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Id Subject Object Predicate Lexical cue
T1 0-12 GO:0051179 denotes Localization
T2 16-19 GO:0006298 denotes MMR
T4 16-19 P22897 denotes MMR
T5 16-19 PR:000002972 denotes MMR
T6 16-19 Q61830 denotes MMR
T3 16-19 CVCL_E779 denotes MMR
T7 20-28 CHEBI:36080 denotes proteins
T9 55-59 D051379 denotes mice
T11 55-59 10095 denotes mice
T8 55-59 PR:000005054 denotes mice
T10 55-59 O89094 denotes mice
T12 96-104 GO:0051324 denotes prophase
T13 118-122 PR:000023324 denotes MutL
T14 118-122 PR:Q93T05 denotes MutL
T15 118-122 PR:P23367 denotes MutL
T16 146-149 GO:0005574 denotes DNA
T18 146-149 SO:0000352 denotes DNA
T17 146-149 CHEBI:16991 denotes DNA
T19 146-149 D004247 denotes DNA
T20 150-165 GO:0006298 denotes mismatch repair
T21 167-170 GO:0006298 denotes MMR
T23 167-170 P22897 denotes MMR
T24 167-170 PR:000002972 denotes MMR
T25 167-170 Q61830 denotes MMR
T22 167-170 CVCL_E779 denotes MMR
T26 276-280 PR:000023326 denotes MutS
T27 276-280 PR:P23909 denotes MutS
T28 276-280 PR:Q2FYZ9 denotes MutS
T31 311-314 P22897 denotes MMR
T32 311-314 PR:000002972 denotes MMR
T33 311-314 Q61830 denotes MMR
T30 311-314 CVCL_E779 denotes MMR
T29 311-314 GO:0006298 denotes MMR
T35 316-319 CHEBI:16768 denotes MSH
T39 316-319 D009074 denotes MSH
T40 316-319 D009074 denotes MSH
T41 316-320 PR:000010666 denotes MSH2
T42 316-320 PR:P25847 denotes MSH2
T43 316-320 PR:P43246 denotes MSH2
T44 316-320 P22711 denotes MSH2
T45 316-320 PR:P22711 denotes MSH2
T46 316-320 PR:P54275 denotes MSH2
T47 316-320 PR:O74773 denotes MSH2
T48 316-320 PR:P43247 denotes MSH2
T49 316-320 PR:Q553L4 denotes MSH2
T50 316-320 PR:O24617 denotes MSH2
T52 321-324 CHEBI:16768 denotes MSH
T56 321-324 D009074 denotes MSH
T57 321-324 D009074 denotes MSH
T58 321-325 PR:O65607 denotes MSH3
T59 321-325 PR:000010667 denotes MSH3
T60 321-325 PR:Q59Y41 denotes MSH3
T61 321-325 PR:P25336 denotes MSH3
T62 321-325 PR:P20585 denotes MSH3
T63 321-325 PR:P26359 denotes MSH3
T64 321-325 PR:P13705 denotes MSH3
T65 321-325 PR:Q1ZXH0 denotes MSH3
T67 329-332 CHEBI:16768 denotes MSH
T71 329-332 D009074 denotes MSH
T72 329-332 D009074 denotes MSH
T73 329-333 PR:000010666 denotes MSH2
T74 329-333 PR:P25847 denotes MSH2
T75 329-333 PR:P43246 denotes MSH2
T76 329-333 P22711 denotes MSH2
T77 329-333 PR:P22711 denotes MSH2
T78 329-333 PR:P54275 denotes MSH2
T79 329-333 PR:O74773 denotes MSH2
T80 329-333 PR:P43247 denotes MSH2
T81 329-333 PR:Q553L4 denotes MSH2
T82 329-333 PR:O24617 denotes MSH2
T84 334-337 CHEBI:16768 denotes MSH
T88 334-337 D009074 denotes MSH
T89 334-337 D009074 denotes MSH
T90 334-338 PR:P52701 denotes MSH6
T91 334-338 PR:P54276 denotes MSH6
T92 334-338 PR:Q9VUM0 denotes MSH6
T93 334-338 PR:Q55GU9 denotes MSH6
T94 334-338 PR:O04716 denotes MSH6
T95 334-338 PR:Q03834 denotes MSH6
T96 334-338 PR:O74502 denotes MSH6
T97 334-338 PR:000010670 denotes MSH6
T99 358-361 CHEBI:16768 denotes MSH
T103 358-361 D009074 denotes MSH
T104 358-361 D009074 denotes MSH
T105 358-362 PR:P40965 denotes MSH4
T106 358-362 PR:000010668 denotes MSH4
T107 358-362 PR:F4JP48 denotes MSH4
T108 358-362 PR:Q99MT2 denotes MSH4
T109 358-362 PR:O15457 denotes MSH4
T110 358-362 PR:Q23405 denotes MSH4
T112 363-366 CHEBI:16768 denotes MSH
T116 363-366 D009074 denotes MSH
T117 363-366 D009074 denotes MSH
T118 363-367 PR:Q6MG62 denotes MSH5
T119 363-367 PR:Q9QUM7 denotes MSH5
T120 363-367 PR:O43196 denotes MSH5
T121 363-367 PR:Q19272 denotes MSH5
T122 363-367 PR:F4JEP5 denotes MSH5
T123 363-367 PR:000010669 denotes MSH5
T124 363-367 PR:Q12175 denotes MSH5
T125 401-405 PR:000023324 denotes MutL
T126 401-405 PR:Q93T05 denotes MutL
T127 401-405 PR:P23367 denotes MutL
T128 418-422 PR:Q9ZRV4 denotes Mlh1
T129 418-422 PR:P38920 denotes Mlh1
T130 418-422 PR:Q54KD8 denotes Mlh1
T132 418-422 PR:Q9JK91 denotes Mlh1
T133 418-422 PR:P97679 denotes Mlh1
T134 418-422 PR:Q9P7W6 denotes Mlh1
T135 418-422 PR:000010442 denotes Mlh1
T136 418-422 PR:P40692 denotes Mlh1
T131 418-422 CVCL_G669 denotes Mlh1
T137 424-428 PR:F4JN26 denotes Mlh3
T138 424-428 PR:Q12083 denotes Mlh3
T139 424-428 PR:000010443 denotes Mlh3
T140 424-428 PR:Q9UHC1 denotes Mlh3
T141 434-437 CHEBI:53396 denotes Pms
T144 434-437 CHEBI:53430 denotes Pms
T146 434-437 CHEBI:8055 denotes Pms
T147 434-438 PR:P54279 denotes Pms2
T148 434-438 PR:F1NQJ3 denotes Pms2
T149 434-438 PR:P38920 denotes Pms2
T150 434-438 PR:000012914 denotes Pms2
T151 434-438 PR:P54278 denotes Pms2
T152 520-524 PR:F4JN26 denotes MLH3
T153 520-524 PR:Q12083 denotes MLH3
T154 520-524 PR:000010443 denotes MLH3
T155 520-524 PR:Q9UHC1 denotes MLH3
T156 550-557 GO:0051321 denotes meiosis
T157 601-605 PR:F4JN26 denotes MLH3
T158 601-605 PR:Q12083 denotes MLH3
T159 601-605 PR:000010443 denotes MLH3
T160 601-605 PR:Q9UHC1 denotes MLH3
T161 610-614 PR:Q9ZRV4 denotes MLH1
T162 610-614 PR:P38920 denotes MLH1
T163 610-614 PR:Q54KD8 denotes MLH1
T165 610-614 PR:Q9JK91 denotes MLH1
T166 610-614 PR:P97679 denotes MLH1
T167 610-614 PR:Q9P7W6 denotes MLH1
T168 610-614 PR:000010442 denotes MLH1
T169 610-614 PR:P40692 denotes MLH1
T164 610-614 CVCL_G669 denotes MLH1
T171 678-681 CHEBI:16768 denotes MSH
T175 678-681 D009074 denotes MSH
T176 678-681 D009074 denotes MSH
T177 678-682 PR:P40965 denotes MSH4
T178 678-682 PR:000010668 denotes MSH4
T179 678-682 PR:F4JP48 denotes MSH4
T180 678-682 PR:Q99MT2 denotes MSH4
T181 678-682 PR:O15457 denotes MSH4
T182 678-682 PR:Q23405 denotes MSH4
T184 683-686 CHEBI:16768 denotes MSH
T188 683-686 D009074 denotes MSH
T189 683-686 D009074 denotes MSH
T190 683-687 PR:Q6MG62 denotes MSH5
T191 683-687 PR:Q9QUM7 denotes MSH5
T192 683-687 PR:O43196 denotes MSH5
T193 683-687 PR:Q19272 denotes MSH5
T194 683-687 PR:F4JEP5 denotes MSH5
T195 683-687 PR:000010669 denotes MSH5
T196 683-687 PR:Q12175 denotes MSH5
T197 717-721 PR:F4JN26 denotes MLH3
T198 717-721 PR:Q12083 denotes MLH3
T199 717-721 PR:000010443 denotes MLH3
T200 717-721 PR:Q9UHC1 denotes MLH3
T202 736-739 CHEBI:16768 denotes MSH
T206 736-739 D009074 denotes MSH
T207 736-739 D009074 denotes MSH
T208 736-740 PR:000010666 denotes MSH2
T209 736-740 PR:P25847 denotes MSH2
T210 736-740 PR:P43246 denotes MSH2
T211 736-740 P22711 denotes MSH2
T212 736-740 PR:P22711 denotes MSH2
T213 736-740 PR:P54275 denotes MSH2
T214 736-740 PR:O74773 denotes MSH2
T215 736-740 PR:P43247 denotes MSH2
T216 736-740 PR:Q553L4 denotes MSH2
T217 736-740 PR:O24617 denotes MSH2
T219 741-744 CHEBI:16768 denotes MSH
T223 741-744 D009074 denotes MSH
T224 741-744 D009074 denotes MSH
T225 741-745 PR:O65607 denotes MSH3
T226 741-745 PR:000010667 denotes MSH3
T227 741-745 PR:Q59Y41 denotes MSH3
T228 741-745 PR:P25336 denotes MSH3
T229 741-745 PR:P20585 denotes MSH3
T230 741-745 PR:P26359 denotes MSH3
T231 741-745 PR:P13705 denotes MSH3
T232 741-745 PR:Q1ZXH0 denotes MSH3
T233 807-819 GO:0000806 denotes Y chromosome
T235 809-819 SO:0000340 denotes chromosome
T236 840-849 SO:0000119 denotes regulated
T237 853-856 CHEBI:53396 denotes Pms
T240 853-856 CHEBI:53430 denotes Pms
T242 853-856 CHEBI:8055 denotes Pms
T243 853-857 PR:P54279 denotes Pms2
T244 853-857 PR:F1NQJ3 denotes Pms2
T245 853-857 PR:P38920 denotes Pms2
T246 853-857 PR:000012914 denotes Pms2
T247 853-857 PR:P54278 denotes Pms2
T248 944-947 CHEBI:53396 denotes Pms
T251 944-947 CHEBI:53430 denotes Pms
T253 944-947 CHEBI:8055 denotes Pms
T254 944-948 PR:P54279 denotes Pms2
T255 944-948 PR:F1NQJ3 denotes Pms2
T256 944-948 PR:P38920 denotes Pms2
T257 944-948 PR:000012914 denotes Pms2
T258 944-948 PR:P54278 denotes Pms2
T259 952-956 PR:000005054 denotes mice
T261 952-956 O89094 denotes mice
T260 952-956 D051379 denotes mice
T262 952-956 10095 denotes mice
T263 977-981 PR:F4JN26 denotes MLH3
T264 977-981 PR:Q12083 denotes MLH3
T265 977-981 PR:000010443 denotes MLH3
T266 977-981 PR:Q9UHC1 denotes MLH3
T269 998-1001 SO:0000352 denotes DNA
T267 998-1001 GO:0005574 denotes DNA
T268 998-1001 CHEBI:16991 denotes DNA
T270 998-1001 D004247 denotes DNA
T272 1031-1034 CHEBI:16768 denotes MSH
T276 1031-1034 D009074 denotes MSH
T277 1031-1034 D009074 denotes MSH
T278 1031-1035 PR:000010666 denotes MSH2
T279 1031-1035 PR:P25847 denotes MSH2
T280 1031-1035 PR:P43246 denotes MSH2
T281 1031-1035 P22711 denotes MSH2
T282 1031-1035 PR:P22711 denotes MSH2
T283 1031-1035 PR:P54275 denotes MSH2
T284 1031-1035 PR:O74773 denotes MSH2
T285 1031-1035 PR:P43247 denotes MSH2
T286 1031-1035 PR:Q553L4 denotes MSH2
T287 1031-1035 PR:O24617 denotes MSH2
T289 1036-1039 CHEBI:16768 denotes MSH
T293 1036-1039 D009074 denotes MSH
T294 1036-1039 D009074 denotes MSH
T295 1036-1040 PR:O65607 denotes MSH3
T296 1036-1040 PR:000010667 denotes MSH3
T297 1036-1040 PR:Q59Y41 denotes MSH3
T298 1036-1040 PR:P25336 denotes MSH3
T299 1036-1040 PR:P20585 denotes MSH3
T300 1036-1040 PR:P26359 denotes MSH3
T301 1036-1040 PR:P13705 denotes MSH3
T302 1036-1040 PR:Q1ZXH0 denotes MSH3
T304 1061-1064 CHEBI:16768 denotes Msh
T308 1061-1064 D009074 denotes Msh
T309 1061-1064 D009074 denotes Msh
T310 1061-1065 PR:000010666 denotes Msh2
T311 1061-1065 PR:P25847 denotes Msh2
T312 1061-1065 PR:P43246 denotes Msh2
T313 1061-1065 P22711 denotes Msh2
T314 1061-1065 PR:P22711 denotes Msh2
T315 1061-1065 PR:P54275 denotes Msh2
T316 1061-1065 PR:O74773 denotes Msh2
T317 1061-1065 PR:P43247 denotes Msh2
T318 1061-1065 PR:Q553L4 denotes Msh2
T319 1061-1065 PR:O24617 denotes Msh2
T321 1073-1076 CHEBI:16768 denotes Msh
T325 1073-1076 D009074 denotes Msh
T326 1073-1076 D009074 denotes Msh
T327 1073-1077 PR:O65607 denotes Msh3
T328 1073-1077 PR:000010667 denotes Msh3
T329 1073-1077 PR:Q59Y41 denotes Msh3
T330 1073-1077 PR:P25336 denotes Msh3
T331 1073-1077 PR:P20585 denotes Msh3
T332 1073-1077 PR:P26359 denotes Msh3
T333 1073-1077 PR:P13705 denotes Msh3
T334 1073-1077 PR:Q1ZXH0 denotes Msh3
T336 1081-1085 D051379 denotes mice
T338 1081-1085 10095 denotes mice
T335 1081-1085 PR:000005054 denotes mice
T337 1081-1085 O89094 denotes mice
T339 1119-1122 GO:0006298 denotes MMR
T341 1119-1122 P22897 denotes MMR
T342 1119-1122 PR:000002972 denotes MMR
T343 1119-1122 Q61830 denotes MMR
T340 1119-1122 CVCL_E779 denotes MMR
T345 1152-1163 SO:0000726 denotes repeat unit
T346 1191-1198 GO:0051321 denotes meiosis

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-226 DRI_Background denotes Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I. Mammalian MutL homologues function in DNA mismatch repair (MMR) after replication errors and in meiotic recombination.
T2 227-369 DRI_Approach denotes Both functions are initiated by a heterodimer of MutS homologues specific to either MMR (MSH2-MSH3 or MSH2-MSH6) or crossing over (MSH4-MSH5).
T3 370-466 DRI_Approach denotes Mutations of three of the four MutL homologues (Mlh1, Mlh3, and Pms2) result in meiotic defects.
T4 467-558 DRI_Outcome denotes We show herein that two distinct complexes involving MLH3 are formed during murine meiosis.
T5 559-688 DRI_Approach denotes The first is a stable association between MLH3 and MLH1 and is involved in promoting crossing over in conjunction with MSH4-MSH5.
T6 689-820 DRI_Approach denotes The second complex involves MLH3 together with MSH2-MSH3 and localizes to repetitive sequences at centromeres and the Y chromosome.
T7 821-957 DRI_Outcome denotes This complex is up-regulated in Pms2-/- males, but not females, providing an explanation for the sexual dimorphism seen in Pms2-/- mice.
T8 958-1199 DRI_Approach denotes The association of MLH3 with repetitive DNA sequences is coincident with MSH2-MSH3 and is decreased in Msh2-/- and Msh3-/- mice, suggesting a novel role for the MMR family in the maintenance of repeat unit integrity during mammalian meiosis.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 108-226 DRI_Background denotes Mammalian MutL homologues function in DNA mismatch repair (MMR) after replication errors and in meiotic recombination.
T2 227-369 DRI_Approach denotes Both functions are initiated by a heterodimer of MutS homologues specific to either MMR (MSH2-MSH3 or MSH2-MSH6) or crossing over (MSH4-MSH5).
T3 370-466 DRI_Approach denotes Mutations of three of the four MutL homologues (Mlh1, Mlh3, and Pms2) result in meiotic defects.
T4 467-558 DRI_Outcome denotes We show herein that two distinct complexes involving MLH3 are formed during murine meiosis.
T5 559-688 DRI_Approach denotes The first is a stable association between MLH3 and MLH1 and is involved in promoting crossing over in conjunction with MSH4-MSH5.
T6 689-820 DRI_Approach denotes The second complex involves MLH3 together with MSH2-MSH3 and localizes to repetitive sequences at centromeres and the Y chromosome.
T7 821-957 DRI_Outcome denotes This complex is up-regulated in Pms2-/- males, but not females, providing an explanation for the sexual dimorphism seen in Pms2-/- mice.
T8 958-1199 DRI_Approach denotes The association of MLH3 with repetitive DNA sequences is coincident with MSH2-MSH3 and is decreased in Msh2-/- and Msh3-/- mice, suggesting a novel role for the MMR family in the maintenance of repeat unit integrity during mammalian meiosis.