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PubMed:16311883 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 129-139 Glycan_Motif denotes hyaluronan https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T2 159-161 Glycan_Motif denotes HA https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T3 167-178 Glycan_Motif denotes chondroitin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT
T4 1052-1062 Glycan_Motif denotes hyaluronan https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T5 1064-1066 Glycan_Motif denotes HA https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T6 1132-1134 Glycan_Motif denotes HA https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T7 1739-1742 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T9 1917-1919 Glycan_Motif denotes HA https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T10 2051-2053 Glycan_Motif denotes HA https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 129-139 https://glytoucan.org/Structures/Glycans/G00017MO denotes hyaluronan
T2 167-178 https://glytoucan.org/Structures/Glycans/G43702JT denotes chondroitin
T3 1052-1062 https://glytoucan.org/Structures/Glycans/G00017MO denotes hyaluronan
T4 1739-1742 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T5 1739-1742 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 167-178 http://www.glycoepitope.jp/epitopes/EP0081 denotes chondroitin
T2 1739-1742 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1159-1163 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T2 1167-1184 http://purl.obolibrary.org/obo/MAT_0000301 denotes connective tissue

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-73 Sentence denotes Serum hyaluronidase aberrations in metabolic and morphogenetic disorders.
TextSentencer_T2 74-188 Sentence denotes Hyaluronidases are endo-glycosidases that degrade both hyaluronan (hyaluronic acid) (HA) and chondroitin sulfates.
TextSentencer_T3 189-326 Sentence denotes Deficiency of hyaluronidase activity has been predicted to result in a phenotype similar to that observed in mucopolysaccharidosis (MPS).
TextSentencer_T4 327-566 Sentence denotes In the present study, we surveyed a variety of patients with phenotypes similar to those observed in MPS, but without significant mucopolysacchariduria to determine if some are based on aberrations in serum hyaluronidase (Hyal-1) activity.
TextSentencer_T5 567-704 Sentence denotes The study included patients with well-characterized dysmorphic disorders occurring on genetic basis, as well as those of unkown etiology.
TextSentencer_T6 705-823 Sentence denotes The purpose of the study was to establish how wide spread were abnormalities in levels of circulating Hyal-1 activity.
TextSentencer_T7 824-930 Sentence denotes A simple and sensitive semi-quantitative zymographic procedure was used for the determination of activity.
TextSentencer_T8 931-1135 Sentence denotes Levels of both beta-N-acetylglucosaminidase and beta-glucuronidase whose activities contribute to the total breakdown of hyaluronan (HA) were also measured, as well as the concentration of circulating HA.
TextSentencer_T9 1136-1349 Sentence denotes Among 48 patients with bone or connective tissue abnormalities, low levels of Hyal-1 activity were found in six patients compared to levels in 100 healthy donors (2.0-3.2 units/microL vs 6(+/- 1 SE) units/microL).
TextSentencer_T10 1350-1652 Sentence denotes These six patients exhibited a wide spectrum of clinical abnormalities, in particular shortened extremities: they included three patients with unknown causes of clinical symptoms, one patient with Sanfilippo disease, one of the seven patients with achondroplasia, and one with hypophosphotemic rickets.
TextSentencer_T11 1653-1861 Sentence denotes Normal levels of serum Hyal-1 activities were found in patients with Morquio disease, GM1 gangliosidosis, I cell-disease, 6 of the 7 patients with achondroplasia, Marfan's-syndrome and Ehlers-Danlos syndrome.
TextSentencer_T12 1862-1910 Sentence denotes No patient totally lacked serum Hyal-1 activity.
TextSentencer_T13 1911-1996 Sentence denotes Serum HA concentration was elevated in patients with Sanfilippo A and I-cell disease.
TextSentencer_T14 1997-2132 Sentence denotes Determination of serum and leukocyte Hyal-1 and serum HA may be useful to evaluate patients with metabolic and morphogenetic disorders.
TextSentencer_T1 0-73 Sentence denotes Serum hyaluronidase aberrations in metabolic and morphogenetic disorders.
TextSentencer_T2 74-188 Sentence denotes Hyaluronidases are endo-glycosidases that degrade both hyaluronan (hyaluronic acid) (HA) and chondroitin sulfates.
TextSentencer_T3 189-326 Sentence denotes Deficiency of hyaluronidase activity has been predicted to result in a phenotype similar to that observed in mucopolysaccharidosis (MPS).
TextSentencer_T4 327-566 Sentence denotes In the present study, we surveyed a variety of patients with phenotypes similar to those observed in MPS, but without significant mucopolysacchariduria to determine if some are based on aberrations in serum hyaluronidase (Hyal-1) activity.
TextSentencer_T5 567-704 Sentence denotes The study included patients with well-characterized dysmorphic disorders occurring on genetic basis, as well as those of unkown etiology.
TextSentencer_T6 705-823 Sentence denotes The purpose of the study was to establish how wide spread were abnormalities in levels of circulating Hyal-1 activity.
TextSentencer_T7 824-930 Sentence denotes A simple and sensitive semi-quantitative zymographic procedure was used for the determination of activity.
TextSentencer_T8 931-1135 Sentence denotes Levels of both beta-N-acetylglucosaminidase and beta-glucuronidase whose activities contribute to the total breakdown of hyaluronan (HA) were also measured, as well as the concentration of circulating HA.
TextSentencer_T9 1136-1349 Sentence denotes Among 48 patients with bone or connective tissue abnormalities, low levels of Hyal-1 activity were found in six patients compared to levels in 100 healthy donors (2.0-3.2 units/microL vs 6(+/- 1 SE) units/microL).
TextSentencer_T10 1350-1652 Sentence denotes These six patients exhibited a wide spectrum of clinical abnormalities, in particular shortened extremities: they included three patients with unknown causes of clinical symptoms, one patient with Sanfilippo disease, one of the seven patients with achondroplasia, and one with hypophosphotemic rickets.
TextSentencer_T11 1653-1861 Sentence denotes Normal levels of serum Hyal-1 activities were found in patients with Morquio disease, GM1 gangliosidosis, I cell-disease, 6 of the 7 patients with achondroplasia, Marfan's-syndrome and Ehlers-Danlos syndrome.
TextSentencer_T12 1862-1910 Sentence denotes No patient totally lacked serum Hyal-1 activity.
TextSentencer_T13 1911-1996 Sentence denotes Serum HA concentration was elevated in patients with Sanfilippo A and I-cell disease.
TextSentencer_T14 1997-2132 Sentence denotes Determination of serum and leukocyte Hyal-1 and serum HA may be useful to evaluate patients with metabolic and morphogenetic disorders.
T1 0-73 Sentence denotes Serum hyaluronidase aberrations in metabolic and morphogenetic disorders.
T2 74-188 Sentence denotes Hyaluronidases are endo-glycosidases that degrade both hyaluronan (hyaluronic acid) (HA) and chondroitin sulfates.
T3 189-326 Sentence denotes Deficiency of hyaluronidase activity has been predicted to result in a phenotype similar to that observed in mucopolysaccharidosis (MPS).
T4 327-566 Sentence denotes In the present study, we surveyed a variety of patients with phenotypes similar to those observed in MPS, but without significant mucopolysacchariduria to determine if some are based on aberrations in serum hyaluronidase (Hyal-1) activity.
T5 567-704 Sentence denotes The study included patients with well-characterized dysmorphic disorders occurring on genetic basis, as well as those of unkown etiology.
T6 705-823 Sentence denotes The purpose of the study was to establish how wide spread were abnormalities in levels of circulating Hyal-1 activity.
T7 824-930 Sentence denotes A simple and sensitive semi-quantitative zymographic procedure was used for the determination of activity.
T8 931-1135 Sentence denotes Levels of both beta-N-acetylglucosaminidase and beta-glucuronidase whose activities contribute to the total breakdown of hyaluronan (HA) were also measured, as well as the concentration of circulating HA.
T9 1136-1349 Sentence denotes Among 48 patients with bone or connective tissue abnormalities, low levels of Hyal-1 activity were found in six patients compared to levels in 100 healthy donors (2.0-3.2 units/microL vs 6(+/- 1 SE) units/microL).
T10 1350-1652 Sentence denotes These six patients exhibited a wide spectrum of clinical abnormalities, in particular shortened extremities: they included three patients with unknown causes of clinical symptoms, one patient with Sanfilippo disease, one of the seven patients with achondroplasia, and one with hypophosphotemic rickets.
T11 1653-1861 Sentence denotes Normal levels of serum Hyal-1 activities were found in patients with Morquio disease, GM1 gangliosidosis, I cell-disease, 6 of the 7 patients with achondroplasia, Marfan's-syndrome and Ehlers-Danlos syndrome.
T12 1862-1910 Sentence denotes No patient totally lacked serum Hyal-1 activity.
T13 1911-1996 Sentence denotes Serum HA concentration was elevated in patients with Sanfilippo A and I-cell disease.
T14 1997-2132 Sentence denotes Determination of serum and leukocyte Hyal-1 and serum HA may be useful to evaluate patients with metabolic and morphogenetic disorders.

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 457-478 HP:0008155 denotes mucopolysacchariduria
AB2 1644-1651 HP:0002748 denotes rickets

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 1547-1565 ORDO:581 denotes Sanfilippo disease
AB2 1598-1612 ORDO:15 denotes achondroplasia
AB3 1722-1737 ORDO:582 denotes Morquio disease
AB4 1739-1757 ORDO:354 denotes GM1 gangliosidosis
AB5 1759-1773 ORDO:576 denotes I cell-disease
AB6 1800-1814 ORDO:15 denotes achondroplasia
AB7 1981-1995 ORDO:576 denotes I-cell disease

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1178-1184 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T2 0-5 http://purl.obolibrary.org/obo/UBERON_0001977 denotes Serum
PD-UBERON-AE-B_T3 528-533 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T4 1670-1675 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T5 1888-1893 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T6 1911-1916 http://purl.obolibrary.org/obo/UBERON_0001977 denotes Serum
PD-UBERON-AE-B_T7 2014-2019 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T8 2045-2050 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T9 1167-1184 http://purl.obolibrary.org/obo/UBERON_0002384 denotes connective tissue
PD-UBERON-AE-B_T10 549-553 http://purl.obolibrary.org/obo/UBERON_3000101 denotes Hyal
PD-UBERON-AE-B_T11 807-811 http://purl.obolibrary.org/obo/UBERON_3000101 denotes Hyal
PD-UBERON-AE-B_T12 1214-1218 http://purl.obolibrary.org/obo/UBERON_3000101 denotes Hyal
PD-UBERON-AE-B_T13 1676-1680 http://purl.obolibrary.org/obo/UBERON_3000101 denotes Hyal
PD-UBERON-AE-B_T14 1894-1898 http://purl.obolibrary.org/obo/UBERON_3000101 denotes Hyal
PD-UBERON-AE-B_T15 2034-2038 http://purl.obolibrary.org/obo/UBERON_3000101 denotes Hyal

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1676-1682 gene:6677 denotes Hyal-1
T1 1722-1737 disease:C0026707 denotes Morquio disease
T2 1676-1682 gene:3373 denotes Hyal-1
T3 1722-1737 disease:C0026707 denotes Morquio disease
T4 1676-1682 gene:6677 denotes Hyal-1
T5 1838-1860 disease:C0013720 denotes Ehlers-Danlos syndrome
T6 1676-1682 gene:3373 denotes Hyal-1
T7 1838-1860 disease:C0013720 denotes Ehlers-Danlos syndrome
R1 T0 T1 associated_with Hyal-1,Morquio disease
R2 T2 T3 associated_with Hyal-1,Morquio disease
R3 T4 T5 associated_with Hyal-1,Ehlers-Danlos syndrome
R4 T6 T7 associated_with Hyal-1,Ehlers-Danlos syndrome

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1159-1163 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T2 1167-1184 Body_part denotes connective tissue http://purl.obolibrary.org/obo/MAT_0000301

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 457-478 Phenotype denotes mucopolysacchariduria HP:0008155
T2 1644-1651 Phenotype denotes rickets HP:0002748

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 298-319 Disease denotes mucopolysaccharidosis http://purl.obolibrary.org/obo/MONDO_0019249
T2 321-324 Disease denotes MPS http://purl.obolibrary.org/obo/MONDO_0019249
T3 428-431 Disease denotes MPS http://purl.obolibrary.org/obo/MONDO_0019249
T4 1547-1565 Disease denotes Sanfilippo disease http://purl.obolibrary.org/obo/MONDO_0018937
T5 1598-1612 Disease denotes achondroplasia http://purl.obolibrary.org/obo/MONDO_0007037
T6 1644-1651 Disease denotes rickets http://purl.obolibrary.org/obo/MONDO_0005520
T7 1722-1737 Disease denotes Morquio disease http://purl.obolibrary.org/obo/MONDO_0018938
T8 1739-1757 Disease denotes GM1 gangliosidosis http://purl.obolibrary.org/obo/MONDO_0018149
T9 1759-1773 Disease denotes I cell-disease http://purl.obolibrary.org/obo/MONDO_0009650
T10 1800-1814 Disease denotes achondroplasia http://purl.obolibrary.org/obo/MONDO_0007037
T11 1816-1833 Disease denotes Marfan's-syndrome http://purl.obolibrary.org/obo/MONDO_0007947
T12 1838-1860 Disease denotes Ehlers-Danlos syndrome http://purl.obolibrary.org/obo/MONDO_0020066
T13 1964-1976 Disease denotes Sanfilippo A http://purl.obolibrary.org/obo/MONDO_0009655
T14 1981-1995 Disease denotes I-cell disease http://purl.obolibrary.org/obo/MONDO_0009650

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 167-178 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT
T2 1739-1742 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 167-178 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081
T2 1739-1742 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 457-478 Phenotype denotes mucopolysacchariduria HP:0008155
T2 1644-1651 Phenotype denotes rickets HP:0002748

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 298-319 Disease denotes mucopolysaccharidosis http://purl.obolibrary.org/obo/MONDO_0019249
T2 321-324 Disease denotes MPS http://purl.obolibrary.org/obo/MONDO_0019249
T3 428-431 Disease denotes MPS http://purl.obolibrary.org/obo/MONDO_0019249
T4 1547-1565 Disease denotes Sanfilippo disease http://purl.obolibrary.org/obo/MONDO_0018937
T5 1598-1612 Disease denotes achondroplasia http://purl.obolibrary.org/obo/MONDO_0007037
T6 1644-1651 Disease denotes rickets http://purl.obolibrary.org/obo/MONDO_0005520
T7 1722-1737 Disease denotes Morquio disease http://purl.obolibrary.org/obo/MONDO_0018938
T8 1739-1757 Disease denotes GM1 gangliosidosis http://purl.obolibrary.org/obo/MONDO_0018149
T9 1759-1773 Disease denotes I cell-disease http://purl.obolibrary.org/obo/MONDO_0009650
T10 1800-1814 Disease denotes achondroplasia http://purl.obolibrary.org/obo/MONDO_0007037
T11 1816-1833 Disease denotes Marfan's-syndrome http://purl.obolibrary.org/obo/MONDO_0007947
T12 1838-1860 Disease denotes Ehlers-Danlos syndrome http://purl.obolibrary.org/obo/MONDO_0020066
T13 1964-1976 Disease denotes Sanfilippo A http://purl.obolibrary.org/obo/MONDO_0009655
T14 1981-1995 Disease denotes I-cell disease http://purl.obolibrary.org/obo/MONDO_0009650

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1534-1541 OrganismTaxon denotes patient 9606
T2 1865-1872 OrganismTaxon denotes patient 9606

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 2024-2033 Cell denotes leukocyte http://purl.obolibrary.org/obo/CL:0000738

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1159-1163 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T3 1167-1184 Body_part denotes connective tissue http://purl.obolibrary.org/obo/UBERON_0002384
T4 1446-1457 Body_part denotes extremities http://purl.obolibrary.org/obo/UBERON_0002101
T5 2024-2033 Body_part denotes leukocyte http://purl.obolibrary.org/obo/CL_0000738

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1159-1163 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T2 1167-1184 Body_part denotes connective tissue http://purl.obolibrary.org/obo/MAT_0000301

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-73 Sentence denotes Serum hyaluronidase aberrations in metabolic and morphogenetic disorders.
TextSentencer_T2 74-188 Sentence denotes Hyaluronidases are endo-glycosidases that degrade both hyaluronan (hyaluronic acid) (HA) and chondroitin sulfates.
TextSentencer_T3 189-326 Sentence denotes Deficiency of hyaluronidase activity has been predicted to result in a phenotype similar to that observed in mucopolysaccharidosis (MPS).
TextSentencer_T4 327-566 Sentence denotes In the present study, we surveyed a variety of patients with phenotypes similar to those observed in MPS, but without significant mucopolysacchariduria to determine if some are based on aberrations in serum hyaluronidase (Hyal-1) activity.
TextSentencer_T5 567-704 Sentence denotes The study included patients with well-characterized dysmorphic disorders occurring on genetic basis, as well as those of unkown etiology.
TextSentencer_T6 705-823 Sentence denotes The purpose of the study was to establish how wide spread were abnormalities in levels of circulating Hyal-1 activity.
TextSentencer_T7 824-930 Sentence denotes A simple and sensitive semi-quantitative zymographic procedure was used for the determination of activity.
TextSentencer_T8 931-1135 Sentence denotes Levels of both beta-N-acetylglucosaminidase and beta-glucuronidase whose activities contribute to the total breakdown of hyaluronan (HA) were also measured, as well as the concentration of circulating HA.
TextSentencer_T9 1136-1349 Sentence denotes Among 48 patients with bone or connective tissue abnormalities, low levels of Hyal-1 activity were found in six patients compared to levels in 100 healthy donors (2.0-3.2 units/microL vs 6(+/- 1 SE) units/microL).
TextSentencer_T10 1350-1652 Sentence denotes These six patients exhibited a wide spectrum of clinical abnormalities, in particular shortened extremities: they included three patients with unknown causes of clinical symptoms, one patient with Sanfilippo disease, one of the seven patients with achondroplasia, and one with hypophosphotemic rickets.
TextSentencer_T11 1653-1861 Sentence denotes Normal levels of serum Hyal-1 activities were found in patients with Morquio disease, GM1 gangliosidosis, I cell-disease, 6 of the 7 patients with achondroplasia, Marfan's-syndrome and Ehlers-Danlos syndrome.
TextSentencer_T12 1862-1910 Sentence denotes No patient totally lacked serum Hyal-1 activity.
TextSentencer_T13 1911-1996 Sentence denotes Serum HA concentration was elevated in patients with Sanfilippo A and I-cell disease.
TextSentencer_T14 1997-2132 Sentence denotes Determination of serum and leukocyte Hyal-1 and serum HA may be useful to evaluate patients with metabolic and morphogenetic disorders.
TextSentencer_T1 0-73 Sentence denotes Serum hyaluronidase aberrations in metabolic and morphogenetic disorders.
TextSentencer_T2 74-188 Sentence denotes Hyaluronidases are endo-glycosidases that degrade both hyaluronan (hyaluronic acid) (HA) and chondroitin sulfates.
TextSentencer_T3 189-326 Sentence denotes Deficiency of hyaluronidase activity has been predicted to result in a phenotype similar to that observed in mucopolysaccharidosis (MPS).
TextSentencer_T4 327-566 Sentence denotes In the present study, we surveyed a variety of patients with phenotypes similar to those observed in MPS, but without significant mucopolysacchariduria to determine if some are based on aberrations in serum hyaluronidase (Hyal-1) activity.
TextSentencer_T5 567-704 Sentence denotes The study included patients with well-characterized dysmorphic disorders occurring on genetic basis, as well as those of unkown etiology.
TextSentencer_T6 705-823 Sentence denotes The purpose of the study was to establish how wide spread were abnormalities in levels of circulating Hyal-1 activity.
TextSentencer_T7 824-930 Sentence denotes A simple and sensitive semi-quantitative zymographic procedure was used for the determination of activity.
TextSentencer_T8 931-1135 Sentence denotes Levels of both beta-N-acetylglucosaminidase and beta-glucuronidase whose activities contribute to the total breakdown of hyaluronan (HA) were also measured, as well as the concentration of circulating HA.
TextSentencer_T9 1136-1349 Sentence denotes Among 48 patients with bone or connective tissue abnormalities, low levels of Hyal-1 activity were found in six patients compared to levels in 100 healthy donors (2.0-3.2 units/microL vs 6(+/- 1 SE) units/microL).
TextSentencer_T10 1350-1652 Sentence denotes These six patients exhibited a wide spectrum of clinical abnormalities, in particular shortened extremities: they included three patients with unknown causes of clinical symptoms, one patient with Sanfilippo disease, one of the seven patients with achondroplasia, and one with hypophosphotemic rickets.
TextSentencer_T11 1653-1861 Sentence denotes Normal levels of serum Hyal-1 activities were found in patients with Morquio disease, GM1 gangliosidosis, I cell-disease, 6 of the 7 patients with achondroplasia, Marfan's-syndrome and Ehlers-Danlos syndrome.
TextSentencer_T12 1862-1910 Sentence denotes No patient totally lacked serum Hyal-1 activity.
TextSentencer_T13 1911-1996 Sentence denotes Serum HA concentration was elevated in patients with Sanfilippo A and I-cell disease.
TextSentencer_T14 1997-2132 Sentence denotes Determination of serum and leukocyte Hyal-1 and serum HA may be useful to evaluate patients with metabolic and morphogenetic disorders.
T1 0-73 Sentence denotes Serum hyaluronidase aberrations in metabolic and morphogenetic disorders.
T2 74-188 Sentence denotes Hyaluronidases are endo-glycosidases that degrade both hyaluronan (hyaluronic acid) (HA) and chondroitin sulfates.
T3 189-326 Sentence denotes Deficiency of hyaluronidase activity has been predicted to result in a phenotype similar to that observed in mucopolysaccharidosis (MPS).
T4 327-566 Sentence denotes In the present study, we surveyed a variety of patients with phenotypes similar to those observed in MPS, but without significant mucopolysacchariduria to determine if some are based on aberrations in serum hyaluronidase (Hyal-1) activity.
T5 567-704 Sentence denotes The study included patients with well-characterized dysmorphic disorders occurring on genetic basis, as well as those of unkown etiology.
T6 705-823 Sentence denotes The purpose of the study was to establish how wide spread were abnormalities in levels of circulating Hyal-1 activity.
T7 824-930 Sentence denotes A simple and sensitive semi-quantitative zymographic procedure was used for the determination of activity.
T8 931-1135 Sentence denotes Levels of both beta-N-acetylglucosaminidase and beta-glucuronidase whose activities contribute to the total breakdown of hyaluronan (HA) were also measured, as well as the concentration of circulating HA.
T9 1136-1349 Sentence denotes Among 48 patients with bone or connective tissue abnormalities, low levels of Hyal-1 activity were found in six patients compared to levels in 100 healthy donors (2.0-3.2 units/microL vs 6(+/- 1 SE) units/microL).
T10 1350-1652 Sentence denotes These six patients exhibited a wide spectrum of clinical abnormalities, in particular shortened extremities: they included three patients with unknown causes of clinical symptoms, one patient with Sanfilippo disease, one of the seven patients with achondroplasia, and one with hypophosphotemic rickets.
T11 1653-1861 Sentence denotes Normal levels of serum Hyal-1 activities were found in patients with Morquio disease, GM1 gangliosidosis, I cell-disease, 6 of the 7 patients with achondroplasia, Marfan's-syndrome and Ehlers-Danlos syndrome.
T12 1862-1910 Sentence denotes No patient totally lacked serum Hyal-1 activity.
T13 1911-1996 Sentence denotes Serum HA concentration was elevated in patients with Sanfilippo A and I-cell disease.
T14 1997-2132 Sentence denotes Determination of serum and leukocyte Hyal-1 and serum HA may be useful to evaluate patients with metabolic and morphogenetic disorders.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-73 Sentence denotes Serum hyaluronidase aberrations in metabolic and morphogenetic disorders.
T2 74-188 Sentence denotes Hyaluronidases are endo-glycosidases that degrade both hyaluronan (hyaluronic acid) (HA) and chondroitin sulfates.
T3 189-326 Sentence denotes Deficiency of hyaluronidase activity has been predicted to result in a phenotype similar to that observed in mucopolysaccharidosis (MPS).
T4 327-566 Sentence denotes In the present study, we surveyed a variety of patients with phenotypes similar to those observed in MPS, but without significant mucopolysacchariduria to determine if some are based on aberrations in serum hyaluronidase (Hyal-1) activity.
T5 567-704 Sentence denotes The study included patients with well-characterized dysmorphic disorders occurring on genetic basis, as well as those of unkown etiology.
T6 705-823 Sentence denotes The purpose of the study was to establish how wide spread were abnormalities in levels of circulating Hyal-1 activity.
T7 824-930 Sentence denotes A simple and sensitive semi-quantitative zymographic procedure was used for the determination of activity.
T8 931-1135 Sentence denotes Levels of both beta-N-acetylglucosaminidase and beta-glucuronidase whose activities contribute to the total breakdown of hyaluronan (HA) were also measured, as well as the concentration of circulating HA.
T9 1136-1349 Sentence denotes Among 48 patients with bone or connective tissue abnormalities, low levels of Hyal-1 activity were found in six patients compared to levels in 100 healthy donors (2.0-3.2 units/microL vs 6(+/- 1 SE) units/microL).
T10 1350-1652 Sentence denotes These six patients exhibited a wide spectrum of clinical abnormalities, in particular shortened extremities: they included three patients with unknown causes of clinical symptoms, one patient with Sanfilippo disease, one of the seven patients with achondroplasia, and one with hypophosphotemic rickets.
T11 1653-1861 Sentence denotes Normal levels of serum Hyal-1 activities were found in patients with Morquio disease, GM1 gangliosidosis, I cell-disease, 6 of the 7 patients with achondroplasia, Marfan's-syndrome and Ehlers-Danlos syndrome.
T12 1862-1910 Sentence denotes No patient totally lacked serum Hyal-1 activity.
T13 1911-1996 Sentence denotes Serum HA concentration was elevated in patients with Sanfilippo A and I-cell disease.
T14 1997-2132 Sentence denotes Determination of serum and leukocyte Hyal-1 and serum HA may be useful to evaluate patients with metabolic and morphogenetic disorders.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 167-178 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT
T2 1739-1742 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 167-178 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081
T2 1739-1742 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1534-1541 OrganismTaxon denotes patient 9606
T2 1865-1872 OrganismTaxon denotes patient 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1159-1163 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T3 1167-1184 Body_part denotes connective tissue http://purl.obolibrary.org/obo/UBERON_0002384
T4 1446-1457 Body_part denotes extremities http://purl.obolibrary.org/obo/UBERON_0002101
T5 2024-2033 Body_part denotes leukocyte http://purl.obolibrary.org/obo/CL_0000738

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 2024-2033 Cell denotes leukocyte http://purl.obolibrary.org/obo/CL:0000738