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PubMed:16574813 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 12-15 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T2 12-15 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T3 193-196 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T4 193-196 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T5 329-332 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T6 329-332 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T7 917-920 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T8 917-920 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T9 1220-1223 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T10 1220-1223 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T11 1465-1468 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T12 1465-1468 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T13 1653-1656 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T14 1653-1656 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T15 1976-1979 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T16 1976-1979 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T17 2020-2023 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T18 2020-2023 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T19 2151-2154 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T20 2151-2154 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 12-15 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T3 193-196 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T5 329-332 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T7 917-920 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T9 1220-1223 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T11 1465-1468 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T13 1653-1656 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T15 1976-1979 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T17 2020-2023 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T19 2151-2154 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 12-15 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T2 12-15 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T3 193-196 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T4 193-196 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T5 329-332 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T6 329-332 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T7 917-920 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T8 917-920 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T9 1220-1223 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T10 1220-1223 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T11 1465-1468 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T12 1465-1468 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T13 1653-1656 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T14 1653-1656 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T15 1976-1979 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T16 1976-1979 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T17 2020-2023 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T18 2020-2023 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T19 2151-2154 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T20 2151-2154 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1144-1149 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 279-285 HP_0002664 denotes cancer
T2 361-367 HP_0002664 denotes cancer
T3 608-613 HP_0002664 denotes tumor
T4 1144-1156 HP_0003003 denotes colon cancer
T5 1144-1156 HP_0100273 denotes colon cancer
T6 1150-1156 HP_0002664 denotes cancer
T7 2181-2187 HP_0002664 denotes cancer
T8 2252-2258 HP_0002664 denotes cancer

uniprot-human

Id Subject Object Predicate Lexical cue
T1 43-47 http://www.uniprot.org/uniprot/P60484 denotes PTEN
T2 682-686 http://www.uniprot.org/uniprot/P60484 denotes PTEN
T3 1068-1072 http://www.uniprot.org/uniprot/P60484 denotes PTEN
T4 1518-1522 http://www.uniprot.org/uniprot/P60484 denotes PTEN
T5 1766-1770 http://www.uniprot.org/uniprot/P60484 denotes PTEN
T6 1923-1927 http://www.uniprot.org/uniprot/P60484 denotes PTEN
T7 625-655 http://www.uniprot.org/uniprot/P60484 denotes phosphatase and tensin homolog
T8 110-113 http://www.uniprot.org/uniprot/P38936 denotes p21
T9 1000-1003 http://www.uniprot.org/uniprot/P38936 denotes p21
T10 1274-1277 http://www.uniprot.org/uniprot/P38936 denotes p21
T11 1305-1308 http://www.uniprot.org/uniprot/P38936 denotes p21
T12 1372-1375 http://www.uniprot.org/uniprot/P38936 denotes p21
T13 114-118 http://www.uniprot.org/uniprot/P38936 denotes WAF1
T14 1004-1008 http://www.uniprot.org/uniprot/P38936 denotes WAF1
T15 1278-1282 http://www.uniprot.org/uniprot/P38936 denotes WAF1
T16 1309-1313 http://www.uniprot.org/uniprot/P38936 denotes WAF1
T17 1376-1380 http://www.uniprot.org/uniprot/P38936 denotes WAF1
T18 1852-1856 http://www.uniprot.org/uniprot/P38936 denotes WAF1
T19 124-127 http://www.uniprot.org/uniprot/Q13177 denotes p27
T20 1496-1499 http://www.uniprot.org/uniprot/Q13177 denotes p27
T21 1878-1881 http://www.uniprot.org/uniprot/Q13177 denotes p27
T22 124-127 http://www.uniprot.org/uniprot/Q9Y3B3 denotes p27
T23 1496-1499 http://www.uniprot.org/uniprot/Q9Y3B3 denotes p27
T24 1878-1881 http://www.uniprot.org/uniprot/Q9Y3B3 denotes p27
T25 124-127 http://www.uniprot.org/uniprot/P40305 denotes p27
T26 1496-1499 http://www.uniprot.org/uniprot/P40305 denotes p27
T27 1878-1881 http://www.uniprot.org/uniprot/P40305 denotes p27
T28 151-153 http://www.uniprot.org/uniprot/Q86U18 denotes PI
T29 768-770 http://www.uniprot.org/uniprot/Q86U18 denotes PI
T30 1100-1102 http://www.uniprot.org/uniprot/Q86U18 denotes PI
T31 1550-1552 http://www.uniprot.org/uniprot/Q86U18 denotes PI
T32 1931-1933 http://www.uniprot.org/uniprot/Q86U18 denotes PI
T33 151-153 http://www.uniprot.org/uniprot/P01298 denotes PI
T34 768-770 http://www.uniprot.org/uniprot/P01298 denotes PI
T35 1100-1102 http://www.uniprot.org/uniprot/P01298 denotes PI
T36 1550-1552 http://www.uniprot.org/uniprot/P01298 denotes PI
T37 1931-1933 http://www.uniprot.org/uniprot/P01298 denotes PI
T38 494-498 http://www.uniprot.org/uniprot/Q13301 denotes MDM2
T39 813-817 http://www.uniprot.org/uniprot/Q13301 denotes MDM2
T40 862-866 http://www.uniprot.org/uniprot/Q13301 denotes MDM2
T41 1110-1114 http://www.uniprot.org/uniprot/Q13301 denotes MDM2
T42 954-960 http://www.uniprot.org/uniprot/P12004 denotes cyclin
T43 1611-1617 http://www.uniprot.org/uniprot/P12004 denotes cyclin
T44 1706-1712 http://www.uniprot.org/uniprot/P12004 denotes cyclin
T45 995-998 http://www.uniprot.org/uniprot/P35790 denotes CKI
T46 1492-1495 http://www.uniprot.org/uniprot/P35790 denotes CKI
T47 1624-1628 http://www.uniprot.org/uniprot/P24941 denotes CDK2
T48 1720-1724 http://www.uniprot.org/uniprot/P11802 denotes CDK4
T49 2061-2091 http://www.uniprot.org/uniprot/P18754 denotes cell cycle regulatory proteins
T50 2061-2082 http://www.uniprot.org/uniprot/O60934 denotes cell cycle regulatory

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 110-113 http://www.uniprot.org/uniprot/P63028 denotes p21
T2 1000-1003 http://www.uniprot.org/uniprot/P63028 denotes p21
T3 1274-1277 http://www.uniprot.org/uniprot/P63028 denotes p21
T4 1305-1308 http://www.uniprot.org/uniprot/P63028 denotes p21
T5 1372-1375 http://www.uniprot.org/uniprot/P63028 denotes p21
T6 1848-1851 http://www.uniprot.org/uniprot/P63028 denotes p21
T7 110-113 http://www.uniprot.org/uniprot/Q62092 denotes p21
T8 1000-1003 http://www.uniprot.org/uniprot/Q62092 denotes p21
T9 1274-1277 http://www.uniprot.org/uniprot/Q62092 denotes p21
T10 1305-1308 http://www.uniprot.org/uniprot/Q62092 denotes p21
T11 1372-1375 http://www.uniprot.org/uniprot/Q62092 denotes p21
T12 1848-1851 http://www.uniprot.org/uniprot/Q62092 denotes p21
T13 110-113 http://www.uniprot.org/uniprot/P39689 denotes p21
T14 1000-1003 http://www.uniprot.org/uniprot/P39689 denotes p21
T15 1274-1277 http://www.uniprot.org/uniprot/P39689 denotes p21
T16 1305-1308 http://www.uniprot.org/uniprot/P39689 denotes p21
T17 1372-1375 http://www.uniprot.org/uniprot/P39689 denotes p21
T18 1848-1851 http://www.uniprot.org/uniprot/P39689 denotes p21
T19 625-655 http://www.uniprot.org/uniprot/O08586 denotes phosphatase and tensin homolog
T20 954-960 http://www.uniprot.org/uniprot/P17918 denotes cyclin
T21 1611-1617 http://www.uniprot.org/uniprot/P17918 denotes cyclin
T22 1706-1712 http://www.uniprot.org/uniprot/P17918 denotes cyclin

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 279-285 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T2 361-367 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T3 398-407 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanism
T4 592-602 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanisms
T5 1150-1156 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T6 1157-1162 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T7 1672-1677 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T8 2181-2187 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T9 2252-2258 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer

GO-BP

Id Subject Object Predicate Lexical cue
T1 26-42 http://purl.obolibrary.org/obo/GO_0051726 denotes tumor suppressor
T2 608-624 http://purl.obolibrary.org/obo/GO_0051726 denotes tumor suppressor
T3 57-67 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T4 2061-2071 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T5 57-79 http://purl.obolibrary.org/obo/GO_0051726 denotes cell cycle progression
T6 2051-2071 http://purl.obolibrary.org/obo/GO_0051726 denotes modulates cell cycle
T7 57-79 http://purl.obolibrary.org/obo/GO_0007050 denotes cell cycle progression
T8 81-96 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T9 1246-1261 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T10 307-316 http://purl.obolibrary.org/obo/GO_0042638 denotes exogenous
T11 368-386 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T12 429-447 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T13 2188-2206 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T14 625-636 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T15 708-719 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T16 775-788 http://purl.obolibrary.org/obo/GO_0043491 denotes AKT signaling
T17 1556-1569 http://purl.obolibrary.org/obo/GO_0043491 denotes AKT signaling
T18 1937-1950 http://purl.obolibrary.org/obo/GO_0043491 denotes AKT signaling
T19 779-788 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T20 1124-1133 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T21 1560-1569 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T22 1941-1950 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T23 954-960 http://purl.obolibrary.org/obo/GO_0016538 denotes cyclin
T24 1611-1617 http://purl.obolibrary.org/obo/GO_0016538 denotes cyclin
T25 1706-1712 http://purl.obolibrary.org/obo/GO_0016538 denotes cyclin
T26 979-982 http://purl.obolibrary.org/obo/GO_0004693 denotes CDK
T27 979-993 http://purl.obolibrary.org/obo/GO_0004861 denotes CDK) inhibitor
T28 979-993 http://purl.obolibrary.org/obo/GO_0045736 denotes CDK) inhibitor
T29 1236-1270 http://purl.obolibrary.org/obo/GO_0045893 denotes dependent transcriptional activity
T30 1236-1270 http://purl.obolibrary.org/obo/GO_1900622 denotes dependent transcriptional activity
T31 1593-1603 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T32 1692-1702 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T33 1781-1797 http://purl.obolibrary.org/obo/GO_0016246 denotes RNA interference
T34 2051-2071 http://purl.obolibrary.org/obo/GO_0051445 denotes modulates cell cycle
T35 2051-2071 http://purl.obolibrary.org/obo/GO_0007346 denotes modulates cell cycle
T36 2098-2120 http://purl.obolibrary.org/obo/GO_0051514 denotes inhibiting cell growth
T37 2098-2120 http://purl.obolibrary.org/obo/GO_0030308 denotes inhibiting cell growth
T38 2098-2120 http://purl.obolibrary.org/obo/GO_0051511 denotes inhibiting cell growth
T39 2098-2120 http://purl.obolibrary.org/obo/GO_0051517 denotes inhibiting cell growth
T40 2109-2120 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T41 2114-2120 http://purl.obolibrary.org/obo/GO_0040007 denotes growth

GO-MF

Id Subject Object Predicate Lexical cue
T1 1419-1430 http://purl.obolibrary.org/obo/GO_0002039 denotes p53-binding
T2 1423-1430 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T3 1423-1430 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T4 1423-1430 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T5 1423-1430 http://purl.obolibrary.org/obo/GO_0005488 denotes binding

GO-CC

Id Subject Object Predicate Lexical cue
T1 57-61 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 368-372 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 429-433 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 2061-2065 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5 2109-2113 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6 1157-1162 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7 1672-1677 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8 625-655 http://purl.obolibrary.org/obo/GO_1990455 denotes phosphatase and tensin homolog
T9 667-677 http://purl.obolibrary.org/obo/GO_0005694 denotes chromosome

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 1144-1149 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 57-67 http://edamontology.org/topic_0612 denotes cell cycle
T2 81-96 http://edamontology.org/topic_0110 denotes transcriptional
T3 81-96 http://edamontology.org/topic_3512 denotes transcriptional
T4 81-96 http://edamontology.org/topic_0203 denotes transcriptional
T5 81-96 http://edamontology.org/topic_3308 denotes transcriptional
T6 161-168 http://edamontology.org/topic_0602 denotes pathway
T7 279-285 http://edamontology.org/topic_2640 denotes cancer
T8 361-367 http://edamontology.org/topic_2640 denotes cancer
T9 474-481 http://edamontology.org/topic_3678 denotes studies
T10 667-677 http://edamontology.org/topic_0624 denotes chromosome
T11 667-677 http://edamontology.org/topic_0654 denotes chromosome
T12 867-874 http://edamontology.org/topic_0078 denotes protein
T13 901-906 http://edamontology.org/topic_3678 denotes study
T14 1053-1060 http://edamontology.org/topic_0078 denotes protein
T15 1150-1156 http://edamontology.org/topic_2640 denotes cancer
T16 1246-1261 http://edamontology.org/topic_3308 denotes transcriptional
T17 1246-1261 http://edamontology.org/topic_0203 denotes transcriptional
T18 1246-1261 http://edamontology.org/topic_0110 denotes transcriptional
T19 1246-1261 http://edamontology.org/topic_3512 denotes transcriptional
T20 1315-1323 http://edamontology.org/topic_0749 denotes promoter
T21 1315-1323 http://edamontology.org/topic_1312 denotes promoter
T22 1315-1323 http://edamontology.org/topic_0111 denotes promoter
T23 1382-1390 http://edamontology.org/topic_0111 denotes promoter
T24 1382-1390 http://edamontology.org/topic_0749 denotes promoter
T25 1382-1390 http://edamontology.org/topic_1312 denotes promoter
T26 2061-2071 http://edamontology.org/topic_0612 denotes cell cycle
T27 2083-2091 http://edamontology.org/topic_0078 denotes proteins
T28 2181-2187 http://edamontology.org/topic_2640 denotes cancer
T29 2252-2258 http://edamontology.org/topic_2640 denotes cancer

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 161-168 http://edamontology.org/data_2600 denotes pathway
T2 867-874 http://edamontology.org/data_1467 denotes protein
T3 867-874 http://edamontology.org/format_1208 denotes protein
T4 1053-1060 http://edamontology.org/format_1208 denotes protein
T5 1053-1060 http://edamontology.org/data_1467 denotes protein
T6 1178-1182 http://edamontology.org/data_0006 denotes data
T7 1288-1297 http://edamontology.org/data_2042 denotes evidenced
T8 1342-1350 http://edamontology.org/data_2048 denotes reporter
T9 1397-1406 http://edamontology.org/operation_3429 denotes construct
T10 2083-2091 http://edamontology.org/data_1467 denotes proteins
T11 2083-2091 http://edamontology.org/format_1208 denotes proteins

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
16574813-3#29#33#gene4193 494-498 gene4193 denotes MDM2
16574813-3#66#79#diseaseC0596263 531-544 diseaseC0596263 denotes tumorigenesis
16574813-4#78#84#gene5111 954-960 gene5111 denotes cyclin
16574813-4#128#132#gene1026 1004-1008 gene1026 denotes WAF1
16574813-4#234#238#gene4193 1110-1114 gene4193 denotes MDM2
16574813-4#268#280#diseaseC0007102 1144-1156 diseaseC0007102 denotes colon cancer
16574813-4#268#280#diseaseC0699790 1144-1156 diseaseC0699790 denotes colon cancer
16574813-4#268#280#diseaseC0007102 1144-1156 diseaseC0007102 denotes colon cancer
16574813-4#268#280#diseaseC0699790 1144-1156 diseaseC0699790 denotes colon cancer
16574813-4#268#280#diseaseC0007102 1144-1156 diseaseC0007102 denotes colon cancer
16574813-4#268#280#diseaseC0699790 1144-1156 diseaseC0699790 denotes colon cancer
29#33#gene419366#79#diseaseC0596263 16574813-3#29#33#gene4193 16574813-3#66#79#diseaseC0596263 associated_with MDM2,tumorigenesis
78#84#gene5111268#280#diseaseC0007102 16574813-4#78#84#gene5111 16574813-4#268#280#diseaseC0007102 associated_with cyclin,colon cancer
78#84#gene5111268#280#diseaseC0699790 16574813-4#78#84#gene5111 16574813-4#268#280#diseaseC0699790 associated_with cyclin,colon cancer
78#84#gene5111268#280#diseaseC0007102 16574813-4#78#84#gene5111 16574813-4#268#280#diseaseC0007102 associated_with cyclin,colon cancer
78#84#gene5111268#280#diseaseC0699790 16574813-4#78#84#gene5111 16574813-4#268#280#diseaseC0699790 associated_with cyclin,colon cancer
78#84#gene5111268#280#diseaseC0007102 16574813-4#78#84#gene5111 16574813-4#268#280#diseaseC0007102 associated_with cyclin,colon cancer
78#84#gene5111268#280#diseaseC0699790 16574813-4#78#84#gene5111 16574813-4#268#280#diseaseC0699790 associated_with cyclin,colon cancer
128#132#gene1026268#280#diseaseC0007102 16574813-4#128#132#gene1026 16574813-4#268#280#diseaseC0007102 associated_with WAF1,colon cancer
128#132#gene1026268#280#diseaseC0699790 16574813-4#128#132#gene1026 16574813-4#268#280#diseaseC0699790 associated_with WAF1,colon cancer
128#132#gene1026268#280#diseaseC0007102 16574813-4#128#132#gene1026 16574813-4#268#280#diseaseC0007102 associated_with WAF1,colon cancer
128#132#gene1026268#280#diseaseC0699790 16574813-4#128#132#gene1026 16574813-4#268#280#diseaseC0699790 associated_with WAF1,colon cancer
128#132#gene1026268#280#diseaseC0007102 16574813-4#128#132#gene1026 16574813-4#268#280#diseaseC0007102 associated_with WAF1,colon cancer
128#132#gene1026268#280#diseaseC0699790 16574813-4#128#132#gene1026 16574813-4#268#280#diseaseC0699790 associated_with WAF1,colon cancer
234#238#gene4193268#280#diseaseC0007102 16574813-4#234#238#gene4193 16574813-4#268#280#diseaseC0007102 associated_with MDM2,colon cancer
234#238#gene4193268#280#diseaseC0699790 16574813-4#234#238#gene4193 16574813-4#268#280#diseaseC0699790 associated_with MDM2,colon cancer
234#238#gene4193268#280#diseaseC0007102 16574813-4#234#238#gene4193 16574813-4#268#280#diseaseC0007102 associated_with MDM2,colon cancer
234#238#gene4193268#280#diseaseC0699790 16574813-4#234#238#gene4193 16574813-4#268#280#diseaseC0699790 associated_with MDM2,colon cancer
234#238#gene4193268#280#diseaseC0007102 16574813-4#234#238#gene4193 16574813-4#268#280#diseaseC0007102 associated_with MDM2,colon cancer
234#238#gene4193268#280#diseaseC0699790 16574813-4#234#238#gene4193 16574813-4#268#280#diseaseC0699790 associated_with MDM2,colon cancer

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 1144-1149 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-169 Sentence denotes Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway.
TextSentencer_T2 170-293 Sentence denotes The simple ganglioside GM3 has been shown to have anti-proliferative effects in several in vitro and in vivo cancer models.
TextSentencer_T3 294-464 Sentence denotes Although the exogenous ganglioside GM3 has an inhibitory effect on cancer cell proliferation, the exact mechanism by which it prevents cell proliferation remains unclear.
TextSentencer_T4 465-875 Sentence denotes Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein.
TextSentencer_T5 876-1163 Sentence denotes Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells.
TextSentencer_T6 1164-1438 Sentence denotes Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites).
TextSentencer_T7 1439-1570 Sentence denotes Additionally, ganglioside GM3 enhances expression of CKI p27(kip1) through the PTEN-mediated inhibition of the PI-3K/AKT signaling.
TextSentencer_T8 1571-1733 Sentence denotes Furthermore, the down-regulation of the cyclin E and CDK2 was clearly observed in GM3-treated HCT116 cells, but the down-regulation of cyclin D1 and CDK4 was not.
TextSentencer_T9 1734-1980 Sentence denotes On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3.
TextSentencer_T10 1981-2121 Sentence denotes These results suggest that ganglioside GM3-stimulated PTEN expression modulates cell cycle regulatory proteins, thus inhibiting cell growth.
TextSentencer_T11 2122-2267 Sentence denotes We conclude that ganglioside GM3 represents a modulator of cancer cell proliferation and may have potential for use in colorectal cancer therapy.
T1 0-169 Sentence denotes Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway.
T2 170-293 Sentence denotes The simple ganglioside GM3 has been shown to have anti-proliferative effects in several in vitro and in vivo cancer models.
T3 294-464 Sentence denotes Although the exogenous ganglioside GM3 has an inhibitory effect on cancer cell proliferation, the exact mechanism by which it prevents cell proliferation remains unclear.
T4 465-875 Sentence denotes Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein.
T5 876-1163 Sentence denotes Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells.
T6 1164-1438 Sentence denotes Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites).
T7 1439-1570 Sentence denotes Additionally, ganglioside GM3 enhances expression of CKI p27(kip1) through the PTEN-mediated inhibition of the PI-3K/AKT signaling.
T8 1571-1733 Sentence denotes Furthermore, the down-regulation of the cyclin E and CDK2 was clearly observed in GM3-treated HCT116 cells, but the down-regulation of cyclin D1 and CDK4 was not.
T9 1734-1980 Sentence denotes On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3.
T10 1981-2121 Sentence denotes These results suggest that ganglioside GM3-stimulated PTEN expression modulates cell cycle regulatory proteins, thus inhibiting cell growth.
T11 2122-2267 Sentence denotes We conclude that ganglioside GM3 represents a modulator of cancer cell proliferation and may have potential for use in colorectal cancer therapy.
T1 0-169 Sentence denotes Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway.
T2 170-293 Sentence denotes The simple ganglioside GM3 has been shown to have anti-proliferative effects in several in vitro and in vivo cancer models.
T3 294-464 Sentence denotes Although the exogenous ganglioside GM3 has an inhibitory effect on cancer cell proliferation, the exact mechanism by which it prevents cell proliferation remains unclear.
T4 465-875 Sentence denotes Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein.
T5 876-1163 Sentence denotes Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells.
T6 1164-1438 Sentence denotes Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites).
T7 1439-1570 Sentence denotes Additionally, ganglioside GM3 enhances expression of CKI p27(kip1) through the PTEN-mediated inhibition of the PI-3K/AKT signaling.
T8 1571-1733 Sentence denotes Furthermore, the down-regulation of the cyclin E and CDK2 was clearly observed in GM3-treated HCT116 cells, but the down-regulation of cyclin D1 and CDK4 was not.
T9 1734-1980 Sentence denotes On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3.
T10 1981-2121 Sentence denotes These results suggest that ganglioside GM3-stimulated PTEN expression modulates cell cycle regulatory proteins, thus inhibiting cell growth.
T11 2122-2267 Sentence denotes We conclude that ganglioside GM3 represents a modulator of cancer cell proliferation and may have potential for use in colorectal cancer therapy.

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1144-1149 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon

DisGeNET

Id Subject Object Predicate Lexical cue
T0 494-498 gene:4193 denotes MDM2
T1 531-544 disease:C0596263 denotes tumorigenesis
R1 T0 T1 associated_with MDM2,tumorigenesis

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1144-1149 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 26-31 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 279-285 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T3 361-367 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T4 608-613 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T5 1144-1156 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T6 2181-2187 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T7 2241-2258 Disease denotes colorectal cancer http://purl.obolibrary.org/obo/MONDO_0005575

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 12-15 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T2 193-196 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T3 329-332 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T4 917-920 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T5 1220-1223 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T6 1465-1468 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T7 1653-1656 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T8 1976-1979 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T9 2020-2023 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T10 2151-2154 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 26-31 Phenotype denotes tumor HP:0002664
T2 279-285 Phenotype denotes cancer HP:0002664
T3 361-367 Phenotype denotes cancer HP:0002664
T4 608-613 Phenotype denotes tumor HP:0002664
T5 1144-1156 Phenotype denotes colon cancer HP:0003003
T6 2181-2187 Phenotype denotes cancer HP:0002664
T7 2241-2258 Phenotype denotes colorectal cancer HP:0003003

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 361-372 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064
T2 1150-1162 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T3 2181-2192 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 57-67 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T2 667-677 Body_part denotes chromosome http://purl.obolibrary.org/obo/GO_0005694
T3 1144-1149 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T4 2061-2071 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-169 Sentence denotes Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway.
TextSentencer_T2 170-293 Sentence denotes The simple ganglioside GM3 has been shown to have anti-proliferative effects in several in vitro and in vivo cancer models.
TextSentencer_T3 294-464 Sentence denotes Although the exogenous ganglioside GM3 has an inhibitory effect on cancer cell proliferation, the exact mechanism by which it prevents cell proliferation remains unclear.
TextSentencer_T4 465-875 Sentence denotes Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein.
TextSentencer_T5 876-1163 Sentence denotes Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells.
TextSentencer_T6 1164-1438 Sentence denotes Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites).
TextSentencer_T7 1439-1570 Sentence denotes Additionally, ganglioside GM3 enhances expression of CKI p27(kip1) through the PTEN-mediated inhibition of the PI-3K/AKT signaling.
TextSentencer_T8 1571-1733 Sentence denotes Furthermore, the down-regulation of the cyclin E and CDK2 was clearly observed in GM3-treated HCT116 cells, but the down-regulation of cyclin D1 and CDK4 was not.
TextSentencer_T9 1734-1980 Sentence denotes On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3.
TextSentencer_T10 1981-2121 Sentence denotes These results suggest that ganglioside GM3-stimulated PTEN expression modulates cell cycle regulatory proteins, thus inhibiting cell growth.
TextSentencer_T11 2122-2267 Sentence denotes We conclude that ganglioside GM3 represents a modulator of cancer cell proliferation and may have potential for use in colorectal cancer therapy.
T1 0-169 Sentence denotes Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway.
T2 170-293 Sentence denotes The simple ganglioside GM3 has been shown to have anti-proliferative effects in several in vitro and in vivo cancer models.
T3 294-464 Sentence denotes Although the exogenous ganglioside GM3 has an inhibitory effect on cancer cell proliferation, the exact mechanism by which it prevents cell proliferation remains unclear.
T4 465-875 Sentence denotes Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein.
T5 876-1163 Sentence denotes Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells.
T6 1164-1438 Sentence denotes Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites).
T7 1439-1570 Sentence denotes Additionally, ganglioside GM3 enhances expression of CKI p27(kip1) through the PTEN-mediated inhibition of the PI-3K/AKT signaling.
T8 1571-1733 Sentence denotes Furthermore, the down-regulation of the cyclin E and CDK2 was clearly observed in GM3-treated HCT116 cells, but the down-regulation of cyclin D1 and CDK4 was not.
T9 1734-1980 Sentence denotes On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3.
T10 1981-2121 Sentence denotes These results suggest that ganglioside GM3-stimulated PTEN expression modulates cell cycle regulatory proteins, thus inhibiting cell growth.
T11 2122-2267 Sentence denotes We conclude that ganglioside GM3 represents a modulator of cancer cell proliferation and may have potential for use in colorectal cancer therapy.
T1 0-169 Sentence denotes Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway.
T2 170-293 Sentence denotes The simple ganglioside GM3 has been shown to have anti-proliferative effects in several in vitro and in vivo cancer models.
T3 294-464 Sentence denotes Although the exogenous ganglioside GM3 has an inhibitory effect on cancer cell proliferation, the exact mechanism by which it prevents cell proliferation remains unclear.
T4 465-875 Sentence denotes Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein.
T5 876-1163 Sentence denotes Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells.
T6 1164-1438 Sentence denotes Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites).
T7 1439-1570 Sentence denotes Additionally, ganglioside GM3 enhances expression of CKI p27(kip1) through the PTEN-mediated inhibition of the PI-3K/AKT signaling.
T8 1571-1733 Sentence denotes Furthermore, the down-regulation of the cyclin E and CDK2 was clearly observed in GM3-treated HCT116 cells, but the down-regulation of cyclin D1 and CDK4 was not.
T9 1734-1980 Sentence denotes On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3.
T10 1981-2121 Sentence denotes These results suggest that ganglioside GM3-stimulated PTEN expression modulates cell cycle regulatory proteins, thus inhibiting cell growth.
T11 2122-2267 Sentence denotes We conclude that ganglioside GM3 represents a modulator of cancer cell proliferation and may have potential for use in colorectal cancer therapy.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-169 Sentence denotes Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway.
T2 170-293 Sentence denotes The simple ganglioside GM3 has been shown to have anti-proliferative effects in several in vitro and in vivo cancer models.
T3 294-464 Sentence denotes Although the exogenous ganglioside GM3 has an inhibitory effect on cancer cell proliferation, the exact mechanism by which it prevents cell proliferation remains unclear.
T4 465-875 Sentence denotes Previous studies showed that MDM2 is an oncoprotein that controls tumorigenesis through both p53-dependent and p53-independent mechanisms, and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a dual-specificity phosphatase that antagonizes phosphatidylinositol 3-kinase (PI-3K)/AKT signaling, is capable of blocking MDM2 nuclear translocation and destabilizing the MDM2 protein.
T5 876-1163 Sentence denotes Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells.
T6 1164-1438 Sentence denotes Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites).
T7 1439-1570 Sentence denotes Additionally, ganglioside GM3 enhances expression of CKI p27(kip1) through the PTEN-mediated inhibition of the PI-3K/AKT signaling.
T8 1571-1733 Sentence denotes Furthermore, the down-regulation of the cyclin E and CDK2 was clearly observed in GM3-treated HCT116 cells, but the down-regulation of cyclin D1 and CDK4 was not.
T9 1734-1980 Sentence denotes On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3.
T10 1981-2121 Sentence denotes These results suggest that ganglioside GM3-stimulated PTEN expression modulates cell cycle regulatory proteins, thus inhibiting cell growth.
T11 2122-2267 Sentence denotes We conclude that ganglioside GM3 represents a modulator of cancer cell proliferation and may have potential for use in colorectal cancer therapy.

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 26-31 Disease denotes tumor MONDO:0005070
T2 279-285 Disease denotes cancer MONDO:0004992
T3 361-367 Disease denotes cancer MONDO:0004992
T4 608-613 Disease denotes tumor MONDO:0005070
T5 1144-1156 Disease denotes colon cancer MONDO:0002032|MONDO:0005575|MONDO:0021063
T8 2181-2187 Disease denotes cancer MONDO:0004992
T9 2241-2258 Disease denotes colorectal cancer MONDO:0005575|MONDO:0024331

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 667-677 Body_part denotes chromosome FMA:67093
T2 1144-1149 Body_part denotes colon FMA:14543

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1144-1149 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 12-15 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T2 193-196 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T3 329-332 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T4 917-920 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T5 1220-1223 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T6 1465-1468 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T7 1653-1656 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T8 1976-1979 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T9 2020-2023 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T10 2151-2154 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 57-67 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T2 667-677 Body_part denotes chromosome http://purl.obolibrary.org/obo/GO_0005694
T3 1144-1149 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T4 2061-2071 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 26-31 Phenotype denotes tumor HP:0002664
T2 279-285 Phenotype denotes cancer HP:0002664
T3 361-367 Phenotype denotes cancer HP:0002664
T4 608-613 Phenotype denotes tumor HP:0002664
T5 1144-1156 Phenotype denotes colon cancer HP:0003003
T6 2181-2187 Phenotype denotes cancer HP:0002664
T7 2241-2258 Phenotype denotes colorectal cancer HP:0003003

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 361-372 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064
T2 1150-1162 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T3 2181-2192 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064