PubMed:16371368 / 2033-2292 JSONTXT

{"project":"sonoma2","denotations":[{"id":"T-76","span":{"begin":62,"end":70},"obj":"POSREG"},{"id":"T-77","span":{"begin":71,"end":89},"obj":"MPA"},{"id":"T-78","span":{"begin":103,"end":110},"obj":"REG"},{"id":"T-79","span":{"begin":138,"end":150},"obj":"INTERACTION"},{"id":"T-80","span":{"begin":159,"end":162},"obj":"POSREG"},{"id":"T-81","span":{"begin":170,"end":175},"obj":"GENE"},{"id":"T-82","span":{"begin":204,"end":208},"obj":"REG"},{"id":"T-83","span":{"begin":222,"end":226},"obj":"REG"}],"relations":[{"id":"R-94","pred":"ThemeOf","subj":"T-81","obj":"T-79"},{"id":"R-95","pred":"ThemeOf","subj":"T-83","obj":"T-82"},{"id":"R-91","pred":"ThemeOf","subj":"T-77","obj":"T-76"},{"id":"R-92","pred":"ThemeOf","subj":"T-79","obj":"T-78"},{"id":"R-93","pred":"ThemeOf","subj":"T-79","obj":"T-80"}],"text":"Taken together, these studies suggest that in addition to the elevated catalytic activity, fundamental changes in physical and functional interactions between GOF mutant SHP-2 and signaling partners also play an important role in SHP-2-related leukemigenesis."}

{"project":"sonoma","denotations":[{"id":"T-81","span":{"begin":62,"end":70},"obj":"POSREG"},{"id":"T-82","span":{"begin":71,"end":89},"obj":"MPA"},{"id":"T-83","span":{"begin":103,"end":110},"obj":"REG"},{"id":"T-84","span":{"begin":163,"end":169},"obj":"VAR"},{"id":"T-85","span":{"begin":170,"end":175},"obj":"GENE"},{"id":"T-86","span":{"begin":204,"end":208},"obj":"REG"},{"id":"T-87","span":{"begin":222,"end":226},"obj":"REG"},{"id":"T-88","span":{"begin":230,"end":243},"obj":"GENE"},{"id":"T-89","span":{"begin":244,"end":258},"obj":"DISEASE"}],"relations":[{"id":"R-151","pred":"ThemeOf","subj":"T-81","obj":"T-82"},{"id":"R-152","pred":"CauseOf","subj":"T-81","obj":"T-83"},{"id":"R-153","pred":"CauseOf","subj":"T-81","obj":"T-84"},{"id":"R-154","pred":"CauseOf","subj":"T-81","obj":"T-86"},{"id":"R-155","pred":"ThemeOf","subj":"T-82","obj":"T-83"},{"id":"R-156","pred":"CauseOf","subj":"T-83","obj":"T-84"},{"id":"R-157","pred":"ThemeOf","subj":"T-83","obj":"T-85"},{"id":"R-158","pred":"CauseOf","subj":"T-83","obj":"T-86"},{"id":"R-159","pred":"CauseOf","subj":"T-83","obj":"T-87"},{"id":"R-160","pred":"CauseOf","subj":"T-83","obj":"T-88"},{"id":"R-161","pred":"ThemeOf","subj":"T-83","obj":"T-89"},{"id":"R-162","pred":"ThemeOf","subj":"T-84","obj":"T-85"},{"id":"R-163","pred":"CauseOf","subj":"T-84","obj":"T-86"},{"id":"R-164","pred":"CauseOf","subj":"T-84","obj":"T-87"},{"id":"R-165","pred":"ThemeOf","subj":"T-85","obj":"T-86"},{"id":"R-166","pred":"ThemeOf","subj":"T-85","obj":"T-87"},{"id":"R-167","pred":"ThemeOf","subj":"T-86","obj":"T-87"},{"id":"R-168","pred":"CauseOf","subj":"T-86","obj":"T-88"},{"id":"R-169","pred":"ThemeOf","subj":"T-86","obj":"T-89"},{"id":"R-170","pred":"ThemeOf","subj":"T-87","obj":"T-88"},{"id":"R-171","pred":"ThemeOf","subj":"T-87","obj":"T-89"}],"text":"Taken together, these studies suggest that in addition to the elevated catalytic activity, fundamental changes in physical and functional interactions between GOF mutant SHP-2 and signaling partners also play an important role in SHP-2-related leukemigenesis."}

{"project":"sentences","denotations":[{"id":"T12","span":{"begin":0,"end":259},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Taken together, these studies suggest that in addition to the elevated catalytic activity, fundamental changes in physical and functional interactions between GOF mutant SHP-2 and signaling partners also play an important role in SHP-2-related leukemigenesis."}