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PubMed:16037491 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 161-167 https://glytoucan.org/Structures/Glycans/G00031MO denotes core 1

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 161-167 Glycan_Motif denotes core 1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-122 Sentence denotes Patients with unsolved congenital disorders of glycosylation type II can be subdivided in six distinct biochemical groups.
TextSentencer_T2 123-279 Sentence denotes Defects in the biosynthesis of N- and core 1 O-glycans may be found by isoelectric focusing (IEF) of plasma transferrin and apolipoprotein C-III (apoC-III).
TextSentencer_T3 280-521 Sentence denotes We hypothesized that IEF of transferrin and apoC-III in combination with sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) of apoC-III may provide a classification for congenital disorders of glycosylation (CDG) patients.
TextSentencer_T4 522-646 Sentence denotes We analyzed plasma from 22 patients with eight different and well-characterized CDG subtypes and 19 cases with unsolved CDG.
TextSentencer_T5 647-782 Sentence denotes Transferrin IEF (TIEF) has been used to distinguish between N-glycan assembly (type 1 profile) and processing (type 2 profile) defects.
TextSentencer_T6 783-840 Sentence denotes We differentiated two different CDG type 2 TIEF profiles:
TextSentencer_T7 841-1027 Sentence denotes The "asialo profile" characterized by elevated levels of asialo- and monosialotransferrin and the "disialo profile" characterized by increased levels of disialo- and trisialotransferrin.
TextSentencer_T8 1028-1111 Sentence denotes ApoC-III IEF gave two abnormal profiles ("apoC-III(0)" and "apoC-III(1)" profiles).
TextSentencer_T9 1112-1252 Sentence denotes The results for the eight established CDG forms exactly matched the theoretical expectations, providing a validation for the study approach.
TextSentencer_T10 1253-1407 Sentence denotes The combination of the three electrophoretic techniques was not additionally informative for the CDG-Ix patients as they had normal apoC-III IEF patterns.
TextSentencer_T11 1408-1497 Sentence denotes However, the CDG-IIx patients could be further subdivided into six biochemical subgroups.
TextSentencer_T12 1498-1736 Sentence denotes The robustness of the methodology was supported by the fact that three patients with similar clinical features ended in the same subgroup and that another patient, classified in the "CDG-IIe subgroup," turned out to have a similar defect.
TextSentencer_T13 1737-1922 Sentence denotes Dividing the CDG-IIx patients in six subgroups narrows down drastically the options of the primary defect in each of the subgroups and will be helpful to define new CDG type II defects.
T1 0-122 Sentence denotes Patients with unsolved congenital disorders of glycosylation type II can be subdivided in six distinct biochemical groups.
T2 123-279 Sentence denotes Defects in the biosynthesis of N- and core 1 O-glycans may be found by isoelectric focusing (IEF) of plasma transferrin and apolipoprotein C-III (apoC-III).
T3 280-521 Sentence denotes We hypothesized that IEF of transferrin and apoC-III in combination with sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) of apoC-III may provide a classification for congenital disorders of glycosylation (CDG) patients.
T4 522-646 Sentence denotes We analyzed plasma from 22 patients with eight different and well-characterized CDG subtypes and 19 cases with unsolved CDG.
T5 647-782 Sentence denotes Transferrin IEF (TIEF) has been used to distinguish between N-glycan assembly (type 1 profile) and processing (type 2 profile) defects.
T6 783-840 Sentence denotes We differentiated two different CDG type 2 TIEF profiles:
T7 841-1027 Sentence denotes The "asialo profile" characterized by elevated levels of asialo- and monosialotransferrin and the "disialo profile" characterized by increased levels of disialo- and trisialotransferrin.
T8 1028-1111 Sentence denotes ApoC-III IEF gave two abnormal profiles ("apoC-III(0)" and "apoC-III(1)" profiles).
T9 1112-1252 Sentence denotes The results for the eight established CDG forms exactly matched the theoretical expectations, providing a validation for the study approach.
T10 1253-1407 Sentence denotes The combination of the three electrophoretic techniques was not additionally informative for the CDG-Ix patients as they had normal apoC-III IEF patterns.
T11 1408-1497 Sentence denotes However, the CDG-IIx patients could be further subdivided into six biochemical subgroups.
T12 1498-1736 Sentence denotes The robustness of the methodology was supported by the fact that three patients with similar clinical features ended in the same subgroup and that another patient, classified in the "CDG-IIe subgroup," turned out to have a similar defect.
T13 1737-1922 Sentence denotes Dividing the CDG-IIx patients in six subgroups narrows down drastically the options of the primary defect in each of the subgroups and will be helpful to define new CDG type II defects.
T1 0-122 Sentence denotes Patients with unsolved congenital disorders of glycosylation type II can be subdivided in six distinct biochemical groups.
T2 123-279 Sentence denotes Defects in the biosynthesis of N- and core 1 O-glycans may be found by isoelectric focusing (IEF) of plasma transferrin and apolipoprotein C-III (apoC-III).
T3 280-521 Sentence denotes We hypothesized that IEF of transferrin and apoC-III in combination with sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) of apoC-III may provide a classification for congenital disorders of glycosylation (CDG) patients.
T4 522-646 Sentence denotes We analyzed plasma from 22 patients with eight different and well-characterized CDG subtypes and 19 cases with unsolved CDG.
T5 647-782 Sentence denotes Transferrin IEF (TIEF) has been used to distinguish between N-glycan assembly (type 1 profile) and processing (type 2 profile) defects.
T6 783-840 Sentence denotes We differentiated two different CDG type 2 TIEF profiles:
T7 841-1027 Sentence denotes The "asialo profile" characterized by elevated levels of asialo- and monosialotransferrin and the "disialo profile" characterized by increased levels of disialo- and trisialotransferrin.
T8 1028-1111 Sentence denotes ApoC-III IEF gave two abnormal profiles ("apoC-III(0)" and "apoC-III(1)" profiles).
T9 1112-1252 Sentence denotes The results for the eight established CDG forms exactly matched the theoretical expectations, providing a validation for the study approach.
T10 1253-1407 Sentence denotes The combination of the three electrophoretic techniques was not additionally informative for the CDG-Ix patients as they had normal apoC-III IEF patterns.
T11 1408-1497 Sentence denotes However, the CDG-IIx patients could be further subdivided into six biochemical subgroups.
T12 1498-1736 Sentence denotes The robustness of the methodology was supported by the fact that three patients with similar clinical features ended in the same subgroup and that another patient, classified in the "CDG-IIe subgroup," turned out to have a similar defect.
T13 1737-1922 Sentence denotes Dividing the CDG-IIx patients in six subgroups narrows down drastically the options of the primary defect in each of the subgroups and will be helpful to define new CDG type II defects.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 161-167 https://glytoucan.org/Structures/Glycans/G00031MO denotes core 1

GlycoBiology-GDGDB

Id Subject Object Predicate Lexical cue
_T1 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00621 denotes congenital disorders of glycosylation type
_T2 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00360 denotes congenital disorders of glycosylation type
_T3 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00343 denotes congenital disorders of glycosylation type
_T4 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00627 denotes congenital disorders of glycosylation type
_T5 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00344 denotes congenital disorders of glycosylation type
_T6 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00626 denotes congenital disorders of glycosylation type
_T7 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00345 denotes congenital disorders of glycosylation type
_T8 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00367 denotes congenital disorders of glycosylation type
_T9 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00346 denotes congenital disorders of glycosylation type
_T10 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00365 denotes congenital disorders of glycosylation type
_T11 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00347 denotes congenital disorders of glycosylation type
_T12 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00364 denotes congenital disorders of glycosylation type
_T13 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00348 denotes congenital disorders of glycosylation type
_T14 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00363 denotes congenital disorders of glycosylation type
_T15 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00349 denotes congenital disorders of glycosylation type
_T16 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00362 denotes congenital disorders of glycosylation type
_T17 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00622 denotes congenital disorders of glycosylation type
_T18 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00361 denotes congenital disorders of glycosylation type
_T19 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00620 denotes congenital disorders of glycosylation type
_T20 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00359 denotes congenital disorders of glycosylation type
_T21 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00352 denotes congenital disorders of glycosylation type
_T22 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00358 denotes congenital disorders of glycosylation type
_T23 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00353 denotes congenital disorders of glycosylation type
_T24 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00625 denotes congenital disorders of glycosylation type
_T25 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00354 denotes congenital disorders of glycosylation type
_T26 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00624 denotes congenital disorders of glycosylation type
_T27 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00355 denotes congenital disorders of glycosylation type
_T28 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00623 denotes congenital disorders of glycosylation type
_T29 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00356 denotes congenital disorders of glycosylation type
_T30 23-65 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00350 denotes congenital disorders of glycosylation type
_T31 23-68 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00351 denotes congenital disorders of glycosylation type II
_T32 23-68 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00343 denotes congenital disorders of glycosylation type II
_T33 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00620 denotes congenital disorders of glycosylation
_T34 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00621 denotes congenital disorders of glycosylation
_T35 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00356 denotes congenital disorders of glycosylation
_T36 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00622 denotes congenital disorders of glycosylation
_T37 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00355 denotes congenital disorders of glycosylation
_T38 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00623 denotes congenital disorders of glycosylation
_T39 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00354 denotes congenital disorders of glycosylation
_T40 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00624 denotes congenital disorders of glycosylation
_T41 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00353 denotes congenital disorders of glycosylation
_T42 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00625 denotes congenital disorders of glycosylation
_T43 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00352 denotes congenital disorders of glycosylation
_T44 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00358 denotes congenital disorders of glycosylation
_T45 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00351 denotes congenital disorders of glycosylation
_T46 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00359 denotes congenital disorders of glycosylation
_T47 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00350 denotes congenital disorders of glycosylation
_T48 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00361 denotes congenital disorders of glycosylation
_T49 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00349 denotes congenital disorders of glycosylation
_T50 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00343 denotes congenital disorders of glycosylation
_T51 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00348 denotes congenital disorders of glycosylation
_T52 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00363 denotes congenital disorders of glycosylation
_T53 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00347 denotes congenital disorders of glycosylation
_T54 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00364 denotes congenital disorders of glycosylation
_T55 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00346 denotes congenital disorders of glycosylation
_T56 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00365 denotes congenital disorders of glycosylation
_T57 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00345 denotes congenital disorders of glycosylation
_T58 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00367 denotes congenital disorders of glycosylation
_T59 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00344 denotes congenital disorders of glycosylation
_T60 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00626 denotes congenital disorders of glycosylation
_T61 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00627 denotes congenital disorders of glycosylation
_T62 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00360 denotes congenital disorders of glycosylation
_T63 468-505 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00362 denotes congenital disorders of glycosylation
_T64 1681-1688 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00362 denotes CDG-IIe
_T65 1681-1688 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00347 denotes CDG-IIe

uniprot-human

Id Subject Object Predicate Lexical cue
T1 231-242 http://www.uniprot.org/uniprot/P02787 denotes transferrin
T2 308-319 http://www.uniprot.org/uniprot/P02787 denotes transferrin
T3 647-658 http://www.uniprot.org/uniprot/P02787 denotes Transferrin
T4 247-261 http://www.uniprot.org/uniprot/P08519 denotes apolipoprotein
T5 264-273 http://www.uniprot.org/uniprot/P02656 denotes III (apoC
T6 324-332 http://www.uniprot.org/uniprot/P02656 denotes apoC-III
T7 426-434 http://www.uniprot.org/uniprot/P02656 denotes apoC-III
T8 1070-1078 http://www.uniprot.org/uniprot/P02656 denotes apoC-III
T9 1088-1096 http://www.uniprot.org/uniprot/P02656 denotes apoC-III
T10 1385-1393 http://www.uniprot.org/uniprot/P02656 denotes apoC-III
T11 413-416 http://www.uniprot.org/uniprot/P20132 denotes SDS

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 231-242 http://www.uniprot.org/uniprot/Q63915 denotes transferrin
T2 308-319 http://www.uniprot.org/uniprot/Q63915 denotes transferrin
T3 647-658 http://www.uniprot.org/uniprot/Q63915 denotes Transferrin
T4 264-273 http://www.uniprot.org/uniprot/P33622 denotes III (apoC
T5 324-332 http://www.uniprot.org/uniprot/P33622 denotes apoC-III
T6 426-434 http://www.uniprot.org/uniprot/P33622 denotes apoC-III
T7 1070-1078 http://www.uniprot.org/uniprot/P33622 denotes apoC-III
T8 1088-1096 http://www.uniprot.org/uniprot/P33622 denotes apoC-III
T9 1385-1393 http://www.uniprot.org/uniprot/P33622 denotes apoC-III

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 115-121 http://purl.bioontology.org/ontology/STY/T096 denotes groups
T2 1282-1297 http://purl.bioontology.org/ontology/NCBITAXON/8004 denotes electrophoretic

GO-BP

Id Subject Object Predicate Lexical cue
T1 47-60 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T2 492-505 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T3 138-150 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T4 247-261 http://purl.obolibrary.org/obo/GO_0005319 denotes apolipoprotein
T5 368-376 http://purl.obolibrary.org/obo/GO_0051923 denotes sulphate

GO-CC

Id Subject Object Predicate Lexical cue
T1 161-165 http://purl.obolibrary.org/obo/GO_0019013 denotes core

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 247-261 http://edamontology.org/topic_2232 denotes apolipoprotein
T2 247-261 http://edamontology.org/topic_0820 denotes apolipoprotein
T3 449-463 http://edamontology.org/topic_2230 denotes classification
T4 716-724 http://edamontology.org/topic_0196 denotes assembly
T5 1237-1242 http://edamontology.org/topic_3678 denotes study

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 449-463 http://edamontology.org/operation_2990 denotes classification
T2 716-724 http://edamontology.org/operation_3433 denotes assembly
T3 746-756 http://edamontology.org/operation_0004 denotes processing
T4 746-756 http://edamontology.org/operation_2409 denotes processing
T5 1168-1175 http://edamontology.org/format_1990 denotes matched
T6 1218-1228 http://edamontology.org/operation_2428 denotes validation
T7 1378-1384 http://edamontology.org/operation_3435 denotes normal
T8 1600-1608 http://edamontology.org/data_1255 denotes features

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
16037491-2#44#52#gene345 324-332 gene345 denotes apoC-III
16037491-2#133#136#gene10993 413-416 gene10993 denotes SDS
16037491-2#146#154#gene345 426-434 gene345 denotes apoC-III
16037491-2#188#225#diseaseC0282577 468-505 diseaseC0282577 denotes congenital disorders of glycosylation
16037491-2#227#230#diseaseC0282577 507-510 diseaseC0282577 denotes CDG
16037491-2#188#225#diseaseC0282577 468-505 diseaseC0282577 denotes congenital disorders of glycosylation
16037491-2#227#230#diseaseC0282577 507-510 diseaseC0282577 denotes CDG
16037491-2#188#225#diseaseC0282577 468-505 diseaseC0282577 denotes congenital disorders of glycosylation
16037491-2#227#230#diseaseC0282577 507-510 diseaseC0282577 denotes CDG
44#52#gene345188#225#diseaseC0282577 16037491-2#44#52#gene345 16037491-2#188#225#diseaseC0282577 associated_with apoC-III,congenital disorders of glycosylation
44#52#gene345227#230#diseaseC0282577 16037491-2#44#52#gene345 16037491-2#227#230#diseaseC0282577 associated_with apoC-III,CDG
44#52#gene345188#225#diseaseC0282577 16037491-2#44#52#gene345 16037491-2#188#225#diseaseC0282577 associated_with apoC-III,congenital disorders of glycosylation
44#52#gene345227#230#diseaseC0282577 16037491-2#44#52#gene345 16037491-2#227#230#diseaseC0282577 associated_with apoC-III,CDG
44#52#gene345188#225#diseaseC0282577 16037491-2#44#52#gene345 16037491-2#188#225#diseaseC0282577 associated_with apoC-III,congenital disorders of glycosylation
44#52#gene345227#230#diseaseC0282577 16037491-2#44#52#gene345 16037491-2#227#230#diseaseC0282577 associated_with apoC-III,CDG
133#136#gene10993188#225#diseaseC0282577 16037491-2#133#136#gene10993 16037491-2#188#225#diseaseC0282577 associated_with SDS,congenital disorders of glycosylation
133#136#gene10993227#230#diseaseC0282577 16037491-2#133#136#gene10993 16037491-2#227#230#diseaseC0282577 associated_with SDS,CDG
133#136#gene10993188#225#diseaseC0282577 16037491-2#133#136#gene10993 16037491-2#188#225#diseaseC0282577 associated_with SDS,congenital disorders of glycosylation
133#136#gene10993227#230#diseaseC0282577 16037491-2#133#136#gene10993 16037491-2#227#230#diseaseC0282577 associated_with SDS,CDG
133#136#gene10993188#225#diseaseC0282577 16037491-2#133#136#gene10993 16037491-2#188#225#diseaseC0282577 associated_with SDS,congenital disorders of glycosylation
133#136#gene10993227#230#diseaseC0282577 16037491-2#133#136#gene10993 16037491-2#227#230#diseaseC0282577 associated_with SDS,CDG
146#154#gene345188#225#diseaseC0282577 16037491-2#146#154#gene345 16037491-2#188#225#diseaseC0282577 associated_with apoC-III,congenital disorders of glycosylation
146#154#gene345227#230#diseaseC0282577 16037491-2#146#154#gene345 16037491-2#227#230#diseaseC0282577 associated_with apoC-III,CDG
146#154#gene345188#225#diseaseC0282577 16037491-2#146#154#gene345 16037491-2#188#225#diseaseC0282577 associated_with apoC-III,congenital disorders of glycosylation
146#154#gene345227#230#diseaseC0282577 16037491-2#146#154#gene345 16037491-2#227#230#diseaseC0282577 associated_with apoC-III,CDG
146#154#gene345188#225#diseaseC0282577 16037491-2#146#154#gene345 16037491-2#188#225#diseaseC0282577 associated_with apoC-III,congenital disorders of glycosylation
146#154#gene345227#230#diseaseC0282577 16037491-2#146#154#gene345 16037491-2#227#230#diseaseC0282577 associated_with apoC-III,CDG

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 707-715 http://rdf.glycoinfo.org/glycan/G00027MO denotes N-glycan

DisGeNET

Id Subject Object Predicate Lexical cue
T0 324-332 gene:345 denotes apoC-III
T1 468-505 disease:C0282577 denotes congenital disorders of glycosylation
T2 324-332 gene:345 denotes apoC-III
T3 507-510 disease:C0282577 denotes CDG
T4 413-416 gene:51119 denotes SDS
T5 468-505 disease:C0282577 denotes congenital disorders of glycosylation
T6 413-416 gene:10993 denotes SDS
T7 468-505 disease:C0282577 denotes congenital disorders of glycosylation
T8 426-434 gene:345 denotes apoC-III
T9 468-505 disease:C0282577 denotes congenital disorders of glycosylation
T10 426-434 gene:345 denotes apoC-III
T11 507-510 disease:C0282577 denotes CDG
R1 T0 T1 associated_with apoC-III,congenital disorders of glycosylation
R2 T2 T3 associated_with apoC-III,CDG
R3 T4 T5 associated_with SDS,congenital disorders of glycosylation
R4 T6 T7 associated_with SDS,congenital disorders of glycosylation
R5 T8 T9 associated_with apoC-III,congenital disorders of glycosylation
R6 T10 T11 associated_with apoC-III,CDG

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 161-167 Glycan denotes core 1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 23-68 Disease denotes congenital disorders of glycosylation type II http://purl.obolibrary.org/obo/MONDO_0005501
T2 468-505 Disease denotes congenital disorders of glycosylation http://purl.obolibrary.org/obo/MONDO_0015286
T3 507-510 Disease denotes CDG http://purl.obolibrary.org/obo/MONDO_0015286
T4 602-605 Disease denotes CDG http://purl.obolibrary.org/obo/MONDO_0015286
T5 642-645 Disease denotes CDG http://purl.obolibrary.org/obo/MONDO_0015286
T6 815-818 Disease denotes CDG http://purl.obolibrary.org/obo/MONDO_0015286
T7 1150-1153 Disease denotes CDG http://purl.obolibrary.org/obo/MONDO_0015286
T8 1350-1356 Disease denotes CDG-Ix http://purl.obolibrary.org/obo/MONDO_0014271
T9 1350-1353 Disease denotes CDG http://purl.obolibrary.org/obo/MONDO_0015286
T10 1421-1424 Disease denotes CDG http://purl.obolibrary.org/obo/MONDO_0015286
T11 1681-1688 Disease denotes CDG-IIe http://purl.obolibrary.org/obo/MONDO_0012118
T12 1681-1684 Disease denotes CDG http://purl.obolibrary.org/obo/MONDO_0015286
T13 1750-1753 Disease denotes CDG http://purl.obolibrary.org/obo/MONDO_0015286
T14 1902-1905 Disease denotes CDG http://purl.obolibrary.org/obo/MONDO_0015286

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 161-167 Glycan denotes core 1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 224-230 Body_part denotes plasma http://purl.obolibrary.org/obo/UBERON_0001969
T2 534-540 Body_part denotes plasma http://purl.obolibrary.org/obo/UBERON_0001969

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 23-68 Disease denotes congenital disorders of glycosylation type II MONDO:0005501
T2 468-505 Disease denotes congenital disorders of glycosylation MONDO:0015286
T3 507-510 Disease denotes CDG MONDO:0015286
T4 602-605 Disease denotes CDG MONDO:0015286
T5 642-645 Disease denotes CDG MONDO:0015286
T6 815-818 Disease denotes CDG MONDO:0015286
T7 1150-1153 Disease denotes CDG MONDO:0015286
T8 1350-1356 Disease denotes CDG-Ix MONDO:0014271
T9 1350-1353 Disease denotes CDG MONDO:0015286
T10 1421-1424 Disease denotes CDG MONDO:0015286
T11 1681-1688 Disease denotes CDG-IIe MONDO:0012118
T12 1681-1684 Disease denotes CDG MONDO:0015286
T13 1750-1753 Disease denotes CDG MONDO:0015286
T14 1902-1905 Disease denotes CDG MONDO:0015286

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 0-8 Organism denotes Patients 9606
T2 512-520 Organism denotes patients 9606
T3 549-557 Organism denotes patients 9606
T4 1357-1365 Organism denotes patients 9606
T5 1429-1437 Organism denotes patients 9606
T6 1569-1577 Organism denotes patients 9606
T7 1653-1660 Organism denotes patient 9606
T8 1758-1766 Organism denotes patients 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-122 Sentence denotes Patients with unsolved congenital disorders of glycosylation type II can be subdivided in six distinct biochemical groups.
T2 123-279 Sentence denotes Defects in the biosynthesis of N- and core 1 O-glycans may be found by isoelectric focusing (IEF) of plasma transferrin and apolipoprotein C-III (apoC-III).
T3 280-521 Sentence denotes We hypothesized that IEF of transferrin and apoC-III in combination with sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) of apoC-III may provide a classification for congenital disorders of glycosylation (CDG) patients.
T4 522-646 Sentence denotes We analyzed plasma from 22 patients with eight different and well-characterized CDG subtypes and 19 cases with unsolved CDG.
T5 647-782 Sentence denotes Transferrin IEF (TIEF) has been used to distinguish between N-glycan assembly (type 1 profile) and processing (type 2 profile) defects.
T6 783-840 Sentence denotes We differentiated two different CDG type 2 TIEF profiles:
T7 841-1027 Sentence denotes The "asialo profile" characterized by elevated levels of asialo- and monosialotransferrin and the "disialo profile" characterized by increased levels of disialo- and trisialotransferrin.
T8 1028-1111 Sentence denotes ApoC-III IEF gave two abnormal profiles ("apoC-III(0)" and "apoC-III(1)" profiles).
T9 1112-1252 Sentence denotes The results for the eight established CDG forms exactly matched the theoretical expectations, providing a validation for the study approach.
T10 1253-1407 Sentence denotes The combination of the three electrophoretic techniques was not additionally informative for the CDG-Ix patients as they had normal apoC-III IEF patterns.
T11 1408-1497 Sentence denotes However, the CDG-IIx patients could be further subdivided into six biochemical subgroups.
T12 1498-1736 Sentence denotes The robustness of the methodology was supported by the fact that three patients with similar clinical features ended in the same subgroup and that another patient, classified in the "CDG-IIe subgroup," turned out to have a similar defect.
T13 1737-1922 Sentence denotes Dividing the CDG-IIx patients in six subgroups narrows down drastically the options of the primary defect in each of the subgroups and will be helpful to define new CDG type II defects.

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 224-230 Body_part denotes plasma FMA:62970
T2 534-540 Body_part denotes plasma FMA:62970

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1653-1660 OrganismTaxon denotes patient 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 224-230 Body_part denotes plasma http://purl.obolibrary.org/obo/UBERON_0001969
T2 534-540 Body_part denotes plasma http://purl.obolibrary.org/obo/UBERON_0001969