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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-137 Sentence denotes In vivo evidences suggesting the role of oxidative stress in pathogenesis of vancomycin-induced nephrotoxicity: protection by erdosteine.
T2 138-456 Sentence denotes The aims of this study were to examine vancomycin (VCM)-induced oxidative stress that promotes production of reactive oxygen species (ROS) and to investigate the role of erdosteine, an expectorant agent, which has also antioxidant properties, on kidney tissue against the possible VCM-induced renal impairment in rats.
T3 457-528 Sentence denotes Rats were divided into three groups: sham, VCM and VCM plus erdosteine.
T4 529-616 Sentence denotes VCM was administrated intraperitoneally (i.p.) with 200mgkg(-1) twice daily for 7 days.
T5 617-652 Sentence denotes Erdosteine was administered orally.
T6 653-905 Sentence denotes VCM administration to control rats significantly increased renal malondialdehyde (MDA) and urinary N-acetyl-beta-d-glucosaminidase (NAG, a marker of renal tubular injury) excretion but decreased superoxide dismutase (SOD) and catalase (CAT) activities.
T7 906-1114 Sentence denotes Erdosteine administration with VCM injections caused significantly decreased renal MDA and urinary NAG excretion, and increased SOD activity, but not CAT activity in renal tissue when compared with VCM alone.
T8 1115-1197 Sentence denotes Erdosteine showed histopathological protection against VCM-induced nephrotoxicity.
T9 1198-1407 Sentence denotes There were a significant dilatation of tubular lumens, extensive epithelial cell vacuolization, atrophy, desquamation, and necrosis in VCM-treated rats more than those of the control and the erdosteine groups.
T10 1408-1477 Sentence denotes Erdosteine caused a marked reduction in the extent of tubular damage.
T11 1478-1723 Sentence denotes It is concluded that oxidative tubular damage plays an important role in the VCM-induced nephrotoxicity and the modulation of oxidative stress with erdosteine reduces the VCM-induced kidney damage both at the biochemical and histological levels.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 451-455 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T4 457-461 OrganismTaxon denotes Rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T7 683-687 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T10 1345-1349 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
2148 77-87 ChemicalEntity denotes vancomycin MESH:D014640
2149 96-110 DiseaseOrPhenotypicFeature denotes nephrotoxicity MESH:D007674
2150 126-136 ChemicalEntity denotes erdosteine MESH:C048498
2151 177-187 ChemicalEntity denotes vancomycin MESH:D014640
2152 189-192 ChemicalEntity denotes VCM MESH:D014640
2153 247-270 ChemicalEntity denotes reactive oxygen species MESH:D017382
2154 272-275 ChemicalEntity denotes ROS MESH:D017382
2155 308-318 ChemicalEntity denotes erdosteine MESH:C048498
2156 357-368 ChemicalEntity denotes antioxidant MESH:D000975
2157 419-422 ChemicalEntity denotes VCM MESH:D014640
2158 431-447 DiseaseOrPhenotypicFeature denotes renal impairment MESH:D007674
2159 451-455 OrganismTaxon denotes rats NCBITaxon:10116
2160 457-461 OrganismTaxon denotes Rats NCBITaxon:10116
2161 500-503 ChemicalEntity denotes VCM MESH:D014640
2162 508-511 ChemicalEntity denotes VCM MESH:D014640
2163 517-527 ChemicalEntity denotes erdosteine MESH:C048498
2164 529-532 ChemicalEntity denotes VCM MESH:D014640
2165 617-627 ChemicalEntity denotes Erdosteine MESH:C048498
2166 653-656 ChemicalEntity denotes VCM MESH:D014640
2167 683-687 OrganismTaxon denotes rats NCBITaxon:10116
2168 718-733 ChemicalEntity denotes malondialdehyde MESH:D008315
2169 735-738 ChemicalEntity denotes MDA MESH:D008315
2170 752-783 GeneOrGeneProduct denotes N-acetyl-beta-d-glucosaminidase NCBIGene:154968
2171 785-788 GeneOrGeneProduct denotes NAG NCBIGene:154968
2172 802-822 DiseaseOrPhenotypicFeature denotes renal tubular injury MESH:D007674
2173 848-868 ChemicalEntity denotes superoxide dismutase MESH:D013482
2174 870-873 ChemicalEntity denotes SOD MESH:D013482
2175 879-887 GeneOrGeneProduct denotes catalase NCBIGene:24248
2176 889-892 GeneOrGeneProduct denotes CAT NCBIGene:24248
2177 906-916 ChemicalEntity denotes Erdosteine MESH:C048498
2178 937-940 ChemicalEntity denotes VCM MESH:D014640
2179 989-992 ChemicalEntity denotes MDA MESH:D008315
2180 1005-1008 GeneOrGeneProduct denotes NAG NCBIGene:154968
2181 1034-1037 ChemicalEntity denotes SOD MESH:D013482
2182 1056-1059 GeneOrGeneProduct denotes CAT NCBIGene:24248
2183 1104-1107 ChemicalEntity denotes VCM MESH:D014640
2184 1115-1125 ChemicalEntity denotes Erdosteine MESH:C048498
2185 1170-1173 ChemicalEntity denotes VCM MESH:D014640
2186 1182-1196 DiseaseOrPhenotypicFeature denotes nephrotoxicity MESH:D007674
2187 1294-1301 DiseaseOrPhenotypicFeature denotes atrophy MESH:D001284
2188 1303-1315 DiseaseOrPhenotypicFeature denotes desquamation MESH:D012871
2189 1321-1329 DiseaseOrPhenotypicFeature denotes necrosis MESH:D009336
2190 1333-1336 ChemicalEntity denotes VCM MESH:D014640
2191 1345-1349 OrganismTaxon denotes rats NCBITaxon:10116
2192 1389-1399 ChemicalEntity denotes erdosteine MESH:C048498
2193 1408-1418 ChemicalEntity denotes Erdosteine MESH:C048498
2194 1555-1558 ChemicalEntity denotes VCM MESH:D014640
2195 1567-1581 DiseaseOrPhenotypicFeature denotes nephrotoxicity MESH:D007674
2196 1626-1636 ChemicalEntity denotes erdosteine MESH:C048498
2197 1649-1652 ChemicalEntity denotes VCM MESH:D014640
2198 1661-1674 DiseaseOrPhenotypicFeature denotes kidney damage MESH:D007674

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 816-822 DiseaseOrPhenotypicFeature denotes injury 0021178

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 88-95 GeneOrGeneProduct denotes induced
T2 194-201 GeneOrGeneProduct denotes induced
T3 233-243 GeneOrGeneProduct denotes production
T4 384-390 GeneOrGeneProduct denotes kidney
T5 423-430 GeneOrGeneProduct denotes induced
T6 494-498 GeneOrGeneProduct denotes sham
T7 761-765 GeneOrGeneProduct denotes beta
T8 768-783 GeneOrGeneProduct denotes glucosaminidase
T9 785-791 GeneOrGeneProduct denotes NAG, a
T10 848-874 GeneOrGeneProduct denotes superoxide dismutase (SOD)
T11 879-887 GeneOrGeneProduct denotes catalase
T12 889-892 GeneOrGeneProduct denotes CAT
T13 894-904 GeneOrGeneProduct denotes activities
T14 1005-1008 GeneOrGeneProduct denotes NAG
T15 1038-1046 GeneOrGeneProduct denotes activity
T16 1056-1059 GeneOrGeneProduct denotes CAT
T17 1060-1068 GeneOrGeneProduct denotes activity
T18 1174-1181 GeneOrGeneProduct denotes induced
T19 1253-1262 GeneOrGeneProduct denotes extensive
T20 1274-1278 GeneOrGeneProduct denotes cell
T21 1279-1292 GeneOrGeneProduct denotes vacuolization
T22 1428-1434 GeneOrGeneProduct denotes marked
T23 1470-1476 GeneOrGeneProduct denotes damage
T24 1517-1523 GeneOrGeneProduct denotes damage
T25 1559-1566 GeneOrGeneProduct denotes induced
T26 1637-1644 GeneOrGeneProduct denotes reduces
T27 1653-1660 GeneOrGeneProduct denotes induced
T28 1661-1667 GeneOrGeneProduct denotes kidney
T29 1668-1674 GeneOrGeneProduct denotes damage

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 384-390 GeneOrGeneProduct denotes kidney
T2 761-765 GeneOrGeneProduct denotes beta
T3 768-783 GeneOrGeneProduct denotes glucosaminidase
T4 848-874 GeneOrGeneProduct denotes superoxide dismutase (SOD)
T5 879-887 GeneOrGeneProduct denotes catalase
T6 889-892 GeneOrGeneProduct denotes CAT
T7 1056-1059 GeneOrGeneProduct denotes CAT
T8 1274-1278 GeneOrGeneProduct denotes cell
T9 1661-1667 GeneOrGeneProduct denotes kidney

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 96-110 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T2 816-822 DiseaseOrPhenotypicFeature denotes injury D014947
T3 1182-1196 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T4 1294-1301 DiseaseOrPhenotypicFeature denotes atrophy D001284
T5 1321-1329 DiseaseOrPhenotypicFeature denotes necrosis D009336
T6 1567-1581 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 768-783 GeneOrGeneProduct denotes glucosaminidase
T2 848-874 GeneOrGeneProduct denotes superoxide dismutase (SOD)
T3 879-887 GeneOrGeneProduct denotes catalase
T4 889-892 GeneOrGeneProduct denotes CAT
T5 1056-1059 GeneOrGeneProduct denotes CAT

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 816-822 DiseaseOrPhenotypicFeature denotes injury 0021178
T2 870-873 DiseaseOrPhenotypicFeature denotes SOD 0019029|0008428
T4 1034-1037 DiseaseOrPhenotypicFeature denotes SOD 0019029|0008428

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 96-110 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T2 431-447 DiseaseOrPhenotypicFeature denotes renal impairment DISEASE
T3 816-822 DiseaseOrPhenotypicFeature denotes injury D014947
T4 1182-1196 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T5 1294-1301 DiseaseOrPhenotypicFeature denotes atrophy D001284
T6 1303-1315 DiseaseOrPhenotypicFeature denotes desquamation DISEASE
T7 1321-1329 DiseaseOrPhenotypicFeature denotes necrosis D009336
T8 1567-1581 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T9 1661-1674 DiseaseOrPhenotypicFeature denotes kidney damage DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 96-110 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T2 431-447 DiseaseOrPhenotypicFeature denotes renal impairment DISEASE
T3 802-822 DiseaseOrPhenotypicFeature denotes renal tubular injury EisukeAdded
T4 1182-1196 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T5 1294-1301 DiseaseOrPhenotypicFeature denotes atrophy D001284
T6 1303-1315 DiseaseOrPhenotypicFeature denotes desquamation DISEASE
T7 1567-1581 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T8 1661-1674 DiseaseOrPhenotypicFeature denotes kidney damage DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 77-87 ChemicalEntity denotes vancomycin http://purl.obolibrary.org/obo/CHEBI_76842|http://purl.obolibrary.org/obo/CHEBI_28001
T3 126-136 ChemicalEntity denotes erdosteine C048498|http://purl.obolibrary.org/obo/CHEBI_135014
T5 177-187 ChemicalEntity denotes vancomycin http://purl.obolibrary.org/obo/CHEBI_76842|http://purl.obolibrary.org/obo/CHEBI_28001
T7 189-192 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T8 247-270 ChemicalEntity denotes reactive oxygen species D017382|http://purl.obolibrary.org/obo/CHEBI_26523
T10 272-275 ChemicalEntity denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T11 308-318 ChemicalEntity denotes erdosteine C048498|http://purl.obolibrary.org/obo/CHEBI_135014
T13 357-368 ChemicalEntity denotes antioxidant ChemicalEntity
T14 419-422 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T15 500-503 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T16 508-511 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T17 517-527 ChemicalEntity denotes erdosteine C048498|http://purl.obolibrary.org/obo/CHEBI_135014
T19 529-532 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T20 617-627 ChemicalEntity denotes Erdosteine C048498|http://purl.obolibrary.org/obo/CHEBI_135014
T22 653-656 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T23 718-733 ChemicalEntity denotes malondialdehyde D008315
T24 735-738 ChemicalEntity denotes MDA http://purl.obolibrary.org/obo/CHEBI_566274|D008315
T26 752-783 ChemicalEntity denotes N-acetyl-beta-d-glucosaminidase D000118
T27 785-788 ChemicalEntity denotes NAG http://purl.obolibrary.org/obo/CHEBI_44337
T28 848-868 ChemicalEntity denotes superoxide dismutase D013482
T29 870-873 ChemicalEntity denotes SOD ChemicalEntity|D013482
T31 879-887 ChemicalEntity denotes catalase D002374
T32 889-892 ChemicalEntity denotes CAT D002374
T33 906-916 ChemicalEntity denotes Erdosteine C048498|http://purl.obolibrary.org/obo/CHEBI_135014
T35 937-940 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T36 989-992 ChemicalEntity denotes MDA http://purl.obolibrary.org/obo/CHEBI_566274|D008315
T38 1005-1008 ChemicalEntity denotes NAG http://purl.obolibrary.org/obo/CHEBI_44337
T39 1034-1037 ChemicalEntity denotes SOD ChemicalEntity|D013482
T41 1056-1059 ChemicalEntity denotes CAT D002374
T42 1104-1107 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T43 1115-1125 ChemicalEntity denotes Erdosteine C048498|http://purl.obolibrary.org/obo/CHEBI_135014
T45 1170-1173 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T46 1333-1336 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T47 1389-1399 ChemicalEntity denotes erdosteine C048498|http://purl.obolibrary.org/obo/CHEBI_135014
T49 1408-1418 ChemicalEntity denotes Erdosteine C048498|http://purl.obolibrary.org/obo/CHEBI_135014
T51 1555-1558 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T52 1626-1636 ChemicalEntity denotes erdosteine C048498|http://purl.obolibrary.org/obo/CHEBI_135014
T54 1649-1652 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 451-455 OrganismTaxon denotes rats
T2 457-461 OrganismTaxon denotes Rats
T3 683-687 OrganismTaxon denotes rats
T4 889-892 OrganismTaxon denotes CAT
T5 1056-1059 OrganismTaxon denotes CAT
T6 1345-1349 OrganismTaxon denotes rats

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T54 1649-1652 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T52 1626-1636 ChemicalEntity denotes erdosteine http://purl.obolibrary.org/obo/CHEBI_135014|C048498
T51 1555-1558 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T49 1408-1418 ChemicalEntity denotes Erdosteine http://purl.obolibrary.org/obo/CHEBI_135014|C048498
T47 1389-1399 ChemicalEntity denotes erdosteine http://purl.obolibrary.org/obo/CHEBI_135014|C048498
T46 1333-1336 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T45 1170-1173 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T43 1115-1125 ChemicalEntity denotes Erdosteine http://purl.obolibrary.org/obo/CHEBI_135014|C048498
T42 1104-1107 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T41 1056-1059 ChemicalEntity denotes CAT D002374
T39 1034-1037 ChemicalEntity denotes SOD D013482|ChemicalEntity
T38 1005-1008 ChemicalEntity denotes NAG http://purl.obolibrary.org/obo/CHEBI_44337
T36 989-992 ChemicalEntity denotes MDA D008315|http://purl.obolibrary.org/obo/CHEBI_566274
T35 937-940 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T33 906-916 ChemicalEntity denotes Erdosteine http://purl.obolibrary.org/obo/CHEBI_135014|C048498
T32 889-892 ChemicalEntity denotes CAT D002374
T31 879-887 ChemicalEntity denotes catalase D002374
T29 870-873 ChemicalEntity denotes SOD ChemicalEntity|D013482
T28 848-868 ChemicalEntity denotes superoxide dismutase D013482
T27 785-788 ChemicalEntity denotes NAG http://purl.obolibrary.org/obo/CHEBI_44337
T26 752-783 ChemicalEntity denotes N-acetyl-beta-d-glucosaminidase D000118
T24 735-738 ChemicalEntity denotes MDA D008315|http://purl.obolibrary.org/obo/CHEBI_566274
T23 718-733 ChemicalEntity denotes malondialdehyde D008315
T22 653-656 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T20 617-627 ChemicalEntity denotes Erdosteine http://purl.obolibrary.org/obo/CHEBI_135014|C048498
T19 529-532 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T17 517-527 ChemicalEntity denotes erdosteine http://purl.obolibrary.org/obo/CHEBI_135014|C048498
T16 508-511 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T15 500-503 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T14 419-422 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T13 357-368 ChemicalEntity denotes antioxidant ChemicalEntity
T11 308-318 ChemicalEntity denotes erdosteine http://purl.obolibrary.org/obo/CHEBI_135014|C048498
T10 272-275 ChemicalEntity denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T8 247-270 ChemicalEntity denotes reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_26523|D017382
T7 189-192 ChemicalEntity denotes VCM http://purl.obolibrary.org/obo/CHEBI_76842
T5 177-187 ChemicalEntity denotes vancomycin http://purl.obolibrary.org/obo/CHEBI_28001|http://purl.obolibrary.org/obo/CHEBI_76842
T3 126-136 ChemicalEntity denotes erdosteine http://purl.obolibrary.org/obo/CHEBI_135014|C048498
T1 77-87 ChemicalEntity denotes vancomycin http://purl.obolibrary.org/obo/CHEBI_28001|http://purl.obolibrary.org/obo/CHEBI_76842
T78779 1056-1059 GeneOrGeneProduct denotes CAT
T4 889-892 GeneOrGeneProduct denotes CAT
T20179 879-887 GeneOrGeneProduct denotes catalase
T2 848-874 GeneOrGeneProduct denotes superoxide dismutase (SOD)
T74427 768-783 GeneOrGeneProduct denotes glucosaminidase
T72179 1661-1674 DiseaseOrPhenotypicFeature denotes kidney damage DISEASE
T81093 1567-1581 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T6 1303-1315 DiseaseOrPhenotypicFeature denotes desquamation DISEASE
T45780 1294-1301 DiseaseOrPhenotypicFeature denotes atrophy D001284
T93384 1182-1196 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T32472 802-822 DiseaseOrPhenotypicFeature denotes renal tubular injury EisukeAdded
T53516 431-447 DiseaseOrPhenotypicFeature denotes renal impairment DISEASE
T27226 96-110 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T63609 1345-1349 OrganismTaxon denotes rats
T80234 1056-1059 OrganismTaxon denotes CAT
T20446 889-892 OrganismTaxon denotes CAT
T61993 683-687 OrganismTaxon denotes rats
T46614 457-461 OrganismTaxon denotes Rats
T67334 451-455 OrganismTaxon denotes rats