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PubMed:16192407 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 109-120 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064
T2 525-536 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064

Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 211-222 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 1375-1386 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 211-222 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T2 1375-1386 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 211-222 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 1375-1386 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-132 Sentence denotes Phenotypic changes induced by expression of beta-galactoside alpha2,6 sialyltransferase I in the human colon cancer cell line SW948.
TextSentencer_T2 133-377 Sentence denotes Beta-galactoside alpha2,6 sialyltransferase (ST6Gal.I), the enzyme which adds sialic acid in alpha2,6-linkage on lactosaminic termini of glycoproteins, is frequently overexpressed in cancer, but its relationship with malignancy remains unclear.
TextSentencer_T3 378-588 Sentence denotes In this study, we have investigated the phenotypic changes induced by the expression of alpha2,6-sialylated lactosaminic chains in the human colon cancer cell line SW948 which was originally devoid of ST6Gal.I.
TextSentencer_T4 589-707 Sentence denotes Clones derived from transfection with the ST6Gal.I cDNA were compared with untransfected cells and mock transfectants.
TextSentencer_T5 708-826 Sentence denotes The ST6Gal.I-expressing clones show (1) increased adherence to fibronectin and collagen IV but not to hyaluronic acid.
TextSentencer_T6 827-1320 Sentence denotes Treatment with Clostridium perfrigens neuraminidase reduces the binding to fibronectin and collagen IV of ST6Gal.I-expressing cells but not that of ST6Gal.I-negative cells; (2) accumulation and more focal distribution of beta1 integrins on the cell surface; (3) different distribution of actin fibers; (4) flatter morphology and reduced tendency to multilayer growth; (5) improved ability to heal a scratch wound; (6) reduced ability to grow at the subcutaneous site of injection in nude mice.
TextSentencer_T7 1321-1565 Sentence denotes Our data suggest that the presence of alpha2,6-linked sialic acid on membrane glycoconjugates increases the binding to extracellular matrix components, resulting in a membrane stabilization of beta1 integrins, further strengthening the binding.
TextSentencer_T8 1566-1723 Sentence denotes This mechanism can provide a basis for the flatter morphology and the reduced tendency to multilayer growth, resulting in a more ordered tissue organization.
TextSentencer_T9 1724-1870 Sentence denotes These data indicate that in the cell line SW948, the effect of ST6Gal.I expression is consistent with the attenuation of the neoplastic phenotype.
T1 0-132 Sentence denotes Phenotypic changes induced by expression of beta-galactoside alpha2,6 sialyltransferase I in the human colon cancer cell line SW948.
T2 133-377 Sentence denotes Beta-galactoside alpha2,6 sialyltransferase (ST6Gal.I), the enzyme which adds sialic acid in alpha2,6-linkage on lactosaminic termini of glycoproteins, is frequently overexpressed in cancer, but its relationship with malignancy remains unclear.
T3 378-707 Sentence denotes In this study, we have investigated the phenotypic changes induced by the expression of alpha2,6-sialylated lactosaminic chains in the human colon cancer cell line SW948 which was originally devoid of ST6Gal.I. Clones derived from transfection with the ST6Gal.I cDNA were compared with untransfected cells and mock transfectants.
T4 708-826 Sentence denotes The ST6Gal.I-expressing clones show (1) increased adherence to fibronectin and collagen IV but not to hyaluronic acid.
T5 827-1320 Sentence denotes Treatment with Clostridium perfrigens neuraminidase reduces the binding to fibronectin and collagen IV of ST6Gal.I-expressing cells but not that of ST6Gal.I-negative cells; (2) accumulation and more focal distribution of beta1 integrins on the cell surface; (3) different distribution of actin fibers; (4) flatter morphology and reduced tendency to multilayer growth; (5) improved ability to heal a scratch wound; (6) reduced ability to grow at the subcutaneous site of injection in nude mice.
T6 1321-1565 Sentence denotes Our data suggest that the presence of alpha2,6-linked sialic acid on membrane glycoconjugates increases the binding to extracellular matrix components, resulting in a membrane stabilization of beta1 integrins, further strengthening the binding.
T7 1566-1723 Sentence denotes This mechanism can provide a basis for the flatter morphology and the reduced tendency to multilayer growth, resulting in a more ordered tissue organization.
T8 1724-1870 Sentence denotes These data indicate that in the cell line SW948, the effect of ST6Gal.I expression is consistent with the attenuation of the neoplastic phenotype.
T1 0-132 Sentence denotes Phenotypic changes induced by expression of beta-galactoside alpha2,6 sialyltransferase I in the human colon cancer cell line SW948.
T2 133-377 Sentence denotes Beta-galactoside alpha2,6 sialyltransferase (ST6Gal.I), the enzyme which adds sialic acid in alpha2,6-linkage on lactosaminic termini of glycoproteins, is frequently overexpressed in cancer, but its relationship with malignancy remains unclear.
T3 378-588 Sentence denotes In this study, we have investigated the phenotypic changes induced by the expression of alpha2,6-sialylated lactosaminic chains in the human colon cancer cell line SW948 which was originally devoid of ST6Gal.I.
T4 589-707 Sentence denotes Clones derived from transfection with the ST6Gal.I cDNA were compared with untransfected cells and mock transfectants.
T5 708-826 Sentence denotes The ST6Gal.I-expressing clones show (1) increased adherence to fibronectin and collagen IV but not to hyaluronic acid.
T6 827-1320 Sentence denotes Treatment with Clostridium perfrigens neuraminidase reduces the binding to fibronectin and collagen IV of ST6Gal.I-expressing cells but not that of ST6Gal.I-negative cells; (2) accumulation and more focal distribution of beta1 integrins on the cell surface; (3) different distribution of actin fibers; (4) flatter morphology and reduced tendency to multilayer growth; (5) improved ability to heal a scratch wound; (6) reduced ability to grow at the subcutaneous site of injection in nude mice.
T7 1321-1565 Sentence denotes Our data suggest that the presence of alpha2,6-linked sialic acid on membrane glycoconjugates increases the binding to extracellular matrix components, resulting in a membrane stabilization of beta1 integrins, further strengthening the binding.
T8 1566-1723 Sentence denotes This mechanism can provide a basis for the flatter morphology and the reduced tendency to multilayer growth, resulting in a more ordered tissue organization.
T9 1724-1870 Sentence denotes These data indicate that in the cell line SW948, the effect of ST6Gal.I expression is consistent with the attenuation of the neoplastic phenotype.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 103-108 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T2 519-524 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 316-322 HP_0002664 denotes cancer
T2 519-531 HP_0003003 denotes colon cancer
T3 519-531 HP_0100273 denotes colon cancer
T4 525-531 HP_0002664 denotes cancer

GlycoBiology-PACDB

Id Subject Object Predicate Lexical cue
_T1 842-864 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC265,LEC313 denotes Clostridium perfrigens

uniprot-human

Id Subject Object Predicate Lexical cue
T1 771-782 http://www.uniprot.org/uniprot/Q8IVI8 denotes fibronectin
T2 902-913 http://www.uniprot.org/uniprot/Q8IVI8 denotes fibronectin

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 771-782 http://www.uniprot.org/uniprot/P11276 denotes fibronectin
T2 902-913 http://www.uniprot.org/uniprot/P11276 denotes fibronectin
T3 1310-1314 http://www.uniprot.org/uniprot/Q9CZA6 denotes nude

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 44-48 http://purl.bioontology.org/ontology/NCBITAXON/3554 denotes beta
T2 44-48 http://purl.bioontology.org/ontology/NCBITAXON/158455 denotes beta
T3 109-115 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T4 133-137 http://purl.bioontology.org/ontology/NCBITAXON/3554 denotes Beta
T5 133-137 http://purl.bioontology.org/ontology/NCBITAXON/158455 denotes Beta
T6 316-322 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T7 525-531 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T8 678-683 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T9 842-853 http://purl.bioontology.org/ontology/NCBITAXON/33954 denotes Clostridium
T10 842-853 http://purl.bioontology.org/ontology/NCBITAXON/1559 denotes Clostridium
T11 842-853 http://purl.bioontology.org/ontology/NCBITAXON/1485 denotes Clostridium
T12 842-853 http://purl.bioontology.org/ontology/NCBITAXON/36835 denotes Clostridium
T13 842-853 http://purl.bioontology.org/ontology/NCBITAXON/1535 denotes Clostridium
T14 842-853 http://purl.bioontology.org/ontology/NCBITAXON/1536 denotes Clostridium
T15 842-853 http://purl.bioontology.org/ontology/NCBITAXON/84029 denotes Clostridium
T16 953-958 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T17 993-998 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T18 1571-1580 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanism
T19 1703-1709 http://purl.bioontology.org/ontology/STY/T024 denotes tissue

GO-BP

Id Subject Object Predicate Lexical cue
T1 475-485 http://purl.obolibrary.org/obo/GO_0097503 denotes sialylated
T2 1187-1193 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T3 1667-1673 http://purl.obolibrary.org/obo/GO_0040007 denotes growth

GO-MF

Id Subject Object Predicate Lexical cue
T1 891-898 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T2 1429-1436 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T3 1557-1564 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 891-898 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T5 1429-1436 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T6 1557-1564 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T7 891-898 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T8 1429-1436 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T9 1557-1564 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T10 891-898 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T11 1429-1436 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12 1557-1564 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T13 891-913 http://purl.obolibrary.org/obo/GO_0001968 denotes binding to fibronectin
T14 1429-1460 http://purl.obolibrary.org/obo/GO_0050840 denotes binding to extracellular matrix
T15 1429-1460 http://purl.obolibrary.org/obo/GO_1990430 denotes binding to extracellular matrix

GO-CC

Id Subject Object Predicate Lexical cue
T1 116-120 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 532-536 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 1071-1075 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 678-683 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 953-958 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6 993-998 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7 1071-1083 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface
T8 1390-1398 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T9 1488-1496 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T10 1440-1453 http://purl.obolibrary.org/obo/GO_0005576 denotes extracellular
T11 1440-1460 http://purl.obolibrary.org/obo/GO_0031012 denotes extracellular matrix
T12 1440-1471 http://purl.obolibrary.org/obo/GO_0044420 denotes extracellular matrix components

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 103-108 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T2 519-524 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T3 1703-1709 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 0-10 http://edamontology.org/topic_0625 denotes Phenotypic
T2 97-102 http://edamontology.org/topic_2815 denotes human
T3 109-115 http://edamontology.org/topic_2640 denotes cancer
T4 235-242 http://edamontology.org/topic_0102 denotes linkage
T5 316-322 http://edamontology.org/topic_2640 denotes cancer
T6 386-391 http://edamontology.org/topic_3678 denotes study
T7 418-428 http://edamontology.org/topic_0625 denotes phenotypic
T8 513-518 http://edamontology.org/topic_2815 denotes human
T9 525-531 http://edamontology.org/topic_2640 denotes cancer
T10 640-644 http://edamontology.org/topic_3512 denotes cDNA
T11 1860-1869 http://edamontology.org/topic_0625 denotes phenotype

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 0-10 http://edamontology.org/data_3275 denotes Phenotypic
T2 418-428 http://edamontology.org/data_3275 denotes phenotypic
T3 1325-1329 http://edamontology.org/data_0006 denotes data
T4 1454-1460 http://edamontology.org/data_2082 denotes matrix
T5 1730-1734 http://edamontology.org/data_0006 denotes data
T6 1860-1869 http://edamontology.org/data_3275 denotes phenotype

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
16192407-0#70#89#gene6480 70-89 gene6480 denotes sialyltransferase I
16192407-0#103#115#diseaseC0007102 103-115 diseaseC0007102 denotes colon cancer
16192407-0#103#115#diseaseC0699790 103-115 diseaseC0699790 denotes colon cancer
70#89#gene6480103#115#diseaseC0007102 16192407-0#70#89#gene6480 16192407-0#103#115#diseaseC0007102 associated_with sialyltransferase I,colon cancer
70#89#gene6480103#115#diseaseC0699790 16192407-0#70#89#gene6480 16192407-0#103#115#diseaseC0699790 associated_with sialyltransferase I,colon cancer

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 103-108 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T2 519-524 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 246-258 http://rdf.glycoinfo.org/glycan/G00055MO denotes lactosaminic
T2 486-498 http://rdf.glycoinfo.org/glycan/G00055MO denotes lactosaminic

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1703-1709 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T2 1710-1722 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organization
PD-UBERON-AE-B_T3 103-108 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T4 519-524 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon

DisGeNET

Id Subject Object Predicate Lexical cue
T0 70-89 gene:6480 denotes sialyltransferase I
T1 103-115 disease:C0699790 denotes colon cancer
T2 70-89 gene:6480 denotes sialyltransferase I
T3 103-115 disease:C0007102 denotes colon cancer
T4 178-186 gene:6480 denotes ST6Gal.I
T5 316-322 disease:C0006826 denotes cancer
T6 178-186 gene:6480 denotes ST6Gal.I
T7 316-322 disease:C1306459 denotes cancer
T8 178-186 gene:6480 denotes ST6Gal.I
T9 350-360 disease:C1306459 denotes malignancy
T10 178-186 gene:6480 denotes ST6Gal.I
T11 350-360 disease:C0006826 denotes malignancy
T12 579-587 gene:6480 denotes ST6Gal.I
T13 519-531 disease:C0699790 denotes colon cancer
T14 579-587 gene:6480 denotes ST6Gal.I
T15 519-531 disease:C0007102 denotes colon cancer
R1 T0 T1 associated_with sialyltransferase I,colon cancer
R2 T2 T3 associated_with sialyltransferase I,colon cancer
R3 T4 T5 associated_with ST6Gal.I,cancer
R4 T6 T7 associated_with ST6Gal.I,cancer
R5 T8 T9 associated_with ST6Gal.I,malignancy
R6 T10 T11 associated_with ST6Gal.I,malignancy
R7 T12 T13 associated_with ST6Gal.I,colon cancer
R8 T14 T15 associated_with ST6Gal.I,colon cancer

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 103-108 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526
T2 519-524 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 103-115 Phenotype denotes colon cancer HP:0003003
T2 316-322 Phenotype denotes cancer HP:0002664
T3 519-531 Phenotype denotes colon cancer HP:0003003

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 103-115 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T2 316-322 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T3 519-531 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T4 1234-1239 Disease denotes wound http://purl.obolibrary.org/obo/MONDO_0021178

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 97-102 OrganismTaxon denotes human 9606
T2 513-518 OrganismTaxon denotes human 9606
T3 842-853 OrganismTaxon denotes Clostridium 1485
T4 1315-1319 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 103-108 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T2 519-524 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T3 1390-1398 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T6 1440-1460 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T7 1488-1496 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T10 1703-1709 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479