PubMed:16567809
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 491-498 | Glycan_Motif | denotes | mannose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ |
| T2 | 1212-1219 | Glycan_Motif | denotes | mannose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 491-498 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | mannose |
| T2 | 1212-1219 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | mannose |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-76 | Sentence | denotes | Polymorphisms in human langerin affect stability and sugar binding activity. |
| T2 | 77-203 | Sentence | denotes | Langerhans cells are specialized skin dendritic cells that take up and degrade antigens for presentation to the immune system. |
| T3 | 204-409 | Sentence | denotes | Langerin, a cell surface C-type lectin of Langerhans cells, can be internalized and accumulates in Birbeck granules, subdomains of the endosomal recycling compartment that are specific to Langerhans cells. |
| T4 | 410-518 | Sentence | denotes | Langerin binds and mediates uptake and degradation of glycoconjugates containing mannose and related sugars. |
| T5 | 519-686 | Sentence | denotes | Analysis of the human genome has identified three single nucleotide polymorphisms that result in amino acid changes in the carbohydrate-recognition domain of langerin. |
| T6 | 687-811 | Sentence | denotes | The effects of the amino acid changes on the activity of langerin were examined by expressing each of the polymorphic forms. |
| T7 | 812-985 | Sentence | denotes | Expression of full-length versions of the four common langerin haplotypes in fibroblasts revealed that all of these forms can mediate endocytosis of neoglycoprotein ligands. |
| T8 | 986-1275 | Sentence | denotes | However, sugar binding assays and differential scanning calorimetry performed on fragments from the extracellular domain showed that two of the amino acid changes reduce the affinity of the carbohydrate-recognition domain for mannose and decrease the stability of the extracellular domain. |
| T9 | 1276-1486 | Sentence | denotes | In addition, analysis of sugar binding by langerin containing the rare W264R mutation, previously identified in an individual lacking Birbeck granules, shows that this mutation abolishes sugar binding activity. |
| T10 | 1487-1646 | Sentence | denotes | These findings suggest that certain langerin haplotypes may differ in their binding to pathogens and thus might be associated with susceptibility to infection. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 110-114 | http://purl.obolibrary.org/obo/MAT_0000284 | denotes | skin |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1618-1645 | HP_0002719 | denotes | susceptibility to infection |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1636-1645 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 110-114 | Body_part | denotes | skin | http://purl.obolibrary.org/obo/MAT_0000284 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 1618-1645 | Phenotype | denotes | susceptibility to infection | HP:0002719 |
Lectin-Jamboree-Sentence
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-76 | Sentence | denotes | Polymorphisms in human langerin affect stability and sugar binding activity. |
| T2 | 77-203 | Sentence | denotes | Langerhans cells are specialized skin dendritic cells that take up and degrade antigens for presentation to the immune system. |
| T3 | 204-409 | Sentence | denotes | Langerin, a cell surface C-type lectin of Langerhans cells, can be internalized and accumulates in Birbeck granules, subdomains of the endosomal recycling compartment that are specific to Langerhans cells. |
| T4 | 410-518 | Sentence | denotes | Langerin binds and mediates uptake and degradation of glycoconjugates containing mannose and related sugars. |
| T5 | 519-686 | Sentence | denotes | Analysis of the human genome has identified three single nucleotide polymorphisms that result in amino acid changes in the carbohydrate-recognition domain of langerin. |
| T6 | 687-811 | Sentence | denotes | The effects of the amino acid changes on the activity of langerin were examined by expressing each of the polymorphic forms. |
| T7 | 812-985 | Sentence | denotes | Expression of full-length versions of the four common langerin haplotypes in fibroblasts revealed that all of these forms can mediate endocytosis of neoglycoprotein ligands. |
| T8 | 986-1275 | Sentence | denotes | However, sugar binding assays and differential scanning calorimetry performed on fragments from the extracellular domain showed that two of the amino acid changes reduce the affinity of the carbohydrate-recognition domain for mannose and decrease the stability of the extracellular domain. |
| T9 | 1276-1486 | Sentence | denotes | In addition, analysis of sugar binding by langerin containing the rare W264R mutation, previously identified in an individual lacking Birbeck granules, shows that this mutation abolishes sugar binding activity. |
| T10 | 1487-1646 | Sentence | denotes | These findings suggest that certain langerin haplotypes may differ in their binding to pathogens and thus might be associated with susceptibility to infection. |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 17-22 | OrganismTaxon | denotes | human | 9606 |
| T2 | 535-540 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 77-93 | Body_part | denotes | Langerhans cells | http://purl.obolibrary.org/obo/CL_0000453 |
| T2 | 110-114 | Body_part | denotes | skin | http://purl.obolibrary.org/obo/UBERON_0000014|http://purl.obolibrary.org/obo/UBERON_0001003|http://purl.obolibrary.org/obo/UBERON_0002097|http://purl.obolibrary.org/obo/UBERON_0002199 |
| T6 | 115-130 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T7 | 189-202 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
| T8 | 246-262 | Body_part | denotes | Langerhans cells | http://purl.obolibrary.org/obo/CL_0000453 |
| T9 | 392-408 | Body_part | denotes | Langerhans cells | http://purl.obolibrary.org/obo/CL_0000453 |
| T10 | 889-900 | Body_part | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL_0000057 |
| T11 | 1086-1099 | Body_part | denotes | extracellular | http://purl.obolibrary.org/obo/GO_0005576 |
| T12 | 1254-1267 | Body_part | denotes | extracellular | http://purl.obolibrary.org/obo/GO_0005576 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 77-93 | Cell | denotes | Langerhans cells | http://purl.obolibrary.org/obo/CL:0000453 |
| T2 | 115-130 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T4 | 246-262 | Cell | denotes | Langerhans cells | http://purl.obolibrary.org/obo/CL:0000453 |
| T5 | 392-408 | Cell | denotes | Langerhans cells | http://purl.obolibrary.org/obo/CL:0000453 |
| T6 | 889-900 | Cell | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL:0000057 |