topic_0654 | denotes | chromosome |
| T12 | 867-874 | http://edamontology.org/topic_0078 | denotes | protein |
| T13 | 901-906 | http://edamontology.org/topic_3678 | denotes | study |
| T14 | 1053-1060 | http://edamontology.org/topic_0078 | denotes | protein |
| T15 | 1150-1156 | http://edamontology.org/topic_2640 | denotes | cancer |
| T16 | 1246-1261 | http://edamontology.org/topic_3308 | denotes | transcriptional |
| T17 | 1246-1261 | http://edamontology.org/topic_0203 | denotes | transcriptional |
| T18 | 1246-1261 | http://edamontology.org/topic_0110 | denotes | transcriptional |
| T19 | 1246-1261 | http://edamontology.org/topic_3512 | denotes | transcriptional |
| T20 | 1315-1323 | http://edamontology.org/topic_0749 | denotes | promoter |
| T21 | 1315-1323 | http://edamontology.org/topic_1312 | denotes | promoter |
| T22 | 1315-1323 | http://edamontology.org/topic_0111 | denotes | promoter |
| T23 | 1382-1390 | http://edamontology.org/topic_0111 | denotes | promoter |
| T24 | 1382-1390 | http://edamontology.org/topic_0749 | denotes | promoter |
| T25 | 1382-1390 | http://edamontology.org/topic_1312 | denotes | promoter |
| T26 | 2061-2071 | http://edamontology.org/topic_0612 | denotes | cell cycle |
| T27 | 2083-2091 | http://edamontology.org/topic_0078 | denotes | proteins |
| T28 | 2181-2187 | http://edamontology.org/topic_2640 | denotes | cancer |
| T29 | 2252-2258 | http://edamontology.org/topic_2640 | denotes | cancer |
EDAM-DFO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 161-168 | http://edamontology.org/data_2600 | denotes | pathway |
| T2 | 867-874 | http://edamontology.org/data_1467 | denotes | protein |
| T3 | 867-874 | http://edamontology.org/format_1208 | denotes | protein |
| T4 | 1053-1060 | http://edamontology.org/format_1208 | denotes | protein |
| T5 | 1053-1060 | http://edamontology.org/data_1467 | denotes | protein |
| T6 | 1178-1182 | http://edamontology.org/data_0006 | denotes | data |
| T7 | 1288-1297 | http://edamontology.org/data_2042 | denotes | evidenced |
| T8 | 1342-1350 | http://edamontology.org/data_2048 | denotes | reporter |
| T9 | 1397-1406 | http://edamontology.org/operation_3429 | denotes | construct |
| T10 | 2083-2091 | http://edamontology.org/data_1467 | denotes | proteins |
| T11 | 2083-2091 | http://edamontology.org/format_1208 | denotes | proteins |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 16574813-3#29#33#gene4193 | 494-498 | gene4193 | denotes | MDM2 |
| 16574813-3#66#79#diseaseC0596263 | 531-544 | diseaseC0596263 | denotes | tumorigenesis |
| 16574813-4#78#84#gene5111 | 954-960 | gene5111 | denotes | cyclin |
| 16574813-4#128#132#gene1026 | 1004-1008 | gene1026 | denotes | WAF1 |
| 16574813-4#234#238#gene4193 | 1110-1114 | gene4193 | denotes | MDM2 |
| 16574813-4#268#280#diseaseC0007102 | 1144-1156 | diseaseC0007102 | denotes | colon cancer |
| 16574813-4#268#280#diseaseC0699790 | 1144-1156 | diseaseC0699790 | denotes | colon cancer |
| 16574813-4#268#280#diseaseC0007102 | 1144-1156 | diseaseC0007102 | denotes | colon cancer |
| 16574813-4#268#280#diseaseC0699790 | 1144-1156 | diseaseC0699790 | denotes | colon cancer |
| 16574813-4#268#280#diseaseC0007102 | 1144-1156 | diseaseC0007102 | denotes | colon cancer |
| 16574813-4#268#280#diseaseC0699790 | 1144-1156 | diseaseC0699790 | denotes | colon cancer |
| 29#33#gene419366#79#diseaseC0596263 | 16574813-3#29#33#gene4193 | 16574813-3#66#79#diseaseC0596263 | associated_with | MDM2,tumorigenesis |
| 78#84#gene5111268#280#diseaseC0007102 | 16574813-4#78#84#gene5111 | 16574813-4#268#280#diseaseC0007102 | associated_with | cyclin,colon cancer |
| 78#84#gene5111268#280#diseaseC0699790 | 16574813-4#78#84#gene5111 | 16574813-4#268#280#diseaseC0699790 | associated_with | cyclin,colon cancer |
| 78#84#gene5111268#280#diseaseC0007102 | 16574813-4#78#84#gene5111 | 16574813-4#268#280#diseaseC0007102 | associated_with | cyclin,colon cancer |
| 78#84#gene5111268#280#diseaseC0699790 | 16574813-4#78#84#gene5111 | 16574813-4#268#280#diseaseC0699790 | associated_with | cyclin,colon cancer |
| 78#84#gene5111268#280#diseaseC0007102 | 16574813-4#78#84#gene5111 | 16574813-4#268#280#diseaseC0007102 | associated_with | cyclin,colon cancer |
| 78#84#gene5111268#280#diseaseC0699790 | 16574813-4#78#84#gene5111 | 16574813-4#268#280#diseaseC0699790 | associated_with | cyclin,colon cancer |
| 128#132#gene1026268#280#diseaseC0007102 | 16574813-4#128#132#gene1026 | 16574813-4#268#280#diseaseC0007102 | associated_with | WAF1,colon cancer |
| 128#132#gene1026268#280#diseaseC0699790 | 16574813-4#128#132#gene1026 | 16574813-4#268#280#diseaseC0699790 | associated_with | WAF1,colon cancer |
| 128#132#gene1026268#280#diseaseC0007102 | 16574813-4#128#132#gene1026 | 16574813-4#268#280#diseaseC0007102 | associated_with | WAF1,colon cancer |
| 128#132#gene1026268#280#diseaseC0699790 | 16574813-4#128#132#gene1026 | 16574813-4#268#280#diseaseC0699790 | associated_with | WAF1,colon cancer |
| 128#132#gene1026268#280#diseaseC0007102 | 16574813-4#128#132#gene1026 | 16574813-4#268#280#diseaseC0007102 | associated_with | WAF1,colon cancer |
| 128#132#gene1026268#280#diseaseC0699790 | 16574813-4#128#132#gene1026 | 16574813-4#268#280#diseaseC0699790 | associated_with | WAF1,colon cancer |
| 234#238#gene4193268#280#diseaseC0007102 | 16574813-4#234#238#gene4193 | 16574813-4#268#280#diseaseC0007102 | associated_with | MDM2,colon cancer |
| 234#238#gene4193268#280#diseaseC0699790 | 16574813-4#234#238#gene4193 | 16574813-4#268#280#diseaseC0699790 | associated_with | MDM2,colon cancer |
| 234#238#gene4193268#280#diseaseC0007102 | 16574813-4#234#238#gene4193 | 16574813-4#268#280#diseaseC0007102 | associated_with | MDM2,colon cancer |
| 234#238#gene4193268#280#diseaseC0699790 | 16574813-4#234#238#gene4193 | 16574813-4#268#280#diseaseC0699790 | associated_with | MDM2,colon cancer |
| 234#238#gene4193268#280#diseaseC0007102 | 16574813-4#234#238#gene4193 | 16574813-4#268#280#diseaseC0007102 | associated_with | MDM2,colon cancer |
| 234#238#gene4193268#280#diseaseC0699790 | 16574813-4#234#238#gene4193 | 16574813-4#268#280#diseaseC0699790 | associated_with | MDM2,colon cancer |
GlycoBiology-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1144-1149 | http://purl.obolibrary.org/obo/MAT_0000526 | denotes | colon |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-169 | Sentence | denotes | Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway. |
| TextSentencer_T2 | 170-293 | Sentence | denotes | The simple ganglioside GM3 has been shown to have anti-proliferative effects in several in vitro and in vivo cancer models. |
| TextSentencer_T3 | 294-464 | Sentence | denotes | Although the exogenous ganglioside GM3 has an inhibitory effect on cancer cell proliferation, the exact mechanism by which it prevents cell proliferation remains unclear. |
| TextSentencer_T4 | 465-875 | Sentence | denotes | Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein. |
| TextSentencer_T5 | 876-1163 | Sentence | denotes | Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells. |
| TextSentencer_T6 | 1164-1438 | Sentence | denotes | Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites). |
| TextSentencer_T7 | 1439-1570 | Sentence | denotes | Additionally, ganglioside GM3 enhances expression of CKI p27(kip1) through the PTEN-mediated inhibition of the PI-3K/AKT signaling. |
| TextSentencer_T8 | 1571-1733 | Sentence | denotes | Furthermore, the down-regulation of the cyclin E and CDK2 was clearly observed in GM3-treated HCT116 cells, but the down-regulation of cyclin D1 and CDK4 was not. |
| TextSentencer_T9 | 1734-1980 | Sentence | denotes | On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3. |
| TextSentencer_T10 | 1981-2121 | Sentence | denotes | These results suggest that ganglioside GM3-stimulated PTEN expression modulates cell cycle regulatory proteins, thus inhibiting cell growth. |
| TextSentencer_T11 | 2122-2267 | Sentence | denotes | We conclude that ganglioside GM3 represents a modulator of cancer cell proliferation and may have potential for use in colorectal cancer therapy. |
| T1 | 0-169 | Sentence | denotes | Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway. |
| T2 | 170-293 | Sentence | denotes | The simple ganglioside GM3 has been shown to have anti-proliferative effects in several in vitro and in vivo cancer models. |
| T3 | 294-464 | Sentence | denotes | Although the exogenous ganglioside GM3 has an inhibitory effect on cancer cell proliferation, the exact mechanism by which it prevents cell proliferation remains unclear. |
| T4 | 465-875 | Sentence | denotes | Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein. |
| T5 | 876-1163 | Sentence | denotes | Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells. |
| T6 | 1164-1438 | Sentence | denotes | Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites). |
| T7 | 1439-1570 | Sentence | denotes | Additionally, ganglioside GM3 enhances expression of CKI p27(kip1) through the PTEN-mediated inhibition of the PI-3K/AKT signaling. |
| T8 | 1571-1733 | Sentence | denotes | Furthermore, the down-regulation of the cyclin E and CDK2 was clearly observed in GM3-treated HCT116 cells, but the down-regulation of cyclin D1 and CDK4 was not. |
| T9 | 1734-1980 | Sentence | denotes | On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3. |
| T10 | 1981-2121 | Sentence | denotes | These results suggest that ganglioside GM3-stimulated PTEN expression modulates cell cycle regulatory proteins, thus inhibiting cell growth. |
| T11 | 2122-2267 | Sentence | denotes | We conclude that ganglioside GM3 represents a modulator of cancer cell proliferation and may have potential for use in colorectal cancer therapy. |
| T1 | 0-169 | Sentence | denotes | Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway. |
| T2 | 170-293 | Sentence | denotes | The simple ganglioside GM3 has been shown to have anti-proliferative effects in several in vitro and in vivo cancer models. |
| T3 | 294-464 | Sentence | denotes | Although the exogenous ganglioside GM3 has an inhibitory effect on cancer cell proliferation, the exact mechanism by which it prevents cell proliferation remains unclear. |
| T4 | 465-875 | Sentence | denotes | Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein. |
| T5 | 876-1163 | Sentence | denotes | Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells. |
| T6 | 1164-1438 | Sentence | denotes | Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites). |
| T7 | 1439-1570 | Sentence | denotes | Additionally, ganglioside GM3 enhances expression of CKI p27(kip1) through the PTEN-mediated inhibition of the PI-3K/AKT signaling. |
| T8 | 1571-1733 | Sentence | denotes | Furthermore, the down-regulation of the cyclin E and CDK2 was clearly observed in GM3-treated HCT116 cells, but the down-regulation of cyclin D1 and CDK4 was not. |
| T9 | 1734-1980 | Sentence | denotes | On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3. |
| T10 | 1981-2121 | Sentence | denotes | These results suggest that ganglioside GM3-stimulated PTEN expression modulates cell cycle regulatory proteins, thus inhibiting cell growth. |
| T11 | 2122-2267 | Sentence | denotes | We conclude that ganglioside GM3 represents a modulator of cancer cell proliferation and may have potential for use in colorectal cancer therapy. |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 1144-1149 | http://purl.obolibrary.org/obo/UBERON_0001155 | denotes | colon |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 494-498 | gene:4193 | denotes | MDM2 |
| T1 | 531-544 | disease:C0596263 | denotes | tumorigenesis |
| R1 | T0 | T1 | associated_with | MDM2,tumorigenesis |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1144-1149 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/MAT_0000526 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 26-31 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T2 | 279-285 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T3 | 361-367 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T4 | 608-613 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T5 | 1144-1156 | Disease | denotes | colon cancer | http://purl.obolibrary.org/obo/MONDO_0021063 |
| T6 | 2181-2187 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T7 | 2241-2258 | Disease | denotes | colorectal cancer | http://purl.obolibrary.org/obo/MONDO_0005575 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 12-15 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T2 | 193-196 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T3 | 329-332 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T4 | 917-920 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T5 | 1220-1223 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T6 | 1465-1468 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T7 | 1653-1656 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T8 | 1976-1979 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T9 | 2020-2023 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T10 | 2151-2154 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 26-31 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 279-285 | Phenotype | denotes | cancer | HP:0002664 |
| T3 | 361-367 | Phenotype | denotes | cancer | HP:0002664 |
| T4 | 608-613 | Phenotype | denotes | tumor | HP:0002664 |
| T5 | 1144-1156 | Phenotype | denotes | colon cancer | HP:0003003 |
| T6 | 2181-2187 | Phenotype | denotes | cancer | HP:0002664 |
| T7 | 2241-2258 | Phenotype | denotes | colorectal cancer | HP:0003003 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 361-372 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |
| T2 | 1150-1162 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T3 | 2181-2192 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 57-67 | Body_part | denotes | cell cycle | http://purl.obolibrary.org/obo/UBERON_2000098 |
| T2 | 667-677 | Body_part | denotes | chromosome | http://purl.obolibrary.org/obo/GO_0005694 |
| T3 | 1144-1149 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/UBERON_0001155 |
| T4 | 2061-2071 | Body_part | denotes | cell cycle | http://purl.obolibrary.org/obo/UBERON_2000098 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-169 | Sentence | denotes | Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway. |
| TextSentencer_T2 | 170-293 | Sentence | denotes | The simple ganglioside GM3 has been shown to have anti-proliferative effects in several in vitro and in vivo cancer models. |
| TextSentencer_T3 | 294-464 | Sentence | denotes | Although the exogenous ganglioside GM3 has an inhibitory effect on cancer cell proliferation, the exact mechanism by which it prevents cell proliferation remains unclear. |
| TextSentencer_T4 | 465-875 | Sentence | denotes | Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein. |
| TextSentencer_T5 | 876-1163 | Sentence | denotes | Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells. |
| TextSentencer_T6 | 1164-1438 | Sentence | denotes | Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites). |
| TextSentencer_T7 | 1439-1570 | Sentence | denotes | Additionally, ganglioside GM3 enhances expression of CKI p27(kip1) through the PTEN-mediated inhibition of the PI-3K/AKT signaling. |
| TextSentencer_T8 | 1571-1733 | Sentence | denotes | Furthermore, the down-regulation of the cyclin E and CDK2 was clearly observed in GM3-treated HCT116 cells, but the down-regulation of cyclin D1 and CDK4 was not. |
| TextSentencer_T9 | 1734-1980 | Sentence | denotes | On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3. |
| TextSentencer_T10 | 1981-2121 | Sentence | denotes | These results suggest that ganglioside GM3-stimulated PTEN expression modulates cell cycle regulatory proteins, thus inhibiting cell growth. |
| TextSentencer_T11 | 2122-2267 | Sentence | denotes | We conclude that ganglioside GM3 represents a modulator of cancer cell proliferation and may have potential for use in colorectal cancer therapy. |
| T1 | 0-169 | Sentence | denotes | Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway. |
| T2 | 170-293 | Sentence | denotes | The simple ganglioside GM3 has been shown to have anti-proliferative effects in several in vitro and in vivo cancer models. |
| T3 | 294-464 | Sentence | denotes | Although the exogenous ganglioside GM3 has an inhibitory effect on cancer cell proliferation, the exact mechanism by which it prevents cell proliferation remains unclear. |
| T4 | 465-875 | Sentence | denotes | Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein. |
| T5 | 876-1163 | Sentence | denotes | Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells. |
| T6 | 1164-1438 | Sentence | denotes | Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites). |
| T7 | 1439-1570 | Sentence | denotes | Additionally, ganglioside GM3 enhances expression of CKI p27(kip1) through the PTEN-mediated inhibition of the PI-3K/AKT signaling. |
| T8 | 1571-1733 | Sentence | denotes | Furthermore, the down-regulation of the cyclin E and CDK2 was clearly observed in GM3-treated HCT116 cells, but the down-regulation of cyclin D1 and CDK4 was not. |
| T9 | 1734-1980 | Sentence | denotes | On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3. |
| T10 | 1981-2121 | Sentence | denotes | These results suggest that ganglioside GM3-stimulated PTEN expression modulates cell cycle regulatory proteins, thus inhibiting cell growth. |
| T11 | 2122-2267 | Sentence | denotes | We conclude that ganglioside GM3 represents a modulator of cancer cell proliferation and may have potential for use in colorectal cancer therapy. |
| T1 | 0-169 | Sentence | denotes | Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway. |
| T2 | 170-293 | Sentence | denotes | The simple ganglioside GM3 has been shown to have anti-proliferative effects in several in vitro and in vivo cancer models. |
| T3 | 294-464 | Sentence | denotes | Although the exogenous ganglioside GM3 has an inhibitory effect on cancer cell proliferation, the exact mechanism by which it prevents cell proliferation remains unclear. |
| T4 | 465-875 | Sentence | denotes | Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein. |
| T5 | 876-1163 | Sentence | denotes | Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells. |
| T6 | 1164-1438 | Sentence | denotes | Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites). |
| T7 | 1439-1570 | Sentence | denotes | Additionally, ganglioside GM3 enhances expression of CKI p27(kip1) through the PTEN-mediated inhibition of the PI-3K/AKT signaling. |
| T8 | 1571-1733 | Sentence | denotes | Furthermore, the down-regulation of the cyclin E and CDK2 was clearly observed in GM3-treated HCT116 cells, but the down-regulation of cyclin D1 and CDK4 was not. |
| T9 | 1734-1980 | Sentence | denotes | On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3. |
| T10 | 1981-2121 | Sentence | denotes | These results suggest that ganglioside GM3-stimulated PTEN expression modulates cell cycle regulatory proteins, thus inhibiting cell growth. |
| T11 | 2122-2267 | Sentence | denotes | We conclude that ganglioside GM3 represents a modulator of cancer cell proliferation and may have potential for use in colorectal cancer therapy. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-169 | Sentence | denotes | Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway. |
| T2 | 170-293 | Sentence | denotes | The simple ganglioside GM3 has been shown to have anti-proliferative effects in several in vitro and in vivo cancer models. |
| T3 | 294-464 | Sentence | denotes | Although the exogenous ganglioside GM3 has an inhibitory effect on cancer cell proliferation, the exact mechanism by which it prevents cell proliferation remains unclear. |
| T4 | 465-875 | Sentence | denotes | Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein. |
| T5 | 876-1163 | Sentence | denotes | Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells. |
| T6 | 1164-1438 | Sentence | denotes | Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites). |
| T7 | 1439-1570 | Sentence | denotes | Additionally, ganglioside GM3 enhances expression of CKI p27(kip1) through the PTEN-mediated inhibition of the PI-3K/AKT signaling. |
| T8 | 1571-1733 | Sentence | denotes | Furthermore, the down-regulation of the cyclin E and CDK2 was clearly observed in GM3-treated HCT116 cells, but the down-regulation of cyclin D1 and CDK4 was not. |
| T9 | 1734-1980 | Sentence | denotes | On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3. |
| T10 | 1981-2121 | Sentence | denotes | These results suggest that ganglioside GM3-stimulated PTEN expression modulates cell cycle regulatory proteins, thus inhibiting cell growth. |
| T11 | 2122-2267 | Sentence | denotes | We conclude that ganglioside GM3 represents a modulator of cancer cell proliferation and may have potential for use in colorectal cancer therapy. |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 26-31 | Disease | denotes | tumor | MONDO:0005070 |
| T2 | 279-285 | Disease | denotes | cancer | MONDO:0004992 |
| T3 | 361-367 | Disease | denotes | cancer | MONDO:0004992 |
| T4 | 608-613 | Disease | denotes | tumor | MONDO:0005070 |
| T5 | 1144-1156 | Disease | denotes | colon cancer | MONDO:0002032|MONDO:0005575|MONDO:0021063 |
| T8 | 2181-2187 | Disease | denotes | cancer | MONDO:0004992 |
| T9 | 2241-2258 | Disease | denotes | colorectal cancer | MONDO:0005575|MONDO:0024331 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 667-677 | Body_part | denotes | chromosome | FMA:67093 |
| T2 | 1144-1149 | Body_part | denotes | colon | FMA:14543 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1144-1149 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/MAT_0000526 |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 12-15 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T2 | 193-196 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T3 | 329-332 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T4 | 917-920 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T5 | 1220-1223 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T6 | 1465-1468 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T7 | 1653-1656 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T8 | 1976-1979 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T9 | 2020-2023 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T10 | 2151-2154 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 57-67 | Body_part | denotes | cell cycle | http://purl.obolibrary.org/obo/UBERON_2000098 |
| T2 | 667-677 | Body_part | denotes | chromosome | http://purl.obolibrary.org/obo/GO_0005694 |
| T3 | 1144-1149 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/UBERON_0001155 |
| T4 | 2061-2071 | Body_part | denotes | cell cycle | http://purl.obolibrary.org/obo/UBERON_2000098 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 26-31 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 279-285 | Phenotype | denotes | cancer | HP:0002664 |
| T3 | 361-367 | Phenotype | denotes | cancer | HP:0002664 |
| T4 | 608-613 | Phenotype | denotes | tumor | HP:0002664 |
| T5 | 1144-1156 | Phenotype | denotes | colon cancer | HP:0003003 |
| T6 | 2181-2187 | Phenotype | denotes | cancer | HP:0002664 |
| T7 | 2241-2258 | Phenotype | denotes | colorectal cancer | HP:0003003 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 361-372 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |
| T2 | 1150-1162 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T3 | 2181-2192 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |