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c_corpus

Id Subject Object Predicate Lexical cue
T1 0-15 GO:0035822 denotes Gene conversion
T2 63-72 SO:0000817 denotes wild-type
T3 73-79 SO:0001023 denotes allele
T4 83-90 D009369 denotes cancers
T5 83-90 D009369 denotes cancers
T6 96-100 PR:Q9ZRV4 denotes MLH1
T7 96-100 PR:P38920 denotes MLH1
T8 96-100 PR:Q54KD8 denotes MLH1
T10 96-100 PR:Q9JK91 denotes MLH1
T11 96-100 PR:P97679 denotes MLH1
T12 96-100 PR:Q9P7W6 denotes MLH1
T13 96-100 PR:000010442 denotes MLH1
T14 96-100 PR:P40692 denotes MLH1
T9 96-100 CVCL_G669 denotes MLH1
T16 101-104 CHEBI:16768 denotes MSH
T20 101-104 D009074 denotes MSH
T21 101-104 D009074 denotes MSH
T22 101-105 PR:000010666 denotes MSH2
T23 101-105 PR:P25847 denotes MSH2
T24 101-105 PR:P43246 denotes MSH2
T25 101-105 P22711 denotes MSH2
T26 101-105 PR:P22711 denotes MSH2
T27 101-105 PR:P54275 denotes MSH2
T28 101-105 PR:O74773 denotes MSH2
T29 101-105 PR:P43247 denotes MSH2
T30 101-105 PR:Q553L4 denotes MSH2
T31 101-105 PR:O24617 denotes MSH2
T32 106-114 SO:0000159 denotes deletion
T33 115-123 CHEBI:78059 denotes carriers
T34 149-166 D015179 denotes colorectal cancer
T35 149-166 D015179 denotes colorectal cancer
T36 276-279 GO:0005574 denotes DNA
T38 276-279 SO:0000352 denotes DNA
T37 276-279 CHEBI:16991 denotes DNA
T39 276-279 D004247 denotes DNA
T40 280-295 GO:0006298 denotes mismatch repair
T41 317-321 PR:Q9ZRV4 denotes MLH1
T42 317-321 PR:P38920 denotes MLH1
T43 317-321 PR:Q54KD8 denotes MLH1
T45 317-321 PR:Q9JK91 denotes MLH1
T46 317-321 PR:P97679 denotes MLH1
T47 317-321 PR:Q9P7W6 denotes MLH1
T48 317-321 PR:000010442 denotes MLH1
T49 317-321 PR:P40692 denotes MLH1
T44 317-321 CVCL_G669 denotes MLH1
T51 326-329 CHEBI:16768 denotes MSH
T55 326-329 D009074 denotes MSH
T56 326-329 D009074 denotes MSH
T57 326-330 PR:000010666 denotes MSH2
T58 326-330 PR:P25847 denotes MSH2
T59 326-330 PR:P43246 denotes MSH2
T60 326-330 P22711 denotes MSH2
T61 326-330 PR:P22711 denotes MSH2
T62 326-330 PR:P54275 denotes MSH2
T63 326-330 PR:O74773 denotes MSH2
T64 326-330 PR:P43247 denotes MSH2
T65 326-330 PR:Q553L4 denotes MSH2
T66 326-330 PR:O24617 denotes MSH2
T67 524-537 D063646 denotes tumorigenesis
T68 524-537 D063646 denotes tumorigenesis
T69 563-585 SO:0001786 denotes loss of heterozygosity
T71 662-667 CHEBI:50406 denotes probe
T70 662-667 SO:0000051 denotes probe
T72 692-696 PR:Q9ZRV4 denotes MLH1
T73 692-696 PR:P38920 denotes MLH1
T74 692-696 PR:Q54KD8 denotes MLH1
T76 692-696 PR:Q9JK91 denotes MLH1
T77 692-696 PR:P97679 denotes MLH1
T78 692-696 PR:Q9P7W6 denotes MLH1
T79 692-696 PR:000010442 denotes MLH1
T80 692-696 PR:P40692 denotes MLH1
T75 692-696 CVCL_G669 denotes MLH1
T82 697-700 CHEBI:16768 denotes MSH
T86 697-700 D009074 denotes MSH
T87 697-700 D009074 denotes MSH
T88 697-701 PR:000010666 denotes MSH2
T89 697-701 PR:P25847 denotes MSH2
T90 697-701 PR:P43246 denotes MSH2
T91 697-701 P22711 denotes MSH2
T92 697-701 PR:P22711 denotes MSH2
T93 697-701 PR:P54275 denotes MSH2
T94 697-701 PR:O74773 denotes MSH2
T95 697-701 PR:P43247 denotes MSH2
T96 697-701 PR:Q553L4 denotes MSH2
T97 697-701 PR:O24617 denotes MSH2
T98 766-773 D009369 denotes cancers
T99 766-773 D009369 denotes cancers
T100 784-798 SO:0000289 denotes microsatellite
T101 784-810 D053842 denotes microsatellite instability
T102 784-810 D053842 denotes microsatellite instability
T103 823-827 PR:Q9ZRV4 denotes MLH1
T104 823-827 PR:P38920 denotes MLH1
T105 823-827 PR:Q54KD8 denotes MLH1
T107 823-827 PR:Q9JK91 denotes MLH1
T108 823-827 PR:P97679 denotes MLH1
T109 823-827 PR:Q9P7W6 denotes MLH1
T110 823-827 PR:000010442 denotes MLH1
T111 823-827 PR:P40692 denotes MLH1
T106 823-827 CVCL_G669 denotes MLH1
T113 831-834 CHEBI:16768 denotes MSH
T117 831-834 D009074 denotes MSH
T118 831-834 D009074 denotes MSH
T119 831-835 PR:000010666 denotes MSH2
T120 831-835 PR:P25847 denotes MSH2
T121 831-835 PR:P43246 denotes MSH2
T122 831-835 P22711 denotes MSH2
T123 831-835 PR:P22711 denotes MSH2
T124 831-835 PR:P54275 denotes MSH2
T125 831-835 PR:O74773 denotes MSH2
T126 831-835 PR:P43247 denotes MSH2
T127 831-835 PR:Q553L4 denotes MSH2
T128 831-835 PR:O24617 denotes MSH2
T129 873-881 SO:0000109 denotes mutation
T130 1030-1034 PR:Q9ZRV4 denotes MLH1
T131 1030-1034 PR:P38920 denotes MLH1
T132 1030-1034 PR:Q54KD8 denotes MLH1
T134 1030-1034 PR:Q9JK91 denotes MLH1
T135 1030-1034 PR:P97679 denotes MLH1
T136 1030-1034 PR:Q9P7W6 denotes MLH1
T137 1030-1034 PR:000010442 denotes MLH1
T138 1030-1034 PR:P40692 denotes MLH1
T133 1030-1034 CVCL_G669 denotes MLH1
T140 1035-1038 CHEBI:16768 denotes MSH
T144 1035-1038 D009074 denotes MSH
T145 1035-1038 D009074 denotes MSH
T146 1035-1039 PR:000010666 denotes MSH2
T147 1035-1039 PR:P25847 denotes MSH2
T148 1035-1039 PR:P43246 denotes MSH2
T149 1035-1039 P22711 denotes MSH2
T150 1035-1039 PR:P22711 denotes MSH2
T151 1035-1039 PR:P54275 denotes MSH2
T152 1035-1039 PR:O74773 denotes MSH2
T153 1035-1039 PR:P43247 denotes MSH2
T154 1035-1039 PR:Q553L4 denotes MSH2
T155 1035-1039 PR:O24617 denotes MSH2
T156 1040-1048 SO:0000109 denotes mutation
T157 1049-1057 CHEBI:78059 denotes carriers
T158 1109-1131 SO:0001786 denotes loss of heterozygosity
T159 1163-1169 D009369 denotes tumors
T160 1163-1169 D009369 denotes tumors
T161 1175-1179 PR:Q9ZRV4 denotes MLH1
T162 1175-1179 PR:P38920 denotes MLH1
T163 1175-1179 PR:Q54KD8 denotes MLH1
T165 1175-1179 PR:Q9JK91 denotes MLH1
T166 1175-1179 PR:P97679 denotes MLH1
T167 1175-1179 PR:Q9P7W6 denotes MLH1
T168 1175-1179 PR:000010442 denotes MLH1
T169 1175-1179 PR:P40692 denotes MLH1
T164 1175-1179 CVCL_G669 denotes MLH1
T171 1180-1183 CHEBI:16768 denotes MSH
T175 1180-1183 D009074 denotes MSH
T176 1180-1183 D009074 denotes MSH
T177 1180-1184 PR:000010666 denotes MSH2
T178 1180-1184 PR:P25847 denotes MSH2
T179 1180-1184 PR:P43246 denotes MSH2
T180 1180-1184 P22711 denotes MSH2
T181 1180-1184 PR:P22711 denotes MSH2
T182 1180-1184 PR:P54275 denotes MSH2
T183 1180-1184 PR:O74773 denotes MSH2
T184 1180-1184 PR:P43247 denotes MSH2
T185 1180-1184 PR:Q553L4 denotes MSH2
T186 1180-1184 PR:O24617 denotes MSH2
T187 1195-1203 SO:0000159 denotes deletion
T188 1204-1212 CHEBI:78059 denotes carriers
T189 1214-1219 PR:Q9Z1M7 denotes Large
T190 1282-1286 PR:Q9ZRV4 denotes MLH1
T191 1282-1286 PR:P38920 denotes MLH1
T192 1282-1286 PR:Q54KD8 denotes MLH1
T194 1282-1286 PR:Q9JK91 denotes MLH1
T195 1282-1286 PR:P97679 denotes MLH1
T196 1282-1286 PR:Q9P7W6 denotes MLH1
T197 1282-1286 PR:000010442 denotes MLH1
T198 1282-1286 PR:P40692 denotes MLH1
T193 1282-1286 CVCL_G669 denotes MLH1
T200 1291-1294 CHEBI:16768 denotes MSH
T204 1291-1294 D009074 denotes MSH
T205 1291-1294 D009074 denotes MSH
T206 1291-1295 PR:000010666 denotes MSH2
T207 1291-1295 PR:P25847 denotes MSH2
T208 1291-1295 PR:P43246 denotes MSH2
T209 1291-1295 P22711 denotes MSH2
T210 1291-1295 PR:P22711 denotes MSH2
T211 1291-1295 PR:P54275 denotes MSH2
T212 1291-1295 PR:O74773 denotes MSH2
T213 1291-1295 PR:P43247 denotes MSH2
T214 1291-1295 PR:Q553L4 denotes MSH2
T215 1291-1295 PR:O24617 denotes MSH2
T217 1350-1355 CHEBI:50406 denotes probe
T216 1350-1355 SO:0000051 denotes probe
T218 1449-1453 PR:Q9ZRV4 denotes MLH1
T219 1449-1453 PR:P38920 denotes MLH1
T220 1449-1453 PR:Q54KD8 denotes MLH1
T222 1449-1453 PR:Q9JK91 denotes MLH1
T223 1449-1453 PR:P97679 denotes MLH1
T224 1449-1453 PR:Q9P7W6 denotes MLH1
T225 1449-1453 PR:000010442 denotes MLH1
T226 1449-1453 PR:P40692 denotes MLH1
T221 1449-1453 CVCL_G669 denotes MLH1
T228 1454-1457 CHEBI:16768 denotes MSH
T232 1454-1457 D009074 denotes MSH
T233 1454-1457 D009074 denotes MSH
T234 1454-1458 PR:000010666 denotes MSH2
T235 1454-1458 PR:P25847 denotes MSH2
T236 1454-1458 PR:P43246 denotes MSH2
T237 1454-1458 P22711 denotes MSH2
T238 1454-1458 PR:P22711 denotes MSH2
T239 1454-1458 PR:P54275 denotes MSH2
T240 1454-1458 PR:O74773 denotes MSH2
T241 1454-1458 PR:P43247 denotes MSH2
T242 1454-1458 PR:Q553L4 denotes MSH2
T243 1454-1458 PR:O24617 denotes MSH2
T244 1459-1467 SO:0000159 denotes deletion
T245 1468-1476 CHEBI:78059 denotes carriers
T246 1568-1586 D015179 denotes colorectal cancers
T247 1568-1586 D015179 denotes colorectal cancers
T250 1656-1662 D009369 denotes tumors
T251 1656-1662 D009369 denotes tumors
T253 1664-1674 SO:0000340 denotes Chromosome
T252 1664-1674 GO:0005694 denotes Chromosome
T254 1725-1734 SO:0000817 denotes wild-type
T255 1735-1741 SO:0001023 denotes allele
T256 1818-1822 SO:0000704 denotes gene
T257 1818-1833 GO:0035822 denotes gene conversion
T258 1847-1868 GO:0006312 denotes mitotic recombination
T259 1872-1880 SO:0000159 denotes deletion
T260 1899-1903 SO:0000704 denotes gene
T263 1912-1918 CVCL_E025 denotes Cancer
T261 1912-1918 D009369 denotes Cancer
T262 1912-1918 D009369 denotes Cancer
T265 1919-1922 PR:P40815 denotes Res
T266 1919-1922 PR:P25241 denotes Res
T267 1919-1922 PR:P08764 denotes Res
T264 1919-1922 UBERON:0000363 denotes Res

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 160-166 HP_0002664 denotes cancer
T2 181-201 HP_0000006 denotes autosomal dominantly
T3 181-211 HP_0000006 denotes autosomal dominantly inherited
T4 212-218 HP_0002664 denotes cancer
T5 450-456 HP_0002664 denotes cancer
T6 766-773 HP_0002664 denotes cancers
T7 1163-1169 HP_0002664 denotes tumors
T8 1385-1391 HP_0002664 denotes cancer
T9 1491-1508 HP_0001428 denotes somatic mutations
T10 1579-1586 HP_0002664 denotes cancers
T11 1656-1662 HP_0002664 denotes tumors
T12 1912-1918 HP_0002664 denotes Cancer

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-124 DRI_Background denotes Gene conversion is a frequent mechanism of inactivation of the wild-type allele in cancers from MLH1/MSH2 deletion carriers.
T2 125-408 DRI_Background denotes Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominantly inherited cancer predisposition syndrome caused by germ line mutations in DNA mismatch repair genes, predominantly MLH1 and MSH2, with large genomic rearrangements accounting for 5% to 20% of all mutations.
T3 409-586 DRI_Background denotes Although crucial to the understanding of cancer initiation, little is known about the second, somatic hit in HNPCC tumorigenesis, commonly referred to as loss of heterozygosity.
T4 587-926 DRI_Approach denotes Here, we applied a recently developed method, multiplex ligation-dependent probe amplification, to study MLH1/MSH2 copy number changes in 16 unrelated Swiss HNPCC patients, whose cancers displayed microsatellite instability and loss of MLH1 or MSH2 expression, but in whom no germ line mutation could be detected by conventional screening.
T5 927-1213 DRI_Background denotes The aims of the study were (a) to determine the proportion of large genomic rearrangements among Swiss MLH1/MSH2 mutation carriers and (b) to investigate the frequency and nature of loss of heterozygosity as a second, somatic event, in tumors from MLH1/MSH2 germ line deletion carriers.
T6 1214-1320 DRI_Background denotes Large genomic deletions were found to account for 4.3% and 10.7% of MLH1 and MSH2 mutations, respectively.
T7 1321-1625 DRI_Background denotes Multiplex ligation-dependent probe amplification analysis of 18 cancer specimens from two independent sets of Swiss and Finnish MLH1/MSH2 deletion carriers revealed that somatic mutations identical to the ones in the germ line occur frequently in colorectal cancers (6 of 11; 55%) and are also present in
T8 1626-1655 Token_Label.OUTSIDE denotes extracolonic HNPCC-associated
T9 1656-1663 DRI_Background denotes tumors.
T10 1664-1910 DRI_Background denotes Chromosome-specific marker analysis implies that loss of the wild-type allele predominantly occurs through locus-restricted recombinational events, i.e., gene conversion, rather than mitotic recombination or deletion of the respective gene locus.
T11 1911-1944 DRI_Unspecified denotes (Cancer Res 2006; (66)2: 659-64).

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
16423994-6#128#132#gene4292 1449-1453 gene4292 denotes MLH1
16423994-6#133#137#gene4436 1454-1458 gene4436 denotes MSH2
16423994-6#247#265#diseaseC1527249 1568-1586 diseaseC1527249 denotes colorectal cancers
16423994-6#318#323#diseaseC1333990 1639-1644 diseaseC1333990 denotes HNPCC
16423994-6#247#265#diseaseC1527249 1568-1586 diseaseC1527249 denotes colorectal cancers
16423994-6#318#323#diseaseC1333990 1639-1644 diseaseC1333990 denotes HNPCC
128#132#gene4292247#265#diseaseC1527249 16423994-6#128#132#gene4292 16423994-6#247#265#diseaseC1527249 associated_with MLH1,colorectal cancers
128#132#gene4292318#323#diseaseC1333990 16423994-6#128#132#gene4292 16423994-6#318#323#diseaseC1333990 associated_with MLH1,HNPCC
128#132#gene4292247#265#diseaseC1527249 16423994-6#128#132#gene4292 16423994-6#247#265#diseaseC1527249 associated_with MLH1,colorectal cancers
128#132#gene4292318#323#diseaseC1333990 16423994-6#128#132#gene4292 16423994-6#318#323#diseaseC1333990 associated_with MLH1,HNPCC
133#137#gene4436247#265#diseaseC1527249 16423994-6#133#137#gene4436 16423994-6#247#265#diseaseC1527249 associated_with MSH2,colorectal cancers
133#137#gene4436318#323#diseaseC1333990 16423994-6#133#137#gene4436 16423994-6#318#323#diseaseC1333990 associated_with MSH2,HNPCC
133#137#gene4436247#265#diseaseC1527249 16423994-6#133#137#gene4436 16423994-6#247#265#diseaseC1527249 associated_with MSH2,colorectal cancers
133#137#gene4436318#323#diseaseC1333990 16423994-6#133#137#gene4436 16423994-6#318#323#diseaseC1333990 associated_with MSH2,HNPCC

DisGeNET

Id Subject Object Predicate Lexical cue
T0 96-100 gene:4292 denotes MLH1
T1 83-90 disease:C0006826 denotes cancers
T2 326-330 gene:4436 denotes MSH2
T3 125-166 disease:C1333990 denotes Hereditary nonpolyposis colorectal cancer
T4 317-321 gene:4292 denotes MLH1
T5 125-166 disease:C1333990 denotes Hereditary nonpolyposis colorectal cancer
T6 1454-1458 gene:4436 denotes MSH2
T7 1639-1644 disease:C1333990 denotes HNPCC
T8 1454-1458 gene:4436 denotes MSH2
T9 1568-1586 disease:C1527249 denotes colorectal cancers
T10 1449-1453 gene:4292 denotes MLH1
T11 1639-1644 disease:C1333990 denotes HNPCC
T12 1449-1453 gene:4292 denotes MLH1
T13 1568-1586 disease:C1527249 denotes colorectal cancers
R1 T0 T1 associated_with MLH1,cancers
R2 T2 T3 associated_with MSH2,Hereditary nonpolyposis colorectal cancer
R3 T4 T5 associated_with MLH1,Hereditary nonpolyposis colorectal cancer
R4 T6 T7 associated_with MSH2,HNPCC
R5 T8 T9 associated_with MSH2,colorectal cancers
R6 T10 T11 associated_with MLH1,HNPCC
R7 T12 T13 associated_with MLH1,colorectal cancers