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UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-98 DRI_Approach denotes Preferential expression of matrix metalloproteinase-9 in mouse skin after sulfur mustard exposure.
T2 99-276 DRI_Approach denotes Matrix metalloproteinases (MMPs), a class of enzymes responsible for the degradation of extracellular matrix proteins, play important roles in inflammatory and immune responses.
T3 277-396 DRI_Background denotes In skin, MMP-2 (gelatinase A) and MMP-9 (gelatinase B) are normally inactive but can be expressed during tissue injury.
T4 397-527 DRI_Approach denotes Both degrade collagen IV and other critical components of the basement membrane zone that separates the epidermis from the dermis.
T5 528-671 DRI_Background denotes The expression of MMP-2 and -9 was studied in sulfur mustard (SM)-exposed ear skin from mice to determine their role in tissue vesicant injury.
T6 672-797 DRI_Background denotes Punch biopsies of mouse ears were collected between 6 and 168 h after exposure to 97.5 mM (0.08 mg) SM diluted in CH(2)Cl(2).
T7 798-987 DRI_Background denotes They were examined histologically and assayed for MMP-2 and -9 expression by gelatinase activity assays, real-time reverse transcriptase-polymerase chain reaction and Western blot analysis.
T8 988-1075 DRI_Outcome denotes A time-related increase in overall gelatinase activity was observed in SM-treated ears.
T9 1076-1243 DRI_Approach denotes At 168 h after SM exposure, the relative levels of MMP-9 mRNA were increased 27-fold and MMP-9 protein 9-fold when compared with the control (CH(2)Cl(2) treated) ears.
T10 1244-1361 DRI_Background denotes In contrast, there were no observable increases in the MMP-2 mRNA or protein levels between treated and control ears.
T11 1362-1526 DRI_Approach denotes These observations suggest the differential expression of MMP-2 and -9 during the cutaneous response to SM injury and suggest a role for MMP-9 in SM-induced injury.

c_corpus

Id Subject Object Predicate Lexical cue
T1 27-33 UBERON:0027368 denotes matrix
T3 27-53 P14780 denotes matrix metalloproteinase-9
T4 27-53 P41246 denotes matrix metalloproteinase-9
T5 27-53 P41245 denotes matrix metalloproteinase-9
T6 27-53 P50282 denotes matrix metalloproteinase-9
T7 27-53 PR:000010491 denotes matrix metalloproteinase-9
T8 27-53 P52176 denotes matrix metalloproteinase-9
T9 27-53 O18733 denotes matrix metalloproteinase-9
T2 27-53 D020780 denotes matrix metalloproteinase-9
T10 57-62 10090 denotes mouse
T11 57-62 D051379 denotes mouse
T12 63-67 UBERON:0002199 denotes skin
T13 63-67 UBERON:0000014 denotes skin
T14 63-67 UBERON:0001003 denotes skin
T15 63-67 UBERON:0002097 denotes skin
T18 74-80 10223 denotes sulfur
T21 74-88 D009151 denotes sulfur mustard
T22 74-88 CHEBI:25434 denotes sulfur mustard
T23 74-88 D009151 denotes sulfur mustard
T24 81-88 D009149 denotes mustard
T25 106-124 D045726 denotes metalloproteinases
T26 126-130 D020782 denotes MMPs
T27 172-183 GO:0009056 denotes degradation
T29 187-207 GO:0031012 denotes extracellular matrix
T30 187-216 D016326 denotes extracellular matrix proteins
T31 201-207 UBERON:0027368 denotes matrix
T33 280-284 UBERON:0002199 denotes skin
T34 280-284 UBERON:0000014 denotes skin
T35 280-284 UBERON:0001003 denotes skin
T36 280-284 UBERON:0002097 denotes skin
T37 286-289 CHEBI:340824 denotes MMP
T40 286-289 CHEBI:59761 denotes MMP
T41 286-291 PR:P08253 denotes MMP-2
T42 286-291 Q9GLE5 denotes MMP-2
T43 286-291 P08253 denotes MMP-2
T44 286-291 Q90611 denotes MMP-2
T46 286-291 PR:Q8MPP3 denotes MMP-2
T47 286-291 P33436 denotes MMP-2
T48 286-291 PR:Q90611 denotes MMP-2
T49 286-291 PR:P33436 denotes MMP-2
T50 286-291 PR:000010479 denotes MMP-2
T51 286-291 PR:P33434 denotes MMP-2
T52 286-291 P33434 denotes MMP-2
T53 286-291 P50757 denotes MMP-2
T45 286-291 GO:0004228 denotes MMP-2
T56 293-305 P08253 denotes gelatinase A
T57 293-305 Q90611 denotes gelatinase A
T59 293-305 PR:000010479 denotes gelatinase A
T60 293-305 P33436 denotes gelatinase A
T61 293-305 P33434 denotes gelatinase A
T62 293-305 P50757 denotes gelatinase A
T58 293-305 D020778 denotes gelatinase A
T63 311-314 CHEBI:340824 denotes MMP
T66 311-314 CHEBI:59761 denotes MMP
T67 311-316 PR:P50282 denotes MMP-9
T68 311-316 PR:P14780 denotes MMP-9
T69 311-316 P14780 denotes MMP-9
T70 311-316 PR:P41245 denotes MMP-9
T71 311-316 P41246 denotes MMP-9
T72 311-316 P41245 denotes MMP-9
T73 311-316 PR:P52176 denotes MMP-9
T74 311-316 P50282 denotes MMP-9
T76 311-316 PR:000010491 denotes MMP-9
T77 311-316 P52176 denotes MMP-9
T78 311-316 O18733 denotes MMP-9
T75 311-316 GO:0004229 denotes MMP-9
T82 318-330 P14780 denotes gelatinase B
T83 318-330 P41246 denotes gelatinase B
T84 318-330 P41245 denotes gelatinase B
T85 318-330 P50282 denotes gelatinase B
T86 318-330 PR:000010491 denotes gelatinase B
T87 318-330 P52176 denotes gelatinase B
T88 318-330 O18733 denotes gelatinase B
T81 318-330 D020780 denotes gelatinase B
T89 382-388 UBERON:0000479 denotes tissue
T91 410-418 2714 denotes collagen
T92 410-418 D003094 denotes collagen
T93 410-418 CHEBI:3815 denotes collagen
T90 410-418 GO:0005202 denotes collagen
T94 459-476 GO:0005604 denotes basement membrane
T95 459-476 UBERON:0005769 denotes basement membrane
T99 501-510 UBERON:0001003 denotes epidermis
T100 501-510 UBERON:0007376 denotes epidermis
T101 520-526 UBERON:0002067 denotes dermis
T102 546-549 CHEBI:340824 denotes MMP
T105 546-549 CHEBI:59761 denotes MMP
T106 546-551 PR:P08253 denotes MMP-2
T107 546-551 Q9GLE5 denotes MMP-2
T108 546-551 P08253 denotes MMP-2
T109 546-551 Q90611 denotes MMP-2
T111 546-551 PR:Q8MPP3 denotes MMP-2
T112 546-551 P33436 denotes MMP-2
T113 546-551 PR:Q90611 denotes MMP-2
T114 546-551 PR:P33436 denotes MMP-2
T115 546-551 PR:000010479 denotes MMP-2
T116 546-551 PR:P33434 denotes MMP-2
T117 546-551 P33434 denotes MMP-2
T118 546-551 P50757 denotes MMP-2
T110 546-551 GO:0004228 denotes MMP-2
T121 574-580 10223 denotes sulfur
T124 574-588 D009151 denotes sulfur mustard
T125 574-588 CHEBI:25434 denotes sulfur mustard
T126 574-588 D009151 denotes sulfur mustard
T127 581-588 D009149 denotes mustard
T129 602-610 UBERON:0001459 denotes ear skin
T134 616-620 PR:000005054 denotes mice
T136 616-620 O89094 denotes mice
T135 616-620 D051379 denotes mice
T137 616-620 10095 denotes mice
T138 648-654 UBERON:0000479 denotes tissue
T139 655-663 CHEBI:78592 denotes vesicant
T140 690-695 10090 denotes mouse
T141 690-695 D051379 denotes mouse
T142 786-790 CHEBI:29361 denotes CH(2
T143 786-790 CHEBI:50728 denotes CH(2
T144 786-790 CHEBI:29358 denotes CH(2
T146 791-795 PR:Q2LK94 denotes Cl(2
T147 791-795 Q5MPA9 denotes Cl(2
T149 791-795 Q1I2R4 denotes Cl(2
T150 791-795 Q3K4G4 denotes Cl(2
T151 791-795 PR:000006311 denotes Cl(2
T152 791-795 PR:O88923 denotes Cl(2
T153 791-795 Q3JUM4 denotes Cl(2
T155 791-795 Q8N568 denotes Cl(2
T156 791-795 D2I3C6 denotes Cl(2
T157 791-795 Q6PGN3 denotes Cl(2
T159 791-795 Q2LK94 denotes Cl(2
T148 791-795 CHEBI:29310 denotes Cl(2
T154 791-795 CHEBI:29413 denotes Cl(2
T158 791-795 CHEBI:29419 denotes Cl(2
T145 791-795 CVCL_RK71 denotes Cl(2
T160 848-851 CHEBI:340824 denotes MMP
T163 848-851 CHEBI:59761 denotes MMP
T164 848-853 PR:P08253 denotes MMP-2
T165 848-853 Q9GLE5 denotes MMP-2
T166 848-853 P08253 denotes MMP-2
T167 848-853 Q90611 denotes MMP-2
T169 848-853 PR:Q8MPP3 denotes MMP-2
T170 848-853 P33436 denotes MMP-2
T171 848-853 PR:Q90611 denotes MMP-2
T172 848-853 PR:P33436 denotes MMP-2
T173 848-853 PR:000010479 denotes MMP-2
T174 848-853 PR:P33434 denotes MMP-2
T175 848-853 P33434 denotes MMP-2
T176 848-853 P50757 denotes MMP-2
T168 848-853 GO:0004228 denotes MMP-2
T178 875-885 Q833V7 denotes gelatinase
T177 875-885 D018093 denotes gelatinase
T179 913-920 SO:0001031 denotes reverse
T180 913-934 P23072 denotes reverse transcriptase
T181 913-934 P21329 denotes reverse transcriptase
T182 913-934 P23071 denotes reverse transcriptase
T183 913-934 P21328 denotes reverse transcriptase
T185 913-934 P23070 denotes reverse transcriptase
T186 913-934 Q9NBX4 denotes reverse transcriptase
T187 913-934 Q95SX7 denotes reverse transcriptase
T184 913-934 D012194 denotes reverse transcriptase
T193 921-934 GO:0003968 denotes transcriptase
T271 921-934 GO:0003899 denotes transcriptase
T295 921-934 GO:0034062 denotes transcriptase
T312 946-951 SO:0000419 denotes chain
T313 946-960 MOP:0000635 denotes chain reaction
T315 1023-1033 Q833V7 denotes gelatinase
T314 1023-1033 D018093 denotes gelatinase
T316 1127-1130 CHEBI:340824 denotes MMP
T319 1127-1130 CHEBI:59761 denotes MMP
T320 1127-1132 PR:P50282 denotes MMP-9
T321 1127-1132 PR:P14780 denotes MMP-9
T322 1127-1132 P14780 denotes MMP-9
T323 1127-1132 PR:P41245 denotes MMP-9
T324 1127-1132 P41246 denotes MMP-9
T325 1127-1132 P41245 denotes MMP-9
T326 1127-1132 PR:P52176 denotes MMP-9
T327 1127-1132 P50282 denotes MMP-9
T329 1127-1132 PR:000010491 denotes MMP-9
T330 1127-1132 P52176 denotes MMP-9
T331 1127-1132 O18733 denotes MMP-9
T328 1127-1132 GO:0004229 denotes MMP-9
T334 1133-1137 SO:0000234 denotes mRNA
T332 1133-1137 D012333 denotes mRNA
T333 1133-1137 CHEBI:33699 denotes mRNA
T335 1156-1160 PR:000022679 denotes fold
T336 1156-1160 PR:Q2FZJ6 denotes fold
T337 1156-1160 PR:A5I112 denotes fold
T338 1156-1160 PR:P24186 denotes fold
T339 1165-1168 CHEBI:340824 denotes MMP
T342 1165-1168 CHEBI:59761 denotes MMP
T343 1165-1170 PR:P50282 denotes MMP-9
T344 1165-1170 PR:P14780 denotes MMP-9
T345 1165-1170 P14780 denotes MMP-9
T346 1165-1170 PR:P41245 denotes MMP-9
T347 1165-1170 P41246 denotes MMP-9
T348 1165-1170 P41245 denotes MMP-9
T349 1165-1170 PR:P52176 denotes MMP-9
T350 1165-1170 P50282 denotes MMP-9
T352 1165-1170 PR:000010491 denotes MMP-9
T353 1165-1170 P52176 denotes MMP-9
T354 1165-1170 O18733 denotes MMP-9
T351 1165-1170 GO:0004229 denotes MMP-9
T359 1171-1178 SO:0000104 denotes protein
T356 1171-1178 CHEBI:36080 denotes protein
T357 1171-1178 CHEBI:11122 denotes protein
T355 1171-1178 GO:0003675 denotes protein
T360 1171-1180 P81124 denotes protein 9
T361 1181-1185 PR:000022679 denotes fold
T362 1181-1185 PR:Q2FZJ6 denotes fold
T363 1181-1185 PR:A5I112 denotes fold
T364 1181-1185 PR:P24186 denotes fold
T365 1218-1222 CHEBI:29361 denotes CH(2
T366 1218-1222 CHEBI:50728 denotes CH(2
T367 1218-1222 CHEBI:29358 denotes CH(2
T368 1223-1227 CVCL_RK71 denotes Cl(2
T369 1223-1227 PR:Q2LK94 denotes Cl(2
T370 1223-1227 Q5MPA9 denotes Cl(2
T372 1223-1227 Q1I2R4 denotes Cl(2
T373 1223-1227 Q3K4G4 denotes Cl(2
T374 1223-1227 PR:000006311 denotes Cl(2
T375 1223-1227 PR:O88923 denotes Cl(2
T376 1223-1227 Q3JUM4 denotes Cl(2
T378 1223-1227 Q8N568 denotes Cl(2
T379 1223-1227 D2I3C6 denotes Cl(2
T380 1223-1227 Q6PGN3 denotes Cl(2
T382 1223-1227 Q2LK94 denotes Cl(2
T371 1223-1227 CHEBI:29310 denotes Cl(2
T377 1223-1227 CHEBI:29413 denotes Cl(2
T381 1223-1227 CHEBI:29419 denotes Cl(2
T383 1299-1302 CHEBI:340824 denotes MMP
T386 1299-1302 CHEBI:59761 denotes MMP
T387 1299-1304 PR:P08253 denotes MMP-2
T388 1299-1304 Q9GLE5 denotes MMP-2
T389 1299-1304 P08253 denotes MMP-2
T390 1299-1304 Q90611 denotes MMP-2
T392 1299-1304 PR:Q8MPP3 denotes MMP-2
T393 1299-1304 P33436 denotes MMP-2
T394 1299-1304 PR:Q90611 denotes MMP-2
T395 1299-1304 PR:P33436 denotes MMP-2
T396 1299-1304 PR:000010479 denotes MMP-2
T397 1299-1304 PR:P33434 denotes MMP-2
T398 1299-1304 P33434 denotes MMP-2
T399 1299-1304 P50757 denotes MMP-2
T391 1299-1304 GO:0004228 denotes MMP-2
T402 1305-1309 SO:0000234 denotes mRNA
T400 1305-1309 D012333 denotes mRNA
T401 1305-1309 CHEBI:33699 denotes mRNA
T406 1313-1320 PR:000000001 denotes protein
T407 1313-1320 SO:0000104 denotes protein
T403 1313-1320 GO:0003675 denotes protein
T404 1313-1320 CHEBI:36080 denotes protein
T405 1313-1320 CHEBI:11122 denotes protein
T408 1420-1423 CHEBI:340824 denotes MMP
T411 1420-1423 CHEBI:59761 denotes MMP
T412 1420-1425 PR:P08253 denotes MMP-2
T413 1420-1425 Q9GLE5 denotes MMP-2
T414 1420-1425 P08253 denotes MMP-2
T415 1420-1425 Q90611 denotes MMP-2
T417 1420-1425 PR:Q8MPP3 denotes MMP-2
T418 1420-1425 P33436 denotes MMP-2
T419 1420-1425 PR:Q90611 denotes MMP-2
T420 1420-1425 PR:P33436 denotes MMP-2
T421 1420-1425 PR:000010479 denotes MMP-2
T422 1420-1425 PR:P33434 denotes MMP-2
T423 1420-1425 P33434 denotes MMP-2
T424 1420-1425 P50757 denotes MMP-2
T416 1420-1425 GO:0004228 denotes MMP-2
T425 1499-1502 CHEBI:340824 denotes MMP
T428 1499-1502 CHEBI:59761 denotes MMP
T429 1499-1504 PR:P50282 denotes MMP-9
T430 1499-1504 PR:P14780 denotes MMP-9
T431 1499-1504 P14780 denotes MMP-9
T432 1499-1504 PR:P41245 denotes MMP-9
T433 1499-1504 P41246 denotes MMP-9
T434 1499-1504 P41245 denotes MMP-9
T435 1499-1504 PR:P52176 denotes MMP-9
T436 1499-1504 P50282 denotes MMP-9
T438 1499-1504 PR:000010491 denotes MMP-9
T439 1499-1504 P52176 denotes MMP-9
T440 1499-1504 O18733 denotes MMP-9
T437 1499-1504 GO:0004229 denotes MMP-9