PubMed:16033090 JSONTXT

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of Her2/neu, steroid receptors (ER and PR), Ki67 and p53 in invasive mammary ductal carcinoma associated with ductal carcinoma In Situ (DCIS) Versus invasive breast cancer alone.\nAIMS: (a) To assess the expression patterns of HER2/neu, steroid receptors (ER and PR), Ki67 and p53 in invasive ductal cancer (IDC) and IDC associated with carcinoma in situ (IDC/DCIS) and (b) to determine if there is a differential expression of these molecular markers between IDC and IDC/DCIS.\nMATERIALS AND METHODS: Paraffin-fixed breast cancer samples, diagnosed with only one histological invasive tumor (IDC (n=130), and IDC/DCIS (n=36) were analyzed by immunohistochemical means. The non-parametric Mann-Whitney and chi2 tests were used to evaluate any statistical differences between different groups. Significance was assumed at p\u003c0.05.\nRESULTS: A significant increase of the tumor grading was observed between IDC and IDC/DCIS (p\u003c0.05). Her2/neu amplification was demonstrated in 49.6% of IDC compared to 31% of IDC/DCIS (p\u003c0.05). ER expression showed no statistical differences between IDC and IDC/DCIS. The PR expression was demonstrated in 71% of IDC with significantly lower intensity than IDC/DCIS (p\u003c0.05). The Ki67 expression was significantly higher (p\u003c0.05) in IDC cases (64%) versus IDC/DCIS (49.7%). No differences were observed between IDC and IDC/DCIS for p53 expression.\nCONCLUSION: We demonstrated significantly different expression patterns of Her2/neu, PR and Ki67 in IDC versus IDC/DCIS. Since these molecular markers play important roles in carcinogenesis and tumor progression, IDC/DCIS could be an important subtype of mammary invasive ductal cancer. Differences in expression of the evaluated markers might suggest a higher malignant potential of invasive carcinomas alone. The lower expression of Her2/neu and Ki67 in IDC/DCIS could implicate a less malignant behavior compared to a differentiated IDC. Additionally, these results might suggest that DCIS might be a malignant preform and the interaction with neoplastic tissue could result in an aggressive type of invasive tumor."}

{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T1","span":{"begin":0,"end":189},"obj":"DRI_Background"},{"id":"T2","span":{"begin":196,"end":487},"obj":"DRI_Approach"},{"id":"T3","span":{"begin":511,"end":678},"obj":"DRI_Background"},{"id":"T4","span":{"begin":679,"end":801},"obj":"DRI_Approach"},{"id":"T5","span":{"begin":802,"end":837},"obj":"DRI_Unspecified"},{"id":"T6","span":{"begin":847,"end":938},"obj":"DRI_Unspecified"},{"id":"T7","span":{"begin":939,"end":1032},"obj":"DRI_Unspecified"},{"id":"T8","span":{"begin":1033,"end":1106},"obj":"DRI_Approach"},{"id":"T9","span":{"begin":1107,"end":1214},"obj":"DRI_Outcome"},{"id":"T10","span":{"begin":1215,"end":1312},"obj":"DRI_Outcome"},{"id":"T11","span":{"begin":1313,"end":1386},"obj":"DRI_Approach"},{"id":"T12","span":{"begin":1399,"end":1507},"obj":"DRI_Outcome"},{"id":"T13","span":{"begin":1508,"end":1673},"obj":"DRI_Challenge"},{"id":"T14","span":{"begin":1674,"end":1797},"obj":"DRI_Challenge"},{"id":"T15","span":{"begin":1798,"end":1927},"obj":"DRI_Outcome"},{"id":"T16","span":{"begin":1928,"end":2105},"obj":"DRI_Challenge"}],"text":"Expression of Her2/neu, steroid receptors (ER and PR), Ki67 and p53 in invasive mammary ductal carcinoma associated with ductal carcinoma In Situ (DCIS) Versus invasive breast cancer alone.\nAIMS: (a) To assess the expression patterns of HER2/neu, steroid receptors (ER and PR), Ki67 and p53 in invasive ductal cancer (IDC) and IDC associated with carcinoma in situ (IDC/DCIS) and (b) to determine if there is a differential expression of these molecular markers between IDC and IDC/DCIS.\nMATERIALS AND METHODS: Paraffin-fixed breast cancer samples, diagnosed with only one histological invasive tumor (IDC (n=130), and IDC/DCIS (n=36) were analyzed by immunohistochemical means. The non-parametric Mann-Whitney and chi2 tests were used to evaluate any statistical differences between different groups. Significance was assumed at p\u003c0.05.\nRESULTS: A significant increase of the tumor grading was observed between IDC and IDC/DCIS (p\u003c0.05). Her2/neu amplification was demonstrated in 49.6% of IDC compared to 31% of IDC/DCIS (p\u003c0.05). ER expression showed no statistical differences between IDC and IDC/DCIS. The PR expression was demonstrated in 71% of IDC with significantly lower intensity than IDC/DCIS (p\u003c0.05). The Ki67 expression was significantly higher (p\u003c0.05) in IDC cases (64%) versus IDC/DCIS (49.7%). No differences were observed between IDC and IDC/DCIS for p53 expression.\nCONCLUSION: We demonstrated significantly different expression patterns of Her2/neu, PR and Ki67 in IDC versus IDC/DCIS. Since these molecular markers play important roles in carcinogenesis and tumor progression, IDC/DCIS could be an important subtype of mammary invasive ductal cancer. Differences in expression of the evaluated markers might suggest a higher malignant potential of invasive carcinomas alone. The lower expression of Her2/neu and Ki67 in IDC/DCIS could implicate a less malignant behavior compared to a differentiated IDC. Additionally, these results might suggest that DCIS might be a malignant preform and the interaction with neoplastic tissue could result in an aggressive type of invasive tumor."}

{"project":"PubMed_Structured_Abstracts","denotations":[{"id":"T1","span":{"begin":196,"end":487},"obj":"OBJECTIVE"},{"id":"T2","span":{"begin":511,"end":837},"obj":"METHODS"},{"id":"T3","span":{"begin":847,"end":1386},"obj":"RESULTS"},{"id":"T4","span":{"begin":1399,"end":2105},"obj":"CONCLUSIONS"}],"text":"Expression of Her2/neu, steroid receptors (ER and PR), Ki67 and p53 in invasive mammary ductal carcinoma associated with ductal carcinoma In Situ (DCIS) Versus invasive breast cancer alone.\nAIMS: (a) To assess the expression patterns of HER2/neu, steroid receptors (ER and PR), Ki67 and p53 in invasive ductal cancer (IDC) and IDC associated with carcinoma in situ (IDC/DCIS) and (b) to determine if there is a differential expression of these molecular markers between IDC and IDC/DCIS.\nMATERIALS AND METHODS: Paraffin-fixed breast cancer samples, diagnosed with only one histological invasive tumor (IDC (n=130), and IDC/DCIS (n=36) were analyzed by immunohistochemical means. The non-parametric Mann-Whitney and chi2 tests were used to evaluate any statistical differences between different groups. Significance was assumed at p\u003c0.05.\nRESULTS: A significant increase of the tumor grading was observed between IDC and IDC/DCIS (p\u003c0.05). Her2/neu amplification was demonstrated in 49.6% of IDC compared to 31% of IDC/DCIS (p\u003c0.05). ER expression showed no statistical differences between IDC and IDC/DCIS. The PR expression was demonstrated in 71% of IDC with significantly lower intensity than IDC/DCIS (p\u003c0.05). The Ki67 expression was significantly higher (p\u003c0.05) in IDC cases (64%) versus IDC/DCIS (49.7%). No differences were observed between IDC and IDC/DCIS for p53 expression.\nCONCLUSION: We demonstrated significantly different expression patterns of Her2/neu, PR and Ki67 in IDC versus IDC/DCIS. Since these molecular markers play important roles in carcinogenesis and tumor progression, IDC/DCIS could be an important subtype of mammary invasive ductal cancer. Differences in expression of the evaluated markers might suggest a higher malignant potential of invasive carcinomas alone. The lower expression of Her2/neu and Ki67 in IDC/DCIS could implicate a less malignant behavior compared to a differentiated IDC. Additionally, these results might suggest that DCIS might be a malignant preform and the interaction with neoplastic tissue could result in an aggressive type of invasive tumor."}