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PubMed:16574713 JSONTXT

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LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 235-241 OrganismTaxon denotes humans NCBItxid:9605

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-93 Sentence denotes Memory function and serotonin transporter promoter gene polymorphism in ecstasy (MDMA) users.
T2 94-399 Sentence denotes Although 3,4-methylenedioxymethamphetamine (MDMA or ecstasy) has been shown to damage brain serotonin (5-HT) neurons in animals and possibly humans, little is known about the long-term consequences of MDMA-induced 5-HT neurotoxic lesions on functions in which 5-HT is involved, such as cognitive function.
T3 400-701 Sentence denotes Because 5-HT transporters play a key element in the regulation of synaptic 5-HT transmission it may be important to control for the potential covariance effect of a polymorphism in the 5-HT transporter promoter gene region (5-HTTLPR) when studying the effects of MDMA as well as cognitive functioning.
T4 702-901 Sentence denotes The aim of the study was to investigate the effects of moderate and heavy MDMA use on cognitive function, as well as the effects of long-term abstention from MDMA, in subjects genotyped for 5-HTTLPR.
T5 902-996 Sentence denotes A second aim of the study was to determine whether these effects differ for females and males.
T6 997-1210 Sentence denotes Fifteen moderate MDMA users (<55 lifetime tablets), 22 heavy MDMA+ users (>55 lifetime tablets), 16 ex-MDMA+ users (last tablet > 1 year ago) and 13 controls were compared on a battery of neuropsychological tests.
T7 1211-1491 Sentence denotes DNA from peripheral nuclear blood cells was genotyped for 5-HTTLPR using standard polymerase chain reaction methods.A significant group effect was observed only on memory function tasks (p = 0.04) but not on reaction times (p = 0.61) or attention/executive functioning (p = 0.59).
T8 1492-1578 Sentence denotes Heavy and ex-MDMA+ users performed significantly poorer on memory tasks than controls.
T9 1579-1661 Sentence denotes In contrast, no evidence of memory impairment was observed in moderate MDMA users.
T10 1662-1719 Sentence denotes No significant effect of 5-HTTLPR or gender was observed.
T11 1720-1908 Sentence denotes While the use of MDMA in quantities that may be considered "moderate" is not associated with impaired memory functioning, heavy use of MDMA use may lead to long lasting memory impairments.
T12 1909-1985 Sentence denotes No effect of 5-HTTLPR or gender on memory function or MDMA use was observed.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
2848 20-41 GeneOrGeneProduct denotes serotonin transporter NCBIGene:6532
2849 72-79 ChemicalEntity denotes ecstasy MESH:D018817
2850 81-85 ChemicalEntity denotes MDMA MESH:D018817
2851 103-136 ChemicalEntity denotes 3,4-methylenedioxymethamphetamine MESH:D018817
2852 138-142 ChemicalEntity denotes MDMA MESH:D018817
2853 146-153 ChemicalEntity denotes ecstasy MESH:D018817
2854 186-195 ChemicalEntity denotes serotonin MESH:D012701
2855 197-201 ChemicalEntity denotes 5-HT MESH:D012701
2856 235-241 OrganismTaxon denotes humans NCBITaxon:9606
2857 295-299 ChemicalEntity denotes MDMA MESH:D018817
2858 308-312 ChemicalEntity denotes 5-HT MESH:D012701
2859 313-331 DiseaseOrPhenotypicFeature denotes neurotoxic lesions MESH:D020258
2860 354-358 ChemicalEntity denotes 5-HT MESH:D012701
2861 408-412 ChemicalEntity denotes 5-HT MESH:D012701
2862 475-479 ChemicalEntity denotes 5-HT MESH:D012701
2863 585-622 GeneOrGeneProduct denotes 5-HT transporter promoter gene region NCBIGene:6532
2864 624-632 GeneOrGeneProduct denotes 5-HTTLPR NCBIGene:6532
2865 663-667 ChemicalEntity denotes MDMA MESH:D018817
2866 776-780 ChemicalEntity denotes MDMA MESH:D018817
2867 860-864 ChemicalEntity denotes MDMA MESH:D018817
2868 892-900 GeneOrGeneProduct denotes 5-HTTLPR NCBIGene:6532
2869 1014-1018 ChemicalEntity denotes MDMA MESH:D018817
2870 1058-1062 ChemicalEntity denotes MDMA MESH:D018817
2871 1100-1104 ChemicalEntity denotes MDMA MESH:D018817
2872 1269-1277 GeneOrGeneProduct denotes 5-HTTLPR NCBIGene:6532
2873 1505-1509 ChemicalEntity denotes MDMA MESH:D018817
2874 1607-1624 DiseaseOrPhenotypicFeature denotes memory impairment MESH:D008569
2875 1650-1654 ChemicalEntity denotes MDMA MESH:D018817
2876 1687-1695 GeneOrGeneProduct denotes 5-HTTLPR NCBIGene:6532
2877 1737-1741 ChemicalEntity denotes MDMA MESH:D018817
2878 1813-1840 DiseaseOrPhenotypicFeature denotes impaired memory functioning MESH:D008569
2879 1855-1859 ChemicalEntity denotes MDMA MESH:D018817
2880 1889-1907 DiseaseOrPhenotypicFeature denotes memory impairments MESH:D008569
2881 1922-1930 GeneOrGeneProduct denotes 5-HTTLPR NCBIGene:6532
2882 1963-1967 ChemicalEntity denotes MDMA MESH:D018817

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 203-210 DiseaseOrPhenotypicFeature denotes neurons 0004466

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 20-41 GeneOrGeneProduct denotes serotonin transporter
T2 180-185 GeneOrGeneProduct denotes brain
T3 197-201 GeneOrGeneProduct denotes 5-HT
T4 243-249 GeneOrGeneProduct denotes little
T5 274-278 GeneOrGeneProduct denotes term
T6 308-312 GeneOrGeneProduct denotes 5-HT
T7 324-331 GeneOrGeneProduct denotes lesions
T8 354-358 GeneOrGeneProduct denotes 5-HT
T9 408-412 GeneOrGeneProduct denotes 5-HT
T10 413-425 GeneOrGeneProduct denotes transporters
T11 475-479 GeneOrGeneProduct denotes 5-HT
T12 585-589 GeneOrGeneProduct denotes 5-HT
T13 590-601 GeneOrGeneProduct denotes transporter
T14 624-632 GeneOrGeneProduct denotes 5-HTTLPR
T15 839-843 GeneOrGeneProduct denotes term
T16 892-900 GeneOrGeneProduct denotes 5-HTTLPR
T17 1269-1277 GeneOrGeneProduct denotes 5-HTTLPR
T18 1293-1303 GeneOrGeneProduct denotes polymerase
T19 1304-1309 GeneOrGeneProduct denotes chain
T20 1687-1695 GeneOrGeneProduct denotes 5-HTTLPR
T21 1922-1930 GeneOrGeneProduct denotes 5-HTTLPR

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 20-41 GeneOrGeneProduct denotes serotonin transporter
T2 173-179 GeneOrGeneProduct denotes damage
T3 180-185 GeneOrGeneProduct denotes brain
T4 197-201 GeneOrGeneProduct denotes 5-HT
T5 243-249 GeneOrGeneProduct denotes little
T6 269-273 GeneOrGeneProduct denotes long
T7 274-278 GeneOrGeneProduct denotes term
T8 300-307 GeneOrGeneProduct denotes induced
T9 308-312 GeneOrGeneProduct denotes 5-HT
T10 324-331 GeneOrGeneProduct denotes lesions
T11 354-358 GeneOrGeneProduct denotes 5-HT
T12 408-412 GeneOrGeneProduct denotes 5-HT
T13 413-425 GeneOrGeneProduct denotes transporters
T14 452-462 GeneOrGeneProduct denotes regulation
T15 475-479 GeneOrGeneProduct denotes 5-HT
T16 585-589 GeneOrGeneProduct denotes 5-HT
T17 590-601 GeneOrGeneProduct denotes transporter
T18 624-632 GeneOrGeneProduct denotes 5-HTTLPR
T19 834-838 GeneOrGeneProduct denotes long
T20 839-843 GeneOrGeneProduct denotes term
T21 892-900 GeneOrGeneProduct denotes 5-HTTLPR
T22 935-944 GeneOrGeneProduct denotes determine
T23 990-995 GeneOrGeneProduct denotes males
T24 1113-1117 GeneOrGeneProduct denotes last
T25 1129-1133 GeneOrGeneProduct denotes year
T26 1204-1209 GeneOrGeneProduct denotes tests
T27 1245-1250 GeneOrGeneProduct denotes cells
T28 1269-1277 GeneOrGeneProduct denotes 5-HTTLPR
T29 1293-1303 GeneOrGeneProduct denotes polymerase
T30 1304-1309 GeneOrGeneProduct denotes chain
T31 1391-1396 GeneOrGeneProduct denotes tasks
T32 1428-1433 GeneOrGeneProduct denotes times
T33 1558-1563 GeneOrGeneProduct denotes tasks
T34 1582-1590 GeneOrGeneProduct denotes contrast
T35 1687-1695 GeneOrGeneProduct denotes 5-HTTLPR
T36 1876-1880 GeneOrGeneProduct denotes long
T37 1881-1888 GeneOrGeneProduct denotes lasting
T38 1922-1930 GeneOrGeneProduct denotes 5-HTTLPR

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 313-323 DiseaseOrPhenotypicFeature denotes neurotoxic DISEASE
T2 1607-1624 DiseaseOrPhenotypicFeature denotes memory impairment DISEASE
T3 1889-1907 DiseaseOrPhenotypicFeature denotes memory impairments DISEASE

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 20-41 GeneOrGeneProduct denotes serotonin transporter
T2 408-425 GeneOrGeneProduct denotes 5-HT transporters
T3 585-601 GeneOrGeneProduct denotes 5-HT transporter
T4 624-632 GeneOrGeneProduct denotes 5-HTTLPR
T5 892-900 GeneOrGeneProduct denotes 5-HTTLPR
T6 1269-1277 GeneOrGeneProduct denotes 5-HTTLPR
T7 1687-1695 GeneOrGeneProduct denotes 5-HTTLPR
T8 1922-1930 GeneOrGeneProduct denotes 5-HTTLPR

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 199-201 DiseaseOrPhenotypicFeature denotes HT 0007699
T2 310-312 DiseaseOrPhenotypicFeature denotes HT 0007699
T3 356-358 DiseaseOrPhenotypicFeature denotes HT 0007699
T4 410-412 DiseaseOrPhenotypicFeature denotes HT 0007699
T5 477-479 DiseaseOrPhenotypicFeature denotes HT 0007699
T6 587-589 DiseaseOrPhenotypicFeature denotes HT 0007699

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 313-331 DiseaseOrPhenotypicFeature denotes neurotoxic lesions DISEASE
T2 1607-1624 DiseaseOrPhenotypicFeature denotes memory impairment DISEASE
T3 1813-1840 DiseaseOrPhenotypicFeature denotes impaired memory functioning DISEASE
T4 1889-1907 DiseaseOrPhenotypicFeature denotes memory impairments DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 313-331 DiseaseOrPhenotypicFeature denotes neurotoxic lesions DISEASE
T2 1607-1624 DiseaseOrPhenotypicFeature denotes memory impairment DISEASE
T3 1813-1840 DiseaseOrPhenotypicFeature denotes impaired memory functioning DISEASE
T4 1889-1907 DiseaseOrPhenotypicFeature denotes memory impairments DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 20-29 ChemicalEntity denotes serotonin D012701|http://purl.obolibrary.org/obo/CHEBI_350546|http://purl.obolibrary.org/obo/CHEBI_28790
T4 72-79 ChemicalEntity denotes ecstasy http://purl.obolibrary.org/obo/CHEBI_1391
T5 81-85 ChemicalEntity denotes MDMA D018817|http://purl.obolibrary.org/obo/CHEBI_1391
T7 103-136 ChemicalEntity denotes 3,4-methylenedioxymethamphetamine http://purl.obolibrary.org/obo/CHEBI_1391
T8 138-142 ChemicalEntity denotes MDMA D018817|http://purl.obolibrary.org/obo/CHEBI_1391
T10 146-153 ChemicalEntity denotes ecstasy http://purl.obolibrary.org/obo/CHEBI_1391
T11 186-195 ChemicalEntity denotes serotonin D012701|http://purl.obolibrary.org/obo/CHEBI_350546|http://purl.obolibrary.org/obo/CHEBI_28790
T14 197-201 ChemicalEntity denotes 5-HT D012701|http://purl.obolibrary.org/obo/CHEBI_28790
T16 295-299 ChemicalEntity denotes MDMA D018817|http://purl.obolibrary.org/obo/CHEBI_1391
T18 308-312 ChemicalEntity denotes 5-HT D012701|http://purl.obolibrary.org/obo/CHEBI_28790
T20 354-358 ChemicalEntity denotes 5-HT D012701|http://purl.obolibrary.org/obo/CHEBI_28790
T22 408-412 ChemicalEntity denotes 5-HT D012701|http://purl.obolibrary.org/obo/CHEBI_28790
T24 475-479 ChemicalEntity denotes 5-HT D012701|http://purl.obolibrary.org/obo/CHEBI_28790
T26 585-589 ChemicalEntity denotes 5-HT D012701|http://purl.obolibrary.org/obo/CHEBI_28790
T28 663-667 ChemicalEntity denotes MDMA D018817|http://purl.obolibrary.org/obo/CHEBI_1391
T30 776-780 ChemicalEntity denotes MDMA D018817|http://purl.obolibrary.org/obo/CHEBI_1391
T32 860-864 ChemicalEntity denotes MDMA D018817|http://purl.obolibrary.org/obo/CHEBI_1391
T34 1014-1018 ChemicalEntity denotes MDMA D018817|http://purl.obolibrary.org/obo/CHEBI_1391
T36 1039-1046 ChemicalEntity denotes tablets D013607
T37 1058-1062 ChemicalEntity denotes MDMA D018817|http://purl.obolibrary.org/obo/CHEBI_1391
T39 1084-1091 ChemicalEntity denotes tablets D013607
T40 1100-1104 ChemicalEntity denotes MDMA D018817|http://purl.obolibrary.org/obo/CHEBI_1391
T42 1118-1124 ChemicalEntity denotes tablet D013607
T43 1505-1509 ChemicalEntity denotes MDMA D018817|http://purl.obolibrary.org/obo/CHEBI_1391
T45 1650-1654 ChemicalEntity denotes MDMA D018817|http://purl.obolibrary.org/obo/CHEBI_1391
T47 1737-1741 ChemicalEntity denotes MDMA D018817|http://purl.obolibrary.org/obo/CHEBI_1391
T49 1855-1859 ChemicalEntity denotes MDMA D018817|http://purl.obolibrary.org/obo/CHEBI_1391
T51 1868-1872 ChemicalEntity denotes lead D007854
T52 1963-1967 ChemicalEntity denotes MDMA D018817|http://purl.obolibrary.org/obo/CHEBI_1391

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 235-241 OrganismTaxon denotes humans

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T52 1963-1967 ChemicalEntity denotes MDMA http://purl.obolibrary.org/obo/CHEBI_1391|D018817
T51 1868-1872 ChemicalEntity denotes lead D007854
T49 1855-1859 ChemicalEntity denotes MDMA http://purl.obolibrary.org/obo/CHEBI_1391|D018817
T47 1737-1741 ChemicalEntity denotes MDMA http://purl.obolibrary.org/obo/CHEBI_1391|D018817
T45 1650-1654 ChemicalEntity denotes MDMA http://purl.obolibrary.org/obo/CHEBI_1391|D018817
T43 1505-1509 ChemicalEntity denotes MDMA http://purl.obolibrary.org/obo/CHEBI_1391|D018817
T42 1118-1124 ChemicalEntity denotes tablet D013607
T40 1100-1104 ChemicalEntity denotes MDMA http://purl.obolibrary.org/obo/CHEBI_1391|D018817
T39 1084-1091 ChemicalEntity denotes tablets D013607
T37 1058-1062 ChemicalEntity denotes MDMA http://purl.obolibrary.org/obo/CHEBI_1391|D018817
T36 1039-1046 ChemicalEntity denotes tablets D013607
T34 1014-1018 ChemicalEntity denotes MDMA http://purl.obolibrary.org/obo/CHEBI_1391|D018817
T32 860-864 ChemicalEntity denotes MDMA http://purl.obolibrary.org/obo/CHEBI_1391|D018817
T30 776-780 ChemicalEntity denotes MDMA http://purl.obolibrary.org/obo/CHEBI_1391|D018817
T28 663-667 ChemicalEntity denotes MDMA http://purl.obolibrary.org/obo/CHEBI_1391|D018817
T26 585-589 ChemicalEntity denotes 5-HT http://purl.obolibrary.org/obo/CHEBI_28790|D012701
T24 475-479 ChemicalEntity denotes 5-HT http://purl.obolibrary.org/obo/CHEBI_28790|D012701
T22 408-412 ChemicalEntity denotes 5-HT http://purl.obolibrary.org/obo/CHEBI_28790|D012701
T20 354-358 ChemicalEntity denotes 5-HT http://purl.obolibrary.org/obo/CHEBI_28790|D012701
T18 308-312 ChemicalEntity denotes 5-HT http://purl.obolibrary.org/obo/CHEBI_28790|D012701
T16 295-299 ChemicalEntity denotes MDMA http://purl.obolibrary.org/obo/CHEBI_1391|D018817
T14 197-201 ChemicalEntity denotes 5-HT http://purl.obolibrary.org/obo/CHEBI_28790|D012701
T11 186-195 ChemicalEntity denotes serotonin http://purl.obolibrary.org/obo/CHEBI_28790|http://purl.obolibrary.org/obo/CHEBI_350546|D012701
T10 146-153 ChemicalEntity denotes ecstasy http://purl.obolibrary.org/obo/CHEBI_1391
T8 138-142 ChemicalEntity denotes MDMA http://purl.obolibrary.org/obo/CHEBI_1391|D018817
T7 103-136 ChemicalEntity denotes 3,4-methylenedioxymethamphetamine http://purl.obolibrary.org/obo/CHEBI_1391
T5 81-85 ChemicalEntity denotes MDMA http://purl.obolibrary.org/obo/CHEBI_1391|D018817
T4 72-79 ChemicalEntity denotes ecstasy http://purl.obolibrary.org/obo/CHEBI_1391
T1 20-29 ChemicalEntity denotes serotonin http://purl.obolibrary.org/obo/CHEBI_28790|http://purl.obolibrary.org/obo/CHEBI_350546|D012701
T76950 1922-1930 GeneOrGeneProduct denotes 5-HTTLPR
T5705 1687-1695 GeneOrGeneProduct denotes 5-HTTLPR
T6 1269-1277 GeneOrGeneProduct denotes 5-HTTLPR
T68270 892-900 GeneOrGeneProduct denotes 5-HTTLPR
T84226 624-632 GeneOrGeneProduct denotes 5-HTTLPR
T3 585-601 GeneOrGeneProduct denotes 5-HT transporter
T2 408-425 GeneOrGeneProduct denotes 5-HT transporters
T80943 20-41 GeneOrGeneProduct denotes serotonin transporter
T84992 1889-1907 DiseaseOrPhenotypicFeature denotes memory impairments DISEASE
T27275 1813-1840 DiseaseOrPhenotypicFeature denotes impaired memory functioning DISEASE
T55621 1607-1624 DiseaseOrPhenotypicFeature denotes memory impairment DISEASE
T10139 313-331 DiseaseOrPhenotypicFeature denotes neurotoxic lesions DISEASE
T98606 235-241 OrganismTaxon denotes humans

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1607-1624 HP_0002354 denotes memory impairment
T2 1813-1828 HP_0002354 denotes impaired memory
T3 1889-1907 HP_0002354 denotes memory impairments