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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 123-260 DRI_Challenge denotes Disruption of blood-brain barrier (BBB), mediated through matrix metalloproteinases (MMPs), is a critical event during cerebral ischemia.
T2 261-424 DRI_Background denotes While neuroprotective effects of estrogens have been well established in ischemic stroke models, the effects of estrogens on BBB integrity remain to be elucidated.
T3 425-601 DRI_Challenge denotes In the present study, we determined effects of 17beta-estradiol (E2) on BBB disruption induced by transient focal cerebral ischemia and its effects on MMP2 and MMP9 activation.
T4 602-739 DRI_Background denotes Transient cerebral ischemia was induced by middle cerebral artery (MCA) occlusion for 1 h followed by reperfusion in ovariectomized rats.
T5 740-812 DRI_Background denotes E2 (100 microg/kg) or vehicle was administered 2 h before MCA occlusion.
T6 813-894 DRI_Approach denotes BBB integrity was determined by fluorescent detection of extravasated Evans blue.
T7 895-1029 DRI_Background denotes In separate experiments, effect of E2 on MMP2 and MMP9 expression and activation was determined by immunoblot and MMPs activity assay.
T8 1030-1169 DRI_Background denotes E2 treatment prevented more than 50% and 30% of BBB disruption in the ischemic cortex and subcortex at 4 h after reperfusion, respectively.
T9 1170-1318 DRI_Background denotes MMP2 and MMP9 expression was elevated at 2 h and peaked at 4 h after reperfusion in the ischemic cortex, which was markedly reduced by E2 treatment.
T10 1319-1417 DRI_Background denotes E2 treatment also attenuated the increase of MMPs activity induced by ischemia-reperfusion injury.
T11 1418-1556 DRI_Challenge denotes In conclusion, estrogens could attenuate BBB disruption induced by transient cerebral ischemia, by inhibition of MMP2 and MMP9 activation.
T12 1557-1735 DRI_Outcome denotes Our results suggest an important role of estrogens as multiple targeting protectants against ischemic stroke on cellular as well as vascular components of central nervous system.

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-16 D004958 denotes 17beta-Estradiol
T2 0-16 CHEBI:16469 denotes 17beta-Estradiol
T3 0-16 D004958 denotes 17beta-Estradiol
T10 7-16 4083 denotes Estradiol
T12 28-47 UBERON:0000120 denotes blood-brain barrier
T15 70-87 D002545 denotes cerebral ischemia
T16 70-87 D002545 denotes cerebral ischemia
T19 79-106 D015427 denotes ischemia-reperfusion injury
T20 79-106 D015427 denotes ischemia-reperfusion injury
T23 110-116 UBERON:0003100 denotes female
T24 117-121 10118 denotes rats
T25 117-121 10116 denotes rats
T26 117-121 D051381 denotes rats
T27 137-156 UBERON:0000120 denotes blood-brain barrier
T30 158-161 UBERON:0000120 denotes BBB
T31 181-187 UBERON:0027368 denotes matrix
T32 181-206 D020782 denotes matrix metalloproteinases
T34 208-212 D020782 denotes MMPs
T35 242-259 D002545 denotes cerebral ischemia
T36 242-259 D002545 denotes cerebral ischemia
T39 267-290 D018696 denotes neuroprotective effects
T40 267-290 D018696 denotes neuroprotective effects
T41 294-303 D004967 denotes estrogens
T42 294-303 D004967 denotes estrogens
T43 294-303 CHEBI:50114 denotes estrogens
T44 373-382 D004967 denotes estrogens
T45 373-382 D004967 denotes estrogens
T46 373-382 CHEBI:50114 denotes estrogens
T47 386-389 UBERON:0000120 denotes BBB
T48 472-488 D004958 denotes 17beta-estradiol
T49 472-488 CHEBI:16469 denotes 17beta-estradiol
T50 472-488 D004958 denotes 17beta-estradiol
T57 479-488 4083 denotes estradiol
T59 497-500 UBERON:0000120 denotes BBB
T60 539-556 D002545 denotes cerebral ischemia
T61 539-556 D002545 denotes cerebral ischemia
T64 576-579 CHEBI:340824 denotes MMP
T67 576-579 CHEBI:59761 denotes MMP
T68 576-580 PR:P08253 denotes MMP2
T69 576-580 Q9GLE5 denotes MMP2
T70 576-580 P08253 denotes MMP2
T71 576-580 Q90611 denotes MMP2
T73 576-580 PR:Q8MPP3 denotes MMP2
T74 576-580 P33436 denotes MMP2
T75 576-580 PR:Q90611 denotes MMP2
T76 576-580 PR:P33436 denotes MMP2
T77 576-580 PR:000010479 denotes MMP2
T78 576-580 PR:P33434 denotes MMP2
T79 576-580 P33434 denotes MMP2
T80 576-580 P50757 denotes MMP2
T72 576-580 GO:0004228 denotes MMP2
T81 585-588 CHEBI:340824 denotes MMP
T84 585-588 CHEBI:59761 denotes MMP
T85 585-589 PR:P50282 denotes MMP9
T86 585-589 PR:P14780 denotes MMP9
T87 585-589 P14780 denotes MMP9
T88 585-589 PR:P41245 denotes MMP9
T89 585-589 P41246 denotes MMP9
T90 585-589 P41245 denotes MMP9
T91 585-589 PR:P52176 denotes MMP9
T92 585-589 P50282 denotes MMP9
T94 585-589 PR:000010491 denotes MMP9
T95 585-589 P52176 denotes MMP9
T96 585-589 O18733 denotes MMP9
T93 585-589 GO:0004229 denotes MMP9
T97 602-629 D002546 denotes Transient cerebral ischemia
T98 602-629 D002546 denotes Transient cerebral ischemia
T103 645-667 UBERON:0001627 denotes middle cerebral artery
T104 652-667 D002539 denotes cerebral artery
T106 652-667 D002539 denotes cerebral artery
T109 669-672 P60254 denotes MCA
T108 669-672 CHEBI:34342 denotes MCA
T111 734-738 10118 denotes rats
T112 734-738 10116 denotes rats
T113 734-738 D051381 denotes rats
T115 798-801 P60254 denotes MCA
T114 798-801 CHEBI:34342 denotes MCA
T116 813-816 UBERON:0000120 denotes BBB
T117 883-893 D005070 denotes Evans blue
T118 883-893 D005070 denotes Evans blue
T119 883-893 CHEBI:82467 denotes Evans blue
T120 936-939 CHEBI:340824 denotes MMP
T123 936-939 CHEBI:59761 denotes MMP
T124 936-940 PR:P08253 denotes MMP2
T125 936-940 Q9GLE5 denotes MMP2
T126 936-940 P08253 denotes MMP2
T127 936-940 Q90611 denotes MMP2
T129 936-940 PR:Q8MPP3 denotes MMP2
T130 936-940 P33436 denotes MMP2
T131 936-940 PR:Q90611 denotes MMP2
T132 936-940 PR:P33436 denotes MMP2
T133 936-940 PR:000010479 denotes MMP2
T134 936-940 PR:P33434 denotes MMP2
T135 936-940 P33434 denotes MMP2
T136 936-940 P50757 denotes MMP2
T128 936-940 GO:0004228 denotes MMP2
T137 945-948 CHEBI:340824 denotes MMP
T140 945-948 CHEBI:59761 denotes MMP
T141 945-949 PR:P50282 denotes MMP9
T142 945-949 PR:P14780 denotes MMP9
T143 945-949 P14780 denotes MMP9
T144 945-949 PR:P41245 denotes MMP9
T145 945-949 P41246 denotes MMP9
T146 945-949 P41245 denotes MMP9
T147 945-949 PR:P52176 denotes MMP9
T148 945-949 P50282 denotes MMP9
T150 945-949 PR:000010491 denotes MMP9
T151 945-949 P52176 denotes MMP9
T152 945-949 O18733 denotes MMP9
T149 945-949 GO:0004229 denotes MMP9
T153 1009-1013 D020782 denotes MMPs
T154 1078-1081 UBERON:0000120 denotes BBB
T155 1109-1115 UBERON:0001851 denotes cortex
T156 1120-1129 UBERON:0000454 denotes subcortex
T160 1170-1173 CHEBI:340824 denotes MMP
T163 1170-1173 CHEBI:59761 denotes MMP
T164 1170-1174 PR:P08253 denotes MMP2
T165 1170-1174 Q9GLE5 denotes MMP2
T166 1170-1174 P08253 denotes MMP2
T167 1170-1174 Q90611 denotes MMP2
T169 1170-1174 PR:Q8MPP3 denotes MMP2
T170 1170-1174 P33436 denotes MMP2
T171 1170-1174 PR:Q90611 denotes MMP2
T172 1170-1174 PR:P33436 denotes MMP2
T173 1170-1174 PR:000010479 denotes MMP2
T174 1170-1174 PR:P33434 denotes MMP2
T175 1170-1174 P33434 denotes MMP2
T176 1170-1174 P50757 denotes MMP2
T168 1170-1174 GO:0004228 denotes MMP2
T177 1179-1182 CHEBI:340824 denotes MMP
T180 1179-1182 CHEBI:59761 denotes MMP
T181 1179-1183 PR:P50282 denotes MMP9
T182 1179-1183 PR:P14780 denotes MMP9
T183 1179-1183 P14780 denotes MMP9
T184 1179-1183 PR:P41245 denotes MMP9
T185 1179-1183 P41246 denotes MMP9
T186 1179-1183 P41245 denotes MMP9
T187 1179-1183 PR:P52176 denotes MMP9
T188 1179-1183 P50282 denotes MMP9
T190 1179-1183 PR:000010491 denotes MMP9
T191 1179-1183 P52176 denotes MMP9
T192 1179-1183 O18733 denotes MMP9
T189 1179-1183 GO:0004229 denotes MMP9
T211 1267-1273 UBERON:0001851 denotes cortex
T212 1364-1368 D020782 denotes MMPs
T215 1389-1416 D015427 denotes ischemia-reperfusion injury
T216 1389-1416 D015427 denotes ischemia-reperfusion injury
T219 1433-1442 D004967 denotes estrogens
T220 1433-1442 D004967 denotes estrogens
T221 1433-1442 CHEBI:50114 denotes estrogens
T222 1459-1462 UBERON:0000120 denotes BBB
T223 1485-1512 D002546 denotes transient cerebral ischemia
T224 1485-1512 D002546 denotes transient cerebral ischemia
T229 1531-1534 CHEBI:340824 denotes MMP
T232 1531-1534 CHEBI:59761 denotes MMP
T233 1531-1535 PR:P08253 denotes MMP2
T234 1531-1535 Q9GLE5 denotes MMP2
T235 1531-1535 P08253 denotes MMP2
T236 1531-1535 Q90611 denotes MMP2
T238 1531-1535 PR:Q8MPP3 denotes MMP2
T239 1531-1535 P33436 denotes MMP2
T240 1531-1535 PR:Q90611 denotes MMP2
T241 1531-1535 PR:P33436 denotes MMP2
T242 1531-1535 PR:000010479 denotes MMP2
T243 1531-1535 PR:P33434 denotes MMP2
T244 1531-1535 P33434 denotes MMP2
T245 1531-1535 P50757 denotes MMP2
T237 1531-1535 GO:0004228 denotes MMP2
T246 1540-1543 CHEBI:340824 denotes MMP
T249 1540-1543 CHEBI:59761 denotes MMP
T250 1540-1544 PR:P50282 denotes MMP9
T251 1540-1544 PR:P14780 denotes MMP9
T252 1540-1544 P14780 denotes MMP9
T253 1540-1544 PR:P41245 denotes MMP9
T254 1540-1544 P41246 denotes MMP9
T255 1540-1544 P41245 denotes MMP9
T256 1540-1544 PR:P52176 denotes MMP9
T257 1540-1544 P50282 denotes MMP9
T259 1540-1544 PR:000010491 denotes MMP9
T260 1540-1544 P52176 denotes MMP9
T261 1540-1544 O18733 denotes MMP9
T258 1540-1544 GO:0004229 denotes MMP9
T262 1598-1607 D004967 denotes estrogens
T263 1598-1607 D004967 denotes estrogens
T264 1598-1607 CHEBI:50114 denotes estrogens
T265 1712-1734 UBERON:0001017 denotes central nervous system
T266 1720-1734 D009422 denotes nervous system
T268 1720-1734 D009422 denotes nervous system

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 242-259 HP_0002637 denotes cerebral ischemia
T2 334-349 HP_0002140 denotes ischemic stroke
T3 343-349 HP_0001297 denotes stroke
T4 539-556 HP_0002637 denotes cerebral ischemia
T5 612-629 HP_0002637 denotes cerebral ischemia
T6 1495-1512 HP_0002637 denotes cerebral ischemia
T7 1650-1665 HP_0002140 denotes ischemic stroke
T8 1659-1665 HP_0001297 denotes stroke

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-122 DRI_Outcome denotes 17beta-Estradiol attenuates blood-brain barrier disruption induced by cerebral ischemia-reperfusion injury in female rats.
T2 123-260 DRI_Challenge denotes Disruption of blood-brain barrier (BBB), mediated through matrix metalloproteinases (MMPs), is a critical event during cerebral ischemia.
T3 261-424 DRI_Background denotes While neuroprotective effects of estrogens have been well established in ischemic stroke models, the effects of estrogens on BBB integrity remain to be elucidated.
T4 425-601 DRI_Challenge denotes In the present study, we determined effects of 17beta-estradiol (E2) on BBB disruption induced by transient focal cerebral ischemia and its effects on MMP2 and MMP9 activation.
T5 602-739 DRI_Background denotes Transient cerebral ischemia was induced by middle cerebral artery (MCA) occlusion for 1 h followed by reperfusion in ovariectomized rats.
T6 740-812 DRI_Background denotes E2 (100 microg/kg) or vehicle was administered 2 h before MCA occlusion.
T7 813-894 DRI_Approach denotes BBB integrity was determined by fluorescent detection of extravasated Evans blue.
T8 895-1029 DRI_Background denotes In separate experiments, effect of E2 on MMP2 and MMP9 expression and activation was determined by immunoblot and MMPs activity assay.
T9 1030-1169 DRI_Background denotes E2 treatment prevented more than 50% and 30% of BBB disruption in the ischemic cortex and subcortex at 4 h after reperfusion, respectively.
T10 1170-1318 DRI_Background denotes MMP2 and MMP9 expression was elevated at 2 h and peaked at 4 h after reperfusion in the ischemic cortex, which was markedly reduced by E2 treatment.
T11 1319-1417 DRI_Background denotes E2 treatment also attenuated the increase of MMPs activity induced by ischemia-reperfusion injury.
T12 1418-1556 DRI_Challenge denotes In conclusion, estrogens could attenuate BBB disruption induced by transient cerebral ischemia, by inhibition of MMP2 and MMP9 activation.
T13 1557-1735 DRI_Outcome denotes Our results suggest an important role of estrogens as multiple targeting protectants against ischemic stroke on cellular as well as vascular components of central nervous system.