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PubMed:16046395 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
16046395_0 377-381 ProteinMutation denotes N40D rs1799971

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-89 Sentence denotes Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.
T2 90-222 Sentence denotes As a primary target for opioid drugs and peptides, the mu opioid receptor (OPRM1) plays a key role in pain perception and addiction.
T3 223-456 Sentence denotes Genetic variants of OPRM1 have been implicated in predisposition to drug addiction, in particular the single nucleotide polymorphism A118G, leading to an N40D substitution, with an allele frequency of 10-32%, and uncertain functions.
T4 457-571 Sentence denotes We have measured allele-specific mRNA expression of OPRM1 in human autopsy brain tissues, using A118G as a marker.
T5 572-681 Sentence denotes In 8 heterozygous samples measured, the A118 mRNA allele was 1.5-2.5-fold more abundant than the G118 allele.
T6 682-1022 Sentence denotes Transfection into Chinese hamster ovary cells of a cDNA representing only the coding region of OPRM1, carrying adenosine, guanosine, cytidine, and thymidine in position 118, resulted in 1.5-fold lower mRNA levels only for OPRM1-G118, and more than 10-fold lower OPRM1 protein levels, measured by Western blotting and receptor binding assay.
T7 1023-1254 Sentence denotes After transfection and inhibition of transcription with actinomycin D, analysis of mRNA turnover failed to reveal differences in mRNA stability between A118 and G118 alleles, indicating a defect in transcription or mRNA maturation.
T8 1255-1374 Sentence denotes These results indicate that OPRM1-G118 is a functional variant with deleterious effects on both mRNA and protein yield.
T9 1375-1559 Sentence denotes Clarifying the functional relevance of polymorphisms associated with susceptibility to a complex disorder such as drug addiction provides a foundation for clinical association studies.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 32-37 OrganismTaxon denotes human NCBItxid:9606
T2 518-523 OrganismTaxon denotes human NCBItxid:9606
T3 700-715 OrganismTaxon denotes Chinese hamster NCBItxid:10029

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
2091 32-37 OrganismTaxon denotes human NCBITaxon:9606
2092 38-56 GeneOrGeneProduct denotes mu opioid receptor NCBIGene:4988
2093 58-63 GeneOrGeneProduct denotes OPRM1 NCBIGene:4988
2094 83-88 SequenceVariant denotes A118G DBSNP:rs1799971
2095 145-163 GeneOrGeneProduct denotes mu opioid receptor NCBIGene:4988
2096 165-170 GeneOrGeneProduct denotes OPRM1 NCBIGene:4988
2097 192-196 DiseaseOrPhenotypicFeature denotes pain MESH:D010146
2098 243-248 GeneOrGeneProduct denotes OPRM1 NCBIGene:4988
2099 291-305 DiseaseOrPhenotypicFeature denotes drug addiction MESH:D019966
2100 356-361 SequenceVariant denotes A118G DBSNP:rs1799971
2101 377-381 SequenceVariant denotes N40D DBSNP:rs1799971
2102 509-514 GeneOrGeneProduct denotes OPRM1 NCBIGene:4988
2103 518-523 OrganismTaxon denotes human NCBITaxon:9606
2104 553-558 SequenceVariant denotes A118G DBSNP:rs1799971
2105 612-616 SequenceVariant denotes A118 DBSNP:rs1799971
2106 669-673 SequenceVariant denotes G118 DBSNP:rs1799971
2107 700-715 OrganismTaxon denotes Chinese hamster NCBITaxon:10029
2108 777-782 GeneOrGeneProduct denotes OPRM1 NCBIGene:100770962
2109 793-854 SequenceVariant denotes adenosine, guanosine, cytidine, and thymidine in position 118 DBSNP:rs1799971
2110 904-909 GeneOrGeneProduct denotes OPRM1 NCBIGene:100770962
2111 910-914 SequenceVariant denotes G118 DBSNP:rs1799971
2112 944-949 GeneOrGeneProduct denotes OPRM1 NCBIGene:100770962
2113 1079-1092 ChemicalEntity denotes actinomycin D MESH:D003609
2114 1175-1179 SequenceVariant denotes A118 DBSNP:rs1799971
2115 1184-1188 SequenceVariant denotes G118 DBSNP:rs1799971
2116 1283-1288 GeneOrGeneProduct denotes OPRM1 NCBIGene:100770962
2117 1289-1293 SequenceVariant denotes G118 DBSNP:rs1799971
2118 1489-1503 DiseaseOrPhenotypicFeature denotes drug addiction MESH:D019966

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 83-88 SequenceVariant denotes A118G
T2 356-361 SequenceVariant denotes A118G
T3 377-381 SequenceVariant denotes N40D
T4 553-558 SequenceVariant denotes A118G

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 38-56 GeneOrGeneProduct denotes mu opioid receptor
T2 58-63 GeneOrGeneProduct denotes OPRM1
T3 145-163 GeneOrGeneProduct denotes mu opioid receptor
T4 165-170 GeneOrGeneProduct denotes OPRM1
T5 192-196 GeneOrGeneProduct denotes pain
T6 243-248 GeneOrGeneProduct denotes OPRM1
T7 411-420 GeneOrGeneProduct denotes frequency
T8 490-494 GeneOrGeneProduct denotes mRNA
T9 509-514 GeneOrGeneProduct denotes OPRM1
T10 532-537 GeneOrGeneProduct denotes brain
T11 617-621 GeneOrGeneProduct denotes mRNA
T12 637-640 GeneOrGeneProduct denotes 2.5
T13 641-645 GeneOrGeneProduct denotes fold
T14 669-673 GeneOrGeneProduct denotes G118
T15 716-721 GeneOrGeneProduct denotes ovary
T16 722-727 GeneOrGeneProduct denotes cells
T17 733-737 GeneOrGeneProduct denotes cDNA
T18 777-782 GeneOrGeneProduct denotes OPRM1
T19 872-876 GeneOrGeneProduct denotes fold
T20 883-887 GeneOrGeneProduct denotes mRNA
T21 904-909 GeneOrGeneProduct denotes OPRM1
T22 910-914 GeneOrGeneProduct denotes G118
T23 933-937 GeneOrGeneProduct denotes fold
T24 944-949 GeneOrGeneProduct denotes OPRM1
T25 950-957 GeneOrGeneProduct denotes protein
T26 986-994 GeneOrGeneProduct denotes blotting
T27 999-1015 GeneOrGeneProduct denotes receptor binding
T28 1060-1073 GeneOrGeneProduct denotes transcription
T29 1106-1110 GeneOrGeneProduct denotes mRNA
T30 1152-1156 GeneOrGeneProduct denotes mRNA
T31 1184-1188 GeneOrGeneProduct denotes G118
T32 1211-1217 GeneOrGeneProduct denotes defect
T33 1221-1234 GeneOrGeneProduct denotes transcription
T34 1238-1242 GeneOrGeneProduct denotes mRNA
T35 1243-1253 GeneOrGeneProduct denotes maturation
T36 1283-1288 GeneOrGeneProduct denotes OPRM1
T37 1289-1293 GeneOrGeneProduct denotes G118
T38 1351-1355 GeneOrGeneProduct denotes mRNA
T39 1360-1367 GeneOrGeneProduct denotes protein
T40 1368-1373 GeneOrGeneProduct denotes yield

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 38-56 GeneOrGeneProduct denotes mu opioid receptor
T2 58-63 GeneOrGeneProduct denotes OPRM1
T3 145-163 GeneOrGeneProduct denotes mu opioid receptor
T4 165-170 GeneOrGeneProduct denotes OPRM1
T5 192-196 GeneOrGeneProduct denotes pain
T6 243-248 GeneOrGeneProduct denotes OPRM1
T7 411-420 GeneOrGeneProduct denotes frequency
T8 490-494 GeneOrGeneProduct denotes mRNA
T9 509-514 GeneOrGeneProduct denotes OPRM1
T10 532-537 GeneOrGeneProduct denotes brain
T11 617-621 GeneOrGeneProduct denotes mRNA
T12 641-645 GeneOrGeneProduct denotes fold
T13 733-737 GeneOrGeneProduct denotes cDNA
T14 777-782 GeneOrGeneProduct denotes OPRM1
T15 872-876 GeneOrGeneProduct denotes fold
T16 883-887 GeneOrGeneProduct denotes mRNA
T17 904-909 GeneOrGeneProduct denotes OPRM1
T18 933-937 GeneOrGeneProduct denotes fold
T19 944-949 GeneOrGeneProduct denotes OPRM1
T20 950-957 GeneOrGeneProduct denotes protein
T21 999-1015 GeneOrGeneProduct denotes receptor binding
T22 1060-1073 GeneOrGeneProduct denotes transcription
T23 1106-1110 GeneOrGeneProduct denotes mRNA
T24 1152-1156 GeneOrGeneProduct denotes mRNA
T25 1221-1234 GeneOrGeneProduct denotes transcription
T26 1238-1242 GeneOrGeneProduct denotes mRNA
T27 1243-1253 GeneOrGeneProduct denotes maturation
T28 1283-1288 GeneOrGeneProduct denotes OPRM1
T29 1351-1355 GeneOrGeneProduct denotes mRNA
T30 1360-1367 GeneOrGeneProduct denotes protein

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 192-196 DiseaseOrPhenotypicFeature denotes pain D010146
T2 291-305 DiseaseOrPhenotypicFeature denotes drug addiction D019966
T3 1489-1503 DiseaseOrPhenotypicFeature denotes drug addiction D019966

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 38-56 GeneOrGeneProduct denotes mu opioid receptor
T2 58-63 GeneOrGeneProduct denotes OPRM1
T3 145-163 GeneOrGeneProduct denotes mu opioid receptor
T4 165-170 GeneOrGeneProduct denotes OPRM1
T5 243-248 GeneOrGeneProduct denotes OPRM1
T6 509-514 GeneOrGeneProduct denotes OPRM1
T7 777-782 GeneOrGeneProduct denotes OPRM1
T8 904-909 GeneOrGeneProduct denotes OPRM1
T9 944-949 GeneOrGeneProduct denotes OPRM1
T10 999-1015 GeneOrGeneProduct denotes receptor binding
T11 1283-1288 GeneOrGeneProduct denotes OPRM1
T12 1360-1373 GeneOrGeneProduct denotes protein yield

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 1211-1217 DiseaseOrPhenotypicFeature denotes defect 0008568

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 192-196 DiseaseOrPhenotypicFeature denotes pain D010146
T2 291-305 DiseaseOrPhenotypicFeature denotes drug addiction D019966
T3 1489-1503 DiseaseOrPhenotypicFeature denotes drug addiction D019966

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 192-196 DiseaseOrPhenotypicFeature denotes pain D010146
T2 291-305 DiseaseOrPhenotypicFeature denotes drug addiction D019966
T3 1489-1503 DiseaseOrPhenotypicFeature denotes drug addiction D019966

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 41-47 ChemicalEntity denotes opioid ChemicalEntity
T2 114-120 ChemicalEntity denotes opioid ChemicalEntity
T3 148-154 ChemicalEntity denotes opioid ChemicalEntity
T4 793-802 ChemicalEntity denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T5 804-813 ChemicalEntity denotes guanosine http://purl.obolibrary.org/obo/CHEBI_16750
T6 815-823 ChemicalEntity denotes cytidine http://purl.obolibrary.org/obo/CHEBI_17562
T7 829-838 ChemicalEntity denotes thymidine http://purl.obolibrary.org/obo/CHEBI_17748
T8 1079-1092 ChemicalEntity denotes actinomycin D http://purl.obolibrary.org/obo/CHEBI_27666

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 32-37 OrganismTaxon denotes human
T2 518-523 OrganismTaxon denotes human
T3 700-715 OrganismTaxon denotes Chinese hamster

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T8 1079-1092 ChemicalEntity denotes actinomycin D http://purl.obolibrary.org/obo/CHEBI_27666
T7 829-838 ChemicalEntity denotes thymidine http://purl.obolibrary.org/obo/CHEBI_17748
T6 815-823 ChemicalEntity denotes cytidine http://purl.obolibrary.org/obo/CHEBI_17562
T5 804-813 ChemicalEntity denotes guanosine http://purl.obolibrary.org/obo/CHEBI_16750
T4 793-802 ChemicalEntity denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T3 148-154 ChemicalEntity denotes opioid ChemicalEntity
T2 114-120 ChemicalEntity denotes opioid ChemicalEntity
T1 41-47 ChemicalEntity denotes opioid ChemicalEntity
T12 1360-1373 GeneOrGeneProduct denotes protein yield
T11 1283-1288 GeneOrGeneProduct denotes OPRM1
T10 999-1015 GeneOrGeneProduct denotes receptor binding
T9 944-949 GeneOrGeneProduct denotes OPRM1
T70344 904-909 GeneOrGeneProduct denotes OPRM1
T15751 777-782 GeneOrGeneProduct denotes OPRM1
T91671 509-514 GeneOrGeneProduct denotes OPRM1
T69329 243-248 GeneOrGeneProduct denotes OPRM1
T54124 165-170 GeneOrGeneProduct denotes OPRM1
T37196 145-163 GeneOrGeneProduct denotes mu opioid receptor
T54143 58-63 GeneOrGeneProduct denotes OPRM1
T90514 38-56 GeneOrGeneProduct denotes mu opioid receptor
T33767 1489-1503 DiseaseOrPhenotypicFeature denotes drug addiction D019966
T54283 291-305 DiseaseOrPhenotypicFeature denotes drug addiction D019966
T55915 192-196 DiseaseOrPhenotypicFeature denotes pain D010146
T95427 700-715 OrganismTaxon denotes Chinese hamster
T15877 518-523 OrganismTaxon denotes human
T17666 32-37 OrganismTaxon denotes human
T68936 553-558 SequenceVariant denotes A118G
T98893 377-381 SequenceVariant denotes N40D
T65631 356-361 SequenceVariant denotes A118G
T75308 83-88 SequenceVariant denotes A118G

sentences

Id Subject Object Predicate Lexical cue
T1 0-89 Sentence denotes Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.
T2 90-222 Sentence denotes As a primary target for opioid drugs and peptides, the mu opioid receptor (OPRM1) plays a key role in pain perception and addiction.
T3 223-456 Sentence denotes Genetic variants of OPRM1 have been implicated in predisposition to drug addiction, in particular the single nucleotide polymorphism A118G, leading to an N40D substitution, with an allele frequency of 10-32%, and uncertain functions.
T4 457-571 Sentence denotes We have measured allele-specific mRNA expression of OPRM1 in human autopsy brain tissues, using A118G as a marker.
T5 572-681 Sentence denotes In 8 heterozygous samples measured, the A118 mRNA allele was 1.5-2.5-fold more abundant than the G118 allele.
T6 682-1022 Sentence denotes Transfection into Chinese hamster ovary cells of a cDNA representing only the coding region of OPRM1, carrying adenosine, guanosine, cytidine, and thymidine in position 118, resulted in 1.5-fold lower mRNA levels only for OPRM1-G118, and more than 10-fold lower OPRM1 protein levels, measured by Western blotting and receptor binding assay.
T7 1023-1254 Sentence denotes After transfection and inhibition of transcription with actinomycin D, analysis of mRNA turnover failed to reveal differences in mRNA stability between A118 and G118 alleles, indicating a defect in transcription or mRNA maturation.
T8 1255-1374 Sentence denotes These results indicate that OPRM1-G118 is a functional variant with deleterious effects on both mRNA and protein yield.
T9 1375-1559 Sentence denotes Clarifying the functional relevance of polymorphisms associated with susceptibility to a complex disorder such as drug addiction provides a foundation for clinical association studies.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 532-537 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 192-196 HP_0012531 denotes pain

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
16046395-2#133#138#geners1799971 356-361 geners1799971 denotes A118G
16046395-2#68#82#diseaseC1510472 291-305 diseaseC1510472 denotes drug addiction
133#138#geners179997168#82#diseaseC1510472 16046395-2#133#138#geners1799971 16046395-2#68#82#diseaseC1510472 associated_with A118G,drug addiction

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
16046395-1#55#73#gene4988 145-163 gene4988 denotes mu opioid receptor
16046395-1#75#80#gene4988 165-170 gene4988 denotes OPRM1
16046395-1#102#106#diseaseC0030193 192-196 diseaseC0030193 denotes pain
16046395-1#122#131#diseaseC0085281 212-221 diseaseC0085281 denotes addiction
16046395-1#102#106#diseaseC0030193 192-196 diseaseC0030193 denotes pain
16046395-1#122#131#diseaseC0085281 212-221 diseaseC0085281 denotes addiction
16046395-2#20#25#gene4988 243-248 gene4988 denotes OPRM1
16046395-2#68#82#diseaseC1510472 291-305 diseaseC1510472 denotes drug addiction
55#73#gene4988102#106#diseaseC0030193 16046395-1#55#73#gene4988 16046395-1#102#106#diseaseC0030193 associated_with mu opioid receptor,pain
55#73#gene4988122#131#diseaseC0085281 16046395-1#55#73#gene4988 16046395-1#122#131#diseaseC0085281 associated_with mu opioid receptor,addiction
55#73#gene4988102#106#diseaseC0030193 16046395-1#55#73#gene4988 16046395-1#102#106#diseaseC0030193 associated_with mu opioid receptor,pain
55#73#gene4988122#131#diseaseC0085281 16046395-1#55#73#gene4988 16046395-1#122#131#diseaseC0085281 associated_with mu opioid receptor,addiction
75#80#gene4988102#106#diseaseC0030193 16046395-1#75#80#gene4988 16046395-1#102#106#diseaseC0030193 associated_with OPRM1,pain
75#80#gene4988122#131#diseaseC0085281 16046395-1#75#80#gene4988 16046395-1#122#131#diseaseC0085281 associated_with OPRM1,addiction
75#80#gene4988102#106#diseaseC0030193 16046395-1#75#80#gene4988 16046395-1#102#106#diseaseC0030193 associated_with OPRM1,pain
75#80#gene4988122#131#diseaseC0085281 16046395-1#75#80#gene4988 16046395-1#122#131#diseaseC0085281 associated_with OPRM1,addiction
20#25#gene498868#82#diseaseC1510472 16046395-2#20#25#gene4988 16046395-2#68#82#diseaseC1510472 associated_with OPRM1,drug addiction

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 83-88 DNAMutation:c|SUB|A|118|G denotes A118G
T2 356-361 DNAMutation:c|SUB|A|118|G denotes A118G
T3 377-381 ProteinMutation:p|SUB|N|40|D denotes N40D
T4 553-558 DNAMutation:c|SUB|A|118|G denotes A118G

DisGeNET

Id Subject Object Predicate Lexical cue
T0 165-170 gene:4988 denotes OPRM1
T1 212-221 disease:C0085281 denotes addiction
T2 145-163 gene:4988 denotes mu opioid receptor
T3 212-221 disease:C0085281 denotes addiction
T4 243-248 gene:4988 denotes OPRM1
T5 291-305 disease:C1510472 denotes drug addiction
T6 243-248 gene:4988 denotes OPRM1
T7 291-305 disease:C0038580 denotes drug addiction
R1 T0 T1 associated_with OPRM1,addiction
R2 T2 T3 associated_with mu opioid receptor,addiction
R3 T4 T5 associated_with OPRM1,drug addiction
R4 T6 T7 associated_with OPRM1,drug addiction

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 532-537 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 192-196 Phenotype denotes pain HP:0012531
T2 291-305 Phenotype denotes drug addiction HP:0033511
T3 1489-1503 Phenotype denotes drug addiction HP:0033511

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 32-37 OrganismTaxon denotes human 9606
T2 518-523 OrganismTaxon denotes human 9606
T3 700-715 OrganismTaxon denotes Chinese hamster 10029

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 532-537 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T3 716-721 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992