Id |
Subject |
Object |
Predicate |
Lexical cue |
TextSentencer_T1 |
0-128 |
Sentence |
denotes |
Primary hyperparathyroidism and osteosarcoma: examination of a large cohort identifies three cases of fibroblastic osteosarcoma. |
TextSentencer_T2 |
129-140 |
Sentence |
denotes |
UNLABELLED: |
TextSentencer_T3 |
141-259 |
Sentence |
denotes |
To study a possible relationship between hyperparathyroidism and osteosarcoma, we reviewed 1234 osteosarcoma patients. |
TextSentencer_T4 |
260-370 |
Sentence |
denotes |
In this cohort, only three patients had a diagnosis of both hyperparathyroidism and fibroblastic osteosarcoma. |
TextSentencer_T5 |
371-502 |
Sentence |
denotes |
These results indicate that hyperparathyroidism is not more prevalent in patients with osteosarcoma than in the general population. |
TextSentencer_T6 |
503-613 |
Sentence |
denotes |
However, the presence of hyperparathyroidism may modify the histologic and cytologic features of osteosarcoma. |
TextSentencer_T7 |
614-627 |
Sentence |
denotes |
INTRODUCTION: |
TextSentencer_T8 |
628-806 |
Sentence |
denotes |
The finding of osteosarcoma in rats receiving human PTH(1-34) raised the question of whether hyperparathyroidism might be a risk factor for development of osteosarcoma in humans. |
TextSentencer_T9 |
807-829 |
Sentence |
denotes |
MATERIALS AND METHODS: |
TextSentencer_T10 |
830-987 |
Sentence |
denotes |
To study a possible relationship between hyperparathyroidism and osteosarcoma, we reviewed the medical records of 1234 osteosarcoma patients seen at The M.D. |
TextSentencer_T11 |
988-1022 |
Sentence |
denotes |
Anderson Cancer Center since 1948. |
TextSentencer_T12 |
1023-1183 |
Sentence |
denotes |
Our study focused on clinical, biochemical, radiologic, and histopathologic findings indicative of primary hyperparathyroidism and the features of osteosarcoma. |
TextSentencer_T13 |
1184-1192 |
Sentence |
denotes |
RESULTS: |
TextSentencer_T14 |
1193-1301 |
Sentence |
denotes |
Of the 1234 cases reviewed, 3 patients had a diagnosis of both primary hyperparathyroidism and osteosarcoma. |
TextSentencer_T15 |
1302-1428 |
Sentence |
denotes |
In two cases, hyperparathyroidism preceded the osteosarcoma, and in one case, both conditions were diagnosed at the same time. |
TextSentencer_T16 |
1429-1547 |
Sentence |
denotes |
In two cases with concomitant hyperparathyroidism and osteosarcoma, features of osteitis fibrocystica were identified. |
TextSentencer_T17 |
1548-1644 |
Sentence |
denotes |
The third patient was treated for hyperparathyroidism 3 years before osteosarcoma was diagnosed. |
TextSentencer_T18 |
1645-1777 |
Sentence |
denotes |
All three patients had histologic features of fibroblastic osteosarcoma, a type that accounts for no more than 20% of osteosarcomas. |
TextSentencer_T19 |
1778-2006 |
Sentence |
denotes |
To assess whether the prevalence of hyperparathyroidism was greater than expected in the normal population, we compared the age- and sex-specific prevalence in our cohort to a population of healthy individuals in Tromso, Norway. |
TextSentencer_T20 |
2007-2234 |
Sentence |
denotes |
This analysis showed no significant differences between the two populations, despite the fact that a higher prevalence of hyperparathyroidism (6.9% versus 1.6%) was noted in the 60- to 69-year-old female osteosarcoma age group. |
TextSentencer_T21 |
2235-2247 |
Sentence |
denotes |
CONCLUSIONS: |
TextSentencer_T22 |
2248-2389 |
Sentence |
denotes |
Our results indicate that hyperparathyroidism is not more prevalent in affected individuals with osteosarcoma than in the general population. |
TextSentencer_T23 |
2390-2582 |
Sentence |
denotes |
The finding of fibroblastic osteosarcoma in all three patients raises the question of whether coexistent hyperparathyroidism may modify the cytologic and histologic features of the malignancy. |
T1 |
0-128 |
Sentence |
denotes |
Primary hyperparathyroidism and osteosarcoma: examination of a large cohort identifies three cases of fibroblastic osteosarcoma. |
T2 |
129-140 |
Sentence |
denotes |
UNLABELLED: |
T3 |
141-259 |
Sentence |
denotes |
To study a possible relationship between hyperparathyroidism and osteosarcoma, we reviewed 1234 osteosarcoma patients. |
T4 |
260-370 |
Sentence |
denotes |
In this cohort, only three patients had a diagnosis of both hyperparathyroidism and fibroblastic osteosarcoma. |
T5 |
371-502 |
Sentence |
denotes |
These results indicate that hyperparathyroidism is not more prevalent in patients with osteosarcoma than in the general population. |
T6 |
503-613 |
Sentence |
denotes |
However, the presence of hyperparathyroidism may modify the histologic and cytologic features of osteosarcoma. |
T7 |
614-627 |
Sentence |
denotes |
INTRODUCTION: |
T8 |
628-806 |
Sentence |
denotes |
The finding of osteosarcoma in rats receiving human PTH(1-34) raised the question of whether hyperparathyroidism might be a risk factor for development of osteosarcoma in humans. |
T9 |
807-829 |
Sentence |
denotes |
MATERIALS AND METHODS: |
T10 |
830-987 |
Sentence |
denotes |
To study a possible relationship between hyperparathyroidism and osteosarcoma, we reviewed the medical records of 1234 osteosarcoma patients seen at The M.D. |
T11 |
988-1022 |
Sentence |
denotes |
Anderson Cancer Center since 1948. |
T12 |
1023-1183 |
Sentence |
denotes |
Our study focused on clinical, biochemical, radiologic, and histopathologic findings indicative of primary hyperparathyroidism and the features of osteosarcoma. |
T13 |
1184-1192 |
Sentence |
denotes |
RESULTS: |
T14 |
1193-1301 |
Sentence |
denotes |
Of the 1234 cases reviewed, 3 patients had a diagnosis of both primary hyperparathyroidism and osteosarcoma. |
T15 |
1302-1428 |
Sentence |
denotes |
In two cases, hyperparathyroidism preceded the osteosarcoma, and in one case, both conditions were diagnosed at the same time. |
T16 |
1429-1547 |
Sentence |
denotes |
In two cases with concomitant hyperparathyroidism and osteosarcoma, features of osteitis fibrocystica were identified. |
T17 |
1548-1644 |
Sentence |
denotes |
The third patient was treated for hyperparathyroidism 3 years before osteosarcoma was diagnosed. |
T18 |
1645-1777 |
Sentence |
denotes |
All three patients had histologic features of fibroblastic osteosarcoma, a type that accounts for no more than 20% of osteosarcomas. |
T19 |
1778-2006 |
Sentence |
denotes |
To assess whether the prevalence of hyperparathyroidism was greater than expected in the normal population, we compared the age- and sex-specific prevalence in our cohort to a population of healthy individuals in Tromso, Norway. |
T20 |
2007-2234 |
Sentence |
denotes |
This analysis showed no significant differences between the two populations, despite the fact that a higher prevalence of hyperparathyroidism (6.9% versus 1.6%) was noted in the 60- to 69-year-old female osteosarcoma age group. |
T21 |
2235-2247 |
Sentence |
denotes |
CONCLUSIONS: |
T22 |
2248-2389 |
Sentence |
denotes |
Our results indicate that hyperparathyroidism is not more prevalent in affected individuals with osteosarcoma than in the general population. |
T23 |
2390-2582 |
Sentence |
denotes |
The finding of fibroblastic osteosarcoma in all three patients raises the question of whether coexistent hyperparathyroidism may modify the cytologic and histologic features of the malignancy. |