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PubMed:16269541 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
16269541_0 734-740 ProteinMutation denotes G2019S rs34637584
16269541_1 744-750 ProteinMutation denotes R1441C rs33939927

c_corpus

Id Subject Object Predicate Lexical cue
T5 0-19 D010300 denotes Parkinson's disease
T6 0-19 D010300 denotes Parkinson's disease
T10 44-51 6308 denotes leucine
T11 44-51 SO:0001437 denotes leucine
T9 44-51 CHEBI:15603 denotes leucine
T12 44-51 D007930 denotes leucine
T13 44-51 CHEBI:25017 denotes leucine
T14 44-51 D007930 denotes leucine
T15 57-63 SO:0001068 denotes repeat
T16 81-96 GO:0016301 denotes kinase activity
T18 115-122 6308 denotes leucine
T19 115-122 SO:0001437 denotes leucine
T17 115-122 CHEBI:15603 denotes leucine
T20 115-122 D007930 denotes leucine
T21 115-122 CHEBI:25017 denotes leucine
T22 115-122 D007930 denotes leucine
T23 128-134 SO:0001068 denotes repeat
T24 144-148 SO:0000704 denotes gene
T25 150-155 PR:Q5S006 denotes LRRK2
T26 150-155 PR:000003033 denotes LRRK2
T27 150-155 PR:Q5S007 denotes LRRK2
T28 163-173 D000067562 denotes late-onset
T29 163-173 D000067562 denotes late-onset
T34 174-193 D010300 denotes Parkinson's disease
T35 174-193 D010300 denotes Parkinson's disease
T38 293-298 PR:Q5S006 denotes LRRK2
T39 293-298 PR:000003033 denotes LRRK2
T40 293-298 PR:Q5S007 denotes LRRK2
T41 362-376 D004198 denotes susceptibility
T42 362-376 D004198 denotes susceptibility
T43 396-414 C566739 denotes autosomal-dominant
T44 464-469 PR:Q5S006 denotes LRRK2
T45 464-469 PR:000003033 denotes LRRK2
T46 464-469 PR:Q5S007 denotes LRRK2
T47 470-474 SO:0000704 denotes gene
T48 479-489 SO:0000673 denotes transcript
T49 493-498 D006801 denotes human
T50 499-504 UBERON:6110636 denotes brain
T51 499-504 UBERON:0000955 denotes brain
T52 534-537 P0A2W4 denotes ORF
T54 534-537 PR:P16320 denotes ORF
T53 534-537 SO:0000236 denotes ORF
T55 561-566 PR:Q5S006 denotes LRRK2
T56 561-566 PR:000003033 denotes LRRK2
T57 561-566 PR:Q5S007 denotes LRRK2
T58 561-574 D000071158 denotes LRRK2 protein
T62 567-574 PR:000000001 denotes protein
T59 567-574 GO:0003675 denotes protein
T63 567-574 SO:0000104 denotes protein
T64 639-648 GO:0005737 denotes cytoplasm
T65 678-706 GO:0005741 denotes mitochondrial outer membrane
T67 698-706 UBERON:0000094 denotes membrane
T69 698-706 UBERON:0000158 denotes membrane
T73 784-791 PR:000000001 denotes protein
T71 784-791 CHEBI:36080 denotes protein
T72 784-791 CHEBI:11122 denotes protein
T74 784-791 SO:0000104 denotes protein
T70 784-791 GO:0003675 denotes protein
T75 826-838 GO:0051179 denotes localization
T76 902-907 PR:Q5S006 denotes LRRK2
T77 902-907 PR:000003033 denotes LRRK2
T78 902-907 PR:Q5S007 denotes LRRK2
T79 1011-1026 GO:0016310 denotes phosphorylation
T80 1075-1079 SO:0001742 denotes gain
T81 1106-1111 PR:Q5S006 denotes LRRK2
T82 1106-1111 PR:000003033 denotes LRRK2
T83 1106-1111 PR:Q5S007 denotes LRRK2
T84 1119-1126 D004194 denotes disease
T85 1119-1126 D004194 denotes disease
T86 1151-1166 GO:0016301 denotes kinase activity

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-97 DRI_Background denotes Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity.
T2 98-263 DRI_Outcome denotes Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) cause late-onset Parkinson's disease (PD) with a clinical appearance indistinguishable from idiopathic PD.
T3 264-435 DRI_Background denotes Initial studies suggest that LRRK2 mutations are the most common yet identified determinant of PD susceptibility, transmitted in an autosomal-dominant mode of inheritance.
T4 436-538 DRI_Approach denotes Herein, we characterize the LRRK2 gene and transcript in human brain and subclone the predominant ORF.
T5 539-707 DRI_Background denotes Exogenously expressed LRRK2 protein migrates at approximately 280 kDa and is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.
T6 708-839 DRI_Approach denotes Familial-linked mutations G2019S or R1441C do not have an obvious effect on protein steady-state levels, turnover, or localization.
T7 840-1050 DRI_Background denotes However, in vitro kinase assays using full-length recombinant LRRK2 reveal an increase in activity caused by familial-linked mutations in both autophosphorylation and the phosphorylation of a generic substrate.
T8 1051-1192 DRI_Challenge denotes These results suggest a gain-of-function mechanism for LRRK2-linked disease with a central role for kinase activity in the development of PD.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
16269541-0#44#72#gene120892 44-72 gene120892 denotes leucine-rich repeat kinase 2
16269541-0#0#19#diseaseC0030567 0-19 diseaseC0030567 denotes Parkinson's disease
16269541-7#55#60#gene120892 1106-1111 gene120892 denotes LRRK2
16269541-7#138#140#diseaseC3160718 1189-1191 diseaseC3160718 denotes PD
44#72#gene1208920#19#diseaseC0030567 16269541-0#44#72#gene120892 16269541-0#0#19#diseaseC0030567 associated_with leucine-rich repeat kinase 2,Parkinson's disease
55#60#gene120892138#140#diseaseC3160718 16269541-7#55#60#gene120892 16269541-7#138#140#diseaseC3160718 associated_with LRRK2,PD