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PubMed:16150730 JSON TXT

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PubMed_ArguminSci

Id	Subject	Object	Predicate	Lexical cue
T1	133-353	DRI_Background	denotes	beta-Amyloid peptides (Abeta) that form the senile plaques of Alzheimer disease consist mainly of 40- and 42-amino acid (Abeta 40 and Abeta 42) peptides generated from the cleavage of the amyloid precursor protein (APP).
T2	354-515	DRI_Background	denotes	Generation of Abeta involves beta-secretase and gamma-secretase activities and is regulated by membrane trafficking of the proteins involved in Abeta production.
T3	516-606	DRI_Approach	denotes	Here we describe a new small molecule, EHT 1864, which blocks the Rac1 signaling pathways.
T4	740-858	DRI_Background	denotes	Rather, EHT 1864 modulates APP processing at the level of gamma-secretase to prevent Abeta 40 and Abeta 42 generation.
T5	859-1024	DRI_Challenge	denotes	This effect does not result from a direct inhibition of the gamma-secretase activity and is specific for APP cleavage, since EHT 1864 does not affect Notch cleavage.
T6	1229-1374	DRI_Background	denotes	EHT 1864 is the first derivative of a new chemical series that consists of candidates for inhibiting Abeta formation in the brain of AD patients.
T7	1375-1518	DRI_Outcome	denotes	Our findings represent the first pharmacological validation of Rac1 signaling as a target for developing novel therapies for Alzheimer disease.

sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-132	Sentence	denotes	RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.
T2	133-353	Sentence	denotes	beta-Amyloid peptides (Abeta) that form the senile plaques of Alzheimer disease consist mainly of 40- and 42-amino acid (Abeta 40 and Abeta 42) peptides generated from the cleavage of the amyloid precursor protein (APP).
T3	354-515	Sentence	denotes	Generation of Abeta involves beta-secretase and gamma-secretase activities and is regulated by membrane trafficking of the proteins involved in Abeta production.
T4	516-606	Sentence	denotes	Here we describe a new small molecule, EHT 1864, which blocks the Rac1 signaling pathways.
T5	607-739	Sentence	denotes	In vitro, EHT 1864 blocks Abeta 40 and Abeta 42 production but does not impact sAPPalpha levels and does not inhibit beta-secretase.
T6	740-858	Sentence	denotes	Rather, EHT 1864 modulates APP processing at the level of gamma-secretase to prevent Abeta 40 and Abeta 42 generation.
T7	859-1024	Sentence	denotes	This effect does not result from a direct inhibition of the gamma-secretase activity and is specific for APP cleavage, since EHT 1864 does not affect Notch cleavage.
T8	1025-1228	Sentence	denotes	In vivo, EHT 1864 significantly reduces Abeta 40 and Abeta 42 levels in guinea pig brains at a threshold that is compatible with delaying plaque accumulation and/or clearing the existing plaque in brain.
T9	1229-1374	Sentence	denotes	EHT 1864 is the first derivative of a new chemical series that consists of candidates for inhibiting Abeta formation in the brain of AD patients.
T10	1375-1518	Sentence	denotes	Our findings represent the first pharmacological validation of Rac1 signaling as a target for developing novel therapies for Alzheimer disease.

Glycosmos6-MAT

Id	Subject	Object	Predicate	Lexical cue
T1	1108-1114	http://purl.obolibrary.org/obo/MAT_0000098	denotes	brains
T2	1222-1227	http://purl.obolibrary.org/obo/MAT_0000098	denotes	brain
T3	1353-1358	http://purl.obolibrary.org/obo/MAT_0000098	denotes	brain

PubmedHPO

Id	Subject	Object	Predicate	Lexical cue
T1	138-145	HP_0011034	denotes	Amyloid
T2	177-191	HP_0100256	denotes	senile plaques
T3	195-212	HP_0002511	denotes	Alzheimer disease
T4	321-328	HP_0011034	denotes	amyloid
T5	1500-1517	HP_0002511	denotes	Alzheimer disease

UseCases_ArguminSci_Discourse

Id	Subject	Object	Predicate	Lexical cue
T1	0-132	DRI_Background	denotes	RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.
T2	133-353	DRI_Background	denotes	beta-Amyloid peptides (Abeta) that form the senile plaques of Alzheimer disease consist mainly of 40- and 42-amino acid (Abeta 40 and Abeta 42) peptides generated from the cleavage of the amyloid precursor protein (APP).
T3	354-515	DRI_Background	denotes	Generation of Abeta involves beta-secretase and gamma-secretase activities and is regulated by membrane trafficking of the proteins involved in Abeta production.
T4	516-606	DRI_Approach	denotes	Here we describe a new small molecule, EHT 1864, which blocks the Rac1 signaling pathways.
T5	607-739	DRI_Unspecified	denotes	In vitro, EHT 1864 blocks Abeta 40 and Abeta 42 production but does not impact sAPPalpha levels and does not inhibit beta-secretase.
T6	740-858	DRI_Background	denotes	Rather, EHT 1864 modulates APP processing at the level of gamma-secretase to prevent Abeta 40 and Abeta 42 generation.
T7	859-1024	DRI_Challenge	denotes	This effect does not result from a direct inhibition of the gamma-secretase activity and is specific for APP cleavage, since EHT 1864 does not affect Notch cleavage.
T8	1025-1228	DRI_Unspecified	denotes	In vivo, EHT 1864 significantly reduces Abeta 40 and Abeta 42 levels in guinea pig brains at a threshold that is compatible with delaying plaque accumulation and/or clearing the existing plaque in brain.
T9	1229-1374	DRI_Background	denotes	EHT 1864 is the first derivative of a new chemical series that consists of candidates for inhibiting Abeta formation in the brain of AD patients.
T10	1375-1518	DRI_Outcome	denotes	Our findings represent the first pharmacological validation of Rac1 signaling as a target for developing novel therapies for Alzheimer disease.

mondo_disease

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	24-31	Disease	denotes	amyloid	http://purl.obolibrary.org/obo/MONDO_0019065
T2	138-145	Disease	denotes	Amyloid	http://purl.obolibrary.org/obo/MONDO_0019065
T3	195-212	Disease	denotes	Alzheimer disease	http://purl.obolibrary.org/obo/MONDO_0004975
T4	321-328	Disease	denotes	amyloid	http://purl.obolibrary.org/obo/MONDO_0019065
T5	1500-1517	Disease	denotes	Alzheimer disease	http://purl.obolibrary.org/obo/MONDO_0004975

Anatomy-MAT

Id	Subject	Object	Predicate	Lexical cue	mat_id
T1	1108-1114	Body_part	denotes	brains	http://purl.obolibrary.org/obo/MAT_0000098
T2	1222-1227	Body_part	denotes	brain	http://purl.obolibrary.org/obo/MAT_0000098
T3	1353-1358	Body_part	denotes	brain	http://purl.obolibrary.org/obo/MAT_0000098

HP-phenotype

Id	Subject	Object	Predicate	Lexical cue	hp_id
T1	177-191	Phenotype	denotes	senile plaques	HP:0100256
T2	195-212	Phenotype	denotes	Alzheimer disease	HP:0002511
T3	1500-1517	Phenotype	denotes	Alzheimer disease	HP:0002511

NCBITAXON

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	1097-1107	OrganismTaxon	denotes	guinea pig	10141

Anatomy-UBERON

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T1	449-457	Body_part	denotes	membrane	http://purl.obolibrary.org/obo/GO_0016020\|http://purl.obolibrary.org/obo/UBERON_0000094\|http://purl.obolibrary.org/obo/UBERON_0000158
T4	1163-1169	Body_part	denotes	plaque	http://purl.obolibrary.org/obo/UBERON_0016482
T5	1212-1218	Body_part	denotes	plaque	http://purl.obolibrary.org/obo/UBERON_0016482
T6	1222-1227	Body_part	denotes	brain	http://purl.obolibrary.org/obo/UBERON_0000955\|http://purl.obolibrary.org/obo/UBERON_6110636
T8	1353-1358	Body_part	denotes	brain	http://purl.obolibrary.org/obo/UBERON_0000955\|http://purl.obolibrary.org/obo/UBERON_6110636