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PubMed:16138344 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-120 Sentence denotes Acute lymphoblastic leukemia in a patient with chronic granulomatous disease and a novel mutation in CYBB: first report.
TextSentencer_T2 121-248 Sentence denotes We report for the first time a child with chronic granulomatous disease (CGD) who developed acute lymphoblastic leukemia (ALL).
TextSentencer_T3 249-342 Sentence denotes The diagnosis of CGD was made at the age of 4 months, by studies of his neutrophil functions.
TextSentencer_T4 343-431 Sentence denotes The superoxide production of the cells was negligible, as was the bactericidal activity.
TextSentencer_T5 432-569 Sentence denotes He was found to have a deficiency of the gp91(phox) subunit of the leukocyte NADPH oxidase, with the X-linked inheritance of the disease.
TextSentencer_T6 570-641 Sentence denotes DNA analysis revealed a C nucleotide insertion between C1028 and T1029.
TextSentencer_T7 642-765 Sentence denotes This insertion has not been described before and causes a frameshift and a premature stop codon at amino-acid position 347.
TextSentencer_T8 766-820 Sentence denotes The mother was found to be a carrier of this mutation.
TextSentencer_T9 821-879 Sentence denotes At the age of 16 months, the patient developed T-cell ALL.
TextSentencer_T10 880-968 Sentence denotes He was treated for 2 years, and today, 10 years since the diagnosis, he is disease-free.
TextSentencer_T11 969-1184 Sentence denotes During the course of ALL and later, he suffered from recurrent severe pyogenic infections, but careful detection of the etiological agent and promptly instituted specific treatment resulted in his complete recovery.
TextSentencer_T12 1185-1358 Sentence denotes Although primary immune deficiencies have been reported to have an increased tendency to develop malignancies, until now there have been no reports of CGD patients with ALL.
T1 0-120 Sentence denotes Acute lymphoblastic leukemia in a patient with chronic granulomatous disease and a novel mutation in CYBB: first report.
T2 121-248 Sentence denotes We report for the first time a child with chronic granulomatous disease (CGD) who developed acute lymphoblastic leukemia (ALL).
T3 249-342 Sentence denotes The diagnosis of CGD was made at the age of 4 months, by studies of his neutrophil functions.
T4 343-431 Sentence denotes The superoxide production of the cells was negligible, as was the bactericidal activity.
T5 432-569 Sentence denotes He was found to have a deficiency of the gp91(phox) subunit of the leukocyte NADPH oxidase, with the X-linked inheritance of the disease.
T6 570-641 Sentence denotes DNA analysis revealed a C nucleotide insertion between C1028 and T1029.
T7 642-765 Sentence denotes This insertion has not been described before and causes a frameshift and a premature stop codon at amino-acid position 347.
T8 766-820 Sentence denotes The mother was found to be a carrier of this mutation.
T9 821-879 Sentence denotes At the age of 16 months, the patient developed T-cell ALL.
T10 880-968 Sentence denotes He was treated for 2 years, and today, 10 years since the diagnosis, he is disease-free.
T11 969-1184 Sentence denotes During the course of ALL and later, he suffered from recurrent severe pyogenic infections, but careful detection of the etiological agent and promptly instituted specific treatment resulted in his complete recovery.
T12 1185-1358 Sentence denotes Although primary immune deficiencies have been reported to have an increased tendency to develop malignancies, until now there have been no reports of CGD patients with ALL.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 213-241 HP_0006721 denotes acute lymphoblastic leukemia
T2 233-241 HP_0001909 denotes leukemia
T3 533-541 HP_0001417 denotes X-linked
T4 533-553 HP_0001417 denotes X-linked inheritance
T5 1202-1221 HP_0002721 denotes immune deficiencies

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
16138344-0#101#105#gene1536 101-105 gene1536 denotes CYBB
16138344-0#0#28#diseaseC0023449 0-28 diseaseC0023449 denotes Acute lymphoblastic leukemia
16138344-0#0#28#diseaseC1961102 0-28 diseaseC1961102 denotes Acute lymphoblastic leukemia
16138344-0#47#76#diseaseC0018203 47-76 diseaseC0018203 denotes chronic granulomatous disease
101#105#gene15360#28#diseaseC0023449 16138344-0#101#105#gene1536 16138344-0#0#28#diseaseC0023449 associated_with CYBB,Acute lymphoblastic leukemia
101#105#gene15360#28#diseaseC1961102 16138344-0#101#105#gene1536 16138344-0#0#28#diseaseC1961102 associated_with CYBB,Acute lymphoblastic leukemia
101#105#gene153647#76#diseaseC0018203 16138344-0#101#105#gene1536 16138344-0#47#76#diseaseC0018203 associated_with CYBB,chronic granulomatous disease

PubCasesHPO

Id Subject Object Predicate Lexical cue
TI1 0-28 HP:0006721 denotes Acute lymphoblastic leukemia
AB1 213-241 HP:0006721 denotes acute lymphoblastic leukemia

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2704 101-105 gene:1536 denotes CYBB
T2705 0-28 disease:C0023449 denotes Acute lymphoblastic leukemia
R1 T2704 T2705 associated_with CYBB,Acute lymphoblastic leukemia
R2 T2704 T2705 associated_with CYBB,Acute lymphoblastic leukemia

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 163-192 ORDO:379 denotes chronic granulomatous disease
TI1 47-76 ORDO:379 denotes chronic granulomatous disease
AB2 266-269 ORDO:379 denotes CGD
AB3 1336-1339 ORDO:379 denotes CGD

DisGeNET

Id Subject Object Predicate Lexical cue
T0 101-105 gene:1536 denotes CYBB
T1 0-28 disease:C0023449 denotes Acute lymphoblastic leukemia
T2 101-105 gene:1536 denotes CYBB
T3 0-28 disease:C1961102 denotes Acute lymphoblastic leukemia
T4 101-105 gene:1536 denotes CYBB
T5 47-76 disease:C0018203 denotes chronic granulomatous disease
R1 T0 T1 associated_with CYBB,Acute lymphoblastic leukemia
R2 T2 T3 associated_with CYBB,Acute lymphoblastic leukemia
R3 T4 T5 associated_with CYBB,chronic granulomatous disease