PubMed:1650477 JSONTXT

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":111,"end":127},"obj":"HP_0002721"}],"text":"Enhancement of human immunodeficiency virus 1 replication in monocytes by 1,25-dihydroxycholecalciferol.\nHuman immunodeficiency virus (HIV) expression and replication are under tight regulatory control. We demonstrate that 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] enhances the replication of monocyte- and lymphocyte-tropic strains of HIV-1 up to 10,000-fold in monocyte cell lines, peripheral blood monocytes, and unfractionated peripheral blood mononuclear cells. 1,25(OH)2D3 is therefore one of the most potent regulators of HIV-1 replication described to date. Precursors of 1,25(OH)2D3 enhance HIV-1 replication in proportion to their affinity for the 1,25(OH)2D3 intracellular receptor, suggesting that 1,25(OH)2D3 influences HIV-1 replication by mechanisms involving this receptor. These studies may have important implications for the design of effective therapy of HIV-1 infection."}

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":61,"end":70},"obj":"cell_type"},{"id":"T2","span":{"begin":366,"end":385},"obj":"cell_line"},{"id":"T3","span":{"begin":387,"end":413},"obj":"cell_type"},{"id":"T4","span":{"begin":419,"end":468},"obj":"cell_type"},{"id":"T5","span":{"begin":661,"end":695},"obj":"protein"}],"text":"Enhancement of human immunodeficiency virus 1 replication in monocytes by 1,25-dihydroxycholecalciferol.\nHuman immunodeficiency virus (HIV) expression and replication are under tight regulatory control. We demonstrate that 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] enhances the replication of monocyte- and lymphocyte-tropic strains of HIV-1 up to 10,000-fold in monocyte cell lines, peripheral blood monocytes, and unfractionated peripheral blood mononuclear cells. 1,25(OH)2D3 is therefore one of the most potent regulators of HIV-1 replication described to date. Precursors of 1,25(OH)2D3 enhance HIV-1 replication in proportion to their affinity for the 1,25(OH)2D3 intracellular receptor, suggesting that 1,25(OH)2D3 influences HIV-1 replication by mechanisms involving this receptor. These studies may have important implications for the design of effective therapy of HIV-1 infection."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":104},"obj":"Sentence"},{"id":"S2","span":{"begin":105,"end":202},"obj":"Sentence"},{"id":"S3","span":{"begin":203,"end":469},"obj":"Sentence"},{"id":"S4","span":{"begin":470,"end":568},"obj":"Sentence"},{"id":"S5","span":{"begin":569,"end":792},"obj":"Sentence"},{"id":"S6","span":{"begin":793,"end":894},"obj":"Sentence"}],"text":"Enhancement of human immunodeficiency virus 1 replication in monocytes by 1,25-dihydroxycholecalciferol.\nHuman immunodeficiency virus (HIV) expression and replication are under tight regulatory control. We demonstrate that 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] enhances the replication of monocyte- and lymphocyte-tropic strains of HIV-1 up to 10,000-fold in monocyte cell lines, peripheral blood monocytes, and unfractionated peripheral blood mononuclear cells. 1,25(OH)2D3 is therefore one of the most potent regulators of HIV-1 replication described to date. Precursors of 1,25(OH)2D3 enhance HIV-1 replication in proportion to their affinity for the 1,25(OH)2D3 intracellular receptor, suggesting that 1,25(OH)2D3 influences HIV-1 replication by mechanisms involving this receptor. These studies may have important implications for the design of effective therapy of HIV-1 infection."}

{"project":"genia-medco-coref","denotations":[{"id":"C2","span":{"begin":15,"end":45},"obj":"NP"},{"id":"C1","span":{"begin":15,"end":57},"obj":"NP"},{"id":"C3","span":{"begin":74,"end":103},"obj":"NP"},{"id":"C4","span":{"begin":223,"end":267},"obj":"NP"},{"id":"C5","span":{"begin":339,"end":344},"obj":"NP"},{"id":"C6","span":{"begin":470,"end":481},"obj":"NP"},{"id":"C7","span":{"begin":583,"end":594},"obj":"NP"},{"id":"C9","span":{"begin":603,"end":608},"obj":"NP"},{"id":"C8","span":{"begin":603,"end":620},"obj":"NP"},{"id":"C10","span":{"begin":638,"end":643},"obj":"NP"},{"id":"C12","span":{"begin":661,"end":672},"obj":"NP"},{"id":"C11","span":{"begin":657,"end":695},"obj":"NP"},{"id":"C13","span":{"begin":713,"end":724},"obj":"NP"},{"id":"C15","span":{"begin":736,"end":741},"obj":"NP"},{"id":"C14","span":{"begin":736,"end":753},"obj":"NP"},{"id":"C16","span":{"begin":778,"end":791},"obj":"NP"},{"id":"C17","span":{"begin":878,"end":883},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C4","obj":"C3"},{"id":"R2","pred":"coref-ident","subj":"C5","obj":"C2"},{"id":"R3","pred":"coref-ident","subj":"C6","obj":"C4"},{"id":"R4","pred":"coref-ident","subj":"C7","obj":"C6"},{"id":"R5","pred":"coref-ident","subj":"C9","obj":"C5"},{"id":"R6","pred":"coref-ident","subj":"C8","obj":"C1"},{"id":"R7","pred":"coref-pron","subj":"C10","obj":"C8"},{"id":"R8","pred":"coref-ident","subj":"C12","obj":"C7"},{"id":"R9","pred":"coref-ident","subj":"C13","obj":"C12"},{"id":"R10","pred":"coref-ident","subj":"C15","obj":"C9"},{"id":"R11","pred":"coref-ident","subj":"C14","obj":"C8"},{"id":"R12","pred":"coref-ident","subj":"C16","obj":"C11"},{"id":"R13","pred":"coref-ident","subj":"C17","obj":"C15"}],"text":"Enhancement of human immunodeficiency virus 1 replication in monocytes by 1,25-dihydroxycholecalciferol.\nHuman immunodeficiency virus (HIV) expression and replication are under tight regulatory control. We demonstrate that 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] enhances the replication of monocyte- and lymphocyte-tropic strains of HIV-1 up to 10,000-fold in monocyte cell lines, peripheral blood monocytes, and unfractionated peripheral blood mononuclear cells. 1,25(OH)2D3 is therefore one of the most potent regulators of HIV-1 replication described to date. Precursors of 1,25(OH)2D3 enhance HIV-1 replication in proportion to their affinity for the 1,25(OH)2D3 intracellular receptor, suggesting that 1,25(OH)2D3 influences HIV-1 replication by mechanisms involving this receptor. These studies may have important implications for the design of effective therapy of HIV-1 infection."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":15,"end":45},"obj":"virus"},{"id":"T2","span":{"begin":61,"end":70},"obj":"cell_type"},{"id":"T3","span":{"begin":74,"end":103},"obj":"lipid"},{"id":"T4","span":{"begin":105,"end":133},"obj":"virus"},{"id":"T5","span":{"begin":135,"end":138},"obj":"virus"},{"id":"T6","span":{"begin":155,"end":166},"obj":"other_name"},{"id":"T7","span":{"begin":223,"end":252},"obj":"lipid"},{"id":"T8","span":{"begin":254,"end":266},"obj":"lipid"},{"id":"T9","span":{"begin":339,"end":344},"obj":"virus"},{"id":"T10","span":{"begin":366,"end":385},"obj":"cell_line"},{"id":"T11","span":{"begin":387,"end":413},"obj":"cell_type"},{"id":"T12","span":{"begin":419,"end":468},"obj":"cell_type"},{"id":"T13","span":{"begin":470,"end":481},"obj":"lipid"},{"id":"T14","span":{"begin":532,"end":537},"obj":"virus"},{"id":"T15","span":{"begin":583,"end":594},"obj":"lipid"},{"id":"T16","span":{"begin":603,"end":608},"obj":"virus"},{"id":"T17","span":{"begin":661,"end":672},"obj":"lipid"},{"id":"T18","span":{"begin":713,"end":724},"obj":"lipid"},{"id":"T19","span":{"begin":736,"end":741},"obj":"virus"},{"id":"T20","span":{"begin":878,"end":883},"obj":"virus"}],"text":"Enhancement of human immunodeficiency virus 1 replication in monocytes by 1,25-dihydroxycholecalciferol.\nHuman immunodeficiency virus (HIV) expression and replication are under tight regulatory control. We demonstrate that 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] enhances the replication of monocyte- and lymphocyte-tropic strains of HIV-1 up to 10,000-fold in monocyte cell lines, peripheral blood monocytes, and unfractionated peripheral blood mononuclear cells. 1,25(OH)2D3 is therefore one of the most potent regulators of HIV-1 replication described to date. Precursors of 1,25(OH)2D3 enhance HIV-1 replication in proportion to their affinity for the 1,25(OH)2D3 intracellular receptor, suggesting that 1,25(OH)2D3 influences HIV-1 replication by mechanisms involving this receptor. These studies may have important implications for the design of effective therapy of HIV-1 infection."}